MEDICINAL CHEMISTRY
Q1. Identify the synthesis of following compound
a. Acetyl choline
b. Carbachol
c. Methacholine
d. Neostigmine
Q2. Identify the synthesis of following compound
a. Edrophonium
b. Pyridostigmine
c. Methacholine
d. Neostigmine
Q3. Cyclohexyl nitrile and N, N-diethylamino is used as starting product in the synthesis of
a. Glycopyrrolate
b. Dicyclomine
c. Homatropine
d. Cyclopentolate
(i ) NH3
CH3 Br
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
Q4. Xanthene 9-carboxylic acid N,N-diethylamino cholroethane is used in the synthesis of
a. Tropicamide
b. Propantheline
c. Procyclidine
d. Dicyclomine
Q5. Which of the following is the structure of Tropicamide
a.
b.
c.
d.
Q6. Identify the synthesis of following compound
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
a. Salbutamol
b. Terbutaline
c. Amphetamine
d. Isoprenaline
Q7. Identify the synthesis of following compound
a. Salbutamol
b. Noradrenaline
c. Amphetamine
d. Phenylephrine
Q8. Identify the synthesis of following compound
a. Salbutamol
b. Phenoxybenzamine
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
c. Tolazoline
d. Naphthazoline
Q9. Identify the synthesis of following compound
a. Salbutamol
b. Propranolol
c. Prazocin
d. Ephedrine
Q10. Identify the synthesis of following compound
a. Phenetolamine
b. Phenoxybenzamine
c. Prazocin
d. Ephedrine
Q11. Identify the synthesis of following compound
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
a. Phenetolamine
b. Phenoxybenzamine
c. Prazocin
d. Propranolol
Q12. Identify the synthesis of following compound
a. Diphenhydramine
b. Doxylamine
c. Mepyramine
d. Pheniramine
Q13. Identify the synthesis of following compound
a. Diphenhydramine
b. Doxylamine
c. Mepyramine
d. Pheniramine
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
Q14. Identify the synthesis of following compound
a. Promethazine
b. Cyclizine
c. Pheniramine
d. Methdilazine
Q15. Identify the synthesis of following compound
a. Promethazine
b. Cyclizine
c. Pheniramine
d. Meclizine
Q16. Identify the synthesis of following compound
a. Phenindamine
b. Cyproheptadine
c. Triprolidine
d. Indomethacin
NaH2
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
Q17. Identify the synthesis of following compound
a. Cimetidine
b. Ranitidine
c. Nizatidine
d. Famotidine
Q18. Which heterocyclic ring is present in Amiloride?
a. Pyrimidine ring
b. Pteridine ring
c. Pyrazine ring
d. Pyridine
Q19. Which diuretic have steroid nucleus?
a. Amiloride
b. Chlorthalidone
c. Triamterene
d. Spironolactone
Q20. Diphenhydramine belongs to antihistaminic class of
a. Ethylene diamine
b. Amino alkyl ether
c. Alkyl amine
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
d. Phenothiazine
Q21. Phenindamine belongs to class of
a. Piperidine
b. Piperazine
c. Ethylene diamine
d. Amino alkyl ether
Q22. Identify the synthesis of following compound
a. Naproxen
b. Ketoprofen
c. Naphthazoline
d. Phenacetin
Q23. Identify the synthesis of following compound
a. Sulindac
b. Indomethacin
c. Phenylbutazone
d. Mefenamic acid
Q24. Identify the synthesis of following compound
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
a. Diclofenac
b. Piroxicam
c. Phenylbutazone
d. Mefenamic acid
Q25. Identify the synthesis of following compound
a. Diclofenac
b. Aminopyrine
c. Phenylbutazone
d. Mefenamic acid
Q26. Hydantoin posses the heterocyclic ring
a. Imidazoline 3,5-dione
b. Imidazoline 2,4-dione
c. Pyrazoline 3,5-dione
d. Thiazoline 2,4-dione
Q27. Phenytoin is
a. 5,5-diphenylimidazoline-2,4 dione
b. 4,4-diphenylimidazoline-2,4-dione
c. 4,4-diphenylimidazoline-3,5-dione
d. 5,5-diphenylpyrazoline-3,5-dione
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
Q28. Antipyretic activity of NASIDS is mostly exhibited due to inhibition of
a. PGE2
b. PGD2
c. PGI2
d. PGF2α
Q29. Which enantiomers of profens are more active?
a. S(+)
b. S(-)
c. R(+)
d. R(-)
Q30. Ephedrine how has many Chiral center
a. 2
b. 3
c. 1
d. 0
Q31. Antazoline a NASID have
a. Imidazoline ring
b. Pyrazoline ring
c. Thiazoline ring
d. Oxazoline ring
Q32. Which of the following is tertiary amine and crosses the BBB?
