Heterophilic Blocking ReagentFrequently Asked Questions

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Q1. HBR?HAMAHAMA?

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/ (species) (epitode) (solid phase)125I 1 (labeled antibody)2 Q2. ? 1 2

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Q3. HBR ?IgG IgG) (binding) (affinity) K-value =105-106

HBR HBR (binder) HBR (steric hinderance) HBR K-value = 109 HBR

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HBR 1000 HBR

1. HBR2. HBR 3. HBR anti- (anti-rabbit, anti-goat, anti-sheep, anti- mouse) 4. HBR subtypes (anti-mouse IgG1, anti-mouse IgG2)5. HBRQ4. HBR ?

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IgG IgM 40 10 (documented) Fc (multi-component) EIA RIA Fc (conjugation) Q5. ?

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() () () (,,)Q6. ? (AIDS) (OKT3) (E. Coli)

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Q7. ?

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HAMA

Q8. HAMA ?HAMA (Human anti-mouse antibody, )

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()

(1) HAMA (human anti-mouse antibodies)(2) (HBR) (HBT)

Q9. (Blocking Reagent)?

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(1) HAMAHAMA IgG (passive blocking agents) IgG (double monoclonal)

(2) (HBR) (HBT) (active blocking reagents) (kinetics)Q9. (Blocking Reagent)?

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HBR :a. HAMA b. c. d. e. Scantibodies HBR Scantibodies HBR ( IgG Scantibodies HBR (spike) (recovery)Scantibodies HBR Scantibodies HBR (reproducibility) Scantibodies HBR Scantibodies HBRIgGScantibodies HBR (conjugates) Q10. HBR

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Scantibodies (donors)IgG

Q11.

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Prevalence of Heterophilic Antibody Interference in Eight Automated Tumor Marker Immunoassays Clinical Chemistry 51, No. 1, 2005

Techniques for Identifying Heterophile Antibody Interference Are Assay Specific: Study of Seven Analytes on Two Automated Immunoassay Analyzers Clinical Chemistry 51, No. 3, 2005

A Hyperthyroid Patient with Measurable Thyroid-stimulating Hormone Concentration A Trap for the Unwary Annals Academy of Medicine

Q12. HBR

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