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KROMATOGRAFI LAPIS
TIPISSENYAWA
PARACETAMOL &ASPIRIN
KIMIA FARMASI II
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KELOMPOK 7 :
PRAWIDYANITI (131031)
RATNA MARIANI (131032)RITA TRISNAYANTI (131033)
SEPTINA DEWI (131034)
SHIERLEY MARLINA (131035)
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TUJUAN PRAKTIKUM
Unt! "#"$%$"& "#t'# $n"$" "#*$!!$n #"&+$%$n+#n,$-$ P$.$/#t$"'* $n A+&.&n
+#/$.$ K.'"$t'.$ L$&+ T&&+
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DASAR TEORI
• Kromatograf adalah tek!k "em!#aha $ag "al!g
%m%m da "al!g #er!g d!g%aka dalam !dagaal!#!# 'arma#et!k(
• Metode Kromatograf La"!# T!"!# )KLT* adalah metode"em!#aha +am"%ra aal!t dega megel%#! melal%!#%at% lem"eg kromatograf lal% mel!hat kom"oe ata%
$ag ter"!#ah dega "e$em"rota ata% "ege+ataata% "e$!ara dega #!ar ,-(
• .alam klt ha#!l/ha#!l $ag d!"eroleh d!gamarkadega me+at%mka !la! R'/$a $ag me%0%k "adam!gra#! relat!1e aal!t terhada" %0%g de"a 'a#e gerakata% el%e2 da !la! !! ter!kat koef#!e d!#tr!%#!kom"oe( Maka !la! R' d!def!#!ka #eaga! 3
R' 4 5arak $ag d!tem"%h #ol%te
5arak $ag d!tem"%h 'a#e gerak
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MONORAI PARAETAMOLM#n.t 6$."$!'# # III %$* 37
N$"$ *$&n : NA/#t,*$"&n'%#n'* $t$ 4%&.'!+&$+#t$n&*&$
R"+ "'*#!* : 8H9O2
#.$t "'*#!* : 151;1< .$"="'*
P#"#.&$n : +#.>! %$>*. t&%; t&$! >#.>$; .$+$+#&!&t $%&t
K#*$.t$n : *$.t $*$" 70 >$&$n $&.; $*$" 7>$&$n #t$n'* (95?) ; $*$" 13 >$&$n $+#t'n P;
$*$" .'&*#n*&!'** 40 >$&$n *&+#.'* P; $*$" 9>$&$n P; *$.t $*$" *$.t$n $*!$*& %&.'!+&$
P#n,&"$n$n : $*$" -$$% t#.tt >$&!;t#.*&nn $.& /$%$,$
K%$+&$t : $n$*#t&!" $n $nt&&.#t&!"
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MONORAI $+&.&nM#n.t $."$!'# E III %$* 43
N$"$ *$&n : A+$" $+#t&*+$*&+&*$t $t$ A+#t'+$*R"+ "'*#!* : 9H8O4
#.$t "'*#!* : 180;1< .$"="'*
P#"#.&$n : %$>*. t&$! >#.-$.n$ $t$ +#.>!%$>*. t&%; t&$! >#.>$ $t$ %$"&.
t&$! >#.>$; .$+$ $+$"
K#*$.t$n : $$! +!$. *$.t $*$" $&.; "$%
*$.t $*$" #t$n'* (95?)P; *$.t $*$"!*'.'6'." $n $*$" #t#. P
P#n,&"$n$n : $*$" -$$% t#.tt .$$t
K%$+&$t : $n$*#t&!" $n $nt&&.#t&!"
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MONORAI ETANOLM#n.t 6$."$!'# # III %$* <5
N$"$ *$&n : $#t%$n'*"R"+ "'*#!* : 2H<O
P#"#.&$n :/$&.$n t&$! >#.-$.n$; @#.n&%; "$%"#n$ $n "$% >#.#.$!; >$ !%$+; .$+$
$n$+ M$% t#.>$!$. #n$n "#">#.&!$nn,$*$ >&. ,$n t&$! >#.$+$
K#*$.t$n : +$n$t "$% *$.t $*$" $&.; $*$"
!*'.'6'" P $n $*$" #t#. PP#n,&"$n$n :$*$" -$$% t#.tt .$$t;
t#.*&nn $.& /$%$,$; &t#"$t +#@!; @$% $.&n,$*$ $&
K%$+&$t : $t t$">$%$n
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M'n'.$ $C$#+tM#n.t 6$."$!'# # III %$* 9<
N$"$ *$&n : AC$ D#+t&*$t$
P#"#.&$n : /$&.$n @#.n&%; t&$ >#.-$.n$;t&$! >#.>$; t&$! "#"n,$& .$+$
P#n,&"$n$n : $*$" -$$% t#.tt>$&!
