1
Sudeep Basu, Ph.D. Global Pract ice Leader, Innovat ion Services sbasu@frost .com
The Growth Pipeline™ Company Powering clients to a future shaped by growth
Microbiome Growth Opportunities
Dec, 8th 2020
2
ELECTRIC VEHICLE (XEV)
Functional Expertise
• Leading the Innovation Services practice to present an integrated IP-Tech-Market perspective
- Managing Strategic Projects on a Global Level
- Advising Corporate R&D, Governments, Universities, and Government R&D institutions on Technology
Innovation & Intellectual Property Strategy, Energy Policy, R&D policy.
- Technology Roadmap Development and Implementation of Technology Transfer Programs
Industry Expertise
Global Consulting and project management experience across various industries
Expert in Technology Strategy, R&D Strategy and Intellectual Property Business Intelligence
Invited speaker, author, panelist, reviewer and conference-chair. Advisor to office’s of heads of state.
Career Highlights
Honorary Guest Faculty & Guest Lecturer at Rutgers University and Stanford University, USA
Reviewer: NIH, National Science Foundation (NSF) and Federal Laboratory Consortium (FLC)
Advisor: Coulter Translational Partnership Program, University of Pittsburgh Feb 2013-
Co-Chair IP & Technology Transfer: VAIL Europe Conference, Wroclaw, Poland, July 2013-
Asst Vice President for Global Partnerships: AUTM International Feb 2014-2016 term
Bio-Engineering Advisory Council Member: University of Missouri, 2014-
RMTM for Cell therapy & Regen Med: Member Standards Development Committee- June 2018-
Voting Member of U.S. TAG for ISO/TC276: BIOTECHNOLOGY : NIST
Education
Ph.D., Brown Cancer Research Center, (USA), American Heart (AHA) Fellow, IPIBS Fellow
Indian Institute of Technology (IIT-Bombay), Mumbai, India, TATA Scholar, CSIR Scholar
University of Mumbai, India,
Sudeep Basu, Ph.D.,
Practice Leader
Innovation Services
Frost & Sullivan, USA
3
MICROBIOME GROWTH TRENDS
Microbiome Patent Publications, Global, 2012-2017
0
500
1000
1500
2000
2500
3000
3500
2012 2013 2014 2015 2016 2017
Nu
mb
er
of
Pat
en
ts P
ub
lish
ed
Key Takeaway: There has been a growing interest in microbiome patent landscape, with 2017 being the most prominent year marked by 3178 patent publications.
113
13.38 12.56
62.9
27.78
50
30
3.25
29
82
10.26
Fun
din
g A
mo
un
t in
Mill
ion
USD
Microbiome Venture Funding, Global, 2015-2017
Key Takeaway: Despite the setback faced by Seres due to SER-109’s Phase II failure, recent VC funding activity has been encouraging across the global microbiome landscape. Synlogic has gained significant attention by developing recombinant microorganisms for disease treatment and raising $116 million through venture funding (2014-2017).
Source: lens.org, Frost & Sullivan
4
SKIN MICROBIOME PATENT FAMILIES DISTRIBUTION BY ENTITY TYPE
Source: Patseer and Frost & Sullivan
Patent Distribution by Company Name, Global, 1996 - 2015 Total 168 patent families relevant to Skin microbiome space were identified for January 1st Jan 2017 to 31st May 2018 timeframe.
The entire patent portfolio was reviewed and clustered by entity type. 60% of the total patents were filed by corporate entities.
