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OVERVIEW: A 350+ page document, with 1,000+ insightful charts Detailed information on each market segment: forging, casting, hip machining, knee machining, spine & trauma machining, coating, instruments, ceramics, cases & trays, marking, packaging, sterilization... Includes our latest research on Additive Manufacturing for Orthopaedics with market analysis, main users & suppliers, top selling products and 2024 forecasts Detailed profiles of the Top 100 CMOs with their market share in each segment THE WORLDWIDE ORTHOPAEDIC & SPINE CONTRACT MANUFACTURING MARKET REPORT 2019-2024 & TOP 100 SUPPLIER PROFILES AVICENNE’S UNIQUE WARRANTY If you are not 100% satisfied with our report, send it back to us with a leer indicating the reasons and we will refund you in full! PUBLISHED JUNE 2020 • 9 TH EDITION NEW • Covid-19 impact on orthopedics: End-market & CMO side • MDR: New European Regulation impact on orthopaedics • Jabil-Depuy deal analysis & forecasts • Worldwide sport medicine market • Robotics for knee and spine • Additive manufacturing update WHY BUY THIS REPORT? Get accurate data and strategic insights on the worldwide US$ 6.2 Bn Orthopaedic Contract Manufacturing market & players For OEMs: obtain detailed information on the top 100 contract manufacturers in the USA, Europe and rest of the world with their background, owners, strengths and specialties. You will find out how big the latest manufacturing trends are (Additive Manufacturing, coating growth, navigation & robotics etc.) For investors & private equity firms: identify the best companies and activities to invest in www.avicenne.com/medical_reports_2.php Download the detailed table of contents

you in full! THE WORLDWIDE ORTHOPAEDIC & …• Milford-CT: spinal implants (closed) trays represent epsilon). Strong cutting tools activity neurosurgery, devices MAIN SERVICES All

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Page 1: you in full! THE WORLDWIDE ORTHOPAEDIC & …• Milford-CT: spinal implants (closed) trays represent epsilon). Strong cutting tools activity neurosurgery, devices MAIN SERVICES All

OVERVIEW:

A 350+ page document, with 1,000+ insightful charts

Detailed information on each market segment: forging, casting, hip machining, knee machining, spine & trauma machining, coating, instruments, ceramics, cases & trays, marking, packaging, sterilization...

Includes our latest research on Additive Manufacturing for Orthopaedics with market analysis, main users & suppliers, top selling products and 2024 forecasts

Detailed profiles of the Top 100 CMOs with their market share in each segment

THE WORLDWIDE ORTHOPAEDIC & SPINE CONTRACT MANUFACTURINGMARKET REPORT 2019-2024& TOP 100 SUPPLIER PROFILES

AVICENNE’S

UNIQUE WARRANTY

If you are not 100% satisfied with our

report, send it back to us with a letter indicating

the reasons and we will refund you in full!

PUBLISHED JUNE 2020 • 9TH EDITION

N E W• Covid-19 impact on orthopedics:

End-market & CMO side

• MDR: New European Regulation

impact on orthopaedics

• Jabil-Depuy deal analysis & forecasts

• Worldwide sport medicine market

• Robotics for knee and spine

• Additive manufacturing

update

WHY BUY THIS REPORT?

Get accurate data and strategic insights on the worldwide US$ 6.2 Bn Orthopaedic Contract Manufacturing market & players

For OEMs: obtain detailed information on the top 100 contract manufacturers in the USA, Europe and rest of the world with their background, owners, strengths and specialties. You will find out how big the latest manufacturing trends are (Additive Manufacturing, coating growth, navigation & robotics etc.)

For investors & private equity firms: identify the best companies and activities to invest in

www.avicenne.com/medical_reports_2.phpDownload the detailed table of contents

Page 2: you in full! THE WORLDWIDE ORTHOPAEDIC & …• Milford-CT: spinal implants (closed) trays represent epsilon). Strong cutting tools activity neurosurgery, devices MAIN SERVICES All

1"WHERE IS GROWTH ?" IN-DEPTH ANALYSIS COVERING 14 SEGMENTS / 62 SUB SEGMENTS ON THE US$ 6.2 BN WORLDWIDE CONTRACT MANUFACTURING MARKET

2 ASSESS YOUR CUSTOMERS' NEEDS WITH OUR DETAILED ANALYSIS OF THE DEMAND FOR OEM CONTRACT MANUFACTURING

Contract Manufacturing segmentation & raw materials usage: 14 segments & 62 sub-segments

For each of the following OEMs below, the following data is provided: Manufacturing strategy with underlying detailed volume and value data Facility locations for each product Outsourcing vs In-house % for implants, instruments, cases & trays, coating, ceramics, packaging In-house vs Contract Manufacturing volumes per product for forging, casting, machining, coating, instruments, cases & trays, etc.

