356 PATENT ABSTRACTS

4558005 4558009

M O N O C L O N A L A N T I - E R Y T H R O P O I E T I N

Eugene Goldwasser, Clifford Kavinsky, Tania L Weiss assigned to University Patents Inc

Hybridoma tumor cell line (ATCC Number CRL 8164). A monoclonal anti-erythropoietin antibody substance, Epoclonalan, produced by said cell line. Use of Epoclonalan in im- monological methods for isolation of natural erythropoietin and for quantitative detection of erythropoietin in fluid samples.

P R O C E S S F O R P R O D U C I N G A N T I B I O T I C A-51568 BY F E R M E N T A T I O N A N D

M I C R O O R G A N I S M

LaVerne D Boeck, Marvin M Hoehn, Gary G Marconi assigned to Eli Lilly and Company

Antibiotic A-51568 is produced by submerged, aerobic fermentation of new Nocardia orientalis NRRL 15232. The antibiotic is effective against gram-positive organisms.

4558006

A.T.C .C , HB8209 A N D I T S M O N O C L O N A L A N T I B O D Y T O

E R Y T H R O P O I E T I N

Joan C Egrie assigned to Kirin-Amgen Inc

Disclosed is a new mouse-mouse hybridoma tumor cell line A.T.C.C. No. HB8209. A mono- clonal antibody produced by said cell line is specifically immunologically reactive with erythropoietin and with a polypeptide whose amino acid sequence is substantially duplicative of a sequence extant is erythropoietin. Disclosed also are procedures for isolation of erythropoietin by affinity purification and for quantitative detection of erythropoietin in fluid samples.

4558008

P R O C E S S F O R P R O D U C T I O N O F A-51568B A N T I B I O T I C

LaVerne D Bocck, Gary G Marconi, Marvin M Hoehn assigned to Eli Lilly and Company

The novel glycopeptide antibiotic A-51568B is produced by submerged, aerobic fermentation of Nocardia orientalis NRRL 15232. A-51568B demonstrates antibiotic activity against gram- positive bacteria.

4558011

M E T H O D F O R P R E P A R A T I O N O F P U R E H E P A T I T I S B S U R F A C E

A N T I G E N F R O M H U M A N P L A S M A

Witol Brzosko, Piotr Janicki, Zbigniew Laskowski, Kazimier Madalinski, Andrzej Dabrowa, Warsaw, Poland assigned to Akademia Medyczna

Method for preparation of pure hepatitis B sur- face antigen HBsAg from human plasma, wherein the initial plasma after being treated to remove lipides and partially remove human plasma proteins, is submitted to digestion with pepsin in amount of 0.01-0.50 rag/rag of protein to selectively decompose the plasma proteins while the antigen remains intact, filtered in a phosphate buffered medium, up to a pH value of 7.1-7.3, through molecular filters passing molecules of up to 100,000 Daltons, the in- fectiosity being subsequently de-activated by means of formaldehyde, in proportion of 1:2000 by volume, for 96 hours.

4558032

S Y N T H E T I C W H O L E B L O O D S U B S T I T U T E A N D A M E T H O D

O F M A K I N G T I l E S A M E

Charles S Ecanow, Bernard Ecanow assigned to Neomed Inc

A composition of matter which comprises a syn- thetic whole blood useful as a substitute for