Patent families Distribution by Entity Type
101, 60%
24, 14%
23, 14%
20, 12%
Corporate
Individual Inventor
Startup
23
19
18
12
8
6
5
2 2 2
1 1 1 1 Cosmetics
Personal Care
Chinese SMEs
Biopharma
Ingredients Supplier
Supplements/cosmetics
NPE / Patent Trolls
Agribiotech/ Cosmetics
Electronics
Others
diagnostics
Financial Institution
Large Pharma
Technology Transfer company
Distribution of 101 Corporate patents by Sector
5
KEY PLAYERS (BASED ON PATENTING ACTIVITY)
Corporates
1. L'Oréal
2. Elwha LLC (A Patent Troll)
3. GOJO Industries
4. Natura Cosmeticos
5. Procter & Gamble
6. Amorepacific
7. Cell Biotech
8. Coreana Cosmetics
9. Henkel
10. Unilever
Research Institutes
1. Harvard University
2. Ohio State University
3. University of California
4. Korea Institute of Science and Technology
5. New York University
6. Hiroshima University
7. Konkuk University
8. Sunchon National University
9. Jeju National University
10. Jiangnan University
Start-ups
1. AObiome
2. Ubiome
3. S-Biomedic
4. Skin Biotherapeutics
5. Yun NV
6. Naked Biome
7. Xycrobe Therapeutics
8. 4D Pharma
9. Tak Circulator
6
PATENT OFFICE-WISE DISTRIBUTION OF SKIN MICROBIOME PATENT PORTFOLIO, 2017-2018*
USA ChinaSouthKorea
WIPO EPO Australia France Japan Brazil Germany
Patent Count 46 31 28 26 12 3 3 3 2 2
0
5
10
15
20
25
30
35
40
45
50
To
tal P
ate
nt
Co
un
t
Patent Office
Patent Distribution by Company Name, Global, 1996 - 2015 The exhibit below shows distribution of Skin Microbiome patent portfolio by patent offices. The USPTO has witnessed the highest
patenting activity. It is followed by patent offices in patent office in China and South Korea.
Skin Microbiome Patent Portfolio Distribution by Patent Offices, Global, 2017-2018*
Source: Patseer
*2018 is current year of the study so data for 2018 was covered till 31st May 2018.
7
SNAPSHOT OF EMERGING RESEARCH TRENDS
Skin 35%
Hair or Scalp 2%
Oral 62%
Home 1%
Microbiome Industry: Percent Distribution of Research Studies across Skin, Hair or
Scalp, Oral and Home Health Applications, Global, 2014-2018 Oral and skin care applications are the key research focus areas. As there is extensive scientific knowledge that’s available for these applications. An FMCG/ CPG player could gain a major competitive advantage as a leading consumer care brand by acquiring or developing a differentiated skin or oral care offering us technologies.
Hair & scalp care applications are also an emerging research interest for microbiome technologies, although there’s a need for additional research to evaluate the impact of incorporating microbial platforms across hair care products.
Home care applications are a relatively niche space for microbiome technologies and may gain research traction in the next few years. Being an early mover in this space might give great head start for microbiome consumer product innovations.
Key Takeaways:
Source: NCBI PubMed, Frost and Sullivan
8
SNAPSHOT OF EMERGING RESEARCH TRENDS
2 2
8
13
10
2014 2015 2016 2017 2018
Nu
mb
er
of
Researc
h S
tud
ies
Hair & Scalp Microbiome Industry: Research Studies, Global, 2014-2018
55
168
220
324
389
2014 2015 2016 2017 2018N
um
ber
of
Researc
h S
tud
ies
Oral Microbiome Industry: Research Studies, Global, 2014-2018
2
5
3
1
3
2014 2015 2016 2017 2018
Nu
mb
er
of
Researc
h S
tud
ies
Home Microbiome Industry: Research Studies, Global, 2014-2018
Source: NCBI PubMed, Frost and Sullivan
38
96
130
171
208
2014 2015 2016 2017 2018
Nu
mb
er
of
Researc
h S
tud
ies
Skin Microbiome Industry: Research Studies, Global, 2014-2018
9
KEY FINDINGS FOR THE GLOBAL MICROBIOME LANDSCAPE
While OTC probiotics have been long established as a important contributor
to human health in general, novel microbiome-based therapies for
gastrointestinal disorders may emerge in the next few years.
