a. Study design schematic
Streptococcus mitis (NCTC-2261)Streptococcus mitis (B6)Streptococcus mitis (SK321)Streptococcus mitis (SK564)Streptococcus mitis (SK597)Streptococcus mitis (ATCC-6249)Streptococcus oralisStreptococcus salivariusStreptococcus sanguinisStreptococcus parasanguinisLactobacillus paracasei (ATCC-27092)Lactobacillus rhamnosus (ATCC-53103)Homo sapiens
Streptococcus mutans serotype c (NN2025)Streptococcus gordoniiLactobacillus acidophilusLactobacillus casei (ATCC-334)Lactobacillus casei (Zhang)Lactobacillus casei (BL23)Lactobacillus salivarius (ATCC-11741)Lactobacillus salivarius (CECT-5713)Lactobacillus salivarius (ACS-116-V-Col5a)Lactobacillus salivarius subsp. salivarius (UCC118)Lactobacillus fermentum (IFO-3956/LMG-18251)Lactobacillus fermentum (ATCC-14931)Lactobacillus fermentum (28-3-CHN)Lactobacillus fermentum (CECT-5716)Bifidobacterium dentium (ATCC-27534)Bifidobacterium longum (strain DJO10A)Veillonella parvula
b. phylogenetic profiles
targ
et s
peci
esan
titar
get
spec
ies
complete proteome sets
Examples of modelable S. mutans virulence factors
Examples of modelable and druggable S. mutans proteins
druggablemutltiple sugar binding protein zDOPE (model reliability) = -1.57drugEBIlity score = 0.76
not druggableproton/lactate pumpzDOPE (model reliability) = -1.73drugEBIlity score = -0.71
favorable profileunknown enzymeresolution = 2.38 ÅdrugEBIlity score = 0.57
comparative modelnonhydrolyzing UDP acetyl-glucosamine epimerasezDOPE (model reliability) = -1.75drugEBIlity score = 0.82
crystal structureglucosamine-6-PO4 deaminaseresolution = 2.03 ÅdrugEBIlity score = 0.77
druggable and favorable profilemajor cell-surface adhesin zDOPE (model reliability) = -1.50drugEBIlity score = 0.41
a. b. c.
d. e. f.
multiple sugar-binding
MS transport ATP-bindingATP-binding transporter
fructose phosphotransferase IIABCfructose phosphotransferase IIBC
fructose phosphotransferase IIAisocitrate dehydrogenase
acetylornithine aminotransferase
purine nucleoside phosphorylaseglycogen synthase
Glu1-PO
4 adenylyltransferasebeta-glucosidase
endoglucanaselactate dehydrogenase
phosphocarrier protein HPr
PEP-phosphotransferaseproton/lactic acid pum
plactose-specific PO
4-transferaseN
'N' D
CHC-sensitive ATPase
signal recognition particleform
yltetrahydrofolate ligasepanthothenate flavoproteinm
alolactic fermentation reg
DN
A-dir RNA polym
eraseglycogen phosphorylase
phosphorylasesucrose phosphorylase
GTF-I 1,3α-branch
glucosyltransferase-SIglucosyltransferase-S
1,4α-glucan branchingdextran glucosidase
glucan-binding protein Asecr peptidoglycan hydrolase
glucan-binding protein CBglB-like G
bp with lipase
GbpC response regulator
major cell-surface adhesin
cell surface antigen I/IIcollagen-binding adhesin
amylase-binding protein A
amylase-binding protein B
ATP-binding transportercom
petence histidine kinasecom
petence transcriptional regbiofilm
