DUKE UNIVERSITY MEDICAL CENTER
CURRICULUM VITAE
Permanent Record
and the
Appointments and Promotions Committee
Date Prepared:
04/28/2017
Name: Michael Lucas James, MD
Primary academic appointment: Associate Professor
Primary academic department: Anesthesiology
Secondary appointment: Neurology
Present academic rank and title: Associate Professor without Tenure, Track 1
Date and rank of first Duke Faculty appointment: 07/01/2006, Assistant Professor
Medical Licensure: North Carolina License #200001390
Date of License: 09/26/2000
Specialty certifications and dates
American Board of Psychiatry & Neurology 05/12/2004
Recertification 2014
Subspecialty Vascular Neurology 04/16/2009
American Board of Anesthesiology 05/25/2007
United Council of Neurological Subspecialties
Neurocritical Care 12/31/2008
Date of birth: 09/26/1973 Place: Baton Rouge, LA USA
Citizen of: United States of America
Education: Institution Date (Year) Degree
High School LSU Laboratory School 1991
College Vanderbilt University 1995 BS
Professional LSU School of Medicine in New Orleans 1999 MD
Scholarly societies:
Psi Chi
Professional training and academic career:
Training: Position/Title Dates
Duke University Medical Center Medical Intern 07/1999 – 06/2000
Neurology Resident 07/2000 – 06/2002
Neurology Chief Resident 07/2002 – 06/2003
Anesthesiology Resident 07/2003 – 06/2006
Neurocritical Care Fellow 07/2005 – 06/2006
Professional appointments:
Assistant Professor Departments of Anesthesiology & Neurology
Duke University 07/2006 – 10/2014
Associate Director Multidisciplinary Neuroprotection Laboratories, Department of
Anesthesiology, Duke University 07/2010 – 06/2015
Associate Director Brain Injury Translational Research Center, Department of Neurology,
Duke University 07/2009 – present
Associate Professor Departments of Anesthesiology & Neurology
Duke University 10/2014 – present
Program Director Neuroanesthesiology Fellowship, Department of Anesthesiology
Duke University 01/2015 – present
Associate Director Clinical Endeavors in Anesthesia Research, Department of Anesthesiology
Duke University 07/2015 – present
Liaison Clinical Research, Duke-NUS Affairs
Duke University 07/2016 – present
Associate Professor Department of Clinical Science
Duke-NUS Graduate Medical School 10/2016 – present
Publications:
Refereed journals:
1. James ML, Panni MK. Extremely prolonged unilateral block (20 hours) with spinal ropivacaine
used for cervical cerclage placement. Anesth Analg. 2005 Mar;100(3):897-8. PMID: 15728090
2. James ML, Husain AM. Brainstem auditory evoked potential monitoring: when is change in wave
V significant? Neurology. 2005 Nov 22;65(10):1551-5. PMID: 16301480
3. Bennett SS, Graffagnino C, Borel CO, James ML. Use of high frequency oscillatory ventilation
(HFOV) in neurocritical care patients. Neurocrit Care. 2007;7(3):221-6. PMID: 17805492
4. James ML, Warner DS, Laskowitz DT. Preclinical models of intracerebral hemorrhage: a
translational perspective. Neurocrit Care. 2008;9(1):139-52. PMID: 18058257
5. James ML, Sullivan PM, Lascola CD, Vitek MP, Laskowitz DT. Pharmacogenomic effects of
apolipoprotein e on intracerebral hemorrhage. Stroke. 2009 Feb;40(2):632-9. PMID: 19109539
6. James ML, Blessing R, Bennett E, Laskowitz DT. Apolipoprotein E modifies neurological
outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in
humans. J Stroke Cerebrovasc Dis. 2009 Mar-Apr;18(2):144-9. PMID: 19251191
7. James ML, Blessing R, Phillips-Bute BG, Bennett E, Laskowitz DT. S100B and brain natriuretic
peptide predict functional neurological outcome after intracerebral haemorrhage. Biomarkers. 2009
Sep;14(6):388-94. PMID: 19505208
8. James ML, Wang H, Venkatraman T, Song P, Lascola CD, Laskowitz DT. Brain natriuretic
peptide improves long-term functional recovery after acute CNS injury in mice. J Neurotrauma.
2010 Jan;27(1):217-28. PMID: 19803787
9. Kim GS, Amato A, James ML, Britz GW, Zomorodi A, Graffagnino C, Zomorodi M, Olson DM.
Continuous and intermittent CSF diversion after subarachnoid hemorrhage: a pilot study. Neurocrit
Care. 2011 Feb;14(1):68-72. PMID: 20596794
10. James ML, Keifer JC. Posterior optic nerve ischemic neuropathy in the setting of
phenoxybenzamine therapy after uneventful spinal fusion. J Neurosurg Anesthesiol. 2011
Apr;23(2):169-70. PMID: 21270647
11. James ML, Olson DM. Brainstem dysfunction as a predictor of death in the nonneurologically
injured. Crit Care Med. 2011 Aug;39(8):2012-3. PMID: 21768813
12. Amato A, Britz GW, James ML, Graffagnino C, Zomorodi AR, Zomorodi ME, Olson DM. An
observational pilot study of CSF diversion in subarachnoid haemorrhage. Nurs Crit Care. 2011 Sep-
Oct;16(5):252-60. PMID: 21824230
13. Laskowitz DT, Lei B, Dawson HN, Wang H, Bellows ST, Christensen DJ, Vitek MP, James ML.
The apoE-mimetic Peptide, COG1410, Improves Functional Recovery in a Murine Model of
Intracerebral Hemorrhage. Neurocrit Care. 2011 Oct 12. PMID: 21989844
14. Indraswari F, Wang H, Lei B, James ML, Kernagis D, Warner DS, Dawson HN, Laskowitz DT.
Statins improve outcome in murine models of intracranial hemorrhage and traumatic brain injury: A
translational approach. J Neurotrauma. 2012 Jan 10. PMID: 22233347
15. James ML, Wang H, Cantillana V, Lei B, Kernagis DN, Dawson HN, Klaman LD, Laskowitz DT.
TT-301 inhibits microglial activation and improves outcome after central nervous system injury in
adult mice. Anesthesiology. 2012 Jun;116(6):1299-311. PMID: 22487803
16. Macy GE, James ML. Guilty by association?*. Crit Care Med. 2012 Jul;40(7):2230-1. PMID:
22710208.
17. Sun W, Peacock A, Becker J, Phillips-bute BG, Laskowitz DT, James ML. Correlation of
leukocytosis with neurological deterioration following supratentorial intracerebral hemorrhage. J
Clin Neurosci. 2012 Aug;19(8):1096-100. Epub 2012 Jun 16. PMID: 22704946
18. Sheng SP, Lei B, James ML, Lascola CD, Venkatraman TN, Jung JY, Maze M, Franks NP,
Pearlstein RD, Sheng H, Warner DS. Xenon Neuroprotection in Experimental Stroke: Interactions
with Hypothermia and Intracerebral Hemorrhage. Anesthesiology. 2012 Nov 7. PMID: 23143806
19. James ML, Olson DM, Graffagnino C. A pilot study of cerebral and haemodynamic physiological
changes during sedation with dexmedetomidine or propofol in patients with acute brain injury.
Anaesth Intensive Care. 2012 Nov;40(6):949-57. Anesthesia & Intensive Care. 2012 Nov; 40(6).
PMID: 23194203
20. Wang H, Anderson LG, Lascola CD, James ML, Venkatraman TN, Bennett ER, Acheson SK,
Vitek MP, Laskowitz DT. ApolipoproteinE mimetic peptides improve outcome after focal
ischemia. Exp Neurol. 2013 Mar;241:67-74. Epub 2012 Dec 6. PMID: 23219883
21. Olson DM, Grissom JL, Williamson RA, Bennett SN, Bellows ST, James ML. Interrater
Reliability of the Bedside Shivering Assessment Scale. Am J Crit Care. 2013 Jan;22(1):70-4.
