Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation in Health Technology – from Development via
Implementation to AssessmentF. Breitenecker, Vienna Univ. of Technology
Niki Popper, dwh Simulation Sevices
Siegfried Wassertheurer, Austrian Inst. of Technology
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
• Modelling and Simulation – Technique since 1970
• 3rd Pillar of Science
Problem Simulation Solution
Abstraktion der
Realität
Theory
Experiment
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
• Modelling and Simulation – Technique since 1970
• 3rd Pillar of Science
• Problem SolutionProblem Simulation Solution
Theory
Experiment
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
• Modelling and Simulation – Technique since 1970
• 3rd Pillar of Science
• Problem Solution
• Aim and Goal ?
Problem Simulation Solution
Theory
Experiment
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
• Modelling and Simulation – Technique since 1970
• 3rd Pillar of Science
• Problem Solution
• Aim and Goal ?
Problem Simulation Solution
Theory
Experiment
Simulation is the process of designing a model of a real system and conducting experiments with this
model for the purpose either of understanding the behavior of the system and its underlying causes or
of evaluating various designs of an artificial system or strategies for the operation of the system.
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
• Modelling and Simulation – Technique since 1970
• 3rd Pillar of Science
• Problem Solution
• Aim and Goal
• Level of Application / Use
Problem Simulation Solution
Theory
Experiment
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
• Modelling and Simulation – Technique since 1970
• 3rd Pillar of Science
• Problem Solution
• Aim and Goal
• Level of Application / Use
DEVELOPMENT - IMPLEMENTATION - DIFFUSION
Problem Simulation Solution
Theory
Experiment
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
DEVELOPMENT - IMPLEMENTATION - DIFFUSION
of a Product / Technique / Strategy (PTS)
PTS PTS
PTS
PTS
PTS
PTS
PTS
PTS
PTS
PTS
PTS
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
DEVELOPMENT - IMPLEMENTATION - DIFFUSION
of a Product / Technique / Strategy (PTS)
PTS PTS
PTS
PTS
PTS
PTS
PTS
PTS
PTS
PTS
PTS
M & S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
DEVELOPMENT - IMPLEMENTATION - DIFFUSION
of a Product / Technique / Strategy (PTS)
PTSPTS
PTS
PTS
PTS
PTS
PTS
PTS
PTS
PTS
PTS
M & S
M & S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
DEVELOPMENT - IMPLEMENTATION - DIFFUSION
of a Product / Technique / Strategy (PTS)
PTSPTS
PTS
PTS
PTS
PTS
PTS
PTS
PTS
PTS
PTS
M & S
M & S
M & S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
DEVELOPMENT - IMPLEMENTATION - DIFFUSION
of a Product / Technique / Strategy (PTS)
M & S M & S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
DEVELOPMENT - IMPLEMENTATION - DIFFUSION
of a Product / Technique / Strategy (PTS)
Mechatronic M&S M & S
Em-bedded
M&S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
DEVELOPMENT - IMPLEMENTATION - DIFFUSION
of a Product / Technique / Strategy (PTS)
Mechatronic M&S M & S ?
Em-bedded
M&S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
DEVELOPMENT - IMPLEMENTATION - DIFFUSION
DIFFUSION
– Assessment at Free Market
M & S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
DEVELOPMENT - IMPLEMENTATION - DIFFUSION
DIFFUSION
– Assessment at Free Market
M & S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
DEVELOPMENT - IMPLEMENTATION - DIFFUSION
DIFFUSION
– Assessment at Free Market
M & S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
DEVELOPMENT - IMPLEMENTATION - DIFFUSION
DIFFUSION
– Assessment at Free Market
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
DEVELOPMENT - IMPLEMENTATION - DIFFUSION
DIFFUSION
– Assessment at Free Market Market M & S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
DEVELOPMENT - IMPLEMENTATION -
of a Product / Technique / Strategy (PTS)
Mechatronic M&S Market M & S
Em-bedded
M&S
MECHATRONICS
ASSESSMENT
DIFFUSION
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
DEVELOPMENT - IMPLEMENTATION -
Mechatronic M&S Market M & S
Em-bedded
M&S
MECHATRONICS
ASSESSMENT
DIFFUSION
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
DEVELOPMENT - IMPLEMENTATION -
M&S M & SHEALTH TECHNOLOGY
ASSESSMENT
DIFFUSION
Embedded M&S
Embedded M&S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
DEVELOPMENT - IMPLEMENTATION -
M & S
HEALTH TECHNOLOGY
DIFFUSION - ASSESSMENT
Limited Market
Controlled Market (Laws)
Health Care Systems
Use depends on Assessment
ASSESSMENT - > DIFFUSION
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
DEVELOPMENT - IMPLEMENTATION -
M&S with Markov – ODE – PDE - CA - AB - NN
HEALTH TECHNOLOGY
ASSESSMENT
DIFFUSION
Embedded M&S
Embedded M&S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Cardiovascular Risk Stratification and Therapy
Optimization in Epidemiology using Simulation
Modelling and Simulation – M & S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Arcus Ao.Ao. abdom inalis
A . fem oralis
A . peronaea
The arterial system in (technical) terms
• Single source (heart)• Branched elasitc tubes for
blood transport (arteries)• Various sinks (organs)• Unsteady pressure gradients
drive the system• Arterial pressures
(systolic/diastolic) are actually the most important inidactors in prevention/treatment
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Pathology (Hypertension)
Prevalence of Hypertension over age and sex (USA 1988-94)
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Costs
Source: Austrian Social Insurance (1999-2004)
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Outcome
• Only 10-15 % of treated patients reach their therapy goals within OECD countries! (Source: WHO, AHA)
• Vienna Study– 7100 Probands– 50 % Hypertensives– 1110 in treatment– 185 (16%) well treated!