All other Challengers

Source : Avicenne 2020

FORG

ING &

CAST

ING

HIP STEM

HIP CUP

TIBIAL KNEE

LF PLATES

LC PLATES

FEMORAL KNEE (SPECIAL

FORGING)

FEMORAL KNEE

TIBIAL KNEE

HIP CUP

HIP STEM

FORG

ING

CAST

ING

MACH

ININ

G

STEM

FEMORAL

CUP

TIBIAL

INSERT

HEAD

LINER

HIP M

ACHI

NING

KNEE

MAC

HINI

NG

SPINE LUMBAR & CAGES

SPINE CERVICAL PLATES

TRAUMA INTERNAL PLATES

TRAUMA SCREWS & OTHERS

SPINE CERVICAL &

CAGES

HIP

KNEE

SPINE

TRAUMA

HIP

KNEE

SPINE

TRAUMA

SPIN

E, TR

AUMA

MA

CHIN

ING

INST

RUME

NTS

MACH

ININ

GCA

SES &

TRAY

S

OTHE

R PRO

CESS

ES

HEAD

LINER

HIP

STEM

KNEE

CUP

SPINE

FEMORAL

TRAUMA

TIBIAL

CERA

MICS

MISC

ELLA

NEOU

SCO

ATIN

GMA

RKIN

G, PA

CKAG

ING &

STER

ILIZA

TION

RAW

MAT

ERIA

LS

HIP STEM FORGED

IMPLANTS

HIP STEM

KNEE FEMORAL CASTED

TRAUMA INTERNAL PLATE

INSTRUMENTS

HIP CUP

KNEE TIBIAL FORGED

CASES & TRAYS

TRAUMA LF & LC PLATE

HIP HEAD

KNEE TIBIAL

HIP CUP CASTED

HIP HEAD CASTED

HIP STEM CASTED

TRAUMA PLATE MACHINED

SPINE LUMBAR MACHINED

HIP CUP FORGED

TRAUMA LF & LC PLATE

SPINE MACHINED

KNEE FEMORAL FORGED

TRAUMA SCREWS, HOOKS

MACHINED

TITAN

IUM

CR-C

OST

AINL

ESS S

TEEL

Page 3: you in full! THE WORLDWIDE ORTHOPAEDIC & …• Milford-CT: spinal implants (closed) trays represent epsilon). Strong cutting tools activity neurosurgery, devices MAIN SERVICES All

Ali MADANIPhone: + 33(0) 144 551 [email protected]

1

Leveraging 25 years of high level contactsand market tracking & modelling

A 360° view ofOrthopaedics

OEM & Contract Manufacturer direct interviews with decision makers thanks to strong links with CEOs, R&D, Marketing, Sales...

Cross-checking of information thanks to our tried & tested operating models

25+ years of historical data on the Orthopaedics & Contract Manufacturing markets

Companies & markets; continuous tracking and detailed market and financial modelling

Highly detailed segmentation

Entire supply chain & all players: OEMs, Contract Manufacturers

All product types: implants, instruments, cases & trays, biologics, cements, ceramics

All manufacturing services: forging, casting, machining, coating, packaging, sterilization

Operating Models &Cross-checking of information

Implants

HipKnee Spine

ExtremitiesTrauma

Contract Manufacturing

Implants Cases trays

Worldwide coverage

Western Europe

Latin America, Middle East, Asia,..

Developed countries

BRICS countries

Other countries

Instruments Biologics

Secondary research

Primary research

Full value chain coverage

Instruments Cases & Trays Implants

Ali MADANI Phone: + 33 1 44 55 19 90 [email protected]

The Worldwide Orthopaedic & Spine Contract Manufacturing

market report 2019-2024

& Top 100 supplier profiles

STORY Orchid is a group of companies merged: Unique Instruments (founded 1977), Stealth Medical Technologies (1992) and Unique Design (2004). In 2005: Orchid Orthopedic Solutions is formed in which all the divisions adopted the ORCHID name. Orchid Orthopedic Solutions consists of eight divisions and five leading technologies 2012: Orchid acquired SANDVIK Medical Solutions 2017: New plasma coating equipment in USA 2017: January, Mike Miller Retires as Orchid’s CEO; Jerry Jurkiewicz Named Successor 2019: Nordic Capital Fund IX acquires Orchid

