Cancer Hyperthermia using MNP’s
Cancer is a class of diseases characterized by out-of-
control cell growth .
Cancer therapy :
Biological therapy
Hormonal therapy
Surgery
Chemotherapy
Radiotherapy
Supportive therapy
Photodynamic-therapy
Hyperthermia
Nanomedicine is the medical application of
nanotechnology
In nanotechnology, a particle is defined as a small
object that behaves as a whole unit in terms of its
transport and properties .
Magnetic nanoparticles are a class of
nanoparticles which can be manipulated using
magnetic field .
Magnetic hyperthermia:Magnetic nanoparticles are used in an experimental
cancer treatment called magnetic hyperthermia in which the fact that nanoparticles heat when they are
placed in an alternative magnetic field is used.
Materials & methods:
1-Raw materials
2- Sample preparation
MNP’s preparation
Characterizationof MNP’s
Transmission Electron
microscopy (TEM)
Dynamic light scattering (DLS)
AtomicForce
Microscopy (AFM)
Cytotoxicity (Tissue Culture)
Cell culture assays are used to assess the
biocompatibility of a material or extract through
the use of isolated cells in vitro.
These techniques are useful in evaluating the
toxicity or irritancy potential of materials and
chemicals.
They provide an excellent way to screen
materials prior to in vivo tests.
Exposed toMF ONLY
With MNP’s&MF
With MNP’sONLY
Control
Cell groups
Cell line
Cell line exposed to MF
0 100 200
0
10
20
30
40
50
60
70
80
90
100
110
%o
f su
rviv
ing
cells
nanoparticles concentration
magnet+nanoparticles
nanoparticles only
magnetic field
Results:
Thanks