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Importance of Meta-Analysis in Medical Research
Dr. Nancy Agnes, Head,
Technical Operations, Pubrica
In-Brief
Meta-analysis Writing Services provides a
statistical approach that incorporates the
findings of multiple studies on the same
subject and can overcome conflicts between
studies. There is a growing use of meta-
analysis, and it plays an important role in
medical science. The basic principles,
measures, benefits, and caveats of writing a
meta-analysis are presented in this study to
help clinicians to understand it in clinical
practice and research. Meta-analysis paper
writing offers major benefit of a meta-
analysis is that it provides a reliable
estimation of the effect size, with
substantially improved statistical capacity,
which is important when a limited sample
size limits the power of the primary study.
Keywords: Meta-analysis Writing Services,
meta-analysis paper writing, writing a
meta-analysis, meta-analysis experts,
writing a meta-analysis paper, conducting
a meta-analysis, meta-analysis research,
meta-analysis in Medical research, meta-
analysis research help, statistical meta-
analysis.
I. INTRODUCTION
New medical studies are always published,
and clinicians face exponentially vast
volumes of new data, to the point that it has
become almost impossible for clinicians to
read and interpret all available medical data.
Furthermore, the research findings are not
reliably reproducible, and the outcomes of
individual studies are frequently inadequate
to provide confident answers. Many studies
have false-positive (type I errors) findings or
cannot detect minor effects (type II errors,
false-negative). Consequently, where the
reported results are contradictory, or the
sample size is too small to be reliable,
clinical decision-making is complicated.
The best suggestion available in the medical
literature is evidence-based medicine. The
best proof of evidence-based medicine
comes from meta-analyses that include a
less biased, more reliable clinical problem
assessment. "Meta" comes from "after" or
"beyond" in Greek; a meta-analysis is an
"analysis of analyses". In other words, it is a
statistical procedure for integrating the
findings of various studies on the same
subject and, in clinical science; it is
becoming famous for resolving
discrepancies. As such, a meta-analysis is an
empirical, quantitative synthesis of research
findings that incorporates the results of
previous studies to improve the statistical
strength and precision for estimating effects
and thus, overcoming the problem of small
sample sizes and inadequate statistical
power. Our meta-analysis experts’ provide a
detailed origins of heterogeneity that can be
examined through meta-analysis and
subgroups associated with the factor of
interest, potentially providing new insights
for future studies.
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II. META-ANALYSIS IN MEDICAL
RESEARCH
Writing a meta-analysis paper itself is a
design of a quantitative, formal,
epidemiological study used to systematically
analyze previous studies' findings to
conclude that research body. Usually, but
not always, randomized, controlled clinical
trials are the basis of the study.
III. HOW TO PERFORM A META-
ANALYSIS
For the statistical analysis of a meta-
analysis, general or specialized statistical
programs, such as STATA, S.A.S., R,
Examination Manager, or Systematic Meta-
Analysis, are used.
The general method of medical studies
meta-analysis
1. Identify relevant research: PubMed,
EMBASE, CENTRAL
2. Check between-study heterogeneity:
Cochran Q test, I2
3. Meta-analysis: fixed/random effect
model, Forrest plot
4. Evaluate sources of the heterogeneity:
subgroup analysis, sensitivity test, meta-
regression
5. Check publication bias: funnel plot,
Egger's regression test, trim and fill method
6. Present meta-analysis result based on
PRISMA
IV. HOW TO WRITE META-ANALYSIS
PAPER
Systematic reviews of writing intervention
studies are a useful approach for recognizing
instructional strategies that can change
students' writing. Meta-analysis is the
systematic approach we have used in this
study. Meta-analysis research approach
summarizes the extent and course of the
impacts of several empirical studies.
A review identifying effective writing
practices at the elementary level will need
for three reasons. First, teacher practices
have raised important questions about the
quality of writing instruction received by
elementary grade students. It is, therefore,
necessary to recognize writing therapies
with proof of efficacy.
