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Yin et al., 2017 Database S2
Table of Contents (click title to directly go to the page) Motif logos of AP2 TFs……………………………………………………………2 Motif logos of bHLH TFs………………………………………………………..2-4 Motif logos of bZIP TFs.……………………………………………………......5-6 Motif logos of CP2 TFs……………………………………………………….......7 Motif logos of DM TFs…………………………………………………………….7 Motif logos of E2F TFs……………………………………………………………7 Motif logos of ETS TFs………………………………………………..............8-9
Motif logos of Forkhead TFs………………………………………………….. 10 Motif logos of GATA TFs…………………………………………………….....11
Motif logos of HMG TFs………………………………………………………...11
Motif logos of Homeobox TFs ………………………………………........12-17
Motif logos of HSF TFs………………………………………………………… 18
Motif logos of IRF TFs…………………………………………………………. 18
Motif logos of MADS TFs……………………………………………………… 18
Motif logos of NFI TFs…………………………………………………………. 19
Motif logos of Nuclear Receptor TFs………………………………........19-20
Motif logos of CUT TFs…………………………………………………........... 21
Motif logos of PAX TFs………………………………………………………… 21 Motif logos of POU TFs………………………………………………………... 22 Motif logos of RFX TFs……………………………………………………….... 23
Motif logos of RHD TFs………………………………………………………... 23
Motif logos of SAND TFs ……………………………………………………… 23 Motif logos of TBX TFs ……………………………………………………… 24 Motif logos of other TFs……………………………………………………….. 24
Motif logos of Znf TFs………………………………………………….. …..25-28
1
Methyl Control TFAP2C
TFAP2E
TFAP2E
TFAP2B
TFAP2A
0.02
DBD MethylMinusTCGA
GCATCCTAGTCAGGCTAAGTCGATCGCGTAAGCT
FL MethylMinus TACG
GCCCTCCGATAGGGCGATGC
FL MethylMinus TCAG
GACT
CGTCCTTCGAGCATAGCTGAGCCGTAAGTC
DBD MethylMinus TCAG
GCCCTTCGAGCATAGCTGATGCGAGTC
FL MethylMinusTAGCGCATCCTTCCGTAAGGAGCGATATCG
DBDTCAG
GCATCGTACTGACTAGGCATACTGGACTGCTACGTAAGCT
FL CTAG
GCCCTCGCGATAGCGGCGGATC
FL TCAG
GACT
CGTACCTGTCGACGATAGCTGATGCCGTAGATC
DBD TCAG
GCATCCTAGTCGAGCATAGCTGACTGCCGTAGTC
FLTCAGGCCCTCGCGTAAGCGGCGAGTC
AP2 TFs
bHLH TFs
Methyl Control TCFL5
SOHLH2
HEY2
HEY2
HEY1
HEY1
HES6
HES7
HES2
HES1
HES5
HES5
BHLHE40
BHLHE41
MLX
MLX
DBD MethylMinus GTCACGTAGTCTGACTAGATCCGTAACTGCTAG
DBD MethylMinusACTG
GTCACATATC
CATGA
TACG
GTA
CGTA
ATCG
DBD MethylMinusGCTA
GCTA
CTGA
AGCT
CTG
GACT
TCAG
GACT
TCGA
CGAT
FL MethylMinus GCTA
GCTA
CGTA
AGTC
CTGA
GAT
TCAG
GATC
TCGA
CGAT
DBD MethylMinus TGCA
GCTA
CTAG
AGTC
CTA
GAC
TCGACTCAGCGTA
FL MethylMinus GCTA
GCTA
CTGA
AGTC
CTG
GCAT
TCGA
GCAT
TCAG
CGTA
DBD MethylMinus GTCA
GCTA
CATG
AGCT
CTGA
GATCAG
GAC
CTGA
GCAT
DBD MethylMinusGTCA
GTCA
TCGAAGCTGA
GAC
TGC
GTAC
GACT
GCTA
DBD MethylMinus GTAC
GTAC
CTAG
AGCT
CATGGATCGA
GATC
TGCA
GCT
DBD MethylMinus GCTA
GCATCATG
AGTC
CTGA
GACT
TCAG
GTC
TCGA
CTGA
DBD MethylMinus GACT
CGAT
AGCTCT
AGCT
CTA
TGCA
TCGA
DBD MethylMinus GACT
TGCACGACTGGACTCGACGTCTGA
DBD MethylMinus GACTTGACCAGCTGATCGACTGCTGA
DBD MethylMinus TGCACATCGGTCGACGT
FL MethylMinus TCGA
CAGTCAGCTGGATCGACGTTCAGCAGT
DBD TGCACAGTCTGACTAGACCGATACTGCATG
DBD CTAG
GTCACTAGAGCGTGTATCAGACTCAGTAGCT
DBD GTCA
GCTACTGA
AGCCTAGATCAGACTTCGACGTA
FL GCTA
GCTACTGA
AGTC
CTGGACT
TCGA
GTAC
TCGA
CGAT
DBD GTCA
GTCACGTAGTCCTGAGCTCGTACTCAGCGTA
FL GCTA
GCTACTAG
AGTC
CTGA
GAC
TCAG
GATC
TCGA
CGAT
FL GTCA
GCAT
CGATATG
CTGA
GCA
TGCGTACTCA
DBD GCAT
GCATCAAGTCGTCAGGATCTGAGCTA
DBD GCTA
GTACCAGTAGCTGTCGACTGACGTA
DBD GTCA
GTACCAAGTCTGTCAGTGCTACGTA
DBD GCAT
GCATCAGCGTCAGGTCGACTGA
DBD GACT
TGACCGAGCCGTCAGACTGCTGA
DBD GACTTGACACGTGACTCTGA
DBDGTCACACGTGCAGT
FLTCAG
GCATCACGTGACGTCTAGCAGT
MethylMinus
2
Methyl Control CLOCK
NPAS2
ARNTL
ARNT2
SREBF1
SREBF1
SREBF2
SREBF2
TFEC
TFE3
TFEB
USF2
USF1
MYCN
MAX
MAX
TFAP4
TFAP4
TFAP4
TFAP4
FERD3L
FERD3L
PTF1A
NEUROG1
NEUROG1
NEUROG2
NEUROG2
NEUROD2
NEUROD1
OLIG2
OLIG2
OLIG3
OLIG3
OLIG3
BHLHE23
BHLHE23
BHLHE22
BHLHA15
BHLHA15
ATOH7
ATOH1
ATOH1
DBD Multiple effects GATC
ACGTCATG
AG
TCGATCGATCTCGATACG
DBD Multiple effects GATC
ACGTCAGTCGATCGATCGAATCG
DBD MethylMinus GACT
TAGCCAGAGTCTCGAGACTTCAGGTAACTGCGTA
DBD MethylMinus AGCTTAGCCGAATGCGCTGCATCGGCAAGTTCG
DBD MethylMinus ACGT
TCACGAAGTC
CTG
CAGCTAGCGTAAGCTCTGA
DBD MethylMinus AGCTAGCCGATATGGCTAGCATCAGGCTAGTCTCGA
DBD MethylMinus AGCT
TCAGCGAT
AGTC
CGTA
ACGT
CTA
CTGA
AGT
TCG
DBD MethylMinus AGCT
CTAGCATTCGATGGAGCCTGCTAG
DBD MethylMinus AGCT
GCATCATCGTGACTGGCAT
DBD MethylMinus AGCT
ACGTCATCGATGACTGCTAG
DBD MethylMinus AGCT
CATGCATCGATGAGCTCATG
FL MethylMinus ACGT
CTAGCATCGACTGCACTCAGT
DBD MethylMinus CAGTCAGATCGTCAGCCAGTTCAGTGCAAGTCCAGTCATCGTCAGTCGAT
FL MethylMinus AGTC
CAGTCATCGTCGCAGTTACG
FL No CpG AGCT
TACGCAGCTCGATGATGCTCGA
FL No CpG AGCT
ACTGCAGTTCGAAGCTTACGCTGACTCGA
DBD No CpG AGCT
TACGCATGTCACAGTCGATGCTCGA
DBD No CpG AGCT
TACGCAGTTGCAAGCTCGTTAGCTCAG
FL No CpG GAT
CTAG
AGCT
ACGTCATGTCCAGTAGTCGATCGAAGTCC
FL No CpG GA
CTAAGC
CAGTCATGCACGTGTGCATCGAGTC
DBD Little effect GACT
CTGATTACCTGAGCTCATAGGCATGACTCGA
DBD No CpG GACT
ACGTCATTGCACGTCGTGCACTGA
FL No CpG AGCT
AGCTCGTATTGCAGCTAGCGTCTCGTCGA
FL No CpG GACT
ACT
CGAGCT
TCG
AGCT
TCGCTCGACTGA
DBD No CpG GACT
ACGTCGAGC
TGCAGCTACGACTTCGACTGA
FL No CpG AGCT
CAGTCAG