regulatory protein Aresponse regulator of BrpA-1response regulator of BrpA-2
lantibiotic mutacin II
lantibiotic mutacin 1140
lantibiotic mutacin M
lantibiotic mutacin B-N
y266bacteriocin Sm
bAbacteriocin secretion protein
bacteriocin peptideundecaprenol kinase
rRNA m
aturation factorm
utacin 1140 modifying enzym
eserine-threonine kinase PknBoxidative stress sensor kinase
collagenase
metabolismattachmentcoordinationproteins by functional similarity
sugar uptake
nutrientuptake
energy storage
acid production
acid tolerance
S. mutans virulence factors
glucan production
glucan attachment
otherattach
quorum sensinglantibioticslantibiotic
regulation
H. sapiensL. rhamnosus (ATCC-53103)L. paracasei (ATCC-27092)S. parasanguinisS. sanguinisS. salivariusS. oralisS. mitis (ATCC-6249)S. mitis (SK597)S. mitis (SK564)S. mitis (SK321)S. mitis (B6)S. mitis (NCTC-2261)
phylogenetic profiles
protein similarity(matching HMM columns / length of protein)
target proteomes
antitarget proteomes
V. parvulaB. longum (strain DJO10A)B. dentium (ATCC-27534)L. fermentum (CECT-5716)L. fermentum (28-3-CHN)L. fermentum (ATCC-14931)L. fermentum (IFO-3956/LMG-18251)L. salivarius subsp. salivarius (UCC118)L. salivarius (ACS-116-V-Col5a)L. salivarius (CECT-5713)L. salivarius (ATCC-11741)L. casei (BL23)L. casei (Zhang)L.casei (ATCC-334)L. acidophilusS. gordoniiS. mutans serotype c (NN2025)
modelable druggable
tractability
Q00749
Q00752
P72477
Q8DUN3
Q8DWE7
Q8DWE6
Q59940
Q59928
Q8DTU4
Q8CWX0
Q8DT53
Q8DUE7
Q8CVC4
P26283
P45596
P45595
P50976
P26426
P95783
Q54431
Q59925
Q8DU74
Q8DWC9
Q8DWG2
Q8DT55
Q8DT31
P10249
P08987
P13470
P49331
Q8DT52
Q99040
Q8DRV2
Q8DWM3
Q8DTF1
Q8DUW9
Q9S151
P11657
P23504
Q76H84
A8AZZ3
A8AUM3
Q8DW05
Q8DS94
Q8DS39
Q8DVR0
Q8DVJ9
Q8DVJ8
O54329
O68586
Q7BV70
P80666
Q5TLL1
Q8DSA3
Q8CVC8
Q05888
Q8DSY7
O68588
Q8DVK1
Q8DT64
Q8DUX4
Adhesin A3VP1 of AntigenI/IIG
lucosamine-6-phosphate deam
inaseM
n-dependent inorganic pyrophosphataseU
nknown function 1377c
Isopropylmalate dehydratase
V-region of antigen I/IIPhosphatase/hydrolase
PhosphataseN
ADP-dependent G
APDH
Unknow
n enzyme
Dihydroorotate dehydrogenase
Dextran glucosidase
Dextran glucosidase
Peptide chain release factorTagatose 1,6-aldolase
Carboxymuconolactone decarboxylase
protein similarity(matching HMM columns / length of protein)
target proteomes
S. mutans PD
Bsdruggable
3IOX
2RI1
1I74
3L7V
2HCU
1JMM
3L7Y
1WVI
2QE0
3IJT
3OIX
2ZID
2ZIC
1ZBT
3IV3
3LVY
H. sapiensL. rhamnosus (ATCC-53103)L. paracasei (ATCC-27092)S. parasanguinisS. sanguinisS. salivariusS. oralisS. mitis (ATCC-6249)S. mitis (SK597)S. mitis (SK564)S. mitis (SK321)S. mitis (B6)S. mitis (NCTC-2261)
UD
P acetylglucosamine epim
erasePhosphorylase
Trans enoyl ACP reductaseO
ligopeptide ABC transporterAnthranilate phosphoribosyltransferase
Periplasmic ferrichrom
e ABC transporterU
DP acetylglucosam
ine carboxyvinyltransferase 1U
DP acetylglucosam