PMID: 23283091
22. James ML, Grau-Sepulveda MV, Olson DM, Smith EE, Hernandez AF, Peterson ED, Schwamm
LH, Bhatt DL, Fonarow GC. Insurance Status and Outcome after Intracerebral Hemorrhage:
Findings from Get with The Guidelines-Stroke. J Stroke Cerebrovasc Dis. 2013 Mar 26. PMID:
23537567
23. James ML, Andersen ND, Swaminathan M, Phillips-Bute B, Hanna JM, Smigla GR, Barfield ME,
Bhattacharya SD, Williams JB, Gaca JG, Husain AM, Hughes GC. Predictors of electrocerebral
inactivity with deep hypothermia. J Thorac Cardiovasc Surg. 2013 Apr 11. PMID: 23582829
24. Ouyang M, McDonagh DL, Phillips-Bute B, James ML, Friedman AH, Gan TJ. Comparison of
Postoperative Nausea between Benign and Malignant Brain Tumor Patients undergoing Awake
Craniotomy: A Retrospective Analysis. Curr Med Res Opin. 2013 Jun 4. [Epub ahead of print]
PMID: 23731201
25. Ouyang M, McDonagh DL, Phillips-Bute B, James ML, Friedman AH, Gan TJ. Does Midline
Shift Predict Postoperative Nausea in Brain Tumor Patients Undergoing Awake Craniotomy? A
Retrospective Analysis. Curr Med Res Opin. 2013 Jun 4. [Epub ahead of print] PMID: 23731200
26. James ML, Dority J, Gray MC, Bellows ST, McDonagh DL, Brambrink AM. Survey of
Anesthesiologists Practicing in American Neurointensive Care Units as Neurointensivists. J
Neurosurg Anesth. 2013 Jul 24. PMID: 23887679
27. Khan S, Adogwa O, Gan TJ, Null UT, Verla T, Gokhale S, White WD, Britz GW, Zomorodi AR,
James ML, McDonagh DL. Efffect of 6% hydroxyethylStarch 130/0.4 in 0.9% sodium chloride
(Voluven®) on complications after subarachnoid hemorrhage: a retrospective analysis.
SpringerPlus. 2013 Jul 15;2(1):314. PMID: 23888282
28. Lei B, Dawson HN, Roulhac-Wilson B, Wang H, Laskowitz DT, James ML. Tumor necrosis
factor alpha antagonism improves neurobehavioral recovery in murine intracerebral hemorrhage. J
Neuroinflammation. 2013 Aug 20;10(1):103. PMID: 23962089
29. Sun W, Pan W, Kranz PG, Hailey CE, Williamson RA, Sun W, Laskowitz DT, James ML.
Predictors of late neurological deterioration after spontaneous intracerebral hemorrhage. Neurocrit
Care. 2013 Aug 24. PMID: 2397979
30. Woo D, Rosand J, Kidwell C, McCauley JL, Osborne J, Brown MW, West SE, Rademacher EW,
Waddy S, Roberts JN, Koch S, Gonzales NR, Sung G, Kittner SJ, Birnbaum L, Frankel M, Testai
FD, Hall CE, Elkind MSV, Flaherty M, Coull B, Chong JY, Warwick T, Malkoff M, James ML,
Ali LK, Worrall BB, Jones F, Watson T, Leonard A, Martinez R, Sacco RI, Langefeld CD. The
Ethnic Variations of Intracerebral Hemorrhage (ERICH) Study protocol. Stroke. 2013 Sep 10.
PMIID: 24021679
31. Olson DM, Zomorodi MG, James ML, Cox CE, Moretti EW, Riemen KE, Graffagnino C.
Exploring the impact of augmenting sedation assessment with physiologic monitors. Aust Crit Care.
2013 Oct 5. PMID: 24103486
32. Williamson RA, Phillips-Bute BG, McDonagh DL, Gary MC, Zomorodi AR, Olson DM, Britz
GW, Laskowitz DT, James ML. Predictors of extraventricular drain-associated bacterial
ventriculitis. J Crit Care. 2013 Oct 11. PMID: 24125770
33. Berger M, Phillips-Bute B, Guercio J, Hopkins TJ, James ML, Borel CO, Warner DS, McDonagh
DL. A novel application for bolus remifentanil: blunting the hemodynamic response to Mayfield
skull clamp placement. Curr Med Res Opin. 2013 Oct 30. PMID: 24161010
34. Umeano O, Phillips-Bute P, Hailey CE, Sun W, Gray MC, Roulhac-Wilson B, McDonagh DL,
Kranz PG, Laskowitz DT, James ML. Sex and age interact to affect early outcome after
intracerebral hemorrhage. PLOS One. 2013 Nov 27;8(11) PMID: 24312335
35. Khan SA, Agrawal A, Hailey CE, Smith TP, Gokhale S, Alexander MJ, Britz GW, Zomorodi AR,
McDonagh DL, James ML. Effect of surgical clipping versus endovascular coiling on recovery
from oculomotor nerve palsy in patients with Posterior Communicating artery aneurysms: a
retrospective comparative study and meta-analysis. Asian J Neurosurg. 2013 Jul;8(3):117-24
PMID: 24403953
36. Wang H, James ML, Venkatraman T, Wilson L, Lyuboslavsky P, Myers S, Lascola CD, Laskowitz
DT. pH sensitive NMDA inhibitors improve outcome in a murine model of SAH. Neurocrit Care.
2014 Feb;20(1):119-31. PMID: 24420693
37. Lei B, Sheng H, Wang H, Lascola CD, Warner DS, Laskowitz DT, James ML. Intrastriatal
injection of autologous blood or clostridial collagenase as murine models of intracerebral
hemorrhage. J Vis Exp. 2014 Jul 3;(89). PMID: 25046028
38. Lei B, Mace B, Dawson HN, Laskowitz DT, James ML. Anti-inflammatory effects of progesterone
in lipopolysaccharide-stimulated BV2 microglia. PLOS One. 2014 Jul 31;9(7). PMID: 25080336
39. Warner DS, James ML, Laskowitz DT, Wijdicks EF. Translational Research In Acute Central
Nervous Injury: Lessons Learned and The Future. JAMA Neuro. 2014 Oct; 71(10): 1311-8. PMID:
25111291
40. Seongtae J, Lei B, Wang H, Dawson HN, James ML. Intravenous immunoglobulin G improves
neurobehavioral and histological outcomes after traumatic brain injury in mice. J Neuroimmunol.
2014 Nov 15;276(1-2):112-8. PMID: 25241288
41. Battey TWK, Valant V, Baedorf Kassis S, Kourkoulis C, Lee C, Anderson CD, Falcone GJ,
Jimenez-Conde J, Fernandez-Cadenas I, Pare G, Rundek T, James ML, Lemmens R, Lee TH,
Tatlisumak T, Kittner SJ, Lindgren A, Mateen FJ, Berkowitz AL, Holliday EG, Majersik J, Maguire
J, Sudlow C, and Rosand J, on behalf of the International Stroke Genetics Consortium.
Recommendations from the International Stroke Genetics Consortium, Part 2: Biological sample
collection and storage. Stroke. 2014 Dec 9. pii: STROKEAHA.114.006851.
42. Gokhale S, Caplan LR, James ML. Sex differences in incidence, pathophysiology, and outcome of
primary intracerebral hemorrhage. Stroke. 2015 Mar;46(3):886-92. doi:
10.1161/STROKEAHA.114.007682. Epub 2015 Feb 5. PMID: 25657181
43. Guercio JR, Nimjee SM, James ML, McDonagh DL. Anesthesia for interventional neuroradiology.
Int Anesthesiol Clin. 2015 Winter;53(1):87-106. doi: 10.1097/AIA.0000000000000044. No abstract
available. PMID: 25551744
44. Walsh KB, Sekar P, Langefeld CD, Moomaw CJ, Elkind MS, Boehme AK, James ML, Osborne J,
Sheth KN, Woo D, Adeoye O. Monocyte count and 30-day case fatality in intracerebral
hemorrhage. Stroke. 2015 Jun 30. pii: STROKEAHA.115.009880. [Epub ahead of print]. PMID
26130090.
45. Feix JA, Peery CA, Gan TJ, Warner DS, James ML, Zomorodi A, McDonagh DL. Intra-operative
hydroxyethyl starch is not associated with post-craniotomy hemorrhage. Springerplus. 2015 Jul
16;4:350. doi: 10.1186/s40064-015-1126-0. PMID: 26191477
46. Hsieh J, Lei B, Sheng H, Venkatraman T, Lascola CD, Warner DS, James ML. Sex-specific effects
of progesterone on early outcome in a rat model of intracerebral hemorrhage. Neuroendocrinology.
2015 Sep 10. PMID: 26356626
47. Lei B, Wang H, Jeong S, Hsieh JT, Majeed M, Dawson H, Sheng H, Warner DS, James ML.
Progesterone Improves Neurobehavioral Outcome in Models of Intracerebral Hemorrhage.