This is an area of growing industry interest as large FMCH companies are
looking towards improving F&B products by introducing probiotic, prebiotic
and in some cases, even non-live probiotic ingredients for targeted health
applications.
The personal care and cosmetic industries have witnessed the launch of
several new companies that are solely focused on offering microbiome-based
skincare products. Not surprisingly, leading cosmetic brands are also interested
in developing new products that incorporate microbiome technologies.
Another interesting area that is starting to get impacted by microbiome
technologies is the heating, ventilation and air conditioning (HVAC) industry.
Re-introduction of probiotics in indoor air environment is the newest trend that
is likely to witness significant traction the coming years.
Source: Frost & Sullivan
10
MICROBIOME TECHNOLOGIES TRANSFORMING SKIN CARE
10
11
SUMMARY OF KEY DRIVERS
Rapid Advances in Microbiome Research Rapid advances across biomarker, bioinformatics and microbiome research platforms have provided actionable insights across the microbiome which can be directly related to human health and disease.
Rising Microbiome Collaborations There has been a lot of collaborative activity for microbiome technologies in the recent past. Some the recent examples include Probi-Symrise collaboration in February 2019 and Lonza-Chr Hansen venture in April 2019.
Increasing Demand for “free from” Ingredients As the consumer focuses towards the use of “free-from” ingredients such as paraben-free and sulfate-free formulations for cosmetic applications, the use of nature-derived prebiotic and prebiotic ingredients help meet the consumer needs.
Increasing Consumer Awareness The modern day consumer is increasingly aware of the health benefits of microbial platforms is consciously investing in health and wellness products across all avenues.
Growing Demand for Personalization There is rising need to personalize consumer care products, hence there is a growing focus on diagnostics.
Source: Frost & Sullivan
Low High
1
2 3
4
5
5 Low High
1
2 3
4
5
5 Low High
1
2 3
4
5
5 Low High
1
2 3
4
5
5 Low High
1
2 3
4
5
5
Key Takeaway: Microbiome technologies are here to stay and will have a growing impact on several industry sectors. The personal care and cosmetic industries have witnessed the launch of several new companies that are solely focused on offering microbiome-based skincare products. Not surprisingly, leading cosmetic brands are also interested in developing new products that incorporate microbiome technologies. Within the consumer care segment, skin and oral care applications take the larger share of the microbiome pie, while home care and indoor air quality are the newest entrants in this space. Moreover, there is likely to be a growing focus on diagnostic applications to personalize microbiome-enabled consumer care products and services.
12
SUMMARY OF KEY CHALLENGES
Clinical Validation of Microbiome Research The biggest challenge for probiotic and other microbiome-enabled technologies is having the right science (high quality, strain-specific, human clinical evidence) to support the health benefits of the organism.
Limited Availability of Shelf Stable Probiotic Strains Frost & Sullivan believes that incorporation of live probiotic strains is restricted by the limited availability of shelf stable probiotic strains. There is a need for the discovery and development of such strains.
Defining Global Regulatory Guidelines Probiotic and microbiome regulations for consumer health vary significantly across the globe and it has been difficult to harmonize health benefits claims regulations across countries.
Achieving Optimal Scalability For live probiotic products, manufacturing and scalability will be a challenge. However, advances in biomanufacturing and biomonitoring platforms will help address that difficulty in the mid-term future.
Restraining Production Costs Probiotic skincare products are likely to be expensive initially. However, as manufacturing is optimized enable time, resource and cost savings, consumer products will become more cost-effective in the future.
Source: Frost & Sullivan
Low High
1
2 3
4
5
5 Low High
1
2 3
4
5
5 Low High
1
2 3
4
5
5 Low High
1
2 3
4
5
5 Low High
1
2 3
4
5
5
Key Takeaway: Strain-specific clinical documentation of health benefits will be the key rate-limiting factor for developing new consumer products across the global probiotic landscape. Low shelf-stability and viability of probiotic strains will also restrict their incorporation in consumer care products. However, rapid research advances are likely to address these challenges in the mid-term future. While there is growing dialogue to define the use of probiotic and associated health claims in F&B and supplement applications, there is need to accelerate regulatory frameworks for use in cosmetic and home hygiene applications.
