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Page 1: cyP3A4 inhibitor A TOXICITY · 2020. 7. 1. · Linagliptin Vildagliptin Saxagliptin Sitagliptin TOXICITY PARA cyP3A4 inhibitor A OF STATINS INHIBIT RELEASE OF INFLAMMATORY CYTOKINES

cyP3A4 inhibitor A TOXICITYOF STATINS

INHIBIT RELEASE OF INFLAMMATORYCYTOKINES

DUE TO MUSCARINIC PARASYMPATHETIC

REST All Effects dueto sympathetic

CAN Also BE USED

TRADIRONALLYconsidered Antidote

NO DOSE ADJUSTMENT IN RENAL DISEASE

Page 2: cyP3A4 inhibitor A TOXICITY · 2020. 7. 1. · Linagliptin Vildagliptin Saxagliptin Sitagliptin TOXICITY PARA cyP3A4 inhibitor A OF STATINS INHIBIT RELEASE OF INFLAMMATORY CYTOKINES

THIopentone Anesthetic

succinylcholineMuscleRelaxant

NOT 1h NSTEM1 ONLY GIVEN IN STEMI

HALFLIFE onlydepend on Vd and CLNot on ABSORPTION

Anticoagulant Like WARFARINCOMPETITIVE INHIBITORXKOR G enzyme

Reduce Yuk dependant clottingfactorslike2,79,10

Ointment produce longlastingeffect

ET iE

Page 3: cyP3A4 inhibitor A TOXICITY · 2020. 7. 1. · Linagliptin Vildagliptin Saxagliptin Sitagliptin TOXICITY PARA cyP3A4 inhibitor A OF STATINS INHIBIT RELEASE OF INFLAMMATORY CYTOKINES

BACTERIOSTATc

INTRACELLUARINUCLEARRECEPTOR

REST All OTHERS GPCR

Page 4: cyP3A4 inhibitor A TOXICITY · 2020. 7. 1. · Linagliptin Vildagliptin Saxagliptin Sitagliptin TOXICITY PARA cyP3A4 inhibitor A OF STATINS INHIBIT RELEASE OF INFLAMMATORY CYTOKINES

o IMAGE FLAGELLATE PIGMENTATION

Page 5: cyP3A4 inhibitor A TOXICITY · 2020. 7. 1. · Linagliptin Vildagliptin Saxagliptin Sitagliptin TOXICITY PARA cyP3A4 inhibitor A OF STATINS INHIBIT RELEASE OF INFLAMMATORY CYTOKINES

BOTH SUPRESS SA and All node

AlwaysProtease inhibitoradded

3 DRUGRegimen is proffered

DEATH due to SPURIOUS DRUG

Min Punishment 10yearsMAX Life imprisonment

POLYVALENT AntiseraIs mainstay forVIPER's TIE

Page 6: cyP3A4 inhibitor A TOXICITY · 2020. 7. 1. · Linagliptin Vildagliptin Saxagliptin Sitagliptin TOXICITY PARA cyP3A4 inhibitor A OF STATINS INHIBIT RELEASE OF INFLAMMATORY CYTOKINES

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