Neuroendocrinology. 2015 Nov 13. PMID: 26562172
48. Hwang DY, Dell CA, Sparks MJ, Watson TD, Langefeld CD, Comeau ME, Rosand J, Battey TW,
Koch S, Perez ML, James ML, McFarlin J, Osborne JL, Woo D, Kittner SJ, Sheth KN. Clinicians
versus formal scales for predicting intracerebral hemorrhage outcomes. Neurology. 2015. Dec 16.
PMID: 26674335
49. Traylor M, Zhang CR, Adib-Samii P, Devan WJ, Parsons OE, Lanfranconi S, Gregory S, Cloonan
L, Falcone GJ, Radmanesh F, Fitzpatrick K, Kanakis A, Barrick TR, Moynihan B, Lewis CM,
Boncoraglio GB, Lemmens R, Thijs V, Sudlow C, Wardlaw J, Rothwell PM, Meschia JF, Worrall
BB, Levi C, Bevan S, Furie KL, Dichgans M, Rosand J, Markus HS, Rost N; International Stroke
Genetics Consortium. Genome-wide meta-analysis of cerebral white matter hyperintensities in
patients with stroke. Neurology. 2015 Dec 16. PMID: 26674333
50. Sheth KN, Martini SR, Moomaw CJ, Koch S, Elkind MS, Sung G, Kittner SJ, Frankel M, Rosand J,
Langefeld CD, Comeau ME, Waddy SP, Osborne J, Woo D; ERICH Investigators. Prophylactic
Antiepileptic Drug Use and Outcome in the Ethnic/Racial Variations of Intracerebral Hemorrhage
Study. Stroke. 2015 Dec;46(12):3532-5. doi: 10.1161/STROKEAHA.115.010875. PMID:
26470777
51. Woo D, Kruger AJ, Sekar P, Haverbusch M, Osborne J, Moomaw CJ, Martini S, Hosseini S, Ferioli
S, Worrall BB, Elkind MV, Sung G, James ML, Testai FD, Langefeld CD, Broderick JP, Koch S,
Flaherty ML. Incontinence and gait disturbance after intraventricular extension of intracerebral
hemorrhage. Neurology. 2016 Feb 5. PMID: 26850978.
52. Berger M, Nadler JW, Friedman A, McDonagh DL, Bennett ER, Cooter M, Qi W, Laskowitz DT,
Ponnusamy V, Newman MF, Shaw LM, Warner DS, Mathew JP, James ML for the MAD-PIA
investigators. The effect of Propofol versus Isoflurane Anesthesia on Human CSF Markers of
Alzheimer’s Disease: Results of a Randomized Trial. J Alzheimers Dis. 2016 Apr 15;52(4):1299-
310. PMID: 27079717
53. Woo D, James ML. Sex differences exist after intracerebral hemorrhage but may not affect
outcome. Neurology. 2016 Jun 8. pii: 10.1212/WNL.0000000000002794. [Epub ahead of print]
PMID: 27281528
54. Koch S, Elkind MS, Testai FD, Brown WM, Martini S, Sheth KN, Chong JY, Osborne J, Moomaw
CJ, Langefeld CD, Sacco RL, Woo D; ERICH Study Investigators. Racial-ethnic disparities in
acute blood pressure after intracerebral hemorrhage. Neurology. 2016 Jul 13. [Epub ahead of print]
PMID: 27412141
55. Crespo V, James ML. Neuromuscular Disease in the Neurointensive Care Unit. Anesthesiol Clin.
2016 Sep;34(3):601-19. PMID: 27521200.
56. Kofke WA, Armstead WM, Gupta DK, Smith M, James ML. Update in Neuroanesthesia-
An Anesthesiology Clinics Issue Affiliated with SNACC. Anesthesiol Clin. 2016 Sep;34(3):xv-xvii.
doi: 10.1016/j.anclin.2016.06.013.
57. Lei B, James ML, Liu J, Zhou G, Venkatraman TN, Lascola CD, Acheson SK, Dubois LG,
Laskowitz DT, Wang H. Neuroprotective pentapeptide CN-105 improves functional and
histological outcomes in a murine model of intracerebral hemorrhage. Sci Rep. 2016 Oct 7;6:34834.
PMID: 27713572
58. James ML, Cox M, Xian Y, Smith EE, Bhatt DL, Schulte PJ, Hernandez A, Fonarow GC,
Schwamm LH. Sex and age interactions and differences in outcomes after intracerebral
hemorrhage. J Womens Health (Larchmt). 2016 Oct 18. [Epub ahead of print]. PMID: 27754758
59. Kidwell CS, Rosand J, Norato G, Dixon S, Worrall BB, James ML, Elkind MSV, Flaherty ML,
Osborne J, Vashkevich A, Langefeld CD, Moomaw CJ, Woo D. Ischemic Lesions, Blood Pressure
Dysregulation, and Poor Outcomes in Intracerebral Hemorrhage. Neurology. 2017 Feb
21;88(8):782-788. PMID: 28122903.
60. Kram B, Kram S, Sharpe M, James ML, Shapiro M. Analgesia and sedation requirements in
mechanically-ventilated trauma patients with acute, pre-injury use of cocaine and amphetamines.
Anest Analg. 2017 Mar;124(3):782-788. PMID: 28098590
61. Babi MA and James ML. Peri-Hemorrhagic Edema and Secondary Hematoma Expansion after
Intracerebral Hemorrhage: From Benchwork to Practical Aspects. Front Neurol. 2017 Jan 19;8:4.
PMID: 28154550
62. James ML, Langefeld CD, Sekar P, Moomaw C, Elkind M, Worrall B, Sheth K, Martini S,
Osborne J, Woo, D. Age and sex interact to affect 90-day outcome after intracerebral hemorrhage.
Neurology. (Accepted)
63. Chen CJ, Brown WM, Moomaw CJ, Langefeld CD, Osborne J, Worrall BB, Woo D, Koch S;
ERICH Investigators. Alcohol use and risk of intracerebral hemorrhage. Neurology. 2017 Apr 26.
pii: 10.1212/WNL.0000000000003952. doi: 10.1212/WNL.0000000000003952. PMID: 28446657
64. Odera U, Wang H, Dawson HN, Lei B, Umeano A, James ML. Female gonadal hormone effects
on microglial activation and functional outcomes in a mouse model of moderate traumatic brain
injury. World J Crit Care. (Accepted)
65. Guha R, Boehme A, Bracho J, Demel S, Li J, Cai X, James ML, Koch S, Langefeld CD, Moomaw
CJ, Osborne J, Sekar P, Sheth KN, Woodrich E, Worral BB, Woo D, Chaturvedi S. Aggressiveness
of care following intracerebral hemorrhage in women and men. Neurology. (Accepted).
66. Ding D, Sekar P, Moomaw CJ, Comeau ME, James ML, Testai F, Flaherty M, Vashkevich A,
Worrall BB, Woo D, Osborne J. Venous Thromboembolism in patients with spontaneous
intracerebral hemorrhage: a prospective multicenter study. (Submitted)
Chapters in books:
1. James ML and Borel CO. Early Postoperative Care: Specific Operations: Neurosurgery IN
Perioperative Medicine: Managing for Outcome. Ed. Newman MF, Fleisher LA, Fink MP. 2007.
2. James ML, Warner DS, Borel CO. Preservation of Organ Dysfunction: Central Nervous System:
Carotid and Intracranial Surgery. IN Perioperative Medicine: Managing for Outcome. Ed. Newman
MF, Fleisher LA, Fink MP. 2007.
3. James ML. Basic Principles: Anesthetic Considerations. IN Introduction to Intraoperative
Monitoring. Ed. Husain, AF. 2008 & 2013.
4. James ML and Dakakni T. Intracerebral Hemorrhage. IN Evidence-based Nursing Care for Stroke
and Neurovascular Conditions. Ed. Alexander SA. 2013.
5. James ML. Anesthesia for the Beating Heart Donor. IN Clinical Decision Support: Critical care
medicine. Ed. Shaw AD. 2012 & 2015.
6. Gokhale S and James ML. Gender differences in incidence, pathophysiology, and outcome of
primary intracerebral hemorrhage. Project: Intracerebral Hemorrhage. InTech. Ed. Chaudhary V.
2014.
