General Pathology:General Pathology:Introduction to the CourseIntroduction to the Course
Lorne Holland, M.D.Lorne Holland, [email protected]@ucdenver.edu
General InformationCOURSE DIRECTOR: Lorne Holland, M.D. Leprino Office Building, Main Laboratory- Rm
280 Email: [email protected] Office: (720) 848-7050
ADMINISTRATIVE COORDINATOR: Jaime Kean Building A01 Room L15-2203 Email: [email protected] Phone (303) 724-3905
Exams
• Sample questions will periodically be posted on Blackboard with answers following shortly
• Before each exam there will be a Q&A session– This is an opportunity for you to ask questions
about the material– This is not meant to be a formal review of all
lecture material• For best responses, please send me your
question(s) a day or two in advance so I know what to expect
Exams
• Multiple-choice, single best answer• 2-3 questions per lecture• Mid-October and December 17th• 2nd exam is cumulative with
approximately 80% new and 20% old• Exams will be timed with 1.5 minutes
allotted for each question
Exams
• How much does a normal human head weigh?– More than twice the average orange– Between 4.4 and 5.3 kilograms– Hair is typically 0.2% to 1.1% of head
weight– It would weigh only 1/6th as much on the
moon
Exams
• Review session immediately after• Answers will be projected• Your chance to ask questions• Only opportunity to review test
answers
Exams
• Grading– Tests are sent to the computer center
for grading where they calculate statistics for each question
– A few questions will have “bad” numbers and will be thrown out•Too hard or too easy•Random answer pattern
Other Tests• Independent study questions
– Posted on Blackboard and due Sept 28th
– May collaborate, but each student must submit their own answers
– Remember, this material is fair game for both exams
• Periodic, unannounced quizzes– Multiple-choice, single best answer and/or
short answer– You can use class notes and textbook– Students not present when the quizzes are
handed out will receive a zero– Lowest quiz score will be dropped
Objectives
• Each lecture will have a set of objectives– This is the bare minimum you should be
getting out of each lecture– If you can not perform the objectives
then it is unlikely you will pass– If you only know material specifically
addressed by the objectives, you will probably pass, but only barely (70-80%)
Odds and Ends• Lecture handouts should be available on
Blackboard 48 hrs before lecture• Exam dates will be firm, but lectures
may occasionally move around a bit. You should have at least 24 hrs warning.
• Please address questions directly to the lecturer. If you do not receive a response within 48 hrs then let me know
• Evaluations after each test. Please complete them so I know what is working and what is not
Pathology
Experimental ClinicalAnatomic
Surgical
Cytology
Autopsy
Hematopath
Gross / Micro
Gross / Micro
Microscopic
Microscopic
Scope of Pathology
Pathology
Experimental ClinicalAnatomic
T.D.M.
Transf. Med
Toxicology
Molecular
Microbiology
Hematology
Chemistry
Virology
Coagulation
Urinalysis
Serology
Point of CareFlow Cytometry
Scope of Pathology
Quick Guide to Microscopy
• Unless otherwise stated, pictures in books and lecture and hemotoxylin and eosin (H&E)– Proteins and starch stain pink– Nucleic acids (DNA, RNA) stain blue– Air, water, sugar and lipids do not stain at all– Naturally colored materials, black, brown, green
Other Colors
• Golden (yellow/brown/green)– Bile
• Brown– Hemosiderin,
lipofuschin (iron)
• Black– Carbon– Melanin
Immunohistochemistry
• Produce antibodies to specific molecules, usually proteins
• Attach a marker of some kind to the antibody
• Wash a tissue section with the labeled antibody
Estrogen receptor-Breast cancer
CD15/30-Hodgkin Lymphoma
Alphafetoprotein-Testicular Cancer
Keratin-Carcinoma, not lymphoma