AGCTCAGCTCGGCTCGATCGA
FL No CpG ATGAGATCTGCATGCGCATCGATGACTCTGAGAACGCATATTAACTCAGCTTCGCTG
DBD No CpG ACTG
ACGTCATGCCATCGTGACTGCA
DBD No CpG AGTC
CAGT
CAAGTTGCACG
TCA
GT
GTCA
TCAG
DBD No CpG AGTC
CGAT
CAAGTTGCACGTCAGTTGCATCAG
DBD No CpG AGTC
CAGCAT
ATCG
TGAC
ACT
TCGGTCGATCG
FL No CpG AGTC
CGATCAAGTTCGACTGTTGCTCAG
DBD No CpG AGTC
CAGCAAGCTCATGGGTCTCGA
FL No CpG AGC
CAGTCAGTTCAAGTTCGAGCAGCTATCG
DBD No CpG ATCG
CAGTCAAGTCTCGAGTCAGGTCGTCATCAG
DBD No CpG AGCT
ACGTCATAGTACCATAGTGCATCGA
DBD No CpG AGTC
CAGTCAAGT
TGC
ACG
TCAGT
GTCA
TCAG
DBD No CpG AGCT
ACGTCAAGTCGAGCTCGCTGCACTAG
DBD No CpG AGCT
AGCCACGGTCCAGTGTCGACTGA
DBD No CpG AGCT
ACGTCAGTGCACGTCGTGCACTGA
DBD GATC
CAGTCAAGTCTGATCGTCTGACATG
DBD GATC
ACGCACGTGTCGACTG
DBD GACT
TAGCCAGAGTCCTGGACTCAGGTACATGCGAT
DBD GACT
TAGCCAGAGTCCTGATCAGGTCATGCGTA
DBD GACT
TACG
CGA
AGC
CGTGCA
TCGCTAATGCTCGA
DBD AGCT
TACGCTGA
AGC
CGTA
GCAT
CTAG
CGAT
AGCT
CTGA
DBD ACGTACCGAGTCCGTGCATCGAGCATATGCCTGA
DBD AGCTTCAGCGAAGTCTGA
GACT
CTAG
CGTAGTCTG
DBDCATG
CGATCATGCTGATGACGTCTGACAGT
DBD CTGA
GACTCAGCGTGACGTCTGGCAT
DBD CTGA
GCATCAGTCTGATGACGTCTGACGAT
DBD CATG
CAGTCACTGTGAGCTCTAGCAGT
FL CATG
CAGTCACGTGAGCTCTAGCAGT
DBD CAGTCGAAGTCCTGACTCAGATCAGTCATGACTGTAGCATGCCATGAGTCCTGATCTAGTACCGTA
DBDGCATCAAGTCTGATCAGTGCTACTGAGCATGACTGCATCAAGTCTGATCAGTCGTA
FL GACT
CTGACAAGTCTGATCGTCTGAGATC
FL AGCT
TACGCACGCTCGATTAGATGCTCGA
FL AGCT
ACTCAGTCGAGCTGCTGACTCGA
DBD AGCT
TACGCACGGTCCGATCGATGCTCGA
DBD ACGT
ACTGCGATGCACGTCGCGTACTCGA
FL GATC
CTAG
AGCT
ACGTCATCGGTCCAGTGCAGTCGATCGAAGTCC
FL GA
CTAAGC
CAGTCATGCACGTGTGCATCGAGTC
DBD GACT
CTAG
GATACGCAGTCCGATGCTCGATGCA
DBD GACT
AGCTCAGTGCAGCTCGCTGCACTGA
FL GACT
ACGTCGAGTCAGTCGTGCACTGA
FL GACT
ACGT
CGAGC
TCG
AGTCAGCTGCACTGA
DBD AGCT
AGCTCAGTCGACGTCGTTGCATCGA
FL AGCT
CAGCGAGCTTCGAGCTTCGGCTCGATCGA
FL ATCGATGC
ATTACGATGCCGATCGTAGATCCTGAGATCCAGCGACTGACTACGGTCACTAG
DBD AT
ACTCA
AGC
GTC
CAG
TCGGCTCTGCA
DBD ATCG
CAGTCAAGTTGCACGTCAGGTGTCATCAG
DBD AGTC
CGAT
CAAGTTGCACGTCAGTTGCATCAG
DBD ACGT
AGCTCATATGCGTACCAGTTGGATGCATCGA
FL AGTC
CGACAAGTTACTCAGTTGCTCGA
DBD ACGT
CAGTCAATGCTGAGTCTCGCGTCTCGA
FL AGCT
CGATCGAGTTCAGCTTCGCGTCTCGA
DBD AGCT
CAGCAAGTTAGTTCGGGTCATCAG
DBD AGCT
ACGTCATG
ATGC
GTCA
CAGTTACGTCGATCGA
DBD AGTC
CAGTCA
AGTC
TGC
ACG
TCAGGTC
GTCA
TCGA
DBD AGCT
ACGTCAGTTCGAACGTGCGTGCACTAG
DBD AGC
AGCCATGTCATGTCAGCT
DBD AGCT
ACGCAGTCGAGCTCGGTCACTGA
MethylMinus
MethylMinus
bHLH TFs
3
Methyl Control NHLH1
NHLH2
NHLH1
TCF21
TCF21
MSC
MSC
MSC
MSC
HAND2
MYOD1
MYOD1
MYOD1
MYOD1
MYOG
MYOG
MYOG
MYOG
MYF6
MYF6
MSGN1
MESP2
ASCL2
ASCL2
ASCL2
ASCL1
TCF12
TCF4
FIGLA
0.0 5
FL Little effect GTAC
GTAC
GATC
GTCA
ACGT
GTCACTACGGTCCGATCGACCTAGTACTCGACAGTCATGCTAG
FL Little effect GATC
GATC
GATC
GCTA
ACGT
GTCACAGTCCGATGCTAGGTACTCGACATGCATGCTAG
DBD Little effect GTCA
GATC
GATC
GCTA
ACTG
TGCACGTAGGTACGATGTCATGGTATCAGCTACTAGCATG
DBD No CpG CTGA
AGTC
CAGTCAGTCGACGTTCGTGTCACTAGGACT
DBD No CpG CTGAAGCT
ACGTCATGTCCAGTTGTGCTCGAGACT
DBD No CpGTCGA
AGCT
ACGTCGAGTGTCACAGTCAGGTGCATCGAGACT
DBD No CpG CTGA
AGT
CAGTCAGTATGC
TCGAGC
TAG
GTCA
GTCA
TCAG
GACT
FL No CpG CTGA
AGCT
ACGTCAGTCAGTCGTGCTCGAGACT
FL No CpG CTGA
AGTC
CAGCATGACTGGTCATCAGGACT
DBD No CpG ACTG
ACGCGACCTGCAGTTCAGCTCTGAGTC
DBD No CpGCGTA
AGCT
AGCTCAGCGCTACGATTCAGTTGCATCGAGACT
DBD Little effect CTGACATCGCAGGCTACGATTCGGCTCGATCGAAGCT
FL No CpG CGTAACGT
ACGTCTATGGCTACGATTCGTGCATCGAGACT
FL Little effect CTAGGACT
ACTGCTAGTCGCTACGATTCAGGATGCATCGAGCAT
DBD No CpGGCTAAGCAGCCAGACTCTGATGTACGTCGGACT
DBD Little effect CTAGACT
ATGCCTAGTGTCACTGTAGTCGATCGAGCAT
FL No CpGGCTAAGCAGCTCAGACTCTAGTGTACGTCGGACT
FL Little effect CTAGGA
ATGCCAAGATCCTGATAGTCGATCGGCAT
DBD No CpGCGTAAGCT
ACGTCAGCATCGTATGTAGCCTGGACT
DBD MethylPlus CTAGGATACGCGAGCTACGTATAGTAGCTCGAGACT
DBD No CpGCTGA
AGCT
CGTACAAGTTACGATGCTCGTGCATCGAACGT
DBD No CpG CGTA
AGCT
ACGT
CAGAG
TAC
ATGTCAG
GTA
TGC
CTG
GACT
DBD No CpG AGTC
GACTCATGCGTCACAGTAGCGACCTGATCGA
FL
MethylMinus
AGCT
GACTCTATCGCTCGATAGCTGATCGA
DBD No CpGAGTC
GACTCATATCGGTCCGATTGACGACTGATCAG
DBD MethylMinusAGCTCACTGCAGTGTCTAG
DBD MethylMinusGACTCACTGCAGTGCTGA
DBD No CpG ATCG
CAGTCACCTGTGCA
FL GTAC
GTAC
GATC
CGTA
CAGT
GTCACTAGGCTACGATTCGAGACTGAGTCATCGACATGCATGCTAG
FL GATC
GTAC
GATC
CTAGCAGT
GTACCAGCTCGATGCTAGGTACTCGACATGCATGCTAG
DBD GATC
GTAC
GATC
GCTACAGT
GTCACAACGCTCGATCAGCTAGGTCTCGACATGCATGCTAG
DBD CTGA
AGTC
CGATCGATAGTTGCAGCTCAGTAGTCACTAGGACT
DBD CGTA
AGCTAGCCAGTCCAGTTCAGCTTCGATCGAAGCT
DBDCTAG
AGCT
ACGTCTACT
GTAC
CAGTTCGATCGATCAGAGCT
DBDCTGA
AGCT
CAGT
CAGT
AGT
TCGAAGCT
TCA
GTCA
GTCA
TCAG
GACT
FL CTGA
AGCT
ACGCAAGCGTCCAGTTGCAGTTGCATCGAGACT
FLCTGA
AGTC
CAGTCGAAGTGCACGTCGTCGTCATCGAGACT
DBD ACGT
ACGTCAGCTCGTAGCCTGAAGTC
DBD CGTA
AGCT
ACGTCAGGCTACGATTGTAGCTCGAAGCT
DBD CTAG
GAC
ATCGCAT
AG
GTC
CGATTCGGA
TCGA
TCG
GACT
FLGCTAACGT
AGCTCAGTGCTACGATTCAGGTAGCCTGAGACT
FL CTGAGACT
ATCGCATAGCGCTACGTATCAGGCATGCATCGAGACT
DBDGCTAAGCT
AGCTCAGACTCTGATCAGTACGTCGAGACT
DBD CTGAGAATCGCTAAGCTGCATCTGATCAGTACTCGATCGAGCAT
FLGCTAAGCAGCTCATGATCCTAGTGTACGCTGGACT
FL CTAGGA
ATCGCAGTCACTGATAGTCGATCGAGACT
DBDGCTA
AGCT
ACGTCAGCATCGTATGTAGCCTGAGACT