7. Guercio J, Nimjee S, James ML, McDonagh DM. Anesthesia for Interventional Neuroradiology. IN
International Anesthesia Clinics: Neuroanesthesia. Ed. Boone DM. 2015.
8. Babi MA and James ML. Cerebral Venous Sinus Thrombosis. IN Manual of Neuroanesthesia:
Principal and Practice. Ed. Prabhakar H. 2016
9. Khan SA and James ML. Flow arrest in cerebrovascular surgery. IN Essentials of Neuroanesthesia.
Ed. Prabhakar H. 2016
10. Crespo-Mejias V and James ML. Neuromuscular disease. IN Anesthesiology Clinics: Advances in
Neuroscience in Anesthesiology and Critical Care. Ed. James ML and Kofke WA. 2016
11. Boone DM. Traumatic Brain Injury. IN Anesthesiology Clinics: Advances in Neuroscience in
Anesthesiology and Critical Care. Ed. James ML and Kofke WA. 2016
12. Dority J. Subarachnoid Hemorrhage. IN Anesthesiology Clinics: Advances in Neuroscience in
Anesthesiology and Critical Care. Ed. James ML and Kofke WA. 2016
13. Hoffman U and James ML. Neurologic Patients Undergoing Non-neurologic Surgery: Parkinson’s
Disease. IN Oxford Textbook in Perioperative Neuroscience and Neuroanaesthesia. Eds Mashour
GA and Englehard K. 2017.
14. Van Wyck D and James ML. Central Nervous System Infection in Neurosurgical Critical Care. IN
Essentials of Neurosurgical Anesthesia and Critical Care. Eds. Brambrink A and Kirsch J. 2017
15. McLawhorn M and James ML. Brain Microdialysis. IN Neuromonitoring Techniques. Ed
Prabhakar H. 2017
Selected abstracts:
Neurocritical Care Society Annual Meeting - October 2006
Sondecker, SB, Graffagnino C, James ML. Use of High Frequency Oscillatory Ventilation
(HFOV) in Neurocritical Care Patients.
Society of Neuroanesthesia and Critical Care Conference - October 2007
Sondecker, SB, Graffagnino C, James ML. Use of High Frequency Oscillatory Ventilation
(HFOV) in Neurocritical Care Patients.
James ML, Wang H, Laskowitz DT. Effect of human APOE genotype on a murine model of
intracerebral hemorrhage
American Society of Anesthesia Annual Meeting - October 2007
Sondecker, SB, Graffagnino C, James ML. Use of High Frequency Oscillatory Ventilation
(HFOV) in Neurocritical Care Patients.
James ML, Husain AH, Hughes GC, Swaminathan M. EEG monitoring maximizes cerebral
protection for intraoperative deep hypothermic circulatory arrest
Neurocritical Care Society Meeting - November 2007
James ML, Wang H, Laskowitz DT. Effect of human APOE genotype on a murine model of
intracerebral hemorrhage.
Blessing B, Laskowitz DT, James ML. ApoE polymorphism affects cerebral edema but not
hematoma size after intracerebral hemorrhage in humans.
Neurocritical Care Society Annual Meeting - October 2008.
Nouh A, Blessing B, Bennett E, Laskowitz DT, James ML. S100b and BNP predict
neurological function after intracerebral hemorrhage in humans.
James ML, Lascola C, Wang H, Laskowitz DT. Brain natriurectic peptide improves
neurological functions after acute CNS injury.
Society for Neuroscience Annual Meeting - November 2008
James ML, Wang H, Laskowitz DT. Effect of human APOE genotype on a murine model of
intracerebral hemorrhage.
American Respiratory Care Congress - December 2008.
Sondecker, SB, Graffagnino C, James ML. Use of High Frequency Oscillatory Ventilation
(HFOV) in Neurocritical Care Patients.
Society of Neuroanesthesia and Critical Care Annual Meeting– October 2009
James ML, Lascola C, Wang H, Laskowitz DT. Brain natriurectic peptide improves
neurological functions after acute CNS injury.
Neurocritical Care Society Annual Meeting – November 2009
Wible E, Olson D, Graffagnino C, James ML. Cerebral oximetry via near infrared spectroscopy
mirrors desaturations of brain tissue partial pressure of oxygen: A case study.
Amato T, James, ML, Britz G, Graffagnino C, Zomorodi M, Zomorodi A, Olson D.
Ventriculostomy and CSF drainage in SAH.
Society for Critical Care Medicine Annual Congress – January 2010
James ML, Lascola C, Song P, Wang H, Laskowitz DT. Brain natriurectic peptide improves
neurological functions after acute CNS injury.
James ML, Britz G, Graffagnino C, Zomorodi M, Zomorodi A, Olson D. Ventriculostomy and
CSF drainage in SAH.
International Anesthesia Research Society – March 2010
James ML, Lascola C, Song P, Wang H, Laskowitz DT. Human recombinant brain natriurectic
peptide improves neurological functions in models of acute CNS injury.
James ML, Wang H, Vitek M, Sullivan P, Lascola C, Laskowitz DT. ApoE-mimetic peptide
modifies outcome in a murine model of intracerebral hemorrhage depending on APOE
genotype.
Korean Neurocritical Care Society Annual Meeting. Seoul, Korea. May 2010
Kim GS, Amato A, James ML, Britz GW, Zomorodi A, Graffagnino C, Zomorodi M, Olson
DM. Comparison of continuous and intermittent cerebrospinal fluid drainage for the prevention
of vasospasm following subarachnoid hemorrhage: A pilot study.
Neurocritical Care Society Annual Meeting – September 2010
James ML, Wang H, Cantillana V, Kernagis DN, Dawson HN, Laskowitz DT. A novel inhibitor
of neuroinflammation improves outcome from acute brain injury.
Society of Critical Care Medicine Annual Congress – January 2011
Kim GS, Amato A, James ML, Britz GW, Zomorodi A, Graffagnino C, Zomorodi M, Olson
DM. Comparison of continuous and intermittent cerebrospinal fluid drainage for the prevention
of vasospasm following subarachnoid hemorrhage: A pilot study.
Neurocritical Care Society Annual Meeting - September 2011
Olson DM, James ML, Graffagnino C. A Physiological Study Comparing Sedation with
Dexmedetomidine Compared to Propofol in Ventilated Patients with Brain Injury.
Olson DM, Sondecker SB, Bellows S, Williamson R, James ML. Results from Inter-rater
Reliability Study of the Bedside Shivering Assessment Scale.
Society for Neuroscience in Anesthesia and Critical Care Annual Meeting – October 2011
James ML, McDonagh DL, Gray MC, Phillips-Bute B, Zomorodi A, Britz GW, Williamson
RA. Predictors of Ventriculitis After Extraventricular Drain Placement.
James ML, Britz GW, Zomorodi A, McDonagh DL, Friedman AF, Phillips-Bute B, Ferrell A,
Emery CE. Predictors of Thromboembolic Complications after Endovascular or Surgical
Treatment of Posterior Communicating Artery Aneurysms.
Dority JS, Gray MC, Williamson RA, McDonagh DL, Brambrink A, James ML.
Neuroanesthesiologists in Neurocritical Care Units.
James ML, Britz GW, Zomorodi A, McDonagh DL, Friedman AF, Phillips-Bute B, Williamson
RA, Agarwal VJ. The Role of Extraventricular Drainage Rates in Surgical Intervention for
Intracranial Pathologies in an ICU Setting.
James ML, Warner DS, Sheng H, Hong J, Lu M, Lei B. Xenon Protects Against Brain Injury in
Both Ischemic and Hemorrhagic Stroke.
James ML, Laskowitz DT, Lascola CD, Myers S, Lyuboslavsky P, Wilson L, Venkatraman T,
Song P, Wang H. pH Sensitive NMDA Inhibitors Improve Outcome in a Murine Model of
SAH.
James ML, Laskowitz DT, Kernagis D, Dawson HN, Lei B, Wang H, Indraswari F. Statins
Modulate Neuroinflammatory Responses and Improve Functional and Histological Outcomes
in Murine Models of Traumatic Brain Injury.
Berger M, McDonagh DM, James ML. The Effect of Inhalational Anesthetics versus Propofol
on Alzheimer’s Disease-related CSF Markers
American Society of Anesthesiology Annual Meeting – October 2011
James ML, McDonagh DL, Gray MC, Phillips-Bute B, Zomorodi A, Britz GW, Williamson
RA. Predictors of Ventriculitis After Extraventricular Drain Placement.
