IMAGING OF HEPATOBILIARY AND PANCREATIC DISEASES
Objectives
State the imaging modalities available to assess the hepatobiliary and pancreatic diseases. Discuss the imaging modalities of choice in different pathological conditions Correlate the imaging with pathology Identify the imaging features of common pathological conditions
Recall – Anatomy
Imaging Methods
Ultrasound CT Nuclear Medicine MRI Contrast studies Plain x-ray
Presentations of patients for imaging
RHC or epigastric pain Abnormal physical examination Jaundice Abnormal lab investigations Infections Staging of tumours Trauma
RHC Pain
Common problem Cholelithiasis - Gall stones
Imaging of choice
US
Why?
Helpful to assess any inflammatory changes or biliary dilatation
Cost
Availability
Other modalities used – HIDA, CT, MRI
USS – Gallstones
Cholecystitis
USCTMRISCINTIGRAPHY
Sonographic Murphy’s sign
Focal tenderness corresponding to the GB
Helps physicians to separate - Acute cholecystitis from gallstones alone.
Complications of Gall stones
1. Cystic duct obstruction2. CBD obstruction3. Pancreatic duct obstruction
Obstructed duct due to distal calculus
CBD
PV
*Note dilated bile ducts
Others
Emphysematous cholecystitis Acalculus cholecysytitis Gall stone ilius
Emphysematous cholecysytitis
Acalculus cholecysytitis
Gall stone ileus
Small Bowel Obstruction at ileocaecal valve due to migration of gallstones that erode into duodenum from GB.
RUQ PAIN Imaging
Ultrasound – 1st CT / HIDA – 2nd ERCP / MRCP-- 3rd
JAUNDICE
Jaundice is the yellow colouration of skin and mucous membranes due to accumulation of bile pigments in blood and their deposition in body tissues
Normal Serum Bilirubin (SB) is 0.3 to 1.0 mg% Jaundice is increased levels of SB > 1.0 mg%
Causes
Over production of Bilirubin (Hemolytic) -*Pre-hepatic From haemolysis of RBC / RBC precusors
Impaired hepatic function (Hepatitic) -*Hepatic Hepatocellular dysfunction in handling bilirubin
Obstruction to bile flow (Obstructive) -*Post-hepatic Intrahepatic cholestasis Extrahepatic Obstruction (Surgical Jaundice)
Imaging
Plays a vital role in establishing the underlying aetiology and planning management. Image-guided interventional techniques are used for therapeutic procedures and for diagnostic
purposes
An Approach to Jaundice
Is it isolated elevation of serum bilirubin? Is it ↑unconjugated or conjugated fraction?
Is it accompanied by other liver test abnormalities? Is hepatocellular or cholestatic?
If cholestatic, is it intra- or extrahepatic? Answered with ,
o History and physical examinationo Interpretation of laboratory tests & radiological tests and procedures
Jaundice – Viral Hepatitis
Imaging – Limited value Acute – usually normal Helps to exclude obstruction Chronic – increased malignancy risk
Hepatitis
Common causes of Post Hepatic (Obstructive) Jaundice
Gallstone Carcinoma of head of pancreas/ ampulla / bile duct Iatrogenic strictures of biliary tree. Perihepatic lymphadenopathy
Evaluation of Obstructive Jaundice
What imaging we need?
Ultrasonography – 1st test ordered. Ultrasonography and CT scanning are useful in distinguishing an obstructing lesion from
hepatocellular Ultrasonography is the most sensitive imaging technique for detecting biliary stones. CT scanning can provide more information about liver and pancreatic parenchymal disease.
MRCP – Most useful for duct stone / Hilar obstruction PTC – Extrahepatic obstr. – drainage ERCP – Distal biliary obstruction Bx. & Rx. Endoscopic US
Obstructive Jaundice- USS
Localize site of obstruction Indicates presence of ( Cause) Calculi, Dilated biliary tract Mass lesions Low cost No radiation Non – invasive
Extra- hepatic bile duct dilatation
Cholangiocarcinoma – USS
Cholangiocarcinoma
Adenocarcinoma that arises from bile duct epithelium
CT
More likely to identify site and nature of obstruction More costly More radiation For diagnosis and for staging in malignant biliary obstruction
CT - Hydatid cyst
CT -Ampullary Carcinoma
Magnetic Resonance Imaging (MRI)
Demonstrate both the site and cause of obstruction
MRI Abdomen
Magnetic Resonance Cholangio-Pancreatography (MRCP)
ERCP (Endoscopic Retrograde Cholangio- Pancreatography)
Diagnostic Therapeutic
ERCP
Irregular dilation of intrahepatic and extrahepatic ducts.
PTC
Diagnostic Therapeutic- Drainage/ Stenting
Periampullary growth (PTC)
T tube cholangiogram
Pancreatic Cancer/Obstructive Jaundice
Altered Lab Ix
Bilirubin Serum Amylase
Pancreatitis
Biliary calculi-obstruction Alcohol- chemical toxicity
Complications of Pancreatitis
Pseudocyst Infection Hemorrhage Pancreatic insufficiency
Pancreatic Abscess
Chronic Pancreatitis
Physical examination findings
Enlarged liver Tender Liver Enlarged spleen Ascites - distention
Hepatoma
Palpable Liver Metastasis
Hepatic Abscess