KU Alzheimer’s Disease Center—The Executive Director’s Perspective
Anne Arthur, BSN, MS, APRN-BCKU Alzheimer’s Disease Center Executive Director
www.kualzheimer.org
Objectives
• Discuss the history of the KU Alzheimer’s Disease Center (KU ADC)
• Identify the accomplishments of the KU ADC since inception
• Explore ways the KU ADC can support investigators
History of the ADC
• NIA-Division of Neuroscience • Established in 1984• Goal: promote research network on AD• 29 centers in the US• National meetings twice a year
Alzheimer’s Disease Centers (ADC)—29
Timeline
1985 1990 1995 2000 2005 2010 2015
NIA establish
es ADCs (
1984)
KU ADC Funded (1
991-1996)
Dr. Jeffrey B
urns joins f
aculty
(2004)
Dr. Russe
ll Swerdlow jo
ins facu
lty (2
007)
ADC resu
bmission to
NIA (2010)
KU ADC funded (8
/15/2011)
ADC application to
NIA (2009)
KU ADC• Director: Russell Swerdlow• 7 Cores• Aims
1-Support AD, AD-related, and brain aging research projects
2-Provide advanced services that facilitate ground-breaking metabolism research
KU ADC Structure
Administrative Core
Clinical CoreData
Management and Statistics Core
NeuropathologyCore
Education and Information
Transfer Core
Neuroimaging Core
Mitochondria Genomics and
Metabolism Core
KU ADC-Specific Cores
Administrative CoreLeader: Russell Swerdlow, MD
• Goals– Provides oversight to the KU ADC– Promotes AD, MCI and brain aging research• Pilot Program• Resource Request
– Expands KUs base of clinical, translational and basic science investigators• Collaborative REsearch Workgroup (CREW) meetings
Advisory Boards
Internal Advisory BoardRandy NudoCarol CleekJoseph DonnellyPaul TerranovaPeter SmithRichard BarohnSteven WarrenSusan KemperRobert Krumlauf
External Advisory BoardCharles DeCarliAngela JeffersonNigel CairnsWalter KukullThomas MontineWilliam JagustTeresa Radebaugh
Projects Supported
• 18 Federal – 2 P01 (Michaelis, Kouhlen)– 7 R01 (Burns, Williams, Berman, Zhu)
• 15 Foundation• 5 Training awards• 11 Therapeutic trials– ADCS– Alzheimer’s Drug Discovery Foundation– Pharmaceutical
Clinical CoreLeader: Jeffrey Burns, MD
• Goals– Cohort of nondemented, MCI and AD subjects– Support and encourage collaborative
interdisciplinary studies• Data• Biological specimens• Clinical research infrastructure
– Burns elected to National ADC Steering Committee and ADC Clinical Task Force
Clinical Core
• 400 well-characterized participantsNormal MCI AD Total
Age > 60 y.o. Any age Any age
Enrolled to date
119 51 58 234
Goal 200 100 100 400
Clinical Core EvaluationClinical
Evaluation(CDR)
Memory Testing
Labs/Physical Function Testing/
DEXA
Visit 1
Visit 2
Visit 3
Yearly
Yearly
Every 3 years
Data Collection• Clinical Evaluation
– Clinical Dementia Rating (CDR) Scale– Neurological Exam
• Memory testing
• Physical Function testing• DEXA scan
MMSELogical Memory I & IIDigit Span Forwards/BackwardsCategory FluencyTrailmaking A & BDigit Symbol
Boston Naming TestBlock DesignStroopFree and Cued SRTLetter Number Sequencing
Specimen Collection
• Processed and stored in the Biospecimen Shared Resource (BSR) Center
PlasmaBuffy CoatPlateletsSerumWhole Blood
Cell-free PlasmaCybrid Cell LinesDNARNA
National Alzheimer’s Coordinating Center (NACC)
• Established by NIA in 1999• Support all ADCs• Database for clinical and neuropath data• Partners – National Alzheimer’s Disease Cell Repository
(NCRAD)– Alzheimer’s Disease Genetics Consortium (ADGC)
• Free to investigators
Data/Specimen Sharing
KU ADC
National Alzheimer’s
Coordinating Center (NACC)
National Cell Repository for
Alzheimer’s Disease (NCRAD)/Alzheimer’s
Disease Genetics Consortium (ADGC)
Clinica
l and
Cogniti
ve da
ta DNA
Data Management and Statistics CoreLeader: Jonathan Mahnken, PhD
• Goals– Provide statistical expertise– Develop Data and Information Management and
Monitoring Systems
• Mahnken elected to NACC Scientific Review Committee 2011-2014
• Present national ADC meeting 10/2012
Neuropathology CoreLeader: Kathy Newell, MD
• Goals– Autopsy human brain tissue from Clinical Core
participants – Autopsy animal models– Neuropathological consultation and specimen
sharing
Scanning and Imaging
Aperio Digital Scanning System Nikon Eclipse 80i + Metamorph
Brain Autopsy Program
• Clinical Core participants• Demented/non-demented brains• Neuropathology Case Conference– 2nd Thursday odd months, 4-5p, 1605 Surgical
Pathology, Microscope Room 2
Education & Information Transfer CoreLeader: Heather Anderson, MD
• Goals– Recruit/retain subjects • KU ADC Clinical Core cohort • Clinical Trial Unit (CTU)