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
1 Paradox – 2 Answers
Only 50 % CHD are related to Hypertension?!
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Circadian Blood Pressure
• 24 h Blood pressure profile
• White coat hypertension
• Masked hypertension
Blood Pressure is time dependent!
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Explanation
Blood pressure depends on the arterial site!
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
How to handle? Dynamics!
Womersley Solution for Navier-Stokes Eq.
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Generalized Transfer Function (GTF)
This approach allows for the first time widespread epidemiological use!
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Ambulatory Pulse Wave Analysis
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Validation
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Example 1: Physiological Case
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Example 2:Non-Dipper
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Example 3:Raiser
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
META – LEVEL: „SIMULATION ON THE MARKET“
– Health Technology
Modelling and Simulation – M & S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
META – LEVEL: „SIMULATION ON THE MARKET“
HEALTH TECHNOLOGY ASSESSMENT
– Using Simulation - Competitor
DT MC CA SD DE PM AB DEVsNN
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
META – LEVEL: „SIMULATION ON THE MARKET“
DIFFERENT (EASIER) APPLICATION
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
DEMANDS: EASY TO USE
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Σ
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
META – LEVEL: „SIMULATION ON THE MARKET“
HEALTH TECHNOLOGY ASSESSMENT
– Using Simulation - Competitors
DT MC CA SD DE PM AB DEVs NN
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
META – LEVEL: „SIMULATION ON THE MARKET“
HEALTH TECHNOLOGY ASSESSMENT
– Using Simulation - Competitors
DT MC CA SD DE PM AB DEVs NN
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
HEALTH TECHNOLOGY ASSESSMENT
Evaluation = Evidence Based Decision Making
For Effective and Efficient Use of Ressources
YES: Do not things without Benefit – “Make it Rational”
NO: Deprive things with Benefit – “Rationalise”
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Dissociation of Prooved Benefit of Costs for Medical Care
Pharmaceutical Application Discovery Costs € (Patient/Year)
Effects (Survival)
Insulin Typ 1 Diabetes 1920 500 Decades
Statins Cardiology 1990 5.000 Years
Monoclonal Antibodies Onkology 2000 50.000 Month/Weeks
Encyme Alternation Metabolism 2010 500.000 ???
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
M&S IN HEALTH TECHNOLOGY ASSESSMENT
Problem 1: Goal Function - LYG, QLYG, ...
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
M&S IN HEALTH TECHNOLOGY ASSESSMENT
Decision
Course of Disease.
Therap. Eff.
Therap. Probl.