ine carboxyvinyltransferase 2Adenylate kinase
D-alanine polyligase
dTDP-glucose dehydratase
Dihydroorotate dehydrogenase
Secreted translocaseβ-galactosidase
Imidazole carboxam
ide isomerase
Acetoin dehydrogenaseBifunctional protein glm
UM
ethionyl-tRNA synthetase
Guanylate kinase
Glycerol dehydrogenase
Phosphataseα-acetolactate synthase
Thiazole pyrodixine kinaseG
lutamyl-tRN
A amidotransferase subA
Bisphosphoglycerate mutase
Manganese inorganic pyrophosphatase
Surface protein I/IIResponse regulator
AdcA-like Zn adhesin lipoproteinAcetyltransferaseD
NA polym
eraseIm
idazole glycerol-PO4 synthase
SAM m
ethyltransferaseG
lucanotransferasetRN
A thiouridylase30S ribosom
al proteinD
ihydrodipicolinate synthasePyrim
idine-nucleoside phosphorylaseO
rotidine 5'-phosphate decarboxylaseU
nknown hydrolase/phosphatase
Maltose operon transcriptional repressor
Uracil phosphoribosyltransferase
ATP synthaseLactose phosphotransferase repressor
Catabolite control proteinATP synthase
Malolactic enzym
eLytTr D
NA-binding
Purine operon repressorTryptophan synthase
tRNA YrdC-m
odifierIsopropylm
alate dehydrataseAdenine phosphoribosyltransferase
Deoxycytidylate deam
inaseRN
A-diphosphate reductaseAdenylate kinase
Glycosyltransferase
Anaerobic RNA-triphosphate reductase
ATP-binding ABC transporterdTD
P keto rhamnose reductase
ATP-binding ABC transporterDTD
P keto rhamnose reductase
Hom
oserine succinyltransferaseCarbam
oyl-phosphate synthaseN
ADP-dependent G
APDH
Unique &
uncharacterizedTellurite resistance protein
Ferrous ion transport proteinPhosphopentom
utaseTranscription regulator
Chorismate m
utasePhosphofructokinase
Cysteine synthaseG
lucan glucosidaseH
istidine kinaseCitrate synthase
Dextran glucosidase
Unknow
n hydrolase/phosphataseU
nknown hydrolase/phosphatase
Tagatose diphosphate aldolaseAm
ino acid aminotransferase
Uracil-D
NA glycosylase
DN
A damage sensor
ATP synthase
V. parvulaB. longum (strain DJO10A)B. dentium (ATCC-27534)L. fermentum (CECT-5716)L. fermentum (28-3-CHN)L. fermentum (ATCC-14931)L. fermentum (IFO-3956/LMG-18251)L. salivarius subsp. salivarius (UCC118)L. salivarius (ACS-116-V-Col5a)L. salivarius (CECT-5713)L. salivarius (ATCC-11741)L. casei (BL23)L. casei (Zhang)L. casei (ATCC-334)L. acidophilusS. gordoniiS. mutans serotype c (NN2025)
Q8DTB7
Q8DT31
Q8DSN4
Q8DW25
Q8DVF6
Q8DUD7
Q8DT57
Q8DT24
Q8DS33
Q53526
P95780
Q8DTV0
Q8DSJ6
P50978
Q8DTR2
Q8DTL3
Q8DSX2
Q8DSW8
Q8DVK6
Q8DVJ3
Q8DV60
Q8DTA6
Q8DSS7
Q8DSG5
P59161
O68579
Q9RFI8
Q8DVJ8
Q8DTN1
Q8DSV5
Q8DWN8
Q8DTR3
Q8DTH5
Q8DT30
Q8DRS4
Q8DWB3
Q8DUE5
Q8DU33
Q8DTV1
Q8DTS3
Q8DT29
Q8DST6
P95789
P26422
O07329
A6PY32
Q8DWC7
Q8DVZ8
Q8DVV6
Q8DVF3
Q8DTG7
Q8DTG5
Q8DT95
Q8DSE5
Q8DV42
Q8DTS0
Q8DSH9
Q8DRY2
Q8DW32
Q8DUS5
Q8DTZ7
O33664
Q8DT96
Q8DUP4
Q59931
Q8DTQ1
Q8DSW3
Q8DVC3
Q8DTU0
Q8DTZ5
Q8DTP2
Q8KWU0
Q8DVJ2
Q99040
Q8DT45
Q59939
Q2HWU5
Q8DV06
Q8DUY6
P26425
Q8DWM1
Q8DTV8
Q8DTC4
P95790
S. mutans proteins
modelable druggable
a.b.