13
MICROBIOME TECHNOLOGIES FOR SKINCARE AND HEALTHY AGING
Microbiome
technologies
for skin care
and anti-aging
applications
Probiotics
Companies such as AOBiome are looking to introduce live probiotic bacteria
on human skin to alleviate inflammatory skin conditions. It’s a niche
application area with very few participants in the space.
Probiotic-derived Products
Probiotic lysates or supernatants have been scientifically documented to
provide anti-aging benefits. Such probiotic-derived ingredients can be useful
to creating topical formulations for personal care applications. For example.
Ganeden offers Bonicel, a supernatant derived from its probiotic, BC30, for
application in cosmetic, anti-aging formulations.
Prebiotics
Prebiotic ingredients are being actively researched for use in personal care
products. Ingredients such as inulin, β-glucan and algae are being actively
researched for applications in skin care formulations. Companies working in
this space include Gallinée and Oskia Skincare.
Targeted Antimicrobials
Antimicrobial products that specifically target pathogenic bacteria are likely
to have a growing market potential. Antimicrobial topical formulations will
have a growing adoption for skin ailments such as acne, eczema and other
inflammatory conditions. For instance, Micreos offers antimicrobial acne
gel.
Microbiome-friendly Ingredients
There is a growing focus towards the use of skin-friendly and pH-balanced
ingredients in skin care formulations so that the natural skin microbiome is not
adversely affected by use of cosmetic products. Companies like Yun are
offering skin-friendly products in this space
Source: Frost & Sullivan
14
S-BIOMEDIC, BELGIUM
(FOUNDED WITH HORIZON 2020 PROGRAM FUNDING IN EU)
14
15
PROBIOTIC FORMULATIONS FOR SKINCARE
Skin care formulations are poised to transform skincare routine with the advent of microbiome-based innovations. Probiotic technologies that use live microbiota in their unique formulations are likely to lead this transformation. Big pharma companies, such as Johnson & Johnson, are helping biotech start-ups such as S-Biomedic, to advance probiotic formulations for therapeutic and cosmetic applications. The key application areas for live probiotic topical formulations are reduction of skin sensitivity, acne and skin spots.
• The company’s initial target area is acne vulgaris, a key reason for the distortion of the skin microbiome.
• The company’s unique skin care formulations are focused towards restoring skin’s natural homeostasis
• Additionally, the products are also focused towards accelerating skin regression towards a healthy sate.
• Other areas of interest include ageing and dandruff treatment
S-Biomedic is currently working to develop a probiotic technology that modulates the skin microbiome.
Innovation Attributes: Technology Description
The company has developed and advanced technological platform that leverages natural strains from the skin microbiome to enhance and restore skin health.
Related Patents
• WO2008002063A1 • US2018142202A1 • WO2018073651A1 • EP3285872A1
TechVision Analysis: Probiotic product for skin care
applications is a technologically challenging space. It is
important for companies claiming topical benefits for probiotic
products to show that live probiotics are viable on skin
surface and can lead to significant benefits to the host.
The company is looking to develop therapeutic and cosmetic formulations for topical application on skin. S-Biomedic selects beneficial bacteria to generate products that can rebalance the skin microflora.
