Medical Immunology DEPARTMENT OF IMMUNOLOGY 1
Immune system itself
Neuro-endocrine system
Components of Immune Regulation
Medical Immunology DEPARTMENT OF IMMUNOLOGY 2
Positive events:
Enhancement of immune
response.
Negative events:
Suppression of immune response.
Effects of Immune Regulation
Medical Immunology DEPARTMENT OF IMMUNOLOGY 3
AgAg APCs
Th1 Tc
B Ab
PMNPMN
NK
Th2
ComplementComplement
Positive events: Enhancement of immune response.
TargetTargetcellscells
MHCMHCCKCK
MHCMHCCKCK
CKsCKs
CKsCKs
Medical Immunology DEPARTMENT OF IMMUNOLOGY 4
AgAg APC
Th1 Tc
B Ab
PMNPMN
NK
Th2
ComplementComplement
Negative events: Suppression of immune response.
TargetTargetcellscells
MHCMHCCKCK
MHCMHCCKCK
CKsCKs
CKsCKs
Ts
Medical Immunology DEPARTMENT OF IMMUNOLOGY 5
AgAg APCs
Th1 Tc
B Ab
PMNPMN
NK
Th2
ComplementComplement
Immune Response(IR)
TargetTargetcellscells
MHCMHCCKCK
MHCMHCCKCK
CKsCKs
CKsCKs
Medical Immunology DEPARTMENT OF IMMUNOLOGY 6
Ag concentration
Medical Immunology DEPARTMENT OF IMMUNOLOGY 7
AgAg APC
Th1 Tc
B Ab
PMNPMN
NK
Th2
ComplementComplement
Antigen Presentation
TargetTargetcellscells
MHCMHCCKCK
MHCMHCCKCK
CKsCKs
CKsCKs
Medical Immunology DEPARTMENT OF IMMUNOLOGY 8
MHC-Ag peptide complex formation ??
Medical Immunology DEPARTMENT OF IMMUNOLOGY 9
AgAg APC
Th1 Tc
B Ab
PMNPMN
NK
Th2
ComplementComplement
Immune Response(IR)
TargetTargetcellscells
MHCMHCCKCK
MHCMHCCKCK
CKsCKs
CKsCKs
Medical Immunology DEPARTMENT OF IMMUNOLOGY 10
APC
Th2Th1
+ +
IFNr
IL-4/10
Th1 and Th2 balance
Medical Immunology DEPARTMENT OF IMMUNOLOGY 11M e d i c a l I m m u n o l o g y 吉 林 大 学 基 础 医 学 院 免 疫 学 教 研 室 7
A n t a g o n i s mA n t a g o n i s m
IL-4
IFN activated Th cellB cell
blocks class switch to IgE induced by IL-4
Target cell Effect
Medical Immunology DEPARTMENT OF IMMUNOLOGY 12
AgAg APC
Th1 Tc
B Ab
PMNPMN
NK
Th2
ComplementComplement
Immune Response(IR)
TargetTargetcellscells
MHCMHCCKCK
MHCMHCCKCK
CKsCKs
CKsCKs
Ts
Medical Immunology DEPARTMENT OF IMMUNOLOGY 13
-- CD4+CD25+ Regulatory T cells
Self-reactiveT cellCD4+CD25+
Treg cells
Medical Immunology DEPARTMENT OF IMMUNOLOGY 14
Medical Immunology DEPARTMENT OF IMMUNOLOGY 15
Suppressive function :
Produce cytokines: IL-10/TGFβ
T-T interaction
Functions of CD4+CD25+ Treg cells
TregTregCD4+CD25+CD4+CD25+
TTCD4+CD25-CD4+CD25-
APCAPC
Medical Immunology DEPARTMENT OF IMMUNOLOGY 16
Functions of CD4+CD25+ Treg cells
Suppressive function :
Produce cytokines:
IL-10/TGFβ
Cell-cell contact
Medical Immunology DEPARTMENT OF IMMUNOLOGY 17
AgAg APC
Th1 Tc
B Ab
PMNPMN
NK
Th2
ComplementComplement
Immune Response(IR)
TargetTargetcellscells
MHCMHCCKCK
MHCMHCCKCK
CKsCKs
CKsCKs
Ts
Medical Immunology DEPARTMENT OF IMMUNOLOGY 18
Antibody Production by B cell
Th2
Medical Immunology DEPARTMENT OF IMMUNOLOGY 19
Ag+
Ab
Antibody responseAntibody response (Humoral immune response)(Humoral immune response)
Medical Immunology DEPARTMENT OF IMMUNOLOGY 20
Ag + Ab mediated B cell
图 12-1 抗原 - 抗体( IgG )复合物交联 BCR 和 FcR -BⅡ 对 B 细胞抑制作用示意
图
B cell
Medical Immunology DEPARTMENT OF IMMUNOLOGY 21
AgAg APC
Th1 Tc
B Ab
PMNPMN
NK
Th2
ComplementComplement
Immune Response(IR)
TargetTargetcellscells
MHCMHCCKCK
MHCMHCCKCK
CKsCKs
CKsCKs
Ts
Medical Immunology DEPARTMENT OF IMMUNOLOGY 22
— Inactivated itself
— Regulated by inhibitor
Regulation of complement
Medical Immunology DEPARTMENT OF IMMUNOLOGY 23
Medical Immunology DEPARTMENT OF IMMUNOLOGY 24
Immune system itself
Neuro-endocrine system
Components of Immune Regulation
Medical Immunology DEPARTMENT OF IMMUNOLOGY 25
Regulations by neuro-endocrine system
Medical Immunology DEPARTMENT OF IMMUNOLOGY 26
Regulations by neuro-endocrine system
Medical Immunology DEPARTMENT OF IMMUNOLOGY 27
AgAg APC
Th1 Tc
B Ab
PMNPMN
NK
Th2
ComplementComplement
TargetTargetcellscells
MHCMHCCKCK
MHCMHCCKCK
CKsCKs
CKsCKs
Ts
Regulation of immune response