PRESENTATION ON
BALO-10
Prepared by:Biplob Kumar Sarker,
Product Executive,Product Management Department
DISEASE PART
Skeletal muscle: Skeletal muscle is a type of striated muscle,
attached to the skeleton. Skeletal muscles are used to facilitate movement,
by applying force to bones and joints; via contraction.
They generally contract voluntarily (via nerve stimulation), although they can contract involuntarily.
DISEASE OF SKELETAL MUSCLE
Spasticity: It is referred to as an unusual “tightness”
stiffness or “pull” of muscles. The word spasm comes from the Greek word
spasmo meaning “drawing pulling”.
SPASTIC DISORDERS
CONT…
Muscle spasm: A spasm is a sudden, involuntary contraction of a
muscle, a group of muscles, or a hollow organ such as a heart, or a similarly sudden contraction of an office.
CONT… Muscular rigidity: Muscle rigidity is a state of firm, tense muscles
with marked resistance to passive movement.
CONT…
Low back pain: Low back pain refers to pain that you feel in your
lower back. You may also have back stiffness, decreased movement of the lower back, and difficulty standing straight.
Intractable hiccups: A hiccups is an involuntary contraction of the
diaphragm that may repeat several times per minute.
CONT…
CONT… Trigeminal neuralgia: Also known as prosopalgin, or Fothergill’s
disease is a neuropathic disorder characterized by episodes of intense pain in the face, originating from the trigeminal nerve.
CONT…
Dysfunctional voiding: Dysfunctional voiding is characterized by an
intermittent and/or fluctuating flow rate due to involuntary intermittent contractions of the periurethral striated or levator muscles during voiding in neurologically normal people.
CONT…
Tension type headache: Headache from tension.
CONT…
Migraine: A migraine is usually a severe headache felt as a
throbbing pain at the front or side of the head.
CONT…
Cluster headache: It is a neurological disorder characterized by
recurrent, severe headaches on the side of the head, typically around the eye.
TREATMENT OPTION
Apply a skeletal muscle relaxant for thee time in a day.
Medicon introduces
Balo-10Baclofen 10 mg
PRODUCT PROFILE
Brand Name : Balo-10
Generic Name : Baclofen
Therapeutic Group :Skeletal Muscle Relaxant
Official specification : BP
Dosage Form : Tablet
Strength : 10 mg
Pack Size : 3x10’s
Selling Price/box : Tk. 198
MRP/ box : Tk. 240
INDICATION
Balo-10 is indicated for the treatment of:
SpasticityMuscle spasmMuscular rigidityLow back painIntractable hiccups
CON…
Trigeminal neuralgiaDysfunctional voidingTension type headacheMigraineCluster headache
MECHANISM OF ACTION
Baclofen, inhibits monosynaptic and polysynaptic reflexes at the spinal level by hyperpolarization of afferent terminals.
Baclofen, enhances the activities of the inhibitory neurotransmitter GABA and Glycin
Baclofen, decreases the release of the excitatory neurotransmitter Aspartate and Glutamate
CON…
DOSAGE AND ADMINISTRATION
Start therapy from the lowest possible dose and gradually increase to achieve optimum result.
Following titration schedule is suggested- 05 mg t.i.d. for 3 days 10 mg t.i.d. for 3 days 15 mg t.i.d. for 3 days 20 mg t.i.d. for 3 days
The total dose should not exceed the maximum of 80 mg daily ( 20 mg q.i.d.)
TARGET DOCTORS
-Medicine Specialist
-Neurologist
-Orthopedic Specialist
-Cardiologist
- Gynecologist
-Potential GPs
-RMP/PC
-Skin and VD Specialist
MAJOR COMPETITORS Brand Name Company
Beklo OpsoninLioresal NovertisSkelofen ACMEFlexibac BeaconRamback MonicoBaclofen ApexSpafen RAKStarbac LeonBacaid 10 LabaidLiosal DeltaLirosal NoveltaMyobac Navana
SHORT-TERM OBJECTIVE
Prescription: Per MPO Prescription target
Five(2) Prescriptions/Day/Target doctors
Sales:Per MPO sales Target Balo-10 Tablet: 30 Boxes
LONG TERM OBJECTIVE
To make Balo-10 a brand leader in Skeletal Muscle Relaxants Preparation by creating prescription from potential qualified doctors.
SPECIAL BENEFITS OF BALO-10
Highly Effective against Spasticity. Ensure confidence in treating acute low-back
syndrome
Safe up to 6 years (long term treatment for spastic disorders)
Higher bio-availability (70-80%) ensures higher clinical effect
CONT…
Very low stress on liver due to low metabolism ( 15 %) on liver
Devoid of dry mouth and sedation Free from Tolperisone like bad smell Co-administration with Ciprofloxacin and oral
contraceptives is feasible.