ACQUISITIONS

2001: Stealth Medical Technologies acquired Hyvac Medical Technologies 2003: Stealth Medical Tech. acquired the biomaterials division of Astro Met 2005 & 2006 : Orchid acquired Bio-Vac and Bio-Coat & Orchid acquired MACDEE 2007: Orchid acquired Anzon, Keller Engineering and Micro Precision Swiss 2008: Orchid acquired Azary Technologies September 2015: Orchid acquired Alhenia a coating provider based in Switzerland employing 60 people December 2015: Orchid completed the acquisition of Cam Bioceramics Coating facility in Suzhou – China March 2016: Expansion of coating capabilities in Suzhou plant: new Vacuum Titanium Plasma Spray coating services

MAIN SHAREHOLDERS 2011: Altor Fund III acquired Orchid from Churchill Equity 2019: January, Nordic Capital acquired a majority from Altor, which retains a significant minority holding

CONTACTS HQ Address: Holt – MI -USA Mr. Ted Bloomfield – Vice President, Innovation and Product Quality Ph: + 1 203 922 01 05 [email protected]

MAIN CUSTOMERS Stryker n°1, Zimmer Biomet n°2, Depuy Synthes n°3 Other challengers: Mathys, LIMA…

PRODUCTION PLANTS 13 production facilities:: USA 1. Holt-MI: HQ & forging and finishing 2. Arab-AL: complex instrumentation 3. Arcadia-CA: complex milling (spinal implants) 4. Bridgeport-MI: grinding, milling and cutting instruments 5. Chelsea-MI : plastic injection molding and machining 6. Farmington Hills – MI – coating & sterile packaging 7. Memphis-TN: porous/Ti-foam coating 8. Oregon City, OR: Investment casting (Co-Cr and stainless) 9. Santa Ana-CA: Swiss turning 10. Shelton – CT : Design , engineering, regulatory & cutting instruments EUROPE 11. Sheffield-UK: casting, forging, machining & finishing 12. Baden-Dättwil- CH : coating (near Zurich, former Alhenia plant) ASIA 13. Suzhou facility: coating (Former Cam Bioceramics plant)

• Pune-India: machining (closed) • Milford-CT: spinal implants (closed)

MAIN SERVICES All services one stop shopping for implants: Forging, casting, machining, finishing, coating, sterile packaging Strong cutting tools activity

MAIN PRODUCTS All types of implants and instruments (Cases & trays represent epsilon). Other: dental instruments & implants, endoscopy, neurosurgery, gynecology, disposable airway devices

NUMBER OF EMPLOYEES 2,140 employees

ACTIVITIES

DESIGN &

CONCEPTION

FORGING OR

CASTING MACHINING

FINISHING &

POLISHING

COATING & SURFACE

TREATMENT

CLEANING &

PACKAGING STERILIZATION

http://www.orchid-ortho.com/

Orchid Orthopedic Solutions

2019 TOTAL REVENUE RANGE (US$380M)

85%

15%

2019 ORTHOPAEDIC REVENUES (US$360M)

IMPLANTS

INSTRUMENTS

Source: Orchid Orthopedic Solutions 2018 & 2019 & 2020

2014 2015 2016 2017 2018 2019

264 275 289 315 331 360

20

Other

Orthopaedics

Whole Ortho manufacturing chain

Core Business

Instruments include cutting tools

Ali MADANIPhone: + 33 1 44 55 19 [email protected]

The Worldwide Orthopaedic & Spine Contract Manufacturing

market report 2019-2024

&Top 100 supplier profiles

1©AVICENNE- 2019

STORYOrchid is a fusion of a group of companies: Unique Instruments (founded 1977), Stealth Medical Technologies (1992) and Unique Design (2004). In 2005: Orchid Orthopedic Solutions is formed in which all the divisions adopted the ORCHID name. Orchid Orthopedic Solutions consists of eight divisions and five leading technologies2012: Orchid acquired SANDVIK Medical Solutions2017: New plasma coating equipment in USA2019: Nordic Capital Fund IX Acquires Orchid

ACQUISITIONS2001: Stealth Medical Technologies acquired Hyvac Medical Technologies2003: Stealth Medical Tech. acquired the biomaterials division of Astro Met2005 & 2006 : Orchid acquired Bio-Vac and Bio-Coat & Orchid acquired MACDEE2007: Orchid acquired Anzon, Keller Engineering and Micro Precision Swiss2008: Orchid acquired Azary TechnologiesSeptember 2015: Orchid acquired Alhenia a coating provider based in Switzerland and employing 60 peopleDecember 2015: Orchid completed the acquisition of Cam Bioceramics Coating facility in Suzhou – ChinaMarch 2016: Expansion of coating capabilities in Suzhou plant: new Vacuum Titanium Plasma Spray coating services