James ML, Britz GW, Zomorodi A, McDonagh DL, Friedman AF, Phillips-Bute B, Ferrell A,
Emery CE. Predictors of Thromboembolic Complications after Endovascular or Surgical
Treatment of Posterior Communicating Artery Aneurysms.
James ML, Laskowitz DT, McDonagh DL, Sun W. Leukocytosis as a Predictor of Neurological
Deterioration after Intracerebral Hemorrhage.
Dority JS, Gray MC, Williamson RA, McDonagh DL, Brambrink A, James ML.
Neuroanesthesiologists in Neurocritical Care Units.
James ML, Britz GW, Zomorodi A, McDonagh DL, Friedman AF, Phillips-Bute B, Williamson
RA, Agarwal VJ. The Role of Extraventricular Drainage Rates in Surgical Intervention for
Intracranial Pathologies in an ICU Setting.
James ML, Warner DS, Sheng H, Hong J, Lu M, Lei B. Xenon Protects Against Brain Injury in
Both Ischemic and Hemorrhagic Stroke.
James ML, Laskowitz DT, Lascola CD, Myers S, Lyuboslavsky P, Wilson L, Venkatraman T,
Song P, Wang H. pH Sensitive NMDA Inhibitors Improve Outcome in a Murine Model of
SAH.
James ML, Laskowitz DT, Kernagis D, Dawson HN, Lei B, Wang H, Indraswari F. Statins
Modulate Neuroinflammatory Responses and Improve Functional and Histological Outcomes
in Murine Models of Traumatic Brain Injury.
James ML, Laskowitz DT, Sullivan P, Mace B, Wang H, Lei B. Gender Bias on Outcome in
APOE Transgenic Mice after Intracerebral Hemorrhage.
International Stroke Conference – February 2012
James ML, Yang JP, Grau-Sepulveda MV, Olson DM, Bhatt DL, Peterson EP, Hernandez AF,
Schwamm LH, Smith EE, Fonarow GC. The Association of Insurance Status, Quality of Care,
and In-Hospital Outcomes among Patients Hospitalized with Intracerebral Hemorrhage:
Findings from GWTG-Stroke.
Neurocritical Care Society Annual Meeting - September 2011
McFarlin JM, Hailey CE, Gray MC, Sun W, Bute BP, Laskowitz DT, McDonagh DM, James
ML. Patient characteristics that correlate with a new, early do-not-resuscitate order in
intracerebral hemorrhage.
Society for Neuroscience in Anesthesia and Critical Care Annual Meeting – October 2012
Lei B, Wang H, James ML. Sex-based differences in a murine model of intracerebral
hemorrhage.
Umeano O, Wang, H, Dawson HN, Lei B, James ML. Estrogen-mediated microglial activation
and its effects on functional outcomes in a murine model of traumatic brain injury.
Komisarow, J, McCord TJ, James ML, Kontos CD. Expression of the receptor tyrosine kinase
Tie1 on inflammatory cells following intracerebral hemorrhage.
Wang, H, Lei B, Wang B, Laskowitz DT, James ML. The apolipoprotein E-based small peptide,
VR55, reduces brain inflammation and improves functional outcomes in a mouse model of
intracerebral hemorrhage.
American Society of Anesthesiology Annual Meeting – October 2012
Berger M, Guercio J, Hopkins T, James ML, Borel CO, Bute BP, Warner DS, McDonagh DM.
A novel therapeutic application for bolus remifentanil: Blunting the hemodynamic response to
Mayfield placement.
Feix JA, Gan TJ, James ML, Warner DS, McDonagh DM. Intra-operative hydroxyethyl starch
(HES) colloid use is not associated with post-craniotomy hemorrhage.
Lei B, Wang H, James ML. Sex-based differences in a murine model of intracerebral
hemorrhage.
Umeano O, Wang, H, Dawson HN, Lei B, James ML. Estrogen-mediated microglial activation
and its effects on functional outcomes in a murine model of traumatic brain injury.
Komisarow, J, McCord TJ, James ML, Kontos CD. Expression of the receptor tyrosine kinase
Tie1 on inflammatory cells following intracerebral hemorrhage.
Wang, H, Lei B, Wang B, Laskowitz DT, James ML. The apolipoprotein E-based small peptide,
VR55, reduces brain inflammation and improves functional outcomes in a mouse model of
intracerebral hemorrhage.
American Academy of Neurology Annual Meeting, March 2013
El-Husseini N, Laskowitz DT, Li YW, Bennett ER, Williams RA, Hailey CE, Richardson K, Li
YJ, James ML. Gp130 SNP rs10940495 is associated with functional outcome following
spontaneous intracerebral hemorrhage.
Neurocritical Care Society Annual Meeting – October 2013
Gokhale S, Kernagis D, Lei B, Li YJ, Warner DS, Laskowitz DT, James ML. Differential gene
expression of sex chromosomes after experimental intracerebral hemorrhage in mice.
Gokhale S, Kernagis D, Lei B, Li YJ, Warner DS, Laskowitz DT, James ML. Sex differences in
expression of hemostatic pathway regulatory genes after experimental intracerebral
hemorrhage in mice.
International Stroke Conference – February 2014
James ML, Sekar P, Moomaw CJ, Sheth KN, Worrall BB, Martini SR, Osborne J, Langefeld
CD, Woo D. Association Of Gender-age Interaction With Outcome After Intracerebral
Hemorrhage In Multiple Ethnicities
Gokhale S, Gokhale S, Kernagis D, Lei B, Li YJ, Warner DS, Laskowitz DT, James ML. Sex-
specific Differential Gene Expression In A Murine Model Of Experimental Intracerebral
Hemorrhage.
Neurocritical Care Society Annual Meeting – September 2014
Jeong S, Lei B, Wang, H, Dawson, HN, James ML. Intravenous immunoglobulin G improves
neurobehavioral and histological outcomes after traumatic brain injury in mice.
Hsieh JT, Lei B, Sheng H, Lascola CD, Venkatraman T, Warner DS, James ML. Sex-specific
efficacy of progesterone on early outcome in a rat model of intracerebral hemorrhage
International Stroke Conference – February 2015
James ML, Sekar P, Langfeld CD, Frankel M, Osborne J, Woo D. Sex-age Interactions And
Differences In Outcomes After Intracerebral Hemorrhage
Lei B, Hsieh J, Sheng H, Dawson H, Warner DS, James ML. Progesterone Improves Long-term
Neurobehavioral Outcome In Models Of Intracerebral Hemorrhage (ICH)
World ICH Conference – May 2017
James ML, Maughan M, Samson A, Worrall BB, Tucker K, Swisher C, Hart J, Laskowitz DT.