-1.57 0.76
-1.02 0.27
-1.25 0.52
-0.30 -0.08
-0.88 0.36
-1.01 0.74
-0.71 0.80
-0.93 -0.85
-0.44 0.36
0.76 0.78
-1.23 -0.15
-1.73 -0.71
-0.85 -0.75
-1.25 0.80
-0.96 0.79
-0.85 0.74
-1.18 0.82
-1.12 0.82
-0.45 -0.70
-0.15 0.39
-0.09 0.80
-0.25 0.77
-1.77 0.55
-0.69 0.77
-1.08 -0.71
-1.59 0.78
-1.50 0.41
-0.37 0.77
-1.88 0.77
0.72 0.81
0.60 -0.97
0.14 -0.41
0.97 0.81
0.86 0.80
0.76 -0.08
0.52 0.80
-0.34 0.80
0.19 0.80
-1.05 0.77
figure 3
-1.75 0.82
-1.12 0.82
-1.01 0.82
-1.13 0.81
-1.33 0.81
-1.46 0.81
-1.10 0.81
-1.18 0.81
-1.44 0.81
-1.04 0.81
-1.82 0.81
-1.35 0.80
-1.23 0.80
-1.87 0.80
-1.14 0.79
-1.04 0.79
-1.03 0.79
-1.09 0.79
-1.36 0.78
-1.20 0.78
-1.38 0.78
-1.24 0.78
-1.27 0.78
-1.13 0.78
-1.20 0.78
-1.50 0.78
-1.17 0.77
-1.88 0.77
-1.37 0.77
-1.23 0.77
-1.36 0.76
-1.47 0.76
-1.41 0.76
-1.08 0.76
-1.20 0.76
-1.71 0.75
-1.63 0.75
-1.07 0.75
-1.45 0.75
-1.82 0.75
-1.63 0.75
-1.39 0.75
-1.14 0.75
-2.20 0.75
-1.11 0.75
-1.47 0.75
-1.14 0.74
-1.12 0.74
-1.22 0.74
-1.06 0.74
-1.63 0.74
-2.10 0.74
-1.30 0.74
-1.19 0.74
-1.15 0.73
-1.10 0.73
-1.13 0.73
-1.08 0.73
-1.14 0.72
-1.58 0.72
-1.19 0.72
-1.39 0.72
-1.32 0.71
-1.30 0.70
-1.40 0.70
-1.41 0.69
-1.30 0.68
-1.95 0.66
-1.90 0.63
-1.43 0.58
-1.13 0.58
-1.13 0.57
-1.17 0.56
-1.77 0.55
-1.30 0.55
-1.35 0.55
-1.74 0.55
-1.59 0.54
-1.18 0.54
-1.94 0.54
-1.25 0.53
-1.53 0.53
-1.52 0.52
-1.42 0.51
figure 4b
0.77
0.77
0.77
0.74
0.74
0.71
0.70
0.70
0.66
0.57
0.56
0.56
0.56
0.56
0.54
0.53
figure 4a
virulence factors 61, literature review
structures81, PDB
proteome2391, UniProt
comparative modeling 616 of 1631, MODELLER
active site analysis110, drugEBIlity
phylogenetic profiles110, HHsearch
uniquecommon rare
metabolism attachment coordinationproteins by functional similarity
sugar uptake
nutrientuptake
energy storage
acid production
acid tolerance
S. m
utan
s viru
lenc
e fa
ctor
s
glucan production
glucan attachment
otherattach
quorum sensing lantibiotics
lantibiotic regulation
H. sapiensL. rhamnosus (ATCC-53103)L. paracasei (ATCC-27092)S. parasanguinisS. sanguinisS. salivariusS. oralisS. mitis (ATCC-6249)S. mitis (SK597)S. mitis (SK564)S. mitis (SK321)S. mitis (B6)S. mitis (NCTC-2261)
phyl
ogen
etic
profi
les
protein similarity(matching HMM columns / length of protein)
targ
et p
rote
omes
antit
arge
t pro
teom
es