Life Expectance
Life Quality
Costs
Problem 2: Data Diversity and Data Quality
„What to Do?“
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Top Down Heterogeneous PopulationM&S IN HEALTH TECHNOLOGY ASSESSMENT
Modelling and Simulation – M & S
Point of View: Bottom Up
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Population
Top Down Heterogeneous PopulationM&S IN HEALTH TECHNOLOGY ASSESSMENT
Modelling and Simulation – M & S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Female Male
Top Down Heterogeneous Population
Top Down: POSSIBLE
M&S IN HEALTH TECHNOLOGY ASSESSMENT
Modelling and Simulation – M & S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Children (f) Children (m)
Adults (f) Adults (m)
Retired (f) Retired (m)
Top Down Heterogeneous Population
Top Down: COMPLEX
M&S IN HEALTH TECHNOLOGY ASSESSMENT
Modelling and Simulation – M & S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
female,adult
< PS
female,adult
PS
female, adult
Secondary
female, adult
Master
male, adult
< PS
male, adult
PS
male, adult
Secondary
male, adult
Master
Children
Adults
Retired
Top Down Heterogeneous Population
Top Down: MORE COMPLEX
M&S IN HEALTH TECHNOLOGY ASSESSMENT
Modelling and Simulation – M & S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Rich
Poor
Children
Adults
Retired
Top Down Heterogeneous Population
Top Down: COMPLEX INCOME
M&S IN HEALTH TECHNOLOGY ASSESSMENT
Modelling and Simulation – M & S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Y N Y N Y N Y N Y N Y N Y N Y N
Rich
Poor
Children
Adults
Retired
Top Down Heterogeneous Population
Top Down: DISEASE CLUSTERING
M&S IN HEALTH TECHNOLOGY ASSESSMENT
Modelling and Simulation – M & S
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Modelling and Simulation – M & S
M&S IN HEALTH TECHNOLOGY ASSESSMENT
Decision
Course of Disease.
Therap. Eff.
Therap. Probl.
Life Expectance
Life Quality
Costs
Problem 3: „The Point of View“
„What to Do?“
Ethics
Politics
Customer
Dealer
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
“The Point of View....”
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Top Down Heterogeneous PopulationModelling and Simulation – M & S
Problem 4: Diversity of Problems
M&S IN HEALTH TECHNOLOGY ASSESSMENT
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Decision
Course of Disease
Therap. Eff.
Therap. Probl.
Life Expectance
Life Quality
Costs
„Decisions have to be made….“
„What to Do?“
Ethics
Politics
Customer
Dealer
Modelling and Simulation – M & S
M&S IN HEALTH TECHNOLOGY ASSESSMENT
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Advanced Structure - Vaccination
Markovian Model
- Decision Tree - Statistics
Real System
ODE (Population & Dynamics)
ODE (definite Population)AB (definite Population)
AB (Population & Dynamics)
M&S IN HEALTH TECHNOLOGY ASSESSMENT
Solutions – Part 1: Technology
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
• Flexible structures for scenarios (Vaccination, Quarantine, etc…)
• Long term population dynamics
• Start-up phase simulation
• Model Generated Herd immunity effects
• White Box Modeling
• Parallelization
• Reusability
Advanced StructureM&S IN HEALTH TECHNOLOGY ASSESSMENT
Solutions – Part 1: Technology
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Feedback to data structure
internal data
(HVB, clinical
trials, …)
external
data
Pool of
Methods
- AB
- SD, ODEs
- couplings
- …
Hybrid
decom-
position
model
com-
parison
Evaluation
Insigths for data structure
external evaluation
Feedback to model pool
Problem
class
definition
economical
point of view
model
demand
Feedback to data structure
Goal
EV
ALU
AT
ION
OF
DIF
FE
RE
NT
MO
DE
LIN
G
TE
CH
NIQ
UE
S F
OR
SIM
UL
AT
ION
OF
EP
IDE
MIC
S
M&S IN HEALTH TECHNOLOGY ASSESSMENT
Solutions – Part 1: Technology
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
M&S IN HEALTH TECHNOLOGY ASSESSMENT
Solutions – Part 2: Data
New Possib.
New Solutions
New Problems
New Respons.
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Analysing Individual Patient Careers and Pathways
Analyse Health Care Sector from a Patients Perspective
Show Impact of Policy Changes on Individuals
Increase Transparency of Changes in Individual Behavior
-> Reduced but Sufficient Information
New Data allows…
M&S IN HEALTH TECHNOLOGY ASSESSMENT
Solutions – Part 2: Data
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
EU Joint Action
(2006-2008/2009+, 2010-2012 www.eunethta.net
35 Organisations
27 European Countries (NICE/ GB, IQWIG/ DE, …)
-> Well defined Rules and Standards for Assessment
SOME DAY INCLUDING M&S
EUnetHTA
M&S IN HEALTH TECHNOLOGY ASSESSMENT
Solutions – Part 3: Strategy
Modelling and Simulation in Health Technology – from Development via Implementation to Assessment
F. Breitenecker, N. Popper, S. Wassertheurer EUROSIM 2010, Prague
MMS
Decision
„Decisions have to be made….“
„What to Do?“
Dealer
HTA-Exp.
Customer
Results
M&S IN HEALTH TECHNOLOGY ASSESSMENT
Solutions – Part 4: Organisation
Ethics Politics
Data Statistics M&S