E. Simko WCVM
References:General:
Thomson's Special Veterinary Pathology W. W. Carlton et. al.
Special:
Muller & Kirk's Small Animal Dermatology
D. W. Scott et. al
Canine & Feline DermatologyG. H. Nesbitt and L. J. Ackerman
Large Animal Dermatology
D. W. Scott
E. Simko WCVM
Der
mis
Epidermis
Primary hair
Secondary hair
Superficial plexus
Elector pili muscle
Sebaceous gland
Middle plexus
Deep plexus
Sweat gland
E. Simko WCVM
Subcutis
Infundibulum
Isthmus
Inferior segmentHair bulb
Dermal papilla
Hair
Anatomy
E. Simko WCVM
Stratum basale
Basment membrane
Stratum spinosum
Stratum cornium
Stratum granulosum
Hemidesmosomes
Desmosomes
E. Simko WCVM
Anatomy
Anatomy - Epidermis
E. Simko WCVM
Melanocytes
Langerhans cells
Merkel cells
Lymphocytes
Exogenous Factors:
• Infectious• Nutritional• Allergic• Physical• Chemical
Endogenous Factors:
• Immunologic• Hereditary• Congenital• Hormonal• Metabolic• Emotional• Internal dz• Age
E. Simko WCVM
Response to injury
OrthokeratoticHyperkeratosis
• Idiopathic seborrhea• Ichtiosis• Vitamin A deficiency
E. Simko WCVM
• Zinc-responsive dermatosis
• Hepatocutaneous syndrome
E. Simko WCVM
ParakeratoticHyperkeratosis
Response to injury
• Irregular
• Regular
• Papillated
• Pseudocarcinomatous
E. Simko WCVM
Response to injury
Response to injury - Hyperplasia
Pseudocarcinomatous
PapillatedRegularIrregularNormal
Hyperplasia
Atrophy/ HypoplasiaNormal Aplasia
E. Simko WCVM
Response to injury
Hyperpigmentation
• Endocrine diseases• Chronic inflammation
E. Simko WCVM
Der
mis
Ep
ider
mis
Response to injury
Hypopigmentation
• Hereditary/Congenital• Aquired with pigmentary
incontinence
E. Simko WCVM
• Physiologic• Pathologic
(Programmed cell death)
cell death initiating inflammation
E. Simko WCVM
Response to injury
Intercellular (Spongiosis)
Non specific inflammatory
change
E. Simko WCVM
Response to injury
Intracellular Edema
• Vacuolar degeneration• Hydropic degeneration• Balooning degeneration
E. Simko WCVM
Response to injury
Vesicle/pustule formation(Autoimmune dz)
Reticular degeneration(Viral diseases)
E. Simko WCVM
Response to injury
E. Simko WCVM
• Autoimmune dz
• Pyoderma
Response to injury
Acanthocyte
E. Simko WCVM
• Exocytosis
• Pustule
• Crust (serous hemorrhgic, cellular)
Response to injury
E. Simko WCVM
• Atrophy
• Inflammation and fibrosis
• Depositions
Response to injury
E. Simko WCVM
Atrophy
• Physiologic
• Pathologic
Response to injury
Anagen
Telogen
Catagen
Controlled by:
• daylight hours • environment• genetic factors• hormones
Modified from Applied Veterinary Histology, W.J.Banks
Modified from Applied Veterinary Histology, W.J.Banks and Small Animal Dermatology, D.W. Scott
Anagen Telogen
Response to injury
Superficial folliculitis
Deep folliculitis
• Furunculosis• Adenitis
E. Simko WCVM
Response to injury