The company leverages the beneficial interactions between skin and commensal flora to develop novel probiotic formulations
Overview Application Area
Source: Frost & Sullivan
16
S-BIOMEDIC’S LEAD INNOVATION FOCUSED TOWARDS ACNE
Ageing
Acne
Dandruff
Concept In Vitro Clinical Prototype Partner
Indication
Developmental Status
Innovation Pipeline Summary, S-Biomedic, 2018
The lead program is focused towards acne vulgaris and clinical studies are likely to be completed in 2019
Initial clinical studies for acne vulgaris are in line with in vitro findings
Early concept studies for ageing and dandruff are in development
Acne >$5B
Ageing >$170
Dandruff >$4B
Global Market Value, 2017
Source: Frost & Sullivan
17
OVERVIEW OF THE PARTNERSHIP LANDSCAPE
01
03
02
04
CG Health Ventures
This strategic partner
helps S-Biomedic with
advice, collaborations and
capital
JLINX
JLINX helps to identify and nurture early-stage start-ups in Europe
Sachsen-Anhalt ESI Fund
This funding helps technology-focused organizations
JLABS & DSM
A resident of the J&J labs program and counts DSM as a key investor/ partner.
18
ANALYSIS OF RESEARCH PARTNERSHIP
Flanders Bio
Cluster Organization
S-Biomedic is a member of Flanders Bio
which is a cluster organization that
enables network economy in a life
sciences driven environment
Regulatory Affairs
The European Non-profit organization, PRI, is focused towards the regulatory landscape for the microbiome space.
The PRI
Source: Frost & Sullivan
19
OVERVIEW OF THE REGIONAL COMPETITIVE LANDSCAPE
Australia
• The Beauty Chef
• Blackmores
• WelleCo
• China & Hong Kong
• DSM (China)
• BioGaia (China)
• Esse Probiotic Skin Care (Hong Kong)
Japan
• Kosé
• Yakult
Korea
• Able C&C
• Goodal (Soko Glam)
• Skin Food
Malaysia
• BLACK PAINT Microbiome Skincare
• GD Manufacturing Sdn Bhd.
Singapore
• BioGaia
• Givaudan
• BetterAir
• Gallinee
Microbiome
Industry: List of
Key Regional
Innovators, Asia
Pacific (APAC),
2019
20
IMPACT OF ETHNIC AND RACIAL INFLUENCES
Source: doi:10.1371/journal.pone.0151990.g001, Frost & Sullivan Analysis
Cutaneous microbial diversity in 645 samples from 110 subjects, based on skin location and beta diversity analysis over time, by ethnic group.
Key Takeaways:
Research has revealed that skin microbiome samples from different ethnic groups were similar to each other when grouped based on the skin site
Despite the microbial conservation unique to skin site, there was distinct clustering observed for population groups such as Caucasian, African Americans, etc.
Ecological zone of the skin is the primary factor that relates to cutaneous microbiota composition
Ethnicity also impacts microbial composition, but is only secondary to the impact of ecological site
21
ADVANCES IN PROBIOTIC TECHNOLOGIES FOR SKINCARE
Overview
Skin care formulations are poised to transform skincare
routine with the advent of microbiome-based innovations.
Probiotic technologies that use live microbiota in their unique
formulations are likely to lead this transformation. Big pharma
companies, such as Johnson & Johnson, are helping biotech
start-ups such as S-Biomedic, to advance probiotic
formulations for therapeutic and cosmetic applications. There
are a few companies, such as Esse and AOBiome, that claim
to introduce live probiotic bacteria topically to provide
skincare benefits. Some companies, such as Azitra, are
looking to develop recombinant microbes that can express
filaggrin to treat skin ailments such as eczema.
Technology Capability
Application Landscape Key Companies
Probiotic product for skin care applications is a
technologically challenging space. It is important for
companies claiming topical benefits for probiotic products to
show that live probiotics are viable on skin surface and can
lead to significant benefits to the host. Additionally, most skin
care formulations are not conducive for bacterial growth.
Hence, skin care formulations in the probiotic space need to
show the growth of skin-friendly microbial species, and also
need to inhibit the growth of pathogenic microorganisms
without using very harsh chemical preservatives. As a result,,
very few companies have been able to successfully claim the
use of live probiotic products in formulations.