V. parvulaB. longum (strain DJO10A)B. dentium (ATCC-27534)L. fermentum (CECT-5716)L. fermentum (28-3-CHN)L. fermentum (ATCC-14931)L. fermentum (IFO-3956/LMG-18251)L. salivarius subsp. salivarius (UCC118)L. salivarius (ACS-116-V-Col5a)L. salivarius (CECT-5713)L. salivarius (ATCC-11741)L. casei (BL23)L. casei (Zhang)L.casei (ATCC-334)L. acidophilusS. gordoniiS. mutans serotype c (NN2025)
mod
elab
le d
rugg
able
trac
tabi
lity
mul
tiple
sug
ar-b
indi
ngM
S tr
ansp
ort A
TP-b
indi
ngAT
P-bi
ndin
g tr
ansp
orte
rfr
ucto
se p
hosp
hotr
ansf
eras
e IIA
BCfr
ucto
se p
hosp
hotr
ansf
eras
e IIB
Cfr
ucto
se p
hosp
hotr
ansf
eras
e IIA
isoc
itrat
e de
hydr
ogen
ase
acet
ylor
nith
ine
amin
otra
nsfe
rase
purin
e nu
cleo
side
pho
spho
ryla
segl
ycog
en sy
ntha
seG
lu1-
PO4
aden
ylyl
tran
sfer
ase
beta
-glu
cosi
dase
endo
gluc
anas
ela
ctat
e de
hydr
ogen
ase
phos
phoc
arrie
r pro
tein
HPr
PEP-
phos
phot
rans
fera
sepr
oton
/lacti
c ac
id p
ump
lact
ose-
spec
ific
PO4-
tran
sfer
ase
N'N
' DCH
C-se
nsiti
ve A
TPas
esi
gnal
reco
gniti
on p
artic
lefo
rmyl
tetr
ahyd
rofo
late
liga
sepa
ntho
then
ate
flavo
prot
ein
mal
olac
tic fe
rmen
tatio
n re
gD
NA-
dir R
NA
poly
mer
ase
glyc
ogen
pho
spho
ryla
seph
osph
oryl
ase
sucr
ose
phos
phor
ylas
eG
TF-I
1,3α
-bra
nch
gluc
osyl
tran
sfer
ase-
SIgl
ucos
yltr
ansf
eras
e-S
1,4α
-glu
can
bran
chin
gde
xtra
n gl
ucos
idas
egl
ucan
-bin
ding
pro
tein
Ase
cr p
eptid
ogly
can
hydr
olas
egl
ucan
-bin
ding
pro
tein
CBg
lB-li
ke G
bp w
ith li
pase
Gbp
C re
spon
se re
gula
tor
maj
or c
ell-s
urfa
ce a
dhes
ince
ll su
rfac
e an
tigen
I/II
colla
gen-
bind
ing
adhe
sin
amyl
ase-
bind
ing
prot
ein
Aam
ylas
e-bi
ndin
g pr
otei
n B
ATP-
bind
ing
tran
spor
ter
com
pete
nce
histi
dine
kin
ase
com
pete
nce
tran
scrip
tiona
l reg
biofi
lm re
gula
tory
pro
tein
Are
spon
se re
gula
tor o
f Brp
A-1
resp
onse
regu
lato
r of B
rpA-
2la
ntibi
otic
mut
acin
IIla
ntibi
otic
mut
acin
114
0la
ntibi
otic
mut
acin
Mla
ntibi
otic
mut
acin
B-N
y266
bact
erio
cin
SmbA
bact
erio
cin
secr
etion
pro
tein
bact
erio
cin
pepti
deun
deca
pren
ol k
inas
erR
NA
mat
urati
on fa
ctor
mut
acin
114
0 m
odify
ing
enzy
me
serin
e-th
reon
ine
kina
se P
knB
oxid
ative
stre
ss s
enso
r kin
ase
colla
gena
se
Q00749
Q00752
P72477
Q8DUN3
Q8DWE7
Q8DWE6
Q59940
Q59928
Q8DTU4
Q8CWX0
Q8DT53
Q8DUE7
Q8CVC4
P26283
P45596
P45595
P50976
P26426
P95783
Q54431
Q59925
