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Computer simulationexperiments of effect of
different autonomic drugs onarterial blood pressure & heart
rate of rats
2
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This tracing represents the effect of NA on BP & HR of a dog,
before & after unknown (X). look carefully at the curve & answer
the following questions:
1. Drug (X) most probably would be 2. Explain its own effect on BP & HR.
3. Complete:NA raises the BP by acting on
4. How does drug (X) affect the pressor effect of NA?..
Noradrenaline (X) Noradrenaline
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Epinephrine would cause a decrease in
mean arterial blood pressure if it isadministered after pre-treatment with :
a. A beta 1 antagonist .
b. An alpha 1 antagonist .
c. A beta 2 antagonist .d. A non-selective beta antagonist.
e. Both alpha 1 and beta 1 antagonist
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The receptors mediating Acetylcholine
reversal are:
1. Muscarinic M2 and M3 receptors.
2. Muscarinic M1 and M3 receptors.3. Nicotinic NM receptors.
4. Nicotinic NN receptors.
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Draw a curve to differentiate between the effect of NA &
adrenaline on BP & HR of an anesthetized dog.
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Questions
1. Why Salicylates did not inhibit mouse
hot plate Method response?
2. What is the mechanism of analgesicactivity of morphine?
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Questions
Hotplate method is used for screening of morphine, while
acetic acid induced writhes is used for screening of NSAIDs.
Prostaglandins and bradykinin are mediators of inflammation. Acetyl saliycilic acid is an example of NSAIDs.
Fill in the space:
..
.
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Questions
The hot plate method is suitable for:
1. evaluation of all types of analgesics2. evaluation of non-narcotic analgesics3. evaluation of narcotic analgesics4. screening ofnon-steroidal anti-
inflammatory drugs
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Questions
Fill in the space:
SedationNo. of micelicking/jumping
before after
Drug
absent55Na
salicylate
present15Morphine
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Questions
Match:
a. Licking of the paw.b. a chemical method.c. mediators of inflammationd. an e.g. of narcotic analgesice. writhesf. a thermal methodg. an e.g. of non
narcotic analgesic
Morphine is ( ) Aspirin is ( ) Acetic acid induces ( ) Hot plate is ( )
Prosaglandins are ( ) Assessment of NSAIDs
is by ( )
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DRUGS ACTING ON EYE
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Determine the nature of the drug applied to
the rabbit's eye based on the following data.
DilatedSize of pupil:
AbsentLight reflex:
Intraocular pressure HighOther observation:
NormalConjunctival blood vessels:
1.The drug is most probably ----------------------
2. Name two different mydriatics used clinically and mention twoimportant therapeutic uses?
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A drug of abuse that causesactive mydriasis is:
a) Morphine.b) Cocaine.
c) Dipivefrine.d) Phenylephrine
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A drug of choice for treatment ofopen angle glaucoma in a patientsuffering from bronchial asthmais:a) PG analogue (latanoprost)
b) Mannitolc) Timolold) Pilocarpine
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A topically applied drug to the eye,would induce mydriasis &cyclopelgia is:
a- Phenylephrine.b- Brimonidine
c- Cocaine.d- Tropicamide.
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Mark (F )or (T):
1. Accomodation for near vision is lost bytopical pilocarpine eye drops.2. Cyclopentolate is a longer-acting mydriatic
drug than tropicamide.
3. Mannitol can be used to treat open angleglaucoma if timolol is contraindicated.
4. Stimulation ofE2-adrenoreceptors in the
ciliary body reduces aqueous humourproduction.
5. Corticosteroids should be avoided in caseof glaucoma.