DBD CTAGGACTACGCGTAGCGCTACGTATCAGTAGCTCGAGCAT
DBDCGTA
GACT
CGTACGAGTACGATGCTCGGTGCACTGACGAT
DBD CGTAAGTACGCAATGTAATTGCGACGTCCTAGATC
DBDGACT
GACTCATGCGCTACGATACGGCTGACTGA
FLAGCT
GACTCACTGCTACGATAGGCTGACTGA
FL ACGTCTGAGCTCTGGACTACTGCTAGGACCATGGATC
DBDGACT
GACTCTATCGGCTACGATTGACGATCTGACTGA
DBDGACTCACTGCGATGTCTGA
DBDGACTCACTGCGATGCTGA
DBD ACTG
CAGTCACCGTGTGCA
No CpG
bHLH TFs
4
Methyl Control TEF
HLF
DBP
DBP
CEBPG
CEBPG
CEBPB
CEBPE
CEBPD
BATF
BATF3
BATF3
FOSB
FOSL1
FOSL1
FOSL1
FOS
JDP2
JDP2
JDP2
JDP2
ATF3
ATF3
ATF4
ATF4
NRL
NRL
MAFA
MAFA
MAFA
MAF
MAF
MAF
MAF
MAFG
MAFG
MAFG
MAFG
MAFG
MAFF
MAFF
MAFF
MAFF
DBD MethylMinusTGCA
GACTTTAGTCGATCAACTGAGACT
FL MethylPlus CTGA
GACTTACGTGCAGCCTGAGCATCAGACGTATGCCTGAGACT
DBD InconclusiveTCGA
GACTTTGAGTCGGACTCACACTGAGACT
FL InconclusiveCTGA
GACTTACTGTAACTGGACT
DBD MethylPlusTCGA
AGCTTTGGATCTGAGATCTCAACATCGAAGCT
FL MethylPlusCGTA
GACTTACGTGCAGATCTGAGACTTCAACTGATGCCTGAGCAT
DBD MethylPlusTCGA
AGCTTTGTACTGATCAACATCGAAGCT
DBD MethylPlusTCGA
AGCTTTGATCTGATCAACACTCGAAGCT
DBD Little effectTGCA
AGCTTGTGGTACTGACTAACATTCGAAGCT
FL No CpGCGAT
CAGT
ACGT
TCG
GCAT
ACGT
CTAGC
CTAG
GTCA
DBD Inconclusive GTAC
AGCTTCAGTACATGCTGGACTACAGAGTCGACATG
FL Inconclusive GTCA
AGCTTC
GTCA
AGCT
CTGGCATACGCAGTAGCTTCGACGAT
DBD Inconclusive GTACAGCT
TCG
GTCA
ATCG
CTGAGCATTACGCAGTAGCTCGACATG
FL No CpG GTCAAGTGCAGCACTGGCTTAGCAGATCACAGT
FL MethylMinus GATCAGTC
TGC
GTCA
AGCT
CTGGCAT
TACG
CGAT
AGTC
TCAG
CATG
FL Little effect AGCT
AGCT
TCG
GCA
ATGC
CTAG
AGCT
CTAG
GAT
DBD MethylMinus GTAC
AGCTGCA
GCTA
AGCT
CTGGATACCGATAGTCTCAGCGTA
FL No CpGCGTA
AGCTTC
GTCA
ACTG
GCTA
TGAC
CAGT
AG
TCGA
GCAT
FL InconclusiveGCAT
GACTTCGA
GTCA
AGTC
TCGA
GCAT
TACG
CAGT
AGC
TCGA
GCTA
DBD No CpG GCTAATGACGATCATCGCGAT
DBD Inconclusive GCAT
AGCTTGTACTGGCATACAATCGACGTA
FL MethylMinus GATC
AGCTTCGTATCGGACTACAAGTCGACTAG
DBD MethylMinus GATC
AGCTGTACTGGATCAATCGACTAG
DBD MethylMinus GATC
GTAC
ACGTGATCGATCATGCCATGCTAG
FL No CpG AGTC
ATGC
ATGC
ATCG
GACTTCAGGACATTCAGTAATCTGAATGC
DBD No CpGAGCT
AGTC
ATGC
TACG
GACTTCAGGCATGTCAGTACAGTCCTGAGATC
DBD No CpG AGCT
ATGC
ATGC
TACG
GATCTCAGGCATCGTAAGCTGATGAC
DBD No CpGTAGCTCAGGCAT
CATG
TCAG
GTAC
ATCG
GCTA
TAGC
CATG
AGTC
GTAC
CGTA
AGTC
TCAG
DBD MethylMinusTGACTCAGGCAT
CATG
TCAG
GTAC
AGTC
CTGA
GCTA
TCAG
CATG
AGTC
GTACCTGA
AGTC
ATCG
FL No CpGTAGCTCAGGCCATTCGTCAACTGATAGCCATGTAGCGTACCTGAAGTC
FL No CpGATGCTCAGGCA
CATG
TCAG
GTAC
ATCG
CGAT
TAGC
CATG
AGTC
GTACCGTAAGTCTACG
FL MethylMinusTAGCTCAGCCATTCAGTACAGTCTCGAGCTATGCACATGAGTCGTCACTAAGCTACG
DBD No CpGAGTC
TCAGGA
CAGT
TC
GTACATG
CTGA
GATC
DBD No CpG AGTC
ATGC
ATGC
ATCG
ATGCTCAGGCAGTCGTAACCTGATAGC
DBD No CpGTAGCTCAG
GCAT
CATG
TCAG
GTAC
ATCG
CGAT
TAGC
CATG
AGTC
GTAC
CGTA
AGTC
ATCG
DBD MethylMinus TAGCTCGA
GTAC
CTAG
TCAG
GTCAACTG
CTGA
GACT
TCAG
CATG
AGTC
GTAC
CGTA
AGTC
TACG
FL No CpGATGCTCAGGACATGTCGTACACTCTGATGAC
FL No CpG TCAGGCA
CAT
TCGA
GTCA
ATCG
CTGA
TGCA
GATC
TAGCGATC
CTAG
AGTC
FL No CpGAGTC
TCAGACATTCAGGTACATCGCATTAGCATGAGTGTACAGTCTCAG
FL MethylMinusATGCTCGGCAGTCGTACTGAGACTCAAGTGTCAGCTATCG
DBD No CpGATGC
TCAGGCA
CAT
TCAG
GTACATCG
GCATTAGC
CATG
AGTGTACGT
AGTC
TACG
DBD MethylMinusATGCTCAGGACTCATGTCAGTACAGCCTGAGACTTGCAGAGTCGTACCGAAGTCATCG
DBDGCTA
GACTTTAGCTGTCGAACTGAGCAT
FLCTGA
GACTTGCA
TGCA
AGC
CTGGTCGACGTATCGCTGAGACT
DBDCGTA
GACTTTGAGCTGATCACACTGAGCAT
FLCGTA
GACTTACTGTAACTGGCAT
DBDCGTA
GACTTAGTGGATCTGAGACTTCAACTATCCTGAGCAT
FL CGTA
GACTTCGA
TGAC
GAT
CTGA
GATC
TCA
ACTG
AGCT
CTGA
GCAT
DBDGTCA
GACTTTGGTACTAGATTCAACATCGAGACT
DBDTCGA
GACTTTGGTACTAGACTAACATCGAGACT
DBDGCTA
GACTTAGTGGTACTAGATCTAACATCGAGCAT
FL GCAT
ACGT
AGCT
TCGA
GCACGT
CTG
AGCGTAGTAC
DBD GCTA
AGCTTCGGTCAAGTCTGCTTGACAGTAGCTTCGACGAT
FL GCTA
AGCTTCGGTCAAGTCTGATACGCAGTACTCGACGAT
DBD GCATAGCT
TCGA
GTCAAGCT
CTAGATACGCAGTAGCTTCGACGAT
FL GTCA
AGCTTCGCTACTGTAGCTGACCGAAGCTTCGACGAT
FL GTAC
AGCTTGCAGTCAACGTCTGAGCATAGCCGATAGCTTCGACAGT
FL AGTC
AGCT
TCGGTAC
ATGC
CTAGTC
CGTA
GATC
DBD GCTA
AGCTTCGGTCAATCGCTGAGACTTCGACAGTAGCTCGACAGT
FLCGAT
AGCTTGCACTGCGTATGACCGTATCGCGAT
FL GCTA
AGCTTCGAGTCAAGCTCTGAGTTACGCAGTAGCTTCGACGTA
DBD GCTA
AGCTCGACGCATTGCTGAGTCCGAT
DBDGCAT
AGCTTGTCACTGTCAGATCGACGTA
FL GACT
AGCTGTACTGATCAATCGCTGA
DBD GCAT
AGCTTGTACTGTCAATCGACGTA
DBD GATC
GTAC
AGCTGACGTCATCGCATGCTAG
FL GATC
GTCA
ACGTGACTGTCATGCCAGTCTAG
FL AGTC
ATGC
ATGC
ATCG
GATCTCAGGCATGTAACTGGATC
DBDGACT
AGTC
ATGC
TACG
GATCTCAGGCATTCAGTACATCCTGAGATC
DBD AGTC
ATGC
ATGC
TACG
GTACTCAGGCATGTACTGAGTAC
DBDTAGCTCAGGACT
CATG
TCAG
GTAC
ACTG
GCTA
TGAC
CATG
ATGC
GTAC
CTGA
AGTC
ATCG
DBDTAGCTCAG
GCAT
CATG
TCAG
GTACAGCT
CTGA
GCTA
TCGA
CATG
ATGC
GTAC
CGT
AGTC
ACTG
FLATCGTCAGGTCATGTACGGTAATGCCTGAAGTCACTGTAGCGATCCTAGAGTC
FLATGCTCAG
GACT
CATG
TACG
GTAC
ATCG
GCAT
TAGC
CATG
ATGC
GTAC
CTGA
AGTC
ATCG
FLTACGTACG
GCAT
CATG
TACG
GTAC
ATCG
CTG
GCTA
TCAG
CAGT
ATGC
GTAC
CGTA
AGTC
TACG
DBDGATCTCAGGACAGT
TCAG
GTAC
ACT
CTGA
GATC
DBD AGTC
ATGC
ATGC
ATCG
TAGCTCGCATGTACTGTGAC
DBDTAGCTCGAGCAT
CATG
TACG
GTAC
ACTG
GCAT
TGAC
CATG
AGTC
GTACCGTAAGTCATCG
DBD TGACTCGAGTCACAGTTCAGGTCAAGCTCTAGGATTCAGCAGTATGCGATCCTGAAGTCACTG
FLAGTCTCAGGCACATGTCGTAACTGAGTAC