MAIN SHAREHOLDERS2011: Altor Fund III acquired Orchid from Churchill Equity2019: January, Nordic Capital acquired a majority from Altor, which will retain a significant minority holding

CONTACTSHQ Address: Holt-USAMr Ted Bloomfield – Vice President, Innovation and Product QualityPh: + 1 203 922 01 [email protected]

MAIN CUSTOMERSStryker n°1, Zimmer n°2, Depuy Synthes n°3Other challengers: Mathys, LIMA…

PRODUCTION PLANTS15 production facilities::1. Holt-MI: forging and finishing2. Bridgeport-MI: grinding, milling and cutting instruments3. Chelsea-MI : plastic injection molding and machining4. Oregon City, OR: Investment casting (Co-Cr and stainless)5. Arcadia-CA: complex milling (spinal implants)6. Santa Ana-CA: Swiss turning (dental drills)7. Memphis-TN: porous/Ti-foam coating design & development8. Arab-AL: complex instrumentation9. Milford-CT: spinal implants10. Shelton-CT: design regulatory11. Southfield-MI: Ha/TPS coating & sterile packaging12. Sheffield-UK: casting, forging, machining & finishing13. Pune-India: machining14. Baden-Dättwil: coating (near Zurich, former Alhenia plant)15. Suzhou facility: coating (Former Cam Bioceramics plant)In 2015, Orchid develops its coating capabilities by acquiring Alhenia and Cam Bioceramics China MAIN SERVICES

All services one stop shopping for implants. Instruments represent only a few %.

MAIN PRODUCTSAll types of implants and instruments (Cases & trays represent epsilon).Others: dental instruments & implants, endoscopy, neurosurgery cutting tools, gynecology, disposable airway devices

NUMBER OF EMPLOYEES2,000 employees in 2018

ACTIVITIES

DESIGN&

CONCEPTION

FORGING OR

CASTINGMACHINING

FINISHING&

POLISHING

COATING &SURFACE

TREATMENT

CLEANING&

PACKAGINGSTERILIZATION

http://www.orchid-ortho.com/

Orchid OrthopedicSolutions

2018 TOTAL REVENUES RANGE (326 MUS$)

64%36%

2018 ORTHOPAEDIC REVENUES (305 MUS$)

IMPLANTS

INSTRUMENTS

Source: Orchid Orthopedic Solutions 2018 & 2019

2014 2015 2016 2017 2018

244 263 287 295 30516 17 18 20 21

Others

Orthopaedics

Whole Ortho manufacturing chain

Core Business

AVICENNE provides four main data components : historical and forecast market size and current market shares on each product/manufacturing method tandem, market breakdown by In-house vs Contract Manufacturing and main OEM buyers, CMO’s main customers / OEM preferred suppliers.

• Implants: Tecomet, Orchid, Viant, Lisi, Avalign, NN, Marle, Norman Noble, PCC, etc. (70+ companies mentioned)

• Instruments: Tecomet, Viant, Intech, NN, Avalign, Autocam Medical, Norwood, Orchid, Lisi, Tegra, KLS, Intech, CoorsTek, etc. (45+)

• Cases & trays: Tecomet, NN, Viant, Avalign, Medin, Intech, Aesculap, RMS, Inomed, etc. (20+)

• Coating: Orchid, Eurocoating, Viant, DOT, APS Materials, Terolab, Medical Group, Medicoat, etc.

• Also main players data for forging, casting, machining Spine & Trauma, instruments manufacturing, cases & trays manufacturing, coating.

3POSITION YOUR OFFER WITH OUR PRICE DASHBOARDS, AVAILABLE FOR EACH PRODUCT BY MANUFACTURING METHOD

5IDENTIFY CONTRACT MANUFACTURING MARKET TRENDS WITH VALUE FORECASTS TO 2024

4UNDERSTAND COMPETITION DYNAMICS WITH MARKET SHARES & COMPANY DATA

6CONTRACT MANUFACTURING COMPANY RANKINGS & TOP 100 SUPPLIER PROFILES

For each product and its manufacturing method, the Average Selling Price (ASP) is provided, with the min/max spread.

The Contract Manufacturing market is growing by 7.6% per year, a higher rate than the general orthopaedic market.The main drivers are, firstly, challengers who outsource more taking market share away from the Majors and, secondly, gradual divestment by the Majors.