A proof of concept study to evaluate the administration of CN-105 in participants with Acute
supraTentorial intraCerebral Hemorrhage (CATCH Trial)
Consultant appointments:
Intensive Care consultant, Duke Raleigh Hospital, Raleigh NC
Anesthesia consultant, Central Regional Hospital, Butner, NC
Anesthesia consultant, Durham Veteran’s Affairs Medical Center, Durham, NC
Speaker Consultant, Hospira Worldwide, Lake Forest, IL – 2010-2012
Professional awards and special recognitions:
Louisiana State Board of Supervisors Scholar – 1995-1999
Ruth L. Kirchstein National Research Scholar – 2006-2009
American Society of Critical Care Anesthesiologists/Hospira Physician Scientist Award – 2009
Society of Neurosurgical Anesthesia and Critical Care/Integra Foundation Travel Award – 2009
Society of Neurosurgical Anesthesia and Critical Care John D. Michenfelder New Investigator
Award - 2009
Society of Critical Care Medicine Scientific Award – 2010
Duke DREAM Young Investigator Award – 2010
Duke Course in Scientific Management and Leadership – 2010
NINDS Clinical Trials Methods Course in Neurology – 2011
Duke-Duke NUS Collaborative Travel Award - 2011
Duke University Department of Medicine Integrated Research Award – 2012
Duke-Duke NUS Collaborative Sabbatical Award – 2013
Society of Critical Care Medicine Presidential Citation – 2013
Best Doctors – 2013, 2014, 2015, 2016
Fellow, American Heart Association – 2014
Neurocritical Care Society Presidential Citation – 2014
Fellow, Neurocritical Care Society – 2015
Organizations and participation:
American Medical Association - 1995 – 2006
North Carolina Medical Society - 1999 – present
American Society of Anesthesiology - 2003 – present
Scientific and Educational Exhibits Committee – 2010 - 2011
Annual Meeting abstract reviewer – 2011 - 2016
Annual Meeting abstract moderator – 2013 - 2015
Clinical Neurosciences Abstract Review Committee – 2012 - 2015
Experimental Neurosciences Abstract Review Committee – 2014 - 2015
Neuroanesthesia Committee – 2014 - 2016
Society of Neurosurgical Anesthesia and Critical Care – 2006 - present
Board of Directors – 2014 - present
Fellowship Committee – 2007 - 2009
Scientific Committee – 2009 - 2015
ICU Committee – 2010 – 2014
Chair – 2014 – present
Perioperative Medicine Interest Group
Co-Chair – 2013-2014
Annual Meeting abstract reviewer – 2009 - 2016
Annual Meeting abstract moderator – 2011 - 2016
Michenfelder Award presenter – 2013, 2015
Society of Critical Care Medicine - 2005 - present
Membership Committee– 2010 - 2015
Vice Chair – 2012
Chair – 2013
Neuroscience Section – 2013 - 2016
Anesthesiology Section – 2012 - 2016
Carolinas/Virginia Chapter – 2013 - 2016
Volunteer Evaluation Task Force – 2013 - 2014
Annual Congress abstract reviewer – 2009 - 2015
Annual Meeting abstract moderator – 2012 - 2014
American Stroke Association - 2000 – present
Stroke Council Early Career Cerebrovascular Development Committee – 2012 - 2014
Neurocritical Care Society - 2006 - present
Fundraising Committee – 2007 - 2012
Research/Clinical Trials Committee – 2011 - 2016
Annual Meeting abstract reviewer – 2008 - 2014
Annual Meeting Committee – 2012 - 2014
Scientific Committee – 2013 - 2014
Annual Meeting abstract moderator – 2013, 2014. 2015, 2016
Annual Meeting Session Moderator – 2014
National Institutes of Health
Loan Repayment Ambassador – 2010 - 2013
Society for Neuroscience - 2008 - present
Society for Clinical and Translational Science – 2010 - present
Annual Meeting abstract reviewer – 2011
International Stroke Genetics Consortium – 2011 – present
Intracerebral Hemorrhage Work Group – 2013-present
Translational Science Work Group – 2014 – 2016
Co-Chair – 2014 – 2015
United Council of Neurological Subspecialties – 2015 – present
At-Large Board of Director – 2015 – present
Departmental duties and responsibilities:
Departmental Research Council 2015 – present
Institutional Review Board 2015 – present
Associate Director, Clinical Anesthesiology Research Endeavors
2015 – present
Program Director, Neuroanesthesiology Fellowship
2015 – 2017
Teaching responsibilities including continuing education:
School of Medicine
Critical Care Intersession Program coordinator 2007, 2008, 2009, 2010
Neuroscience ICU Tour Director 2009, 2010
Housestaff Education:
Anesthesiology Resident Lecture Series
“Board Review of Intraoperative Monitoring” 2006, 2007, 2008, 2012
“Board Review of Post-operative Neuropathy” 2006, 2007, 2008, 2009
“Basics of Neurophysiology” – 2012, 2013, 2014
“Intraoperative Neurophysiologic Monitoring” – 2011, 2012, 2013, 2014, 2015
Electrophysiology Conference
“Late potentials” July 2006
GVT Anesthesia Conference
“Neurological monitoring for carotid surgery” April 2007
Neurointensive Care Lecture Series
“Advances in Management of Intracerebral Hemorrhage” 2006, 2007, 2008
“Sedation in the NeuroICU” 2006, 2007, 2008
Neurology Resident Lecture Series
“Update on Intracerebral Hemorrhage” 2006, 2007, 2008, 2009, 2010, 2011,
2014, 2015
“Management of Subarachnoid Hemorrhage” - 2008
Neurosurgical Resident Board Review Lecture Series
“Neurosurgical Anesthesia and Cerebral Physiology” 2006, 2007, 2008
“Surgical Management of Intracerebral Hemorrhage” - 2008
Pediatric Anesthesia Conference
“Intraoperative monitoring for pediatric neuro-anesthesia” August 2006
Pediatric Neurology Conference
“Disorders of cranial size” September 2006
School of Nursing Education
Nurse Practioner Lecture Series
“Blood Gas Analysis” 2006, 2007, 2008
“Neurophysiology” 2006, 2007, 2008
“Ventilation & Airway Management in the NeuroICU” 2006, 2007, 2008
“Intubation Workshop” 2010
Certified Registered Nurse Anesthetist Lecture Series
“Neuroanesthesia Bascis” 2007, 2008
University of North Carolina – Chapel Hill School of Nursing
Physician-Nurse Communications Seminar February 2009
Invited Presentations:
Local:
Duke Anesthesiology Academic Evening
Abstract Evaluator – 2009 - 2012
Poster Presentation Moderator – 2009 - 2013
Duke Anesthesiology Grand Rounds
“Hyperoxia: use in modern anesthesia” April 2006
“Translational models of neuronal injury and anesthetic implications” November 2007
“Acute CNS Injury: attempting translational research” August 2010
“Sex differences in gene expression after intracerebral hemorrhage in mice” January
2012
“APOE to Sex Differences: The circuitous route of science” October 2012
“Bench to Bedside to Bench: Translational research in acute CNS injury” December 2013
Duke Critical Care Grand Rounds
“Management of intracerebral hemorrhage & update on ongoing clinical trials” March
2007
“Statins in Acute CNS Injury: the Evidence” March 2009
Duke Neuroscience Grand Rounds
“Evaluating auditory evoked potential changes in the operating room” March 2006
“Preclinical models of intracerebral hemorrhage” January 2007
“Sex-specific recovery after intracerebral hemorrhage” October 2013
Duke Neurosurgical Grand Rounds
“Translating APOE into therapeutic trials for intracerebral hemorrhage” January 2017
Duke Stroke Conference
“Minimally Invasive Surgery for Intracerebral Hemorrhage” April 2007
“Statins Before and After Stroke” March 2009
“Translational Failures in Neuroprotection” December 2010
“APOE to Sex Differences in Intracerebral Hemorrhage” December 2012
“Progesterone as a Treatment for Acute Intracerebral Hemorrhage” April 2014
Regional:
North Carolina Society of Electrophysiology Technicians, Greenville, NC, May 2015
“Anesthesia for Neural Monitoring”
dCRUE Lecture Series, Duke University, Durham, NC, October 2016
“Translational Research as a Junior Faculty”\
Duke Clinical Research Institute Lecture Series, DCRI, Durham, NC October 2016
“Neuroscience Medicine: Focus on Translation”
National:
Neurocritical Care Society Certification for Neurocritical Care Review Course, Las Vegas, NV,
2007
“Acid-base Physiology in the ICU”
University of Washington – St. Louis Grand Rounds
“Translational models of intracerebral hemorrhage” March 2007
Society for Neurosurgical Anesthesia and Critical Care Annual Meeting, New Orleans, LA, 2009
“John D. Michenfelder Lecture – Natriuretic peptides and brain injury”
Society of Critical Care Medicine Annual Congress, Miami, FL, 2010
“Cerebral ischemia-reperfusion injury – basic science refresher”
Neurocritical Care Society, Annual Meeting, San Francisco, CA, 2010
“Research in Brain Injury Workshop - BNP Modulates Recovery from Stroke”
Society for Neurosurgical Anesthesia and Critical Care Annual Meeting, San Diego, CA, 2010
“Translating Clinical Research into Clinical Practice”
Society of Critical Care Anesthesiology Annual Meeting, Washington, DC, 2012
“APOE to Sex Differences: FAER and evolving science”
Neurocritical Care Society Annual Meeting, Philadelphia, PA, October 2013
“Inflammation in Intracerebral Hemorrhage”
Society of Critical Care Medicine Annual Congress, San Francisco, CA, February 2014
"New Member Orientation to SCCM and Congress"
Neurocritical Care Society Annual Meeting, Seattle, WA, September 2014
“Intravenous immunoglobulin G improves neurobehavioral and histological outcomes
after traumatic brain injury in mice.”
