I. Pavlik
Mycobacterium tuberculosis in animal and human populations and bovine tuberculosis in human population in
Central European countries during the years 1990 to 1999
Veterinary Research Institute, Brno, Czech Republic
Mycobacterium tuberculosis complex:
• M. tuberculosis • M. africanum• M. bovis• M. bovis BCG• M. bovis subsp. caprae (M. caprae) • M. canettii • M. microti• M. pinnipedi
Dvorska et al., Vet. Med.-Czech, 46, 2001, 309-328. http://www.vri.cz/docs/vetmed/46-12-309.pdf
M. tuberculosis H37Rv
M.africanum
M. tuberculosisManila genotype
M. tuberculosisBeijing genotype
M. bovis BCG
M. bovis
M. bovis subsp. caprae
M. bovis subsp. capraeM. bovis subsp. caprae
M. tuberculosisseal genotype
M. microti type vole
M. microti type Ilama
M. canetti
M. bovis
Spoligotypes of members of M. tuberculosis complex
Dvorska et al., Vet. Med.-Czech, 46, 2001, 309-328. http://www.vri.cz/docs/vetmed/46-12-309.pdf
Pavlik et al., Vet. Med. Czech, 2002, 45-51. http://www.vri.cz/docs/vetmed/47-3-45.pdf
Pavlik et al., Vet. Med. Czech, 2002, 45-51. http://www.vri.cz/docs/vetmed/47-3-45.pdf
(10.3 mil.)
Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf
Pavlik et al., Vet. Med. Czech, 2003, 90-98.
(5.4 mil.)
Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf
Pavlik et al., Vet. Med. Czech, 2003, 90-98.
(4.5 mil.)
Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf
Pavlik et al., Vet. Med. Czech, 2003, 90-98.
(2.0 mil.)
Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf
Pavlik et al., Vet. Med. Czech, 2003, 90-98.Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf
Pavlik et al., Vet. Med. Czech, 2003, 90-98. http://www.vri.cz/docs/vetmed/48-4-90.pdf
M. tuberculosis v tuberculous lesions in pigs
• Norway 1970-1975: 3 004/+ 3 (0.1%), Flesja et al., 1978
• England 1953-1968: 626/+67 (10.7%), Lesslie and Birn,
1970
• USA 1973-1977: 2 036/+ 1 (0.01%), Thoen et al., 1981
• BRD 1961-1970: 2 055/+ 10 (0.49%), Schliesser, 1976
• Slovakia 1972: 1 421/+ 1 (0.07%), Popluhar et al.,1974
• Total: 9 142/+ 82 (0.90%)
Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf
Cited references see in paper:
M. tuberculosis v tuberculous lesions in cattle
• BRD 1961-1970: 1 135/ + 2 (0.20%) Schliesser, 1976
• Slovakia 1970: 553/ + 1 (0.18%) Popluhar et al., 1970
• England 1953-1968: 14 439/ +13 (0.09%) Lesslie and Birn, 1970
• USA 1973-1977: 7 007/ + 1 (0.01%) Thoen et al. 1981
• Total: 23 134/ +82 (0.90%)
Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf
Cited references see in paper:
M. tuberculosis v tuberculous lesions in wild animals
• USA: 29 (6.1%) from 474 nonhuman primates and wild ruminants
(Thoen et al., 1981).
Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf
Cited reference see in paper:
Sources of infection for animalsOld visitors
Purchased infected animals
13
17
1990-1999 13
Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf
Animals in zoological garden Gdansk in Poland infected with M. tuberculosis
(1990-1999)
African elephant (Loxodonta africana) 1 1997
Agouti (Dasyprocta aguti) 1 1997
Tapir (Tapirus terrestris) 1 1999
Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf
Sources of infection for animals
Infected man excreting causal agent of human tuberculosis by:
• sputum, • less often urine, or • faeces.
(Thoen and Steele, 1995; Grange, 1996).
Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf
Cited references see in paper:
External environment – source of infection?
• In Slovakia M. tuberculosis was isolated from river water with waste water from tuberculosis hospital
(Laktis et al., 1970).
Pavlik et al., Vet. Med. Czech, 2003, 83-89. http://www.vri.cz/docs/vetmed/48-4-83.pdf
Cited reference see in paper:
Thank you for your attention