Process Control in Biomanufacturing
Mary Jane Kurtz
&
George Taliadouros
Minuteman Regional High School
Bioman Conference July 2009
What is Process Control?
• Use of instruments to carry out a process
• Input information : measured variables temperature, oxygen, pH
• Output directions: manipulated variables heat, pressure gauge, valve
Motion and Process Control
• Motion control – position or velocity
• Process control – temperature, pressure, flow, level, pH,humidity, chemical compounds
• Two types of control of either of these– Batch processing– Continuous processing
Driving a Car: An Everyday Example of Process Control
• Control Objective
• Measured variable
• Manipulated variable (or controlled variable)
• Sensor
• Actuator
• Controller
• Disturbance
• Maintain car in lane
• Location on the road
• Steering of car
• Driver’s eyes
• Driver’s arms/steering wheel
• Driver
• Curve in the road
Open Loop Control
• Valve controls flow of water: Open Loop
Closed Loop Control
• Control Process : Closed Loop
Process Control Diagram
Error detector
Error signal controller
Controlleroutput signal
Actuator
Energy or Fuel
Manufacturingprocess
Controlled variable
Measured variable
Disturbances
Measurement devices
FeedbackSignal
Set Point +-
Importance of Process Control for the Bio-Process Industries
• Improved product quality
• Faster and less expensive process validation
• Increased production rates
Biomanufacturing Tanks
DO Control in a Bio-Reactor
Air
AC
Variable SpeedAir Compressor
AT
Setpoint
Controlling a Process
• Using Robolab you will learn how to control a process using a computer
• You will begin with a simple task : How to start and stop a fan
• How to control the variables in the process
• Finally, you will be create a program that will control a greenhouse
RBX Controls
• Inputs are measured variables seen as numbersTemperature sensor
Touch sensor
Light sensor
• Outputs are manipulated variables seen as lettersMotor
light
Time to Try it Out !!!
Go to Robo Lab station
and try to make a fan