“NCS – SNACC Symposium – Intraoperative Disasters”, moderator
Society for Neuroscience in Anesthesia and Critical Care, New Orleans, LA, October 2014
“ENLS Workshop”
“NCS – SNACC Symposium – Intraoperative Disasters”, moderator
Neurocritical Care Society Annual Meeting, Scottsdale, AZ, October, 2015
“NCS – SNACC Symposium – Organ Procurement”, moderator
12th
New York Symposium on Neurological Emergencies and Neurocritical Care, New York
Academy of Medicine, June 2016
“Optimizing Anesthesia in Thrombectomy”
“Stroke Crossfire”
“The Difficult Airway in Coma”
“Precision Fluid Resuscitation”
American Association of Neuroscience Nurses Triad Chapter Annual Meeting, December 2016
“Intracerebral Hemorrhage”
“Spinal Cord Compression Syndromes”
“Traumatic Spinal Cord Injury”
World ICH Conference, Baltimore, MD, May 2017
“A proof of concept study to evaluate the administration of CN-105 in participants
with Acute supraTentorial intraCerebral Hemorrhage (CATCH Trial)"
Visiting Professorships
Beth Israel Deaconess, Boston, MA, March 2015, “Management of Aneurismal
Subarachnoid Hemorrhage”
University Cincinnati, Cincinnati, OH, April 2016, “Anesthesiology in Stroke Research”
University of Pennsylvania, Philadelphia, PA, May 2016, “Adventures in Translational
Research”
International:
Duke-National University of Singapore Visiting Professor, Singapore, February 2012
“Sex effects outcome after intracerebral hemorrhage”
Society of Critical Care Medicine Annual Congress, San Juan, PR, 2013
"New Member Orientation to SCCM and Congress"
Duke-National University of Singapore Visiting Professor, Singapore, July 2013
“The Many Hats of the Clinician Scientist”
“Translating Sex-specific Brain Recovery after Intracerebral Hemorrhage”
KKH Hospital Visiting Professor, Singapore, July 2013
“Becoming a Clinician-scientist”
Baxter Biotherapeutics Medical Affairs Meeting, March 2014
“Gammagard Improves Outcomes in a Murine Model of Closed Head Injury”
Singapore General Hospital Neuroanesthesia Interest Group, Singapore, May 2014
“Intraoperative Management for Aneurismal Surgery”
3rd Singapore-Duke Anaesthesia Conference, Singapore, November 2015
“What's Best for the Brain - the Ideal Neuroanaesthetic”
“A Stroke of Bad Luck - How to Prevent Perioperative CVAs”
“Applied Neurophysiology & Neuropharmacology”
“Let's Do Away With Expensive Awareness Monitors”
5th
Symposium of Intraoperative Monitoring of the Latinamerican Chapter of the IFCN,
Guadalajara, Jalisco, Mexico, May 2016
“Anesthetic Effects on Intraoperative Monitoring”
“Effective Communication Between the Surgical Team”
Duke-National University of Singapore Visiting Professor, Singapore, October 2016
“Perils of Translational Research”
SingHealth Academic Hour, Singapore, March 2017
“Managing Transitions: Growing Up in Academic Medicine”
Neuro Anaesthesia and Critical Care Society of Great Britain and Ireland Annual Meeting,
London, May 2017
“Trauma: Optimal care from battlefield to Critical Care”
Mentoring
Nouh A, MD, Duke Post-graduate – “Use of bedside proteomics to predict outcome after acute
CNS injury”, 2008
Zomorodi M, RN PhD, Duke Translational Nursing Institute – “Sedation scales and bispectral
index in patients with acute CNS injury”, 2008
Wible E, MD, Neurointensive Care Fellow – “Comparison of Cerebral Oximetry Monitoring and
CT Perfusion anaLysis In Subarachnoid Hemorrhage”, 2009-2010
Johnson K, Duke MS-III – “Precedex versus Propofol-Awakening for Reducing Brain Injury
Expansion; A phase IV Single Center Cross Over Clinical Study Comparing Two Different
Sedations”, 2008-2009
Kim GS, MD, Clinical Training Program Research Fellow – “Comparison of continuous and
intermittent cerebrospinal fluid drainage for the prevention of vasospasm following
subarachnoid hemorrhage”, 2009-2010
Halley, N RN, Duke Translational Nursing Institute Grant – “Ventriculostomy in SAH: Open or
Not”, Duke Translational Nursing Institute Grant, 2010-2011
Williamson RA, Duke Post-graduate – “Predictors of ventriculitis after extraventricular drain
placement”, 2010-2011
Agarwal V, MD , Neurosurgical resident– “The Role of Extraventricular Drainage Rates in
Surgical Intervention for Intracranial Pathologies in an ICU Setting”, 2011 - 2012
Roulhac-Wilson B, Duke Undergraduate – “Association of cerebral edema formation with early
neurological deterioration after intracerebral hemorrhage in humans”, Neuroscience Fellow in
the Duke Institute of Brain Sciences, 2011
Emery CE, Duke Post-graduate – “Predictors of thromboembolic complications after securing
posterior communicating artery aneurysm”, 2011 -2012
Berger M MD, Duke Anesthesiology, ACES Resident – “Modulation of A-beta CSF
concentrations by anesthetic technique”, 2010-2013
Umeano O, Duke MS-III, – “Gender effects on endothelial progenitor cells after traumatic brain
injury in murine models”, 2011 – 2012
El-Husein N, MD, Vascular Neurology Fellow – “Proteogenomic expression after human ICH”,
2011 - 2012
Fransisca I, Duke-NUS MS-III – “Statins modulate neuroinflammatory responses and improve
functional and histological outcomes in murine models of traumatic brain injury and
intracerebral hemorrhage”, Abstract Award to Society for Neuroscience in Anesthesia and
Critical Care Annual Meeting, 2010-2012
Sun Wei, MD, Clinical Training Program Research Fellow – “Correlation of leukocytosis with
early neurological deterioration following supratentorial intracerebral hemorrhage”, 2010-2011
Sun Weiping, MD, Clinical Training Program Research Fellow, 2011-2012
Dority J MD, Neuroanesthesia Fellow – “Survey of Neuroanesthesiologists in Neurointensive
Care in the US”, 2011 - 2012
Jeong S MD, Chonnam National University Medical School Post Doctoral Candidate -
Immunoglobulin G for treatment of severe traumatic brain injury", 2012-2014
Zhang Y MD, Clinical Training Program Research Fellow– “Genomic predictors of outcome
after intracerebral hemorrhage”, 2012-2013
Gokhale S MD, Duke Neurointensive Care Fellow – “Sex differences in incidence, underlying
pathophysiology, and outcome of primary intracerebral hemorrhage”
Hsieh J MS-III, Duke-NUS Medical School - “Sex differences in response to progesterone in
models of intracerebral hemorrhage”, 2013-2014
Xie Y MD, Neuroanesthesia Fellow - “Sex differences in proteogenomic expression after
intracerebral hemorrhage in mice”, 2013-2014
Hoffman U MD, Neuroanesthesia Fellow – “Anesthetic management of patients with
Parkinson’s Disease”, 2014-2015
Crespos V MD, Neuroanesthesia Fellow – “Neuromuscular disease in the neurointensive care
unit”, 2015-2016
Babi A MD, Neurointensive Care Fellow – “Urine biomarkers of acute kidney injury after
intracerebral hemorrhage”, 2015-2017
MacLawhorn M MD, Neuroanesthesia Fellow – “Neuromonitoring: Microcatheters and
Microdialysis”
Christianson T MD, Critical Care and Neurocritical Care Fellow – “Incidence and outcome of
acute respiratory distress syndrome after intracerebral hemorrhage”
Christian Hernandez, Neurocritical Care Fellow – “Role of mean arterial pressure in hemorrhage
expansion and cerebral edema formation after intracerebral hemorrhage”
Hashmi N MD, Duke University Faculty – “Stroke-Related Early Tracheostomy Versus
Prolonged Orotracheal Intubation in Neurocritical Care Trial (SETPOINT)”
Journal Peer-reviewer
Anesthesiology
Anesthesia and Analgesia
Annals of Neurology
Biomarkers
Biomed Central Anesthesiology
Brain, Behavior, and Immunity
Critical Care
Critical Care Medicine
European Journal of Neurology
Experimental Neurology
Journal of Cerebral Blood Flow and Metabolism
Journal of Critical Care
Journal of Neuroinflammation
Journal of Neurological Sciences
Journal of Neurology
Journal of Neurology, Neurosurgery, and Psychiatry
Journal of Visualized Experiments
Metabolic Brain Disease
Neurocritical Care
Neurology
Neurological Research
Neurological Sciences
Neurosurgery
Open Journal of Anesthesiology
PLOSOne
Stroke and Vascular Neurology
Translational Stroke Research
Editorial Board
BMC Neurology
Frontiers of Neurology
Journal of Neurosurgical Anesthesiology
Neurocritical Care
Basic Science Editor 03/2015 – present
Open Journal of Anesthesiology
Proceedings of Singapore HealthCare
Study Section Grant Reviewer
American Institute of Biological Sciences
CCCRP 13-14, 2013
American Heart Association
Cerebrovascular Disease and Stroke, 2014, 2015, 2016
Brain – 3, 2015
National Institute of Neurological Diseases and Stroke
ZNS1 SRB-G (05)/NSD-K Study Section, March 2016
ZNS1 SRB G(10) Study Section, November 2016
National Institute of General Medical Sciences
2017/08 ZGM1 TRN-4 (LN), April 2017
Areas of research interests list:
Mechanisms of microglial-mediated acute inflammation
Models of intracerebral hemorrhage
Translational models of neuronal injury
Acute intracerebral hemorrhage clinical trials
Proteogenomic interactions after intracerebral hemorrhage
Effects of sex and gender on recovery after intracerebral hemorrhage
Research Support:
NIH/NINDS 1R01NS069763-01 (PI: Woo; Duke site-PI: James) 12/20/2011-12/20/2017
Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH)
This discovery phase, multi-center case-control study will improve our understanding of the
epidemiology of Intracerebral hemorrhage among minorities including the relative importance of
potential candidate genes. There is no overlap with the proposed project.