The key application areas for live probiotic topical
formulations are reduction of skin sensitivity, acne, and skin
spots. The products are also beingg used for slowing ageing
process. Yun offers a live probiotic spray for foot care
applications. AOBiome, a very innovative probiotic company,
, offers a water-based mist formulation having ammonia-
oxidizing bacteria that can be used regularly instead of a
shower, to prevent destruction of the healthy skin microbiota after a bath. Another company, Azitra, is looking to developing recombinant microbes for topical applications
AOBiome Esse Gallinée
Yun Azitra
22
THE GROWING USE OF PROBIOTIC-DERIVED FORMULATIONS FOR ENHANCING SKINCARE
Overview
There are several cosmetic companiess that use probiotic-
derived ingredients for skincare applications. Some of the
typical ingredients in this space include Lactobacillus extract,
Lactococcus ferment lysate and post-biotic products such as
lactic acid. Companies also use probiotic ferment filtrate or
broth derived from microbial fermentation for enhanced skin
health. Possibly one of the foremost technology in this space
is that offered by Estée Lauder, the Miracle Broth formulation
derived from sea kelp fermentation and used in the
company’s signature Crème de la Mer product. There are
several start-up companies that are also looking to delve in to
this space of probiotic-derived cosmetics.
Technology Capability
Application Landscape Key Companies
From a technology standpoint, it’s relatively easier to
introduce probiotic-derived ingredients in skincare
formulations. Most probiotic-derived cosmetics do not require
refrigeration as they do not use live microorganisms in the
products. Furthermore, such ingredients do not require major
changes in preservative process and do not affect the
product shelf-life. A growing emphasis on wellness in
skincare products is likely to fuel the use of such ingredients
in topical formulations, especially when it comes to alleviating
skin sensitivity, redness and irritation. Probiotic-derived
ingredients are likely to transform the cosmetic industry by
restoring the skin microbiome balance.
Most of the applications for topical probiotic-derived
formulations help to reduce skin sensitivity, redness, irritation,
rosacea, acne and aging. While aiding the restoration of
skin’s natural barrier functions, most formulations containing
collagen also help to restore skin’s natural firmness and
prevent sagging. Companies such as Ganeden, offer
probiotic-derived ingredients for skin care and anti-aging
applications. The company’s anti-aging ingredient, Bonicel, is
a supernatant derived from their proprietary BC30 probiotic
line and is primarily used in various cosmetic products.
Clinique Glowbiotics MD Estée Lauder
Tula Aurelia Skincare
23
NOVEL SKIN-FRIENDLY FORMULATIONS FUELING THE ADOPTION OF INNOVATIVE PREBIOTIC INGREDIENTS
Overview
Several cosmetic companies are developing novel
formulations that contain ingredients that serve as food for
the beneficial microorganisms on the skin surface. Such
ingredients, or ‘prebiotics’ typically comprise plant sugars and
oligosaccharides such as alpha-glucan oligosaccharide, beta-
glucan or carbohydrates derived from microalgal origins.
Certain cosmetic brands offer a combination of prebiotic and
probiotic ingredients to enable a more holistic skincare
regime. Some of the key companies in this space include
Gallinée, Glowbiotics MD and Novexpert. The prebiotic
ingredient space is likely to be a growing focus area for
cosmetic industries in the near future.
Technology Capability
Application Landscape Key Companies
Prebiotic ingredients are shelf-stable and relatively easier to
incorporate within cosmetic formulations. There is a growing
focus towards the incorporations of such plant sugars into
topical formulations. One of the key differentiators of such
topical formulations will be the availability of scientific data
that back the benefit claims of the skin care products
organically-sourced prebiotic ingredients are likely to be a
part of luxury cosmetic brands initially,. However, this trend
may change as more products start incorporating a shift
towards the use of naturally-derived prebiotics in the near to
mid-term future.