FL TCAGGACCATGTACGGTACATCGCTGATGCAGATCTACGGACTCTGAAGTC
FLATGCTCAGGCAT
CAT
TACG
GTAC
ATCG
GCATTGAC
CATG
ATGC
GTACCGTA
AGTC
TACG
FLATGCTCAGGCA
CATG
TCAG
GTAC
AGTC
CTGA
GACT
TCGA
CATG
ATGC
GTACCTG
AGTC
TACG
DBDATGCTCAG
GCAT
CATG
TACG
GTAC
ACTG
CGAT
TAGC
CATG
ATGC
GTAC
CTGA
AGTC
ATCG
DBDTAGCTCAG
GCAT
CATG
TACG
GTACAGTC
CTGA
GACT
TCAG
CATG
ATGC
GTACCGAT
AGTC
ATCG
MethylMinus
bZIP TFs
5
Methyl Control CREM
CREB1
CREB1
CREB1
CREB1
CREB3L4
CREB3L4
CREB3L4
CREB3
CREB3
CREB3
CREB3L1
CREB3L1
CREB3L1
CREB3L1
CREB3L1
CREB3L1
ATF6
ATF6
ATF6B
ATF6B
ATF6B
XBP1
XBP1
JUND
JUND
JUN
JUN
JUNB
ATF2
ATF2
CREB5
CREB5
ATF7
BACH2
BACH2
NFE2
0.0 5
DBD MethylMinusCGTA
GACTTCGA
GTCA
ATGC
TCGA
GCTTACG
CAGT
AGTC
CTGA
GCAT
FL MethylMinusCGTA
GACTTCG
GTCA
AGTC
CTGAGCATACGCAGTAGTCTCGACGAT
DBD MethylMinus GCTA
GACTTCAG
GCTA
ATCG
CTAGGATCTAGGATTCAGAGTC
DBD MethylMinusCGTA
GACT
TCGAGTCA
AGTC
TCGGCTACG
CAGT
AGC
CTGA
GCAT
DBD MethylMinusGTCA
GACTGACTGATCAAGCT
DBD MethylMinus GTCA
GACT
TCG
GCTA
ATGC
CTGTTACGCAGTAGTCTCGACATG
DBD MethylMinus CTGA
GTAC
CAGT
CTGAAGCTGAGATTCGAGCTAGTCACATGACTG
DBD MethylMinus CTAG
GTAC
CATGCATG
AGTCCTA
GACTCACAGTAGCTCTGACATG
FL MethylMinus CTGA
GTAC
CATG
CAGTAGCT
GACTCCAGTAGCTCTGACATG
FL MethylMinus TCGA
GTAC
CATG
CGATAGTCTAGACTCAGGCATGTCACATGACGT
FL MethylMinus GTAC
GACTTCGAGTCAAGTCTGGCTACCAGTAGCTTCGACTAG
FL MethylMinus TCAGGTCAGCACTAAGCTACAGTAGCTTCGACAGT
FL MethylMinus TCAGGACAGTCGTAAGCTGAGACTCGCTAGTCCTAGTC
FL Multiple effects TCAGGTCAGCTACGACCTAGACTTGCAAGTCCTGAAGCT
DBD Multiple effectsGACTTCAGGACAGTCGACCTAGACTCAGGACTTGCAAGTCCTAGAGCT
DBD MethylMinus TCAGGATC
CAGT
CGATAGCCTGGACTTCGGTCAGTCACTAGAGTC
DBD MethylMinus TCAGGATC
CAGT
CTAGAG
CTAG
GACTTCAG
CAGT
AGCT
CTGA
CAGT
DBD MethylMinus TCGA
GTCA
AGCTTCGAGAGTCCGTAGACTAGGCATGTCATAGTCGTAC
DBD MethylMinus GCTA
AGCTTCGTACACCTGATCACATGAGCTCGACAGT
DBD MethylMinus GCAT
GACT
TCGA
GTCA
AGC
CTAGTATAGCCAGTAGCTCGACGAT
DBD MethylMinus TCAGGATC
CATG
CGATACCTAGCATTCGCAGTAGTCTGACAGT
FL MethylMinus CTGA
GTAC
CAGT
CTAG
AGTCCATGGACTTCGACATGAGCCTGACGAT
FL MethylMinus GCTA
AGCT
TCA
GTAC
AGT
CTGGC
TACG
CGAT
AGTC
TCGA
CGTA
DBD MethylMinus GCTA
AGTCTGGCTAACGTCAGTTGACCAGAGTTACCGAT
DBD MethylMinus GCATAGTTCGTCACTGGCTATGACCATGAGTCACGA
FL MethylMinus GTCAAGCTTCAGTACTGCGTTAGCCAAGTCGCAGT
FL MethylMinus GTCAAGCTCGGTAGCTATGACCAAGTCGACAGT
DBD MethylMinus GCTAAGCT
TCGTACCGATAGCAAGTCGACGAT
DBD MethylMinus GCAT
AGCT
TC
GTCAACTGTCGGCATACCATGAGTCGACGTA
FL MethylMinusGCAT
AGCT
TCAGTAC
ATGC
CTGA
GCAT
TCAG
CAGT
AGTC
TCGA
GCTA
DBD MethylMinus GACT
AGCT
TC
GTCAATTCGAGCTAGCCAGAGTCGACGTA
FL MethylMinus GATCAGCTTCGTATCGGTCAAGTCGACTAG
DBD MethylMinusGTACAGCT
TC
GTAC
ATGC
TCGA
GCATTACG
CATG
AGCTCGA
CATG
DBD
MethylMinus
ATGC
ATGC
ATGC
GCTACATGAGCTCGTACGTCAGTCGCGTAAGCTTACGTACGTACG
DBD No CpGCGATAGCT
TC
GTCACTGCTATGACCAGAGTCGAGCTA
DBD CGAT
GACTTCGA
GTCAAGTCCAG
GACT
TCGA
CAGT
AGTC
CTGA
GCAT
FLCGTA
GACTTCGA
GTCA
ATGC
CTGGAC
TAC
CAGT
AGCT
CTGA
GCAT
DBD GACT
TGCA
GCAT
ATCCTGATCCTGGACTAGCCGTAACTGTCGA
DBD CGTA
GACTTCGA
GTCA
ATGC
CTG
GA
TACG
CAGT
AGCT
CTGA
GCAT
DBDGCTAGACTTCGTCAAGCCGTCAAGTC
DBD GTAC
GACT
TCG
GCTA
AGTCCTGGACTCGA
CGAT
AGTC
CTGA
CGAT
DBD CTGA
GTAC
CATG
CAGTAGCTCAGGACTCAGGTCAGTACCATGACTG
DBD TCGA
GTAC
CATG
CATG
AGC
CTGA
GAC
TCGA
CGAT
AGCT
CTGA
CGTA
FL TCGA
GTAC
CATG
CATGAGCTGACTCAGCAGTAGCTCTGACGAT
FL TCGAGATC
CATG
CGTAAGTCTAGATCGCATTGCACATGCAGT
FL GCTA
GACTTCAG
GTCAAGT
CTGATCACAGTAGCTCTGACGAT
FL TCAGGACCAGCAACCGTACAGTAGCTCTGACGAT
FL TCGAGATC
CAGT
CATGAGCGCTCGGTACGTCACTAGAGCT
FL TCAG
GTACAGCGATCGGATCAGACTTGCAGACTCGTAGACT
DBDGACTTCGAGACTCAGTCATGACGCTAGACTCAGGACTTGCAAGCTCTAGAGCT
DBD TCAGGATC
CATG
CATGAGCCTAGCATTCGAGTACGTACCTAGAGCT
DBD TCAGGATC
CAGTCAACGCTGATCACAGTAGCTCTGACAGT
DBD TCGA
GTCA
AGCTTGTACAGCGTCGATGTACATAGTCGCTA
DBD GTCA
AGCTTGTCACGTCAGATCGACAGT
DBD GTCA
AGCTTGCGTCACGCGTCGCAGACGTCGACAGT
DBD TCAGGTACCATCTAACCGCTGCCAGAGCCTGACAGT
DBD TCAG
GTAC
CATG
CGAT
AGCCGCATGCGACTGTACCTAATCG
FLGCTA
GTAC
CAGT
CTAG
AGTCCAGACTCACATGAGTCCTGACGAT
FL GCTA
AGCT
TCA
GTCA
ATGC
CTGGA
TACG
CAGTAGCT
CTGA
CGAT
DBD GCAT
AGTC
TGCA
GCTAATCG
CTGA
GACTGA
AGCT
TCAG
CGAT
DBD GCTA
GACTTAGCGTCAATGCCTAGACTTCACAGTAGCTTCAGCGTA
FL GATCAGCTTGCA
GTAAGC
CTG
GACTTCAG
CAGT
AGC
TCGA
CTAG
FL GCTAAGCTTCG
GCT
ATCCTGA
GTACCATG
AG
TCAG
CAGT
DBD GATCAGCTTGACGTACGCTGCTCGACAGTACGTTCGCGAT
DBDGCTA
GACTTCAG
GTCAAGTC
CTGAGC
TACG
CAGT
AGTC
CTGA
CGAT
FLCGAT
GACTTCAG
GCAT
ATGC
CTGGCAT
TCAG
ACGT
AGTC
CTGA
GCAT
DBDGCTA
GACTTCGA
GTCA
ATGC
CTGAGCTA
TCAG
CAGT
AGCT
TCGA
GCTA
FLGACTAGCTTGTCAACTGTCCAGTATCGACGTA
DBDGTCAAGCTTGTAACTGATCATATCGACGTA
DBD ATGC
ATGC
ATGC
GCTACATG
AGCTGACCGTGCATCGCGTAAGCTTACGTACGTCAG
DBD ATGC
ATGC
ATGC
GTCA
CGAATTAGAAGCGTCGACTCGCTAACGTTACGTACGTAGC
DBD GCAT
AGCTGACCGTATGCATCGCGTA
MethylMinus
No CpG
bZIP TFs
6
Methyl Control GRHL1
TFCP2
TFCP2
UBP1
TFCP2L1
0.05
DBD MethylPlus AGTC
AGTC
ATGCCATGGTACGTACTCAGTCAG
FL MethylPlus ATATC
CG
CTAG
GACGAT
TAC
TAGC
TCAG
AGTCATGC
ATGCCCTGAGATGCATACTACG
DBD MethylPlus ATGC
ATGCCGT
CTAG
GATC
GC
TACG
TCAG
TCAG
AGTC
AGTC
ATGCCGCTAGGATCGCATACGTACG
DBD MethylPlus ATGC
ATGC
CG