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METODE PRAKTIKUMALAT 3 6A7AN 3
1%$">#. 1 Et$n'*
2P*$t +&*&/$ #* <0 254 2 AC$#+t
3K$/$ 3 L$.t$n P$.$/#t$"'*
4K#.t$+ %+ A44 L$.t$n $+&.&n5P&n+#t
<A.*'@& #*$+
7#!#. *$++
8P&$ !$&*#.9tt#.
10S&n$. U
11'.'n !$/$
12P#n$.&+
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ARA KERJA :
D&!. *$t +&*&/$ #* $.& >$-$% #n$n @$.$! 1 /" $n &&+&
t$n$ $$ >$$&$n !&.& $n !$n$n; +#$n!$n $$ >$&$n $t$+&>#.& @$.$! F /"
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D&!. $n@$n n'$ *$.t$n +$"#* $$ *$t +&*&/$ #*!#"&$n &%&tn n&*$& R6 *$.t$n +$"#*
P*$t +&*&/$ &$">&* #n$n &n+#t *$* &>&$.!$n +$"$& !#.&nS#t#*$% !#.&n *$t +&*&/$ &+&n$.& #n$n +&n$. U $n &>#.&t$n$ $$ n'$ *$t +&*&/$
P*$t +&*&/$ #* &"$+!!$n !#$*$" /%$">#. ,$n t#*$% >#.&+&#t$n'* $n $&.; &&$"!$n %&n$ *$t +&*&/$ #* t#.>$+$%& '*#%6$+# #.$! +$"$& >$t$+ $t$+ ,$n t#*$% &>#.& $.&+ F /"
S#t#*$% *$t +&*&/$ #* !#.&n; &+&n$.& #n$n +&n$. U nt!"#*&%$t $$n,$ *$.t$n $+&.&n $n *$.t$n $.$/#t$"'*$$ *$t +&*&/$ #*
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HASIL PRAKTIKUMPeotola #am"el "ada Plat #!l!+a
gel #etelah"lat #!l!+a gel #ele#a! "eotola
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Se$a8a $ag telah Platd!ma#%kka ke dalam
meem"el "ada "lat +hamer $ager!#! el%e
d!l!hat dega #!ar ,1 $ag telahd!0e%hka
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Plat d!kel%arka dar! Plat $ag telahker!g2
+hamer #etelah el%e d!detek#!
megg%aka
a!k me+a"a! ata# ata# "lat #!ar ,1
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Peadaa oda dega Megh!t%gR'
"e#!l
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• N&*$& R6 $$ +'t A
J$.$! ,$n &t#"% 6$+# #.$! : 3;5 /"
J$.$! ,$n &t#"% +'*t# : 3;2 /"
N&*$& R6 G 3;2 /" = 3;5 /"
G 92:;
• N&*$& R6 $$ +'t
J$.$! ,$n &t#"% 6$+# #.$! : 3;5 /" J$.$! ,$n &t#"% +'*t# : 3;3 /"
N&*$& R6 G 3;3/" =3;5 /"
G 92:<
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PEMAHASAN• Pada "rakt!k%m kal! !! d!lak%ka "em!#aha
#e$a8a "ara+etamol da a#"!r! dega +arakromatograf la"!# t!"!#( Se$a8a "ara+etamolmer%"aka #e$a8a $ag er#!'at "olar#edagka a#"!r! #e$a8a $ag er#!'at o"olar (
• Kromatograf la"!# t!"!# adalah #%at% metode"em!#aha $ag d!da#arka "ada d!#tr!%#!#e$a8a d!dalam d%a 'a#e $a!t% 'a#e d!am $ag!a#a d!g%aka adalah #!l!ka gel =9 F >?< da 'a#e
gerak $ag d!g%aka mer%"aka +am"%ra dar!d%a "elar%t $a!t% etaol da a!r dega"erad!ga : 3 ; #ea$ak @ml( Semak! "olar#%at% "elar%t ata% +am"%ra "elar%t maka#emak! 0a%h "elar%t ter#e%t aka meggerakka