Prebiotic ingredients are mostly derived from plant sources
and are consumed by beneficial skin microorganisms. When
combined with probiotic and probiotic-derived for a wide
range of skin conditions such as acne, redness, irritation,
sensitivity, rosacea and eczema. Such products may also be
useful to reduce visible sings of skin aging such as wrinkles
and fine lines. Furthermore, as prebiotics are derived from
natural sources they are less likely to have adverse effects on
human skin.
Gallinée Glowbiotics MD Novexpert
Vantage Specialty
Ingredients Greenaltech
24
NOVEL TARGETED ANTIMICROBIAL FORMULATIONS
Overview
In 2016,the US FDA issued a rule that prohibited the use of
antibacterial ingredients such as triclosan in topical
antibacterial washes as they were not shown to have long
term benefits when compared to regular washes.
Furthermore, studies have revealed that triclosan, being a
broad spectrum bactericidal agent, can adversely effect the
beneficial skin microflora and cause drug resistance in
pathogenic bacteria. Such non-specific antimicrobials can
also reduce the levels of histone deacetylaces (HDACs) in
skin cells which is needed for maintaining an optimal balance
of the skin’s commensal bacteria. Thus, there is a need for
developing targeted antimicrobial ingredients.
Technology Capability
Application Landscape Key Companies
As there is growing consumer awareness of the harmful
effects of long term use of topical broad-spectrum
antimicrobial agents, more users are looking towards natural
and gentle skincare formulations that do not harm the
beneficial skin microflora. Hence, companies such as Nerd
Skincare, US, are offering targeted antimicrobial formulations
that help the growth of the beneficial microflora to restore the
skin’s natural balance and enable enhanced immunity against
pathogenic bacteria. Another company, Micreos, offers the
Staphefekt SA.100 enzyme ingredient in topical formulation
that is specifically targeted against Staphylococcus aureus,
(including MRSA).
Targeted antimicrobial ingredients are being used for several
cosmetic skin care applications, especially for the treatment
of acne, eczema, rosacea and skin irritation. Ingredients that
help the growth of the skin’s natural microflora or specifically
inhibit the growth of pathogenic bacteria are likely to garner
increased acceptance moving forward, especially across a
wide range of innovative skincare formulations.
Nerd Skincare Micreos
Naked Biome
25
INNOVATIVE MICROBIOME-FRIENDLY FORMULATIONS
Overview
Several companies that offer probiotic skin formulations also
offer several products that are pH balanced and skin-biome
friendly. Most products in this space use ingredients that do
not alter the microflora of the skin, although they may not
have any active probiotic formulations.
Key Companies
Technology Capability
This technology platforms is likely to garner growing focus as
it offers biome-friendly formulations that may not necessarily
use any active probiotic ingredient. Hence, they do not face
the typical technological hurdles associated with the
development of a skincare formulation that contain live
probiotic microorganisms or probiotic-derived metabolites.
Application Landscape
Most products in this space offer solutions for skin dryness,
irritation. Unlike other probiotic products that are targeted for
specific skin conditions, microbiome-friendly formulations
help to improve skin health, without harming the skin
microbiome in any way.
Yun AOBiome
Esse
26
MARKET SEGMENTATION PREDICTIONS– DISEASE
1%
17%
38% 15%
10%
3%
7%
2% 2% 5%
Disease Segments
Cancer Type II Diabetes
Gastrointestinal Disorders Infection Disease
Oral health Women's health
Skin Disorders Respiratory Disorders
Liver Disorders Obesity & Metabolic Disorders
13%
8%
26%
16%
7%
6%
6%
8%
7% 3%
Disease Segments
Cancer Type II Diabetes
Gastrointestinal Disorders Infection Disease
Oral health Women's health
Skin Disorders Respiratory Disorders
Liver Disorders Obesity
~2020 ~2025
27
Sudeep Basu Global Practice Leader
CONTACTS
Bernard Weber Director Commercial Solutions