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GSK3 Signaling

029_12_A

KR

Reelin Role of GSK3 in Neurodegenerative and Neurological Diseases

p110

Ptdins(3,4,5)P3

APOER2VLDLR

NPxY motif

Reelin

inactive

PI3-K pGSK3p85

DAB1 pAKTSrc

Family

P

p110

Ptdins(3,4,5)P3

Insulin receptor

Insulin

inactiveactive

active

PI3-Kinase

pGSK3

p85

IRS

elF2B

pAKT

PDK1

Glycogensynthase

Proteinsynthesis

Glycogensynthesis

Hedgehog

Wnt

Phosphorylationand cleavage of Ci

No ligand

Ptc

SmoCK1

CK1Fu

Sufu Cos2Ci GSK3

PKA

PKA

Nucleus

Transcription

No cleavage, full lengthCi translocates to nucleus

Presence of ligand

Ptc

SmoFu

Sufu

GSK3

Nucleus

Transcription

Ci

PPHh

Cos2

Ci

P

Frizzled

Frizzledco-receptors Wnt

DestructioncomplexGSK3

Dishevelled

β-cateninβ-catenin

β-cateninβ-cateninpathway

β-catenin

UbUbUbU

UbUbU

Ub

Ub

FRAT

CK1

APC

Axin

Proteasome

Nucleus

Kny

pe

k

RO

R2

LR

P5/

6

i

Diversin

TCF/LEF

β-catenin Transcription

PP

Paired helicalfilaments

Tau-P

Dopamine

GSK3

GSK3

GSK3

D2

Re

cep

tor

β-arrestin-2

γ-secretase

PP2A

AKT

Nβ-secretase

α-secretase

β

A

AP

P

C

Aβ

Increased cleavageof APP into Aβ in

Alzheimer's disease

Tau hyperphoshorylation inAlzheimer's disease and

other tauopathies

e

Regulation of dopamine receptor D2signaling effects - implications

for schizophrenia

GSK3activity

Neurofibrillarytangles

TauTau

Cargo Cargo

Featured productsTau (phospho S396) antibody [E178] (ab32057)

Clonality Applications Host Species reactivity

M IHC-P, WB, ICC, IP Rabbit Mouse, Rat, Human

Immunohistochemistical detection of Tau (phospho S396) antibody [E178] (ab32057)

on formaldehyde-fixed paraffin-embedded human salivary gland sections.

This antibody has been cited in 2 publications and has received 3 star

reviews: Excellent

Wnt1 antibody (ab15251)

Clonality Applications Host Species reactivity

P IHC-P, IHC-Fr, WB Rabbit Mouse, Human

ICC/IF image of ab15251 stained mouse 3T3 cells. The secondary antibody (green) was Alexa

Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. DAPI was used to stain

the cell nuclei (blue). Alexa Fluor® 594 WGA was used to label plasma membranes (red).

This antibody has been cited in 7 publications and has received 6 star

reviews: Excellent

Insulin

Produced in collaboration with Dr Claudie Hooper Copyright © 2012 Abcam, All Rights Reserved. The Abcam logo is a registered trademark.