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Page 1: Dopamine Signaling in Parkinson's Disease web handout

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Pathway Diagram Key © 2003–2020 Cell Signaling Technology, Inc.

Akt

D2-type D1-type D2-type D1-type

cAMP

JNKMKK4/7

CellSurvival

CDK5

mTORC2

Apoptosis

Cell Stress,Cytokines

Environmental Toxins,Neurotoxins

GeneticMutations

MicrogliaActivation

Apoptosis

LRRK2 MutationPINK1 Mutation

Misfolding

Transcription

AggregationLewy Bodies

Proteosomal Degradation

Post-Synaptic Signaling Blocked

Neurodegeneration

Dopamine

Dopamine

DopaDecarboxylase

Tyrosine L-DOPA

DopamineMetabolism

Normal State Parkinson’s Disease State

Ca2+

Na+

ROS DJ-1

PINK1

PKA

PP1

CREB CREM ATF

DARPP-32

DARPP-32

Parkin

AC

TyrosineHydroxylase

REDD1

α-synuclein

α-synuclein

GαsGαi β,γβ,γ

Dopamine Signaling in Parkinson’s Disease

AM

PAR

NM

DA

R

AM

PAR

NM

DA

R

rev. 12/02/19

Dopamine Signaling in Parkinson's Disease

rev. 12/02/19

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