CTAG
GATC
GCA
TACG
TCAG
TCAG
AGTC
AGTC
ATGC
CGT
CTAG
GATC
GC
TACG
TACG
DBD MethylPlus ATGCCGCTAGGATCGCTACTACGCTAGGATCAGTCATGCCGCTAGGATCGCTAC
DBD AGTCAGTC
ATGCCCTAGGTACGTACTCAGTCAG
FL ATGC
ATCGACTGCAGTACTACTGCAATGCACGATCCTGGATGCATGCTGAC
DBD ATGC
ATGC
CG
CTAG
GATC
GCA
TACG
TACG
CTAG
AGTC
AGTC
ATGC
CGT
CTAG
GATC
GCA
TACG
TACG
DBD AGTC
AGTC
CGCTA
GAT
GC
TCA
TCGA
CTAG
GACT
AGTC
AGTCGCTAG
GAT
GC
TCA
TCAG
DBD AGTC
CG
CTAG
GATC
GC
TAC
TCAG
CTAG
GACT
AGTC
AGTCG
CTAG
GATC
GC
TCAG
CP2 TFs
Methyl Control DMRT3
DMRTA1
DMRTA2
DMRT1
DMRTC2
DMRTC2
DMRTC2
DMRTC2
0.0 2
DBD No CpG AGTC
ATGC
ATGC
TACG
TCGAGTATCTACGATGCGATGCTACGTCAG
FL No CpG ATGC
ATGC
TACG
TCGAGTACTACAGTCATGTAGCTCAG
DBD No CpG ACTG
ATGC
TAGC
TCGAGTTACGTACGAGTCCAATGCTAGCTGAC
FL No CpG ATCG
ATCG
TAGC
TCGAGACATTACGACGTCGAGTTCAGTCGA
FL MethylMinus GATCATGCACTGAATAACAGC
FL No CpG ATCG
ATGC
TACG
TCGAGAACTGTCAGAGCTCGAATGTCAGTGCA
DBD
MethylMinus
ATGC
ATGC
TACG
TCGAGCAACTTACGATGCATGTACGTCAG
DBD AGTC
ATGC
ATGC
TACG
TCGAGATCTACAGCTATCGTACGTCAG
FL ATGC
ATGC
TACG
TCGAGTACTACAGCATGTAGCTCAG
DBD ATCG
ATGC
TACG
TCGAGTTACGTACGAGTCCATGCTAGCTGCA
FL ATGC
ATGC
TACG
TCGAGACTTACGAGCATGTACGTCAG
FL GACTATCGATCTAGCATATGTACATGCAAGCT
FL ATGC
ATGC
TACG
TGCAGTACTTCAGAGTCATGCTACGTGAC
DBD GACTATGC
ATCG
CTAGGATCTAACAACGT
DBD ATCG
ATGC
TACG
TGCAGCACTTACGACTCGATGTACGTGACNo CpG
DM TFs
Methyl Control E2F2
E2F2
E2F3
E2F1
E2F7
E2F8
E2F4
0. 1
DBD MethylMinus GCATCG
GCATCGT
GACTCTGCATCGTCAGTCGCGTA
DBD Little effect AGTC
TAGC
TACG
TAGC
TGACGATCGCCAGTCGCATGATCGATGCTACGTAGCTCAG
DBD Little effect AGTC
TAGC
TACGTACGTAGCGCATGCAGTCCGTAATCGATGCATCGATGCTCAG
DBD MethylMinus TAGCTACGTGCATCCGCAGCTGGCACCGTAACGATCGATCATGC
DBD Little effectTAGC
TACGTCAG
TACG
CAGT
CGATCGTACCGTACTAGATGCATCGATCGATCG
DBD GTAC
CTGAGACCTGAGCATCTGATCCGTAGCATTCGAATCG
DBD GACT
TAGC
TAGC
TAGC
TAGC
GCATGCCAGACGCGATACTGTACGTAGCTACGCTGA
DBD AGTC
TAGC
TAGCTACGTGACGCAGCGCCGTACTGATGCATGCATCGTCAG
FLAGTC
TAGC
TAGC
TAGC
TGAC
GCAGCCGCGCGTACTGATCGTACGTACGTCAG
DBDATCGTAGTTCCCGCCCAAATAT
DBDTACG
TACGTCAG
TACG
CGAT
CGCGATCGTCGTAATCGACTGACTGATCG
DBD TAGC
TAGC
TGAC
TGAC
GCAGCCGCGCGTACTGTACGTACGTACG
MethylMinus
MethylMinus
E2F TFs
7
Methyl Control ELF3
ELF3
ELF3
ELF3
ELF3
ELF3
ELF5
ELF5
ETV7
ETV7
SPIB
SPIB
FLI1
FLI1
FLI1
FLI1
ERG
ERG
ERG
ERG
FEV
ETV3
ETV3
ETV2
ETS2
GABPA
DBD MethylMinus AT
CAGT
CAGACGGAAGATCGAAGTCAGCTATCGATCGAGTCACGTACTGATGCATGCATGCATCGATCGATCG
FL MethylMinus AT
CGTA
CAGACGCGTAGATGATCGAGTCGACTAGCTTAGCTGACCTAGACGTACTGAGTCATCATATCATCG
DBD MethylMinus AGTCATG
CGTA
GACT
AGCGGAATCGACTCAGAGTC
FL MethylMinus AGTC
ATGC
GCTA
GACT
AGCGGAATCGACTCGAGATC
FL MethylMinusCGTA
ACGTGTGATCATCGACTTCAGAGTCCTGATAGTAGCATCTTGCAGCTA
FL MethylMinus AGTC
CTGA
TAGC
TAGC
CATG
CATG
GCATGTACGTACATCGATCGGACTTCAG
DBD MethylMinus AGTC
ATGC
TAGC
GACT
AGCTGGAAGCATCGATC
FL MethylMinus GATC
ATGC
ATGC
ATGC
GACT
GACTGAGAATGCATCAGGATC
DBD MethylMinus AGCT
AGTC
CAGT
CAGGATACATGTCCGTGTCATCAGTCGA
DBD MethylMinus GATCAGTC
CAGT
CAGGGAAATCGAGCTCGACGAT
FL MethylMinus GACT
AGTC
CGA
CAGGGACGATCGACTTCGACGAT
FL MethylMinusGACTAGTC
CAGCAGGATACATGTCCGTGTCATCAGCGTA
DBD MethylMinus AGCT
AGTC
CGAT
ACGGGAATCAGCTCGAGACT
DBD MethylMinus AGCTAGTCCAGCAGGATACATGTCCGTGTCATCAGTCGA
FL MethylMinusGACT
AGTC
CAGT
CAGGGAATCAGCTTCGAGCAT
FL MethylMinusAGTCAGTC
CGAT
CAGGGATACATGTCCGTGCTATCAGCTAG
DBD MethylMinus GACT
AGTC
CAG
CAGGAATCGACTCGAGACT
DBD MethylMinusATGCAGTC
CATGCAGGGCATACATGTCAGCGTCGTCATCAGTACG
DBD MethylMinus AGTC
CTGA
ACGTGGAATCGACTCAGGATCCGATCTAGAGTCCTGTAGTCCTGCAGCATTCAG
DBD MethylMinus GATC
AGTC
CGAT
ACGGAATCGACTCAGGATC
FL MethylMinus AGTC
AGCT
CGATACGGAATCGATCGAGCCTTAGTCCTGGCTATCGATCAG
DBD MethylMinusAGCTAGTC
CGAT
CAGGGATATCGACTTCGAGATC
DBD ATCG
CGAT
CGACAGGTGAAAGATCGAAGTCACGTCATGGTCACGATCAGTCAGTATCGATCGATCGATCGATCGTACG
DBD GCATATGCTACGAGCTAGCCAGGATACTCGGACTCTGAGACT
DBD CGATATGTAGCTGACGACGCAGATTACGCCTGAGACT
DBDTCGA
ATG
TAGC
AGCTCAGGTAATATCGGACTGAGCAT
FL ATGC
CGAT
CGACAGGGAATCGATCAAGTCAGCTATCGCTAGGCATGCATAGCTATGCATGCATGCATGCATCGATCG
FL GCATTGCAGATCTCGACCGGCGCAGTGATCTGAGACT
DBDAGTC
ATGC
CGTA
GACT
CAGGGTACTATCGGACTGCAGATC
FL GACTATGC
CAGT
CGATCAGTGGTCATCATCGGACTTCGAGATC
FL CGAT
CAGTGAGATCATCGGACTTCAGAGTCCTGATAGCTAGCCGTCAGCTA
FL AGTC
CTGA
TAGCTAGCATGCTGA
GCTAGTCAGTCAATCGATCGGACTTCAG
DBD AGTC
ATGC
TAGC
GCAT
CGAT
GACGTCAACACGCATCAGGATC
FL AGTC
ATGC
ATGC
ATGC
GACT
CAGT
GAGTAATGCATTCAGAGTC
DBDAGCTAGTC
CGAT
CAGGATACATGTCCGTGCTATCAGTCGA
DBDAGCTAGTC
CGATCAGGAATCGACTTCGACGAT
FLGACTAGTC
CGACAGGAATGACTCGAGCAT
FLGACTAGTCCGACAGGATAATTCCGTGTCTCAGCTGA
DBDAGCT
AGTC
CGAT
CAGGGAATCAGCTTCGAGCAT
DBDAGCTAGTC
CAGT
CAGGCGATACATGTCACGGTCGTCATCAGTCGA
FLGCATAGTC
CGAT
CAGGAATCGACTTCGAGCAT
FLGACTAGTC
CGATCAGGGATACATGTCCGTCGCTATCAGCTGA
DBDGACTAGTC
CGACAGGTACATCGACTCGAGACT
DBDACGTAGTC
CTAGCAGCGATACATGTCCGTGTACTCAGTACG
DBD AGTC
CGTACAGGGATATCGGATAGCGTACGCTACTAGAGCCTTAGTACATCGTCGCTATAC
DBDGACTAGTC
CGAT
CAGGGTAATCGACTTCAGGATC
FLGATCAGTC
CGACAGGAATCGATCGAGCCTTAGTCCGTGCTTCAGCTAG
DBDGACTAGTC
CGATCAGGTAATCGACTCGAGACT
MethylMinus
MethylMinus
MethylMinus
MethylMinus
ETS TFs
8
Methyl Control ETV1