a. Pyridostigmine
b. Physostigmine
c. Neostigmine
d. Edrophonium
Q33. 4-chloro-6-amino-1,3-benzenesulfonamide and formic acid are starting material for synthesis of
a. Hydrochlorthiazide
b. Chlorthiazide
c. Benzthiazide
d. Polythiazide
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
Q34. 2,4-dichloro benzoic acid and furfurylamine are starting product for synthesis of
a. Furosemide
b. Bumetanide
c. Chlorthalidone
d. Chlorthiazide
Q35. Pthalic anhydride and chlorobenzene are starting product for synthesis of
a. Phenindamine
b. Cyproheptadine
c. Chlorthalidone
d. Chlorthiazide
Q36. 2,3-dichlorophenoxyacetic and butrylchloride are stating product for the synthesis of
a. Ethacrynic acid
b. Triamterene
c. Amiloride
d. Furosemide
Q37. Pteridine ring is present in
a. Amiloride
b. Triamterene
c. Chlorthalidone
d. Spirolactone
Q38. Benzylnitrile and nitrosopyrimidine are the starting product for
a. Amiloride
b. Triamterene
c. Chlorpheniramine
d. Naphthazoline
Q39. 2,6-dichloro5-formylpyrimidine and hydrazine are starting product of
a. Allopurinol
b. Colchicine
c. Probenecid
d. Sulfinpyrazone
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
Q40. 4-hydroxy-3-hydroxymethyl Benzaldehyde and tertiary butylbenzylamine are involved in the synthesis
of
a. Terbutaline
b. Salbutamol
c. Isoprenaline
d. Albuterol
Q41. Identify the synthesis of following compound
a. Halothane
b. Enflurane
c. Isoflurane
d. Methoxyflurane
Q42. Identify the synthesis of following compound
a. Phenobarbitone
b. Mephobarbitone
c. Secobarbitone
d. Pentobarbitone
Q43. Identify the synthesis of following compound
a. Amobarbitone
b. Secobarbitone
c. Pentobarbitone
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
d. Phenobarbitone
Q44. Identify the synthesis of following compound
a. Glutethimide
b. Methqualone
c. Meprobamate
d. Paraldehyde
Q45. Identify the synthesis of following compound
a. Diazepam
b. Nitrazepam
c. Flurazepam
d. Alprazolam
Ethylisopentylethylmalonate urea
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
Q46. Identify the synthesis of following compound
a. Phenytoin
b. Trimethadione
c. Phensuximide
d. Primidone
Q47. Identify the synthesis of following compound
a. Imipramine
b. Carbamazepine
c. Amitriptyline
d. Primidone
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
Q1. Which of the following anthelmintics is not a carbamic methyl ester?
1. Cyclobendazole 2. Thiabendazole 3. Albendazole 4. Parbendazole
Q2. Acyclovir is a analogue of
1. Uracil 2. Adenine 3. Guanine 4. Thymidine
Q3. Sulfamethoxazole is having
1. Isoxazole ring 2. Oxazole ring 3. 1, 3, 4 thiadiazole 4. Imidazole
Q4. Which of the following drug is amphoteric in nature?
1. Chloramphenicol 2. Amphotericin B 3. Macrolides 4. Penicillins
Q5. Which isomer of Chloramphenicol is more active?
1. R, R 2. R, S 3. S, S 4. All are equally active
Q6. Which of the following is not true about cycloserine?
1. It is derived from amino acids 2. It inhibits cell wall synthesis 3. Having oxazolidine ring 4. Highly
nephrotoxic
Q7. How many chiral centers are present in oxytetracycline?
1. 4 2. 5 3. 6 4. 7
Q8. Which of the following drug is para-hydroxy acetanilide derivative?
1. Niclosamide 2. Diloxanide 3. Pyrazinamide 4. Teclozan
Q9. How many chiral centers are present in steroid nucleus?
1. 4 2. 5 3. 6 4. 7
Q10. Primaquine is derivative of-
1. 8-aminoquinoline 2. 4-aminoquinoline 3. Biguanides 4. Napthaquinone
Q11. In steroid nucleus A/B, B/C, C/D rings are fused in the manner of-
1. Cis- Cis -Trans 2. Trans-Cis-trans 3. Cis-Trans-Cis 4. Trans-Cis-Cis
Q12. Which of the following is not having steroid nucleus?
