Youseph Yazdi, Ph.D. Corporate Director, Science and Technology

Corporate Office of Science and Technology

© Copyright Johnson & Johnson 2004

Nanotechnology Applications in Health CareWorld Environment Center Nanotech RoundtableNew York, NYMarch 11, 2005

Youseph Yazdi, Ph.D.

Corporate Director, Science and Technology

WEC Nanotech Rountable NY | March 11, 2005 | Y. Yazdi, Ph.D.2

Health Care Applications of Nanotechnology

World’s Largest Comprehensive Health Care Company…

Medical Device and Diagnostics

Consumer Products

Pharmaceutical

$8.3($0.31)

$16.9($2.2)

$22.1($3.5) AVEENO



Corporate Office of Science & Technology: Collaboration Hub

Medical Device and Diagnostics

Consumer Products

Pharmaceutical

AVEENO

Promote CollaborationPromote Innovation

Develop New Businesses



Nanotechnology in Nature: Our Design and Proof-of-Principle Lab

Spider silk is 100 times stronger than steel per unit weight

Bacterial flagellar motors convert energy with near 100% efficiency. Typical auto engine is ~30% efficient

trillion neurons self-assemble to form 1016 contacts, ten orders of magnitude greater contact density than on a Pentium chip

Source: Larry Bock, Nanosys, Inc.

Nature is not biased to what humans can see and manipulate -- it is optimized on all scales



From nature to nanotech: now we are in the game…

“nano is the scale of light, the scale of life”



Most significant development: nanotech “picks & shovels”

Nanoscale imaging, characterization, modeling, simulation, prototyping tools

“you can’t go where to can’t see…”

- Microscope --> Lister theory of microbial basis of disease --> J&J’s first products,

antiseptic bandages

- How will aM and zM detection of PSA, HIV, effect clinical disease management --> we

can’t know until we can see it!



Biggest Hurdle: Hype (negative or positive)

1988: Drexler “Engines of Creation”

Negative: ‘grey goo’, M. Creighton, MD, HRH Prof Prince Charles, Bill Joy…

‘Positive’: Fantastic Voyage…

?!

1985: Smalley, Curl, Rice U. (go Owls!) discover shape of C-60



Not just the lay press…Reading past the nano

“A nanomolecular approach to the nanofabrication of nanoparticles using a nanooptical nanochemical nanobioreactor”

[ref: Bogus Journal, October 2004]



Tissue Engineering:- scaffolds to promote tissue growth- tissue engineering of bone, cartilage, skin, arteries, nerves

Nanocomposites:- improved mechanical properties for orthopedic and other implants

Coatings for Implants:- improve osteointegration, faster fixation

Diagnostics:- identifying and quantifying rare events- evaluating the impact of anti-cancer agents in treatment and clinical

trials Tissue Ablation:

- technologies for localized tumor ablation- targeting for minimal collateral damage

Current

Some Key Opportunity Spaces for Medical Device Apps of Nanotech



Some Key Opportunity Spaces for Pharma Apps of Nanotech

Drug Delivery- nanocapsules, liposomes, targeted delivery

Tools for Drug Discovery and Drug Development- micro and nano fluidics- biomarkers & bar codes- nano-milling for solubility/stabilization

Multifunctional Therapeutics: Combining…- targeting- recognition- drug release- monitoring

Supramolecular Drug Design- self-assembly in targeted manner- synthetic peptides



Key Opportunity Spaces in Nanotech for Consumer Products

Improved Materials- responsive to physical or chemical changes- improved moisture and thermal handling properties

Improved Adhesives- based on physical (vs chemical) properties of materials- self-cleaning, more versatile

Nanodispersives- for delivery of therapeutic agents- increased bioavailability of active ingredients

Cosmetics- improved wear-resistance- change in response to environment

Consumer Diagnostics



ALZA- broad range of expertise and capabilities in key areas of nanotechnology- product interests: drug delivery, drug formulation

Center Biomaterials and Adv Tech (CBAT)- Implantable biomaterials- Drug-device combinations- Tissue Engineering Scaffolds- Drug Delivery technologies- Microspheres and Microdispersives

JJ Medical Microsystems- newly formed center for MEMS R&D- focus on select product development efforts

The Stealth Liposome. ALZA

Internal Johnson & Johnson Nanotech and MEMS Expertise

Cells Scaffold

Scaffold to promote tissue growth for tissue

engineering

image courtesy of MEMS Clearinghouse



Summary: An Industry View of ‘Nanotechnology’

not a platform or a specific field of technology, rather, the natural

progression of all fields of science and technology in understanding

and manipulating matter on a smaller and smaller scale.

not just smaller -- enables development of new materials and systems

with novel properties, features

expected to have a substantial impact on almost every field of

science, industry, health care

today, most activity still in the realm of science not tech

manage like other technologies: surveillance, relationships, organic

entry, avoid hype, focus on real impact on health care



Nanotechnology: a test of industry’s ability to manage new science

"Wherever this field leads, it is likely to

follow the well-known pathway of

incredible results leading to unrealistic

expectations followed by sobering

complications and disappointments - and

ultimately, cautious optimism."

- Drs Roger Latham and Peter Oettgen, Harvard Medical School



a few thoughts on environmental issues…

Nanotech is not fundamentally new, rather a stage in a continuum of human

control over matter

Modern ‘Nanotech’ can reduce risk by enabling us to measure, model,

understand and control what people and nature have been doing all along, and

better assess the impact of new products

NYT, February 22, 2005 “Tiny Is Beautiful: Translating 'Nano' Into Practical”, KENNETH CHANG



Our Credo

…We must maintain in good orderthe property we are privileged to use,

protecting the environment and natural resources…

General Robert Wood Johnson, 1943

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Youseph Yazdi, Ph.D. Corporate Director, Science and Technology