ETV1
ETV5
ETV5
ETV4
ETV4
ETV4
ETV4
ELK1
ELK1
ELK3
ELK3
ELK3
ELK3
ELK4
ELK4
ELF1
ELF1
ELF1
ELF1
ELF4
ELF4
ELF2
ELF2
ELF2
ELF2
SPDEF
SPDEF
0.0 5
FL MethylMinusGATCAGTC
CAGT
CAGGCT
GTACATCGGACTCAGAGTC
DBD MethylMinus GACT
AGTC
CGAT
CAGGGATCATCGGACTTCGAGATC
DBD MethylMinus GACT
AGTC
CGAT
CAGGGAATCGGACTCGAGATC
DBD No CpG AGTC
CGAT
ACGTGATC
GATC
ACGT
ACTGGAGTCAAGCTATGCGACTTCGAGATC
FL MethylMinusGACTAGTC
CGAT
CAGGGTAATCGGACTTCGAAGTC
FL No CpG AGCT
CGAT
ACTG
GTA
GAC
ACG
ACTGGTCAACGATGCGACTTCGAGACT
DBD MethylMinusGACTAGTC
CGAT
CAGGGTACTATCGGACTTCGAAGTC
DBD No CpG AGTC
CGAT
ACGTGCAT
GAT
ACGT
ACTGGACT
GTCA
AGCT
ATGC
GACT
TCGA
GATC
FL MethylMinusGACT
AGTC
CGAT
CAGTGGATATCGGACTTCGAGATC
DBD MethylMinusAGCTAGTC
CGAT
CAGGGTATCATCGACTTCGAGACT
DBD MethylMinusGACT
AGTC
CGAT
CAGGGTACTATCGGACTTCGAGACT
FL MethylMinusAGCT
AGTC
CAGT
CAGGTACTATCGACTTCGAGATC
FL MethylMinusGACT
AGTC
CGATCAGTGGATCATCGGACTTCGAGATC
FL MethylMinus ATGC
ATCG
CATGCGAT
CAGGTGACAATGCGACTCAGGACT
FL MethylMinus AGTC
ATGC
TGCA
GCAT
CAGTGACGTAACATGACTCGAGATC
DBD MethylMinus AGCT
ATGC
CAGT
CGAT
ACGAGATATCGATCTCAGGACT
DBD MethylMinus GATC
ATGC
TGCA
GCAT
CAGTGAGACTATCGACTCGAGATC
DBD MethylMinus ATGCATCG
CATGCGAT
ACGGAATGACTCAGAGCT
DBD MethylMinus AGTCATGC
TCGA
GCATCAGGCTGATATCGACTCAGGATC
DBD MethylMinus ATGC
ATCG
ACTG
CGAT
ACGGAATCGACTCAGAGCT
DBD MethylMinus AGTC
ATGC
TCGA
GCACAGGGATCATCGACTCAGGATC
FL MethylMinus ATGC
ATCG
CAGTCAGTACGGATAGACTCAGAGCT
FL MethylMinus AGTC
ATC
TCG
CGAT
CATGTCGCAGAGTGATGACAGCT
DBD MethylMinusGACTATGC
ACGT
CTAG
ACGGCGATCAGACTTCAGGTAC
FL MethylMinusGATCATGC
ACGT
CTGA
CAGTGTAATCAGACTTCGAAGTC
FLGACT
AGTC
CAGT
CAGGTC
GTCACGTATCGACTTCGAAGTC
DBDGCAT
AGTC
CGATCAGGGTCATCATCGGACTTCGAGACT
DBDGCTA
AGTC
CGAT
CAGGTACTATCGACTTCGAGATC
FLGCATAGTC
CGACAGGTAATCGACTCGAGATC
FL
DBDGACTAGTC
CGATCAGGTAATCGACTCGAGATC
FLATCG
AGTC
CGATCTGTGTACAATCGCATCGAAGCT
DBDGATCAGTCACGCTGTAATCGTCGGATC
DBDAGCT
AGTC
CGATCGGGTACATCGACTTCGAGATC
DBD CGTA
TCAGCTGTGACAGTCACGATCGGACTCATGACTG
FL AGTCCGATCAGGTACATCGACTTCGAGATC
FL CGAT
TCGA
CAGTGATATAGTCTCGGACTCATGAGTC
FLCGTA
AGTC
CGTACAGGGTAATATCGGACTTCGAGACT
FL GCAT
TACGCTGTGAACATCAGTCGGCATCATGATGC
FL ATGCATCG
CATG
CGAT
CATGGACTACTATCGGACTTCAGAGTC
FL ATGC
ATGC
TCGA
GCATCAGGGAAATCGACTTCAGAGTC
DBD ATGCATCG
CATG
CGACAGTGGACATCGACTTCAGGACT
DBD AGTC
ATGC
TCGA
GCATCATGCGATATCGGACTTCAGGATC
DBDATGCATCG
CATG
CGACAGGTGAACATGATCGAGACT
DBDGATCAGTC
TCGA
GCACAGCGAACATCGATCGAGATC
DBDATCGATCG
CATG
CGACAGGGAAATGATCAGGATC
DBDGATC
AGTC
TCGA
GCACAGGAATCGGATCGAGATC
FL ATGCATCG
CATG
CGACAGGAATGACTCAGAGCT
FL AGTC
ATGC
TCGA
GCACAGGAAGACTCAGGATC
DBDGACTATGC
ACGT
CGA
CAGGGATACGGACTTCAGAGTC
FLGATCATGC
CAGT
CGAT
CAGGTATACGACTTCAGGATC
MethylMinus
MethylMinus
MethylMinus
ETS TFs
9
Methyl Control FOXR2
FOXQ1
FOXI1
FOXI1
FOXL2
FOXA1
FOXA1
FOXA1
FOXA3
FOXA3
FOXA2
FOXB1
FOXC2
FOXC2
FOXD2
FOXD2
FOXD3
FOXE1
FOXG1
FOXK1
FOXJ3
FOXJ2
FOXP1
FOXP3
FOXO4
FOXO3
FOXN2
0.0 5
FL No CpG AGTC
CTAG
AGC
TCAAATGCAGCTAGCTAGATCGATACGAGCTTACGATGC
DBD No CpG TCAG
TACG
AGTC
TCAG
GACTCA
ACG
ACTG
AGCTCTGATGCATGC
DBD No CpGATGC
TAGC
ATGC
AGCT
TCAG
GAC
TACG
ACTACTAGTCTAGTATCG
FL No CpG ATCG
ACGT
CTAG
GACT
TAGACGT
ATGACTCATGAGCTATCGTACG
FL MethylPlus ACTG
AGCT
CTG
GAC
TACG
CAGT
ACTG
AGCTCTGA
AGTC
CTAG
FL No CpG CTGA
GCAT
TCAG
TAGCAGTC
ATGGATC
TCACGATGATGCTAGTATCGATCGCGAT
FL No CpG TCAG
TAGC
AGCT
TAGCGATC
TCGAACTAGCACTCGAGTTATGATGAGACCTAGTACGTCAGATCGAGTC
DBD No CpGTCGA
TAGC
AGTC
TAGCGACT
TCAG
ACTG
ACTAG
CTA
AGC
TACG
FL No CpG CGTA
CGAT
TCGA
TACG
AGCT
ATGCGAC
TCAACGACTAGCTAGATCGATCGCGTA
FL No CpG TCAG
TACG
AGTC
TAGCGATCTCACTAATCATATTGAGATCTAGTAGCTCAGATGCAGTC
DBD No CpGCTAG
TACG
AGTC
TAGCGATC
TCA
CATACACTCAGTGATGTGACAGTCTAGATGCTCAGATGCGATC
DBD No CpGTCAG
TACG
AGTC
TACGGACT
TCAGACGTACGATCTCAGTAGCTAGCGTACAGTCCTGAATGCTCAGATGCAGTC
DBD No CpGCTAG
TACG
AGCT
CTAGGACT
TCAG
ACTACTGAGTCCTAGTCATCG
DBD No CpG GACT
TCAG
ACGT
ACTG
AGCT
CTACTGACTGAGTCCTGAGTCTACG
DBD No CpG CTAG
ATCGAGCGACGACGTCATCATCGCTGAAGCTACTAGAGCT
DBD No CpG GACT
TCGA
TACG
AGTC
CTGAGACT
TCA
ACTG
ACTG
AGTC
CTGA
AGTC
TAGC
DBD No CpG CAGT
CTAG
TACG
AGCT
CTAG
GACTCGACTGACTAGCTCTGATGC
DBD No CpG CGTA
CAGT
CTAG
TAAGATCGAGCTTCAACACTACCTAGTATCGTCAG
DBD MethylPlus ATCG
AGCT
CTG
GAC
TCA
ACTG
ACTG
AGCT
CTAGCT
CTAG
DBD MethylPlus AGTC
CTAGGAC
TCA
ACTGACTGACTAGATCG
DBD No CpG TAGC
TAGCTCAG
GATTATGGATTACGACACAGCCTGAAGTCATGC
DBD No CpG TACGCAG
GACATGACTGCAAGTCCTGCTGAAGTCTCAGCGTAGACTCATGAGTCCTAGCGATCTGACGATATGCTCAGGACTCGATATCGCATATCGAGCCTAAGTCATCG
FL MethylMinusCGTAATGTATATGTCACGTGAGCACTAGATGATTACGGCAT
DBD No CpG AGTC
CTAGGAC
TCAG
ACTG
ACTG
ACTG
CTAGTC
CTAG
DBD No CpG TCAG
TACGCAGT
CGAT
CTA
CTGA
ATCGCA
ACTG
CAGT
GCA
DBD MethylMinus ATGCGCA
CTGA
AGTCTGA
CATG
GACT
TCGA
TAGC
AGCT
CTAG
GTCA
ATTCGA
GACGAT
ATCG
FL AGTC
TCAG
AGCT
TCAAATGCAGTCTACGTTAATATCGACGTTAGCAGCTATCGATCG
DBD TCGA
TACG
AGTC
TCAG
AGCTAC
ACTG
ACTG
AGTCCGA
ATGC
ATGC
DBDGATC
TAGC
ATGC
AGCT
TCGAGACTACG
ACTACTGAGTCTATGCATCG
FL ATC
ATGC
TCGA
GATTACGATCACAGTCACGTTACG
FL ACTG
AGCT
CTGA
GAC
TCAG
ACTG
ACTG
ACGTCTAGCATCG
FL CGTA
CGAT
TCAG
TACAGT