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
1. Finastride 2. Nondrolone 3. Flutamide 4. Megestrol
Q13. 9α fluoro - 11β,17,21-trihydroxy -16α-methyl pregna1,4-diene 3,20 dione is
1. Paramethsone 2. Triamcinolone 3. Prednesolone 4. Betamethasone
Q14. . 9α fluoro - 11β,16α,17,21-tetrahydroxy pregna1,4-diene 3,20 dione is
1. Paramethsone 2. Triamcinolone 3. Fludrocortisone 4. Betamethasone
Q15. Which of the following is antiandrogenic?
1. Tamoxifen 2. Mifepristone 3. Clomiphene 4. Flutamide
Q16. Which heterocyclic ring is present in Amiloride?
1. Pyrimidine ring 2. Pteridine ring 3. Pyrazine ring 4. Pyridine
Q17. Which diuretic have steroid nucleus?
1. Amiloride 2. Chlorthalidone 3. Triamterene 4. Spironolactone
Q18. Benorylate is condensation product of ……………………………………………………………….
Q19. Diphenhydramine belongs to antihistaminic class of
1. Ethylene diamine 2. Amino alkyl ether 3. Alkyl amine 4. Phenothiazine
Q20. Match the following heterocyclic ring present in drugs-
1. Imidazole a. Cimetidine
2. Thiazole b. Ranitidine
3. Furan c. Astemizole
4. Benzimidazole d. Terfenadine
5. 1,1 dioxothiazine e. Thiazolidine
6. Sulbactam f. Oxazolidine
7. Clavulinic acid g. Albendazole
h. Piroxicam
Q21. Choose the correct statement for estrogen
1.
2.
3.
4.
5.
6.
7.
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
1. Ring D is benzenoid and have OH grp at C17 Phenolic
2. Ring A is quinonoid and have OH grp at C3 alcoholic
3. Ring A is benzenoid and have OH grp at C3 Phenolic
4. Ring D is quinonoid and have OH grp at C17 alcoholic
Q22. Phenindamine belongs to class of
1. Piperidine 2. Piperazines 3. Ethylene diamine 4. Amino alkyl ether
Q23. Match the following
1. Benzimidazole Zalcitabine
2. Imidazole Metronidazole
3. Thymidine Stavudine
4. 17β hydroxy- 17α methyl 3 oxo androst-4ene Meconazol
5. Salicylic acid derivative Nondrolone
6. Piperazine ring Mthyltestosterone
7. Morpholino Diloxanide
8. Ethanol derivative Niclosamide
9. Acetanilide derivative Nitrofurazone
10. Oxazolidine Nimorazole
Citerizine
Mebendazole
Q24. Which of the moiety is responsible for diuretic activity in acetazolamide?
1. 1, 3, 4-thiazole ring 2. N-acetyl grp 3. Sulphamoyl grp 4. Secondary amino grp
Q25. Which isomer of diethyl stilbosterol is more active?
1. Cis 2. Trans 3. E 4. Z
Q26. Identify True/False (T/F) statement
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
1. In steroid nucleus confirmation is boat shape (T/F)
2. Paramethsone have 9α fluoro, 16α-methyl-17α-hydroxy grp (T/F)
3. Halofantrine is quinoline methanol (T/F)
4. Sesquiterpene lactone is artimisnin (T/F)
5. Ciprofloxacin have Piperazine ring attached to 1st position (T/F)
6. Vidarabine is adenine analogue (T/F)
7. Pyrantel is pyridine analogue (T/F)
8. Trimethoprim is pyrimidine analogue (T/F)
9. Sulphalene have Pyrazine ring (T/F)
10. Azteonam is monobactam (T/F)
11. Clavulinic acid thiazolidine ring (T/F)
12. Active anti inflammatory metabolite of sulfasalazine is pyridyl sulphanilamide (T/F)
13. Phenyl butazone is synthesized from hydrazine derivative (T/F)
14. Fenbufen is carbonyl propionic acid (T/F)
15. Mefenamic acid is arylacetic acid derivative (T/F)
16. Oxicams are N-heteroaryl carboxamide derivatives (T/F)
17. Chlorthiazide have 1,1 dioxo 1,2 thiazine ring (T/F)
Synthesis of some important drugs
1. Acetazolamide 14. Allopurinol
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
2. Polythiazide 15. Phenylbutazone
3. Mebendazole 16. Indomethacin
4. Niclosamide 17. Mepyramine
5. Metronidazole 18. Promethazine
6. Diloxanide 19. Cimetidine
7. Mefenide 20. Nalixidic acid
8. Meconazol
9. Proquanil
10. Trimethoprim
11. Clofazimine
12. Chlorthalidone
13. Mefenamic acid
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com
www.bpha
rmstu
f.com