Avicenne is also the creator of IMPLANTS, a worldwide conference focusing on Strategy, Innovation & Regulatory in the orthopaedic world. The 2019 and 16th edition of IMPLANTS attracted more than 150 international decision-makers for 2 days of presentations, tutorials and business networking. The speakers highlighted how manufacturing techniques and purchasing strategies are evolving, how Robotics and Additive Manufacturing will alter the future landscape and how to cope with Regulatory burdens.Ali Madani’s tutorials have featured among the presentations most highly rated by participants. In this presentation you will hear about:• Orthopedic Market perspectives and main issues,• Orthopedic Contract Manufacturing Markets.

SURVEY METHODOLOGY BASED ON DIRECT INTERVIEWS AND 28 YEARS OF EXTENSIVE MODELLING

Example of profile:

M U

S$

2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024

CAGR 2019-2024: 7.6%

CAGR 2012-2019: 7.2% CAGR 2019-2024

Implants:8.3%

Cases: 5.7%

Instrum: 6.8%

www.tutorials.implants-event.com

Forging Hip stems

Hip cups

Femoral knee (oxinium)

Knee tibial

Trauma LC plates

US$

Casting Knee tibial

Knee femoral

Hip cup

Hip Stem

US$

2 0 2 0International conference on innovation,

manufacturing and purchasing strategies in orthopedics

TUTORIAL SESSIONSHyatt Regency Orlando (Florida) Wednesday 25 March 2020 - 6:00 / 9:30 pm

Page 4: you in full! THE WORLDWIDE ORTHOPAEDIC & …• Milford-CT: spinal implants (closed) trays represent epsilon). Strong cutting tools activity neurosurgery, devices MAIN SERVICES All

PRODUCT OPTIONSPlease select:

Main report PDF via E-mail - €4,600

Ad hoc studies – please call or email us

3 WAYS TO ORDER1 - Order Online 2 - E-mail the order form to [email protected] - Mail the order form to AVICENNE,

42, avenue de la Grande Armée - 75017 PARIS, FRANCE

PAYMENT OPTIONS1 - Online payment on Avicenne website2 - By credit card: Mastercard or Visa onlyType of card:Card number:Expiration date:Name of the cardholder:Security number (3 digits on the back of your card):

3 - Bank transfer

CUSTOMER INFORMATION

First name: Surname:

Job Title:

Company:

Email:

Address:

City/Country:

Phone: Fax:

Intra-community VAT Number (Mandatory for EU Companies):

PAYMENTTotal € (see above)

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Date, Signature & Stamp

ORDER FORM

For a corporate license, please contact us: a Corporate (or multi-user) license is needed for any organization in which more than one user in at least two different locations will access the report. Please add VAT for French companies.

MAIN REPORTWorldwide Orthopaedic & Spine Contract Manufacturing Market Report 2019-2024 & Top 100 supplier profiles

NUMBER OF PAGESNUMBER OF EXHIBITS SINGLE-USER LICENSEPRODUCT OPTIONS

350+ pages

1,000+ exhibits€4,600

WORLDWIDE ORTHOPAEDIC & SPINE CONTRACT MANUFACTURING MARKET REPORT 2019-2024& TOP 100 SUPPLIER PROFILES PUBLISHED JUNE 2020 • 9TH EDITION

OTHER CONSULTING SERVICES: AD HOC STUDIES, VENDOR, COMMERCIAL & STRATEGIC DUE DILIGENCEAVICENNE was founded in 1992 by Ali Madani and has been operating on strategic and marketing studies in the medical sector since then. AVICENNE has advised major players in this industry (Medtronic, Stryker, Zimmer Biomet, Depuy Synthes, etc.) with their strategy development and implementation, technical and economic appraisals, mergers and acquisitions. AVICENNE has also advised many Private Equity firms on acquisitions and build-ups. AVICENNE has worked with mid-size companies on their entry strategy for new markets, adjacencies or new geographic territories as well as business model improvements and partnership strategies. Globally, AVICENNE has been involved in more than 320 projects for 100+ customers in the medical device industry. AVICENNE has published several annual surveys such as “European orthopaedic Market” and “Worldwide orthopaedic Contract Manufacturing market and top 100 supplier profiles”. AVICENNE’s Managing Partner, Ali Madani is a speaker at and chairman of several medical device conferences worldwide. He founded “IMPLANTS” a medical device industry conference and exhibition, focusing on manufacturing, innovation and buying strategies, which he has chaired ever since.

Contact Ali Madani Managing Partner of Avicenne

Phone: +33 1 44 55 19 90 Email: [email protected]

: www.avicenne.com/medical_reports_2.php