ATGCGACTCACACACTAATGCATCGCGAT
FL TCAG
TACG
AGTC
TAGCGATCTCGAACTATCATGTCAGTAGCTACGTGACGACTCTAGTACGTCAGATGCGATC
DBDTCGA
TAGC
GATGAGTTGCACGACGATGCTGAACTGATCG
FL CGTA
CGAT
TCAGTAAGATGGATCACACACTAATGCATGCCGAT
FL TCAG
TAC
AGTC
TAGCGATCTCACTATATTCAGTATATGAGACCTAGTACGTCAGATGAGTC
DBDCTGA
TACG
AGCT
TAGCGATC
TCAG
CATG
ACT
ATGC
TCAGCTAGCTGACTGACAGTCCTAGATCGTCGAATGCGATC
DBD TCAG
TACG
AGTC
TAGC
GATC
TCAACACTATTCAGTAGTAGCGTAAGTCCTAGATCGTCAGATGCAGTC
DBDTCGA
ATCG
AGCT
CATG
GACTCA
ACACTGAGCTAGACTG
DBD GACT
TCAG
ACG
ACGT
AGC
CTACTGACTGAGTCCTAGAGTCCATG
DBD ATCG
ATC
AGT
CGAT
AGC
ACTTCAGACATGCTAGTTACGTACGATGC
DBD GCAT
TCAG
TACAGCTATCGGACTCAACACGATGCTATGCATCG
DBDCGAT
CTAG
TACG
AGCT
CTAG
GACTCACGTACTGAGTCCTGATGC
DBD CGTA
CAGTCGA
TAAGCATGCAGTCACACACAGATGCTCAG
DBDCAGTACGT
CTAG
GACTACGT
ACT
ACTGCTAATCGCTAG
ATGC
ATGC
TACGGAC
TCAG
ACGT
ACTG
AGTC
CTAGTCATCGDBD
GACT
TAGC
CTAG
GACTCGAATACTATGCCTAGAGTC
DBD AGTC
CTGA
GACTTAC
ACACTAGTCTAGTATCG
DBD TAGC
TAGCTGACGATTATGGATTACGACACTAGCCTGAATCGATGC
DBDTAGCTACGGATCAGTGACTGAGTCCTGACTGAAGTCTCAGGCATCAGTCGATTAGCTCAGAGCTCTGAGCATAGTCTCAGGACTGCATATCGCATATCGAGTCTATGCACTG
FL CGTAATGTATATGTATTCGTAACTAGATATTAGCAT
DBD AGCT
CGTAGAC
TCGA
ACTG
ACT
AGTCCTAGC
CTAG
DBD TACG
TACGCAGT
CATG
CATCTATGCTAGCCTAGGACT
DBDATGC
CTAGGATCCATGGATCTCGACGTAGACTTCAGATCGAGTCCTGAGCATAGTCCTAGGATCCTGAGTACTACG
No CpG
Forkhead TFs
T T
10
Methyl Control GATA3
GATA3
GATA2
GATA1
GATA5
GATA5
GATA5
GATA5
GATA6
GATA4
0.02
FL MethylPlus ATCGATATCAGTCGATGACACGTTCAGCTAGTAG
FL No CpG ATCGTACATCTCAATGCAGCAGCTAGCCAGTTAGC
DBD No CpGGCTA
ATCGGATATCGAGTCCGTAGACT
DBD No CpG GCAT
ATCGTCAG
ACTG
ACTG
GTCA
GATC
ATGC
CTAG
CAGTTGAC
TAGCAGTC
TAGC
CGTA
FL No CpGCGTA
ATCGGATATCAGTGCTAAGCTATCG
FL MethylPlus ATCGGCAT
ATGCTGACATCGAGTCCGATGACTATCGTACGCAGTTAGC
DBD No CpGCGTA
ATCGGATATCAGTGCTAAGCTATGC
DBD MethylPlus ATCGGCATATCGTCGAATCGAGTCCGATGACTACTGTAGCCTAGTAGC
DBD Little effect ATCGGCTAGCTGATCGAGTCCGTAGACTACTGTACGCAGTTAGC
DBD No CpGCGAT
ATCGGATATCATGCGCTAAGCTATCG
FL ACTGTACATGTGAATCAGCGATGACATGCTACGCTAGTAGC
FL ACTGCATAGTCTCGATCGACGCACGTTGACCAGTTAGC
DBD GACT
CTAGGATACTGACTGCGTAGACT
DBD GACTAGCT
TCGAACGTACGTGCAGATCAGTCCTAGACGTTGACTGCAAGCTTACGCTGA
FL CGTA
ATCGGATATATGGCTAGACTACGT
FL ATCGGCATATTCATGCAGTCCGATGACTACTGTACGCAGTTAGC
DBDCGTA
ATCGGATATCGAGTCGCTAGACTGACT
DBD ACTGGAT
ACTTCG
ATCG
AGTC
CGAT
GACT
ACTG
TGCA
CAGT
TAGC
DBDCTAGGTACAGTTCAATCAGTCCGTGACTAGTCTCGACAGTTAGC
DBDGCAT
ATCGGAGTAATCGTGACTCTAG
Methyl Control TCF7L1
TCF7L1
LEF1
LEF1
LEF1
LEF1
TCF7
TCF7
BBX
SOX8
SOX8
SOX9
SOX10
SOX10
SOX18
SOX7
SOX4
SOX12
SOX14
SOX14
SOX3
SOX30
0.05
DBD No CpG AGTC
GCA
ATGTACGTACATGAGTCGCTA
DBD MethylMinus AGTC
CTAG
ACGT
TAGCTGCGATGGACTCGAGATCAGTTGACGATCATCG
DBD No CpG AGTC
CGTA
ATTACGAATATCGATGGCAT
DBD MethylMinus ATGCTGAACGTTACGCAGATCGCGACTCGTAGCTTGACGTACATGC
FL No CpG AGTC
GCTA
ATTACGAATAGATGGCAT
FL MethylMinus ATGC
CTAG
ACGT
TACGCAGATCGGACTCGAGCAGTTAGCGATCATGC
DBD No CpG AGTC
CGTA
ATTACGATATACTGATGCGCAT
DBD MethylMinus ATGC
CTAG
AGCT
TACCG
GCA
GATCGTAGCTCGGCAGTTAGCGATCATCG
DBD No CpG TGACGAACTG
ATGCCTAGGATCTAGCTCAGGTACTACGTGCCTACTG
FL No CpG AT
CTAAGCTAGCGATCGACTAGCTTCGACTGACTAGATCGTGCTGACTA
DBD No CpG ATCG
GTACAGCTATCGCTGATGATGTAGGATCGCAT
DBD No CpG ATCG
GTCA
ACGTACCAGAGTCAGTCGCTA
DBD No CpG AGCTACAATAGATCGCATGCATCGTACTAGATTTGTATCGA
FL No CpG AGTCATCTGAAGCTAGCGACTGACTACGTTGCACTGACTGAATCGTCGTGACTATCAG
DBD No CpGACGTATCTGAATAGATCCGAT
DBD No CpG ATGCCTATCACGTTAGATCTACGCTAGATTGCATAGGATACG
DBD No CpGGATC
AGCTACTGAAATCGGATCGACTAGCT
DBD MethylMinus ATCG
CAGT
CAGT
GTACATGCAGCTGAACTGACGTTCAGACT
DBD No CpGCTAG
TGCA
ACTGATGCCTGAG
ATCG
TAC
GATC
GATC
FL MethylMinus CAGT
CGAT
GACT
ATCG
ACTGCTATCATGTAC
FL No CpGACTG
GTAC
ACGTATCCACGATCGTACGATCGCAT
DBD No CpG GCTA
AGCTATCTGAGATAGCAT
DBD AGTC
GCAT
ATTCGCGAAGTATGATCGGCAT
DBD ATGC
CTAG
ACGT
TAGCCT
GC
GATGGACTCGATGATCGATTGACGATCATGC
DBD AGCT
CGT
ATGCTACGAATGACTATGCGCAT
DBD ATGC
CTAG
ACGT
TAGCCTGCGATCGAGACTCGATGATCAGTTGACGATCATGC
FL AGTC
GCT
ATTCGAATGCATGCGCAT
FL ATGC
CTAG
ACGT
TACTGCGATGGACTCGAGACAGTTGACGATCATGC
DBD AGTC
CGT
ATGTCGTAACTGATGCGCTA
DBD ATGC
CTAG
ACGT
TAGCCTGA
GCA
GATGAGCTCGTGATCAGTTAGCGATCATCG
DBD TAGGAACTATGCGTAGATCCGTACTAGGCATTACTGACCTAATC
FL AT
CTGAAGCTAGCGACTGCATGCATCGTACGTACTGAATCGTCGTGACTA
DBD ACGT
GATCAGTCATCTGATACTTACGGATCGCAT
DBD ACTG
GATCAGCTATCTAACTGTACGGATCGACT
DBD ACTGATCAATAGATGCATGCATCGATCTAATTTGTATGAC
FL AGTCATCTGAAGCTAGCGACTGACTACGTTGCACTGACTGAATCGTCGTGACTATCGA
DBD CGAT
AGTCCAGCTACGTTCGACGA
DBD ATGCCTATCACGTTAGATCATGCCTAGATTGCATAGGATAGC
DBD GATC
AGCTACGTAAATCGGATCGACTGACT
DBD ACTG
CATG
CTAG
GTACACGAGCCTAACGTTCAGGCAT
DBD CGAT
GTCA
CAGTATCGCTGAACTATCGTGGATCGTCA
FL CAGTCTAG
GTAC
ATGC
ATC
CTGAAACTTGCGTAC
FL CGAT
TGCA
CGTAATCG
CAACATCGTGCGAGTCA
DBD GCTAAGCTATGCTGAGCACGTTAGGCTA
GATA TFs
HMG TFs
11
Methyl Control SIX2
SIX2
SIX1
SIX1
SIX6
SIX3
SIX4
TGIF1
TGIF2
TGIF2
TGIF2LY
TGIF2LX
TGIF2LX
MEIS3
MEIS2
MEIS2
PKNOX1
PKNOX1
PKNOX2
IRX5
IRX1
IRX3
PBX1
PBX1
PROX1
DPRX
LHX1
LHX5
LHX5
LHX4
LHX4
LHX4
LHX4
LMX1A
LMX1A
LMX1B
LMX1B
LMX1B
LMX1B
ISL1
ISL1
ISL2
LHX6
LHX6
LHX6
LHX8
LHX8
LHX8