Second, there is a growing agreement that is
waiting to fix literacy issues until later
grades. It is not sufficient to have their roots
in earlier phases.
Thirdly, only with elementary grade
students, there is no systematic meta-
analysis of writing treatments performed.
V. META-ANALYSIS IN
QUANTITATIVE & STATISTICAL
RESEARCH
Meta-analysis in Medical research
methodology includes examining the theory,
processes, and results of qualitative research
and synthesizing these observations into new
ways of thinking about phenomena.
Meta-analysis research help reflects the
research strategy in Quantitative research,
especially in health sciences, which results
from various studies using similar
techniques, data sets and analytical methods.
Meta-synthesis often takes place within a
precise academic and theoretical framework,
and that context ultimately influences the
content and type of interpretations.
Therefore, we have realized that all
constructors of phenomena are
fundamentally historical and that even our
best understandings will still be subject to
changes that may arise over time and in
various contexts.
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VI. THE RESEARCH PROCESSES IN
META-STUDY
The meta-analysis includes study
accompanied by synthesis. Four components
are used in the research procedures of the
meta-study: meta-data-analysis, meta-
method, meta- theory and meta-synthesis.
1) Meta-Data-Analysis
• Identifying an analytic strategy
• Developing filing and coding system
• Categorizing the data
• Discussing and interpreting findings as
they relate to a research question
Meta-data-analysis is the study using
retrieving "processed data" of published
research results in a specific substantive
field of investigation. This approach is
aggregative and informative, requiring
researchers to analyze several accounts of a
phenomenon to uncover the similarities and
differences between accounts.
2) Meta-Method
• Specifying methodological characteristics
of selected reports
• Elaborating on how methodological factors
influenced research findings
The analysis of the rigour and
epistemological soundness of the research
methods used in research studies is a meta-
method. Since methodological choices play
a significant role in directing future research
in a particular field of study, meta-method
contributes to the theory's advancement and
provides a conscious forward movement
strategy.
3) Meta-Theory
• Identifying primary cognitive Para
diagrams/schools of thought that will
represent in the theoretical frameworks and
emerging theory of reports
• Relating theory to larger social, historical,
cultural, and political context
• Uncovering significant assumptions under-
lying specific theories
4) Meta-Synthesis Meta-synthesis will derive from the results
of the analytic components.
• Critically interpreting the strengths and
limitations of the various discrete
contributions to the field
• Uncovering significant assumptions under-
lying specific theories
• Searching for alternative explanations for
paradoxes and contradictions within the field
Hence, meta-analysis as a methodological
strategy to help us link subjective with
objective realities, speculative truths with
probable truths, and theoretically intriguing
possibilities with practical, real-world
applications.
VII. CONCLUSION
In medical science, statistical meta-analysis
covers a broad range of subjects, from risk
factors to prognosis. Therefore, for a wide
range of subjects, including biomarkers,
genetic factors, diagnosis, and treatment,
meta-analysis is appropriate. It is also a
useful tool for integrating the findings of
Copyright © 2021 pubrica. All rights reserved 2
multiple studies and critically summarizing
existing literature on a particular
topic. Meta-analysis is the invaluable bridge
between past and future research studies.
Therefore, understanding meta-analysis is
valuable for clinicians in the process while
making clinical decisions.
REFERENCES
1. Guyatt GH, Sackett DL, Sinclair JC, Hayward R,
Cook DJ, Cook RJ. User's guide to the medical
literature. IX. A method for grading health care
recommendations. Evidence-Based Medicine Working
Group. JAMA. 1995;274:1800–1804.
2. Murad MH, Montori V.M., Ioannidis J.P., et al. How
to read a systematic review and meta-analysis and
apply the results to patient care: users' guides to the
medical literature. JAMA. 2014;312:171–179
3. Button KS, Ioannidis JP, Mokrysz C, et al. Power
failure: why small sample size undermines
neuroscience reliability. Nat Rev
Neurosci. 2013;14:365–376.