Q8DU74
Q8DWC9
Q8DWG2
Q8DT55
Q8DT31
P10249
P08987
P13470
P49331
Q8DT52
Q99040
Q8DRV2
Q8DWM3
Q8DTF1
Q8DUW9
Q9S151
P11657
P23504
Q76H84
A8AZZ3
A8AUM3
Q8DW05
Q8DS94
Q8DS39
Q8DVR0
Q8DVJ9
Q8DVJ8
O54329
O68586
Q7BV70
P80666
Q5TLL1
Q8DSA3
Q8CVC8
Q05888
Q8DSY7
O68588
Q8DVK1
Q8DT64
Q8DUX4
Adhe
sin
A3VP
1 of
Anti
genI
/II
Glu
cosa
min
e-6-
phos
phat
e de
amin
ase
Mn-
depe
nden
t ino
rgan
ic p
yrop
hosp
hata
seU
nkno
wn
func
tion
1377
cIs
opro
pylm
alat
e de
hydr
atas
eV-
regi
on o
f anti
gen
I/II
Phos
phat
ase/
hydr
olas
ePh
osph
atas
eN
ADP-
depe
nden
t GAP
DH
Unk
now
n en
zym
eD
ihyd
roor
otat
e de
hydr
ogen
ase
Dex
tran
glu
cosid
ase
Dex
tran
glu
cosid
ase
Pepti
de c
hain
rele
ase
fact
orTa
gato
se 1
,6-a
ldol
ase
Carb
oxym
ucon
olac
tone
dec
arbo
xyla
se
protein similarity(matching HMM columns / length of protein)
3IOX
2RI1
1I74
3L7V
2HCU
1JMM
3L7Y
1WVI
2QE0
3IJT
3OIX
2ZID
2ZIC
1ZBT
3IV3
3LVY
H. sapiensL. rhamnosus (ATCC-53103)L. paracasei (ATCC-27092)S. parasanguinisS. sanguinisS. salivariusS. oralisS. mitis (ATCC-6249)S. mitis (SK597)S. mitis (SK564)S. mitis (SK321)S. mitis (B6)S. mitis (NCTC-2261)
UD
P ac
etyl
gluc
osam
ine
epim
eras
ePh
osph
oryl
ase
Tran
s en
oyl A
CP re
duct
ase
Olig
opep
tide
ABC
tran
spor
ter
Anth
rani
late
pho
spho
ribos
yltr
ansf
eras
ePe
ripla
smic
ferr
ichr
ome
ABC
tran
spor
ter
UD
P ac
etyl
gluc
osam
ine
carb
oxyv
inyl
tran
sfer
ase
1U
DP
acet
ylgl
ucos
amin
e ca
rbox
yvin
yltr
ansf
eras
e 2
Aden
ylat
e ki
nase
D-a
lani
ne p
olyl
igas
edT
DP-
gluc
ose
dehy
drat
ase
Dih
ydro
orot
ate
dehy
drog
enas
eSe
cret
ed tr
ansl
ocas
eβ-
gala
ctos
idas
eIm
idaz
ole
carb
oxam
ide
isom
eras
eAc
etoi
n de
hydr
ogen
ase
Bifu
nctio
nal p
rote
in g
lmU
Met
hion
yl-t
RNA
synt
heta
seG
uany
late
kin
ase
Gly
cero
l deh
ydro
gena
sePh
osph
atas
eα-
acet
olac
tate
syn
thas
eTh
iazo
le p
yrod
ixin
e ki
nase
Glu
tam
yl-t
RNA
amid
otra
nsfe
rase
sub
ABi
spho
spho
glyc
erat
e m
utas
eM
anga
nese
inor
gani
c py
roph
osph
atas
eSu
rfac
e pr
otei
n I/
IIRe
spon
se re
gula
tor
AdcA
-like
Zn
adhe
sin
lipop
rote
inAc
etyl
tran
sfer
ase
DN
A po
lym
eras
eIm
idaz
ole
glyc
erol
-PO
4 sy
ntha
seSA
M m
ethy
ltran
sfer
ase
Glu
cano
tran
sfer
ase
tRN
A th
iour
idyl
ase
30S
ribos
omal
pro
tein
Dih
ydro
dipi
colin
ate
synt
hase
Pyrim
idin
e-nu
cleo
side
pho
spho
ryla
seO
rotid
ine
5'-p
hosp
hate
dec
arbo
xyla