NIH/NINDS UO1NS074425 (PI: Selim; Duke site-PI: James) 09/2012-08/2017
High-Dose Deferoxamine in Intracerebral Hemorrhage (HI-DEF)
The main purpose of this study is to determine whether treatment with deferoxamine mesylate is
of sufficient promise to improve outcome before pursuing a larger clinical trial to examine its
effectiveness as a treatment for brain hemorrhage. There is no overlap with the proposed project.
NIH/NIGMS 1R21GM202359-01 (PI: Maccarini; Co-PI: James) 09/2014-08/2017
A novel low-cost and noninvasive device to measure deep temperature in the body
The goal of this project is a create and validate a non-invasive and entirely passive system that
safely measures deep tissue temperature in humans.
NIH/NINDS 1U01NS080824-01A1 (PI: Hanley; Duke site-PI: James)
Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III (MISTIE III)
A phase III, randomized, case-controlled, open-label, 500-subject clinical trial of minimally
invasive surgery plus rt-PA in the treatment of intracerebral hemorrhage (ICH).
NIH/NINDS 1 R21 NS087157-01 (PI: Warner; Co-I: James)
Xenon As A Therapeutic in Experimental Intracerebral Hemorrhage
The goal of this work is to perform essential preclinical studies to guide clinical xenon trials for
patients with intracerebral hemorrhage.
NIH 2UM1 HL08895 (PI: Smith, Sub-I: James) 07/01/07-01/31/18
Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine
The Cardiothoracic Surgical Trials Network (CSTN) is an NIH sponsored network of sites
through which the NIH will conduct multiple, collaborative, proof-of-concept, clinical protocols
to evaluate surgical and minimally invasive interventional strategies to improve the treatment of
cardiovascular disease in adult populations.
NIH 0255-3106-4609 (PI: Mathew, Co-I: James) 10/15/2008-01/31/2018
Network for Cardiothoracic Surgical Investigations in Cardiovascular Medicine-Consortium
Agreement - Duke University Neurocognitive Core Laboratory (DUNCL)
The Duke University Neurocognitive Core Laboratory will conduct all quality assurance
activities including reviewing of testing audiotapes, generating performance review documents,
and providing feedback on accuracy and completeness to the enrolling sites.
NIH/NHLBI 1R01130443-01A1 (PI: Mathew, Sub-I: James)
Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest
This phase II trial will assess the effects of hypothermia and circulatory arrest on long-term
cognitive outcomes in patients undergoing aortic arch surgery.
Pending Research
AHA (PI: James)
Exploring menopausal and gonadal hormonal effects on intracerebral hemorrhage
This project will define the sex-specific differences in recovery after intracerebral hemorrhage in
humans. Further, it will determine associations between gonadal hormones and outcome after
intracerebral hemorrhage. These data will be used to gonadal hormones for potential therapeutic
development through future R01 funding. There is no overlap with the proposed project.
National Institutes of Health (PI: James)
A phase 2 open label stud of CN-105 in intracranial hemorrhage
This project seeks to translate a novel apoE-mimetic peptide from compelling preclinical
application through successful phase 1 testing into human clinical trials after intracerebral
hemorrhage
National Institutes of Health (site-PI: James)
Hyperbaric Oxygen Brain Injury Treatment (HOBIT) Trial: A Multicenter, Randomized,
Prospective Phase II Adaptive Clinical Trial Evaluating the MostEffective Hyperoxia
Treatment Paradigm for Severe Traumatic Brain Injury
This trial is designed as a multicenter, prospective, randomized, adaptive Phase II trial to assess
efficacy in patients with severe TBI of the combination of treatment parameters (pressure and
intervening normobaric hyperoxia [NBH]) that is most likely to demonstrate improvement in the
rate of good neurological outcome versus control in a subsequent confirmatory trial.
Completed Research
Cephalogics (PI: James) 06/2016-12/2017
Novel non-invasive optical tomography in vasospasm after subarachnoid hemorrhage
The purpose of this study is to test the feasibility and safety of a multi-channel optical oximetry
device for measuring cerebral oxygenation.
Cephalogics (PI: James) 06/2013-12/2014
Novel non-invasive optical tomography in hemispheric stroke
The purpose of this study is to test the feasibility and safety of a multi-channel optical oximetry
device for measuring cerebral oxygenation.
AHA Scientist Development Grant – (PI: James; Mentor: Laskowitz) 07/01/2009-12/31/2013
Microglial-mediated Inflammation in a Murine Model of Intracerebral Hemorrhage as a
Paradigm for Targeted Pharmacogenomic Intervention
This professional society grant evaluates the role of microglial activation in a murine model
of intracerebral hemorrhage as a rationally-derived target for pharmacogenomic therapeutic
intervention. There is no overlap with the proposed project.
Baxter HealthCare Corporation (PI: James) 01/01/2012-12/31/2013
Gammagard Improves Outcomes in Murine Models of Closed Head Injury and Subarachnoid
Hemorrhage
In the current proposal, we will test whether IVIG is protective in clinically relevant models of
closed head injury and subarachnoid hemorrhage that we have validated in our laboratory. There
is no overlap with the proposed project.
Hospira Inc. – (PI: Olson; Co-PI: James) 07/28/2009–07/28/2012
Cerebral Perfusion Pressure using Precedex and Other Sedatives
The purpose of this investigator-initiated clinical trial is to evaluate the effects of different
sedation regimens on cerebral perfusion pressure in patients after acute CNS injury requiring
intracranial pressure monitoring. There is no overlap with the proposed project.
Duke Translational Nursing Institute – (PI: Olson, Co-PI: James) 1/15/2010-1/15/2011
Ventriculostomy in SAH: Open or Not?
A randomized control trial of two methods of cerebral spinal fluid management. This study
explores the association between intracranial pressure, cerebral spinal fluid drainage and
cerebral artery vasospasm after acute subarachnoid hemorrhage.
NIH/NINDS 1R34NF056638-01 - (PI: Hanley; Duke PI: James)
Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage
The purpose of this Phase III randomized clinical trial is to compare a policy of early
extraventricular drain use and recombinant tissue plasminogen activator with best conventional
management in the treatment of subjects with intraventricular hemorrhage and obstruction of the
3rd
or 4th
ventricles by blood.
FAER Mentored Research Training Grant – Translational Science (PI: James; Mentor:
Laskowitz/ Warner) 07/01/2009-06/30/2010
Pharmacogenomic Influence of ApoE and Mimetic Peptide on Neurological Outcomes as a
Paradigm for Targeted Therapeutic Development in a Murine Model of Intracerebral
Hemorrhage
This professional society grant evaluated the interaction between endogenous apolipoprotein
E and exogenously administered mimetic peptides on neurological and neuroinflammatory
outcomes after intracerebral hemorrhage in a mouse model.
NIH/NIGMS T32 GM08600-13 – (PI: Warner) 07/01/06-06/30/09
Integrated Training In Anesthesiology Research
Goal: Provide a programmatic environment for post-doctoral research training in the fields of
anesthesiology and critical care medicine.