LHX9
LHX9
LHX9
LHX9
FL Little effectACGT
CGTA
GACT
TCGA
AGCT
TAGC
CTGA
AGTC
TCAG
GATC
DBD Little effectGACT
CGTA
GACT
TGCA
AGCT
TCAG
CTGA
GACT
TCAG
GTCA
FL Little effect GACT
CGTA
GACTGAGTTAGCTAAGCTTCGAGATC
DBD Little effect AGCT
CAGT
GACTTGCACGTGCTAAGCTTCGAGTCA
DBD Little effectGACT
CGTA
GACT
TCGAGC
TCGACGT
AGC
CTGA
GTCA
DBD Little effect GACT
CGTA
GCAT
TGATCCTAGAGCTCTAGGTAC
DBD Little effect CAGT
CTGA
GACT
TGC
AGC
TACG
CGT
AGC
TCAG
TGCA
DBD No CpG TCAG
GCTA
ATGC
CTAG
AGCT
GTCA
CAGT
TCG
GATC
TACG
CTGA
AGTC
FL No CpGGATCTCAGATCAGTGTCACGTA
DBD No CpG TCAG
GACT
ATGCCTGA
AGTC
GTCA
CGAT
TCAG
GTCA
TACGCGTA
AGTC
DBD MethylPlus TCAGGCTA
ATGC
CTGA
AGTC
GCTA
CGAT
TCAG
GATC
TACG
CGTA
AGTC
DBD MethylPlus TCAG
GCAT
ATGC
CTGA
AGT
GCTA
CAGT
TCAG
GACT
TACG
CGTA
AGTC
FL MethylPlus TCAG
GCTA
ATGCCTAG
AGT
GCTACGATTCAGATCTACGCGTAAGTC
DBD MethylPlus TCGA
GCTA
ATGC
CTG
AGTC
GCTA
CGAT
TCAGGATTACGCGATAGTC
FL MethylPlus TCAG
GCTA
ATGC
CTAG
AGTC
GCTA
CGAT
TCAGGATCTACGCGATAGTC
DBD MethylPlus TCAG
GCAT
ATGCCTGAAGT
GCTA
CGAT
TCAGATCTACGCGATAGTC
DBD MethylPlus TCAGGCAT
ATGCCATGAGTCGCTACGATTCAGGATCTACGCGTAAGTC
FL MethylPlus TCAGGACATGCCTAGGCTCGATCGATACGCTAGTC
DBD MethylPlus TCAGGCTA
ATGCCTGAAGGCTACGATTCGATACGCGTAAGTC
DBD MethylPlus ATGC
CTGA
GATC
CTAG
GCTA
TACG
ATCG
CAGT
ATCG
ATGC
CTGA
GATC
CTAG
GATC
TCAG
DBD MethylPlusTGAC
AGTC
CGTA
GATC
CTAG
GACT
CTGA
AGTC
GATC
TACG
ACGT
AGTC
CTGA
GATC
CTGA
GCAT
TCAG
TACG
DBD MethylPlus TAGC
AGTC
CTG
GACT
TCAG
GACT
ATCG
TAGC
TAGC
TACG
ATCG
ATGC
CTGA
GTAC
CTAG
GATC
TCAG
ATCG
DBD MethylPlus GATC
TGCAGCTA
AGTC
TGCA
TGCA
GCT
AGTC
CTG
GATC
FL MethylPlus GTATGACGCA
AGTC
TACG
TGGACATTCGTC
DBD MethylMinus TCGA
AGTC
ATCG
GTCA
AGTC
CTAGGACTACGCGTATAGCTCAGGACT
DBD No CpG AGTC
GACT
ACTTACGTATGCATGCTAGCTGA
DBD MethylPlusCAGT
TGACCTAGATCATCAGATGCCTGA
FL MethylPlusCGATTAGCCAGATCATACGAGCATCG
FL No CpG GCTA
TCAACGTATTCGAGATCG
DBD No CpGCGTA
TCAGCTATTCGAGGACT
FL No CpGTCGATCAG
AGCTATTCGAAGTCAGCT
FL MethylPlusCTAG
TAGC
CATG
GATCAGTCAGAGCTATGC
DBD MethylPlus CTGA
TGACCAT
GATCAGTACGAGCACGT
DBD No CpG CTGA
TCGA
ACGTAGTGTGACAGCTCGAT
DBD MethylPlus CTGA
TAGCAGGATGTACGAATCG
DBD No CpGAGCT
TAGC
TGAC
TCGA
TCAG
ACGTATCGTGCAAGTACTG
DBD MethylPlus CTGA
TGAC
CAGT
GATCTCG
TAATATGC
FL No CpG AGTC
TACG
TAGCTCGTAATTAATCG
FL MethylPlus CATG
TGACAGGTCTCAGATGC
DBD No CpG GCTACTACATTTACATAGCT
FL No CpG GCATCTAAT
CATGTGTACATCAGCT
DBD No CpG GCTACTGATCATTGTACGATCGAGTC
FL MethylPlus CAGTTGACTAGATCGTAGAGATC
FL No CpG CGTA
TCAGCATTCGAGCAGT
FL No CpG TACG
AGTCAGCTTGACTGACGACTGACGACGTCGACTATGC
FL MethylPlus CAGTTAGCGATCTCAATGGATC
FL No CpG TCA
AGTC
AGTC
TGAC
TCAG
GACT
CTG
ACGT
AGCT
TCGA
TCAG
ATGC
FL No CpG CGTA
TCAG
AGCATTCGAGACGT
FL No CpG CTGA
TCAG
ACTGACTTTGCAAGTAGTC
DBD No CpG CGTA
TCAG
ACGATTCTGAGAGCT
DBD MethylPlus CAGTTAGCCGATTACGGATC
FL MethylPlus CAGTTGCACGATCTCA
ATC
AGTC
FL CAGT
CGTA
GCAT
TCG
AGCT
TACG
CTGA
AGCT
CTAG
CTGA
DBD CAGT
CGTA
GACT
TCGA
AGCT
TACG
CTGA
AGCT
TCGA
CGTA
FLGACT
CGTA
GACTGC
AGC
TAC
CTA
AGCT
TCAG
GTAC
DBD CAGT
CTGA
GACTGATGCATGAGTCTCAGTCAG
DBDGCAT
CGTA
GCATTGA
AGTCG
CAGT
AGCT
TCAG
TCGA
DBDCGTA
CGAT
GACT
TGAGTCATGAGTCTCGACTGA
DBD CAGT
CGTAGTCA
TGCA
AGTC
TGCACTG
AGTC
TCGA
TGCA
DBD TACG
GCAT
ATGC
CGTA
AGCT
GCTA
CGAT
TCGA
GACT
TACG
CAGT
ATGC
FLGATCTACGGATCAGTCGTCACGTA
DBD TACGGTCA
ATGC
CTGA
AGCT
GCTA
CGATTCAG
GATC
TACG
CGTA
ATGC
DBD TCAGGCAT
ATGC
CTAG
AGTC
GCTA
CGAT
TCAG
GATC
TACG
CGTA
AGTC
DBD TACG
GCAT
ATGCCTAG
AGTC
GCTA
CGAT
TCAG
GCTA
TACG
CGTA
ATGC
FL TCAGGCAT
ATGCCTAG
AGTC
GCTA
CGAT
TCAG
GACT
TACG
CGTA
AGTC
DBD TCAGGCTA
ATGCCTAG
AGT
GCTA
CGAT
TCAG
GATC
TACG
CGTA
AGTC
FL TCAGGCAT
ATGCCTAGAGTGCTACGATTCAGATCTACGCGTAAGTC
DBD TCAGGCA
ATGCCTAAGCTACGATTCGATCTACGCGTAATGC
DBD TCAGGCTA
ATGCCTAG
AGTC
GCTA
CGAT
TCAG
GTAC
TACG
CGTA
AGTC
FL TCAGGCATGCAGGCTACGATTCGTACCGTAGTC
DBD TCAGGCAT
ATGCCTAG
AGT
GCTA
CGAT
TCAGATCTACGCGTAAGTC
DBDATGC
CTGA
AGTC
TCAG
GACT
TCAG
ATCG
TGCATAGC
AGTCCTGA
AGTC
TCAG
GACT
TCAG
DBD TAGC
AGTC
CTGA
AGTC
TCAG
GACT
TACG
TAGC
ATGC
TACG
TACG
AGTC
CTGA
AGTC
TCAG
GATC
TCAG
ATCG
DBD TAGACTCTATCAGACTATCGATGCTACGATGCTACGTAGCCTGAAGTTGATGAATC
DBD TGACTGGTAAGTCTGCATGACGCAGCTGAAGTC
FL TGACTGGCATACTGTGACTGCAGAGCTTCGAGACT
DBD TGCAAGTC
ACTGGTC
GAT
CTA
GAC
TACG
CAGT
TAGC
TCAG
GCAT
DBD AGCTGCAT
ACTGTACGTATGCATGCTGACGTA
DBDGCTA
CTAG
ACGTATCGTTCGAATGCCGAT
FL GCTA
TCACATTCGAGACGT
DBD GTCA
TCAGCATTCGAGCGAT
FLTCGATCA
AGCATTCGAGTCAGCT
DBD TCGATCGAATCTAGCACGT
DBD AGCT
TACG
TAGC
TCGA
TCAACATTACAGTACTG
FL AGTC
TAGC
TAGCTCGTAATTACACTG
DBD GCTACTACATTGTACATAGCT
FL GCATCTATCATTGATACATCGAGCT
DBD GCATCTACATTGATCAATGCAGCT
FL CGTATC
AGCATTCGAGCGAT
FL TACG
AGCT
AGC
TCGA
TGCA
GACCTGAGCTACGTTCGATCAGAGTC
FL TACG
AGTC
ACGT
TGAC
TGAC
GACT
CTGA
ACGT
ACTGTCG
TCAG
ATGC
FL CGTA
TCAGCATTCGAGGACT
DBD
FL
CGATCACATTAGACT
CTGA
TCACTATTGAGAGCT
Homeobox TFs
12
Methyl Control HOXB6
HOXB6
HOXA6
HOXA6
HOXB7
HOXB7
HOXB7
HOXB7
HOXA7
HOXA7
HOXA5
HOXA5
HOXA5
HOXA5
HOXB5
HOXB5
HOXB5
HOXB5
HOXA4
HOXD4
HOXD4
HOXD4
HOXD4
HOXC4
HOXC4
HOXB4
HOXB4
HOXB8
HOXB8
HOXC8
HOXC8
HOXD8
HOXD8
HOXD3
HOXD3
PDX1
PDX1
HOXA2
HOXA2
HOXA2