– Train students and health professionals– Increase awareness of AD and the KU ADC
Recruitment/Retention
• Presentations• Newsletters• Social Media– Facebook– Twitter– Electronic newsletter
• Birthday Cards• Annual Appreciation Breakfast
Recruitment SourcesGrayHawk
Public Pre-sentation
Brochure
Health Care Professional
KU ADC Website
Newspaper Ad
RadioFamily
Friend
Other
TV
Recruitment Flow
Clinical Core
Ed Core
Clinical Trial Unit
Investigator-Initiated studies
Education/Outreach
• Seminar Series on Health, Aging and Dementia– Partner with LCOA and GPGEC
• Alzheimer’s and Aging Research Colloquium– Partner with LCOA and GPGEC
• Healthy Aging Symposium– Partner with JCCC
• Annual Appreciation Breakfast• Lectures/presentations• Student observership
Neuroimaging CoreLeader: William Brooks, PhD
• Goals– Advanced scientific support and subsidized scans
for AD research– Advanced training and education in imaging– Develop novel imaging techniques for studies in
AD
Hoglund Brain Imaging Center
• Instrumentation– 3 Tesla Siemens Skyra human MRI scanner– 9.4T Varian/Agilent animal MRI scanner– PET/CT Scanner (General Electric DST) (including cyclotron
CTI (Siemens RDS 111)– 151-channel whole-head CTF MEG unit (including
simultaneous 160 channel EEG)
Novel Imaging Techniques
• Translation of imaging protocols to new 3T scanner
• Glutathione (GSH) spectroscopic imaging sequence
• Vitamin C spectroscopic imaging sequence under development
• Neurochemical profile from MRS
Mitochondrial Genomics& Metabolism Core
Leaders: Eli Michaelis, MD, PhD & Mary L. Michaelis, PhD
• Goals– Prepare mitochondria, protein extracts, DNA, and
RNA– Prepare cybrid cell lines– Perform mtDNA sequencing and 8-OH-2-dG
measurements– Assist in AD mitochondrial research
Support for Investigators
• Pilot Grant Program• Resource Requests• Collaborative REsearch Workgroup (CREW)
Meetings
Pilot Grant Program
• 3-4 grants awarded annually (July 1st)– Dr. Nudo, Landon COA, funded 1 project yr 1 & 2
• $30,000 awarded/grant• RFA 2nd week in December• New and established investigators eligible to
apply• Contact: Eric Vidoni, PhD
Resource Requests
• Investigators conducting research on aging, MCI and AD can apply– Consultation– Services– Research materials
• http://www.kualzheimers.org/alzheimers-disease-center/researcher-resources/researcher-resource-request.html
Biospecimen Resources
• Brain Tissue• Buffy Coat• Cell-free Plasma• Cybrid Cell Lines• DNA• RNA
• Muscle• Plasma• Platelets• Serum• Whole Blood
Database Access
• Alzheimer’s Disease Neuroimaging Initiative• National Alzheimer’s Coordinating Center• Kansas University Brain Aging Project
Metabolism & Mitochondria Resources
• Physical fitness, glucose tolerance, metabolic rate, and body composition testing
• Structural brain neuroimaging of humans and animals• Metabolic neuroimaging of humans and animals
(FDG PET, AV-45 and MRS)• Biochemical assays • Mitochondria, protein extracts, DNA, and RNA• Cybrid cell lines• mtDNA sequencing and 8-OH-2-dG measurements
CREW Meetings
• Collaborative REsearch Workgroup (CREW) meetings
• 3rd Monday of every month in Clinical Research Center
• All investigators in aging and dementia welcome to attend
How you can help
• Refer study participants• Collaborate with us• Spread the word• Cite us• Complete REDCap survey for any KU ADC-
affiliated publications, presentations, etc.https://redcap.kumc.edu/surveys/?s=Tpmj5i
KU ADC TeamAdministrative CoreRussell Swerdlow, MDJeffrey Burns, MDAnne Arthur, APRNEric Vidoni, PhDBrad Amstein, BSClinical CoreJeffrey Burns, MDAnne Arthur, APRNRussell Swerdlow, MDHeather Anderson, MDDavid Johnson, PhDPhyllis SwitzerHilary Dubinsky, BSDiane CunninghamAshley ThompsonEducation and Information Transfer CoreHeather Anderson, MDAngela Van SciverMitochondrial, Genomics and Metabolism CoreEli Michaelis, MD, PhDMary Lou Michaelis, PhDRussell Swerdlow, MDXinkun Wang, PhD
Data Management and Statistics CoreJonathan D. Mahnken, PhDHung-Wen (Henry) Yeh, PhDRuss Waitman, PhDBhargav Adagarla, MSSuzanne Hunt, MSCathy Price, BSMani Nair, MS, MBAMegan Parks, AADan Connolly, BSAlexandra Brown, BSNeuropathology CoreKathy Newell, MDCynthia GouvionNeuroimaging CoreWilliam Brooks, PhDIn-Young Choi, PhD, MRPhil Lee, PhD, MRLaura Martin, PhDCary Savage, PhDReg Dusing, MD
How to Contact KU ADCKU Alzheimer’s Disease Center
(913) [email protected]
www.kualzheimer.org
Research Requestshttp://
www.kualzheimers.org/alzheimers-disease-center/researcher-resources/researcher-resource-request.html
Data Corehttp://biostatistics.kumc.edu