seU
nkno
wn
hydr
olas
e/ph
osph
atas
eM
alto
se o
pero
n tr
ansc
riptio
nal r
epre
ssor
Ura
cil p
hosp
horib
osyl
tran
sfer
ase
ATP
synt
hase
Lact
ose
phos
phot
rans
fera
se re
pres
sor
Cata
bolit
e co
ntro
l pro
tein
ATP
synt
hase
Mal
olac
tic e
nzym
eLy
tTr D
NA-
bind
ing
Purin
e op
eron
repr
esso
rTr
ypto
phan
syn
thas
etR
NA
YrdC
-mod
ifier
Isop
ropy
lmal
ate
dehy
drat
ase
Aden
ine
phos
phor
ibos
yltr
ansf
eras
eD
eoxy
cytid
ylat
e de
amin
ase
RNA-
diph
osph
ate
redu
ctas
eAd
enyl
ate
kina
seG
lyco
syltr
ansf
eras
eAn
aero
bic
RNA-
trip
hosp
hate
redu
ctas
eAT
P-bi
ndin
g AB
C tr
ansp
orte
rdT
DP
keto
rham
nose
redu
ctas
eAT
P-bi
ndin
g AB
C tr
ansp
orte
rDT
DP
keto
rham
nose
redu
ctas
eH
omos
erin
e su
ccin
yltr
ansf
eras
eCa
rbam
oyl-p
hosp
hate
syn
thas
eN
ADP-
depe
nden
t GAP
DH
Uni
que
& u
ncha
ract
erize
dTe
llurit
e re
sista
nce
prot
ein
Ferr
ous
ion
tran
spor
t pro
tein
Phos
phop
ento
mut
ase
Tran
scrip
tion
regu
lato
rCh
oris
mat
e m
utas
ePh
osph
ofru
ctok
inas
eCy
stei
ne sy
ntha
seG
luca
n gl
ucos
idas
eH
istid
ine
kina
seCi
trat
e sy
ntha
seD
extr
an g
luco
sidas
eU
nkno
wn
hydr
olas
e/ph
osph
atas
eU
nkno
wn
hydr
olas
e/ph
osph
atas
eTa
gato
se d
ipho
spha
te a
ldol
ase
Amin
o ac
id a
min
otra
nsfe
rase
Ura
cil-D
NA
glyc
osyl
ase
DN
A da
mag
e se
nsor
ATP
synt
hase
V. parvulaB. longum (strain DJO10A)B. dentium (ATCC-27534)L. fermentum (CECT-5716)L. fermentum (28-3-CHN)L. fermentum (ATCC-14931)L. fermentum (IFO-3956/LMG-18251)L. salivarius subsp. salivarius (UCC118)L. salivarius (ACS-116-V-Col5a)L. salivarius (CECT-5713)L. salivarius (ATCC-11741)L. casei (BL23)L. casei (Zhang)L. casei (ATCC-334)L. acidophilusS. gordoniiS. mutans serotype c (NN2025)
Q8DTB7
Q8DT31
Q8DSN4
Q8DW25
Q8DVF6
Q8DUD7
Q8DT57
Q8DT24
Q8DS33
Q53526
P95780
Q8DTV0
Q8DSJ6
P50978
Q8DTR2
Q8DTL3
Q8DSX2
Q8DSW8
Q8DVK6
Q8DVJ3
Q8DV60
Q8DTA6
Q8DSS7
Q8DSG5
P59161
O68579
Q9RFI8
Q8DVJ8
Q8DTN1
Q8DSV5
Q8DWN8
Q8DTR3
Q8DTH5
Q8DT30
Q8DRS4
Q8DWB3
Q8DUE5
Q8DU33
Q8DTV1
Q8DTS3
Q8DT29
Q8DST6
P95789
P26422
O07329
A6PY32
Q8DWC7
Q8DVZ8
Q8DVV6
Q8DVF3
Q8DTG7
Q8DTG5
Q8DT95
Q8DSE5
Q8DV42
Q8DTS0
Q8DSH9
Q8DRY2
Q8DW32
Q8DUS5
Q8DTZ7
O33664
Q8DT96
Q8DUP4
Q59931
Q8DTQ1
Q8DSW3
Q8DVC3
Q8DTU0
Q8DTZ5
Q8DTP2
Q8KWU0
Q8DVJ2
Q99040
Q8DT45
Q59939
Q2HWU5
Q8DV06
Q8DUY6
P26425
Q8DWM1
Q8DTV8
Q8DTC4
P95790
S. m
utan
s pr
otei
nsm
odel
able
dru
ggab
leb.