#e$a8a "olar a!k "ada "lat #!l!ka gel(
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5!ka #e$a8a o "olar #edag d!aal!#!#2 t!dak akaada "e!gkata $ag $ata dalam 0arak m!gra#!dega "e!gkata "olar!ta# "ada 'a#e gerakkarea #e$a8a ter#e%t erm!gra#! me%0% m%ka"elar%t( Me#k!"% a!r er#!'at "olar terda"atke#%l!ta/ke#%l!ta dalam "egg%aa a!r m%r!#eaga! 'a#e gerak karea a$ak #e$a8a orga!k#agat #%kar lar%t dalam a!r2 0ad! a!r m%r! !a#a$a
d!g%aka dalam 'a#e gerak $ag megad%g"elar%t orga!k(
• Fa#e gerak $ag d!g%aka #ea$ak @ml $agd!ma#%kka ke dalam +hamer kem%d!a d! 0e%hka( El%e )'a#e gerak* d!0e%hka dega
+ara +hamer d!t%t%" ra"at da d!d!amka( Pro#e#!! d!lak%ka agar atmo#'er dalam +hamerter0e%hka dega %a" "elar%t( Pe0e%ha %daradalam +hamer dega %a" aka meghet!ka"eg%a"a "elar%t #ama hal$a dega "ergeraka"elar%t dalam KLT
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• S!l!ka gel adalah ad#ora $ag "al!ga$ak d!g%aka %t%k KLT( La0%
m!gra#! #e$a8a "ada "lat #!l!ka geltergat%g "ada "olar!ta#$a( Padalama 8akt% tertet% #e$a8a/#e$a8a $ag "al!g "olar ergeraka!k dega 0arak "al!g "edek "ada"eat ter#e%t #edagka #e$a8a$ag "olar!ta#$a "al!g ke+!l
ergerak "al!g 0a%h(• Lar%ta A#"!r! da "ara+etamol
d!totolka "ada "lat KLT( Seel%m$a
d!%at 0arak ata# da a8ah "ada
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Peotola d!lak%ka #eke+!l m%gk!da #e#em"!t m%gk!( 5!ka "eotolaterlal% e#ar maka aka me%r%kare#ol%#!( Peotola $ag t!dak te"at
0%ga aka me$eaka er+ak
me$ear da megha#!lka "%+akgada #eh!gga da"at meggag%ha#!l aal!#!#( Setelah #am"el dalar%ta ak% d!totolka "ada "latKLT 2"lat KLT d!l!hat d!a8ah #!ar ,-"ada "a0ag gelomag >?< m(Caha$a dega "a0ag gelomag
>?< m d!g%aka %t%k meerag!
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SIMPULAN
1 S#n,$-$ P$.$/#t$"'* $n A+&.&n +#>$$&+$"#* $*$" K.'"$t'.$ L$&+ T&&+ #n$n6$+# #.$!n,$ "#nn$!$n /$".$n#t$n'*:$&. (9:1) $n 6$+# &$"n,$ *$t +&*&/$ #*
<0 254
2 H$.$ R6 $$ +'t A 0;91 $n %$.$ +'t 0;94
3 D&*&%$t $.& %$.$ R6 n,$; "$!$ $$t&+&"*!$n >$%-$ +#n,$-$ t#.+#>t $$*$%+#n,$-$ P$.$/#t$"'* !$.#n$ +#*$&n %$.$ R6n,$
,$n "&.&; $.$/#t$"'* +#n&.& >#.+&6$t '*$.+$"$ #n$n +&6$t #*#nn,$ S#$n!$n $+&.&n>#.+&6$t n'n '*$.; %$* &n& "#n,#>$>!$n $+&.&nt#.t$%$n &t#"$t $-$*= t&$! >#.@$*$n n$&!
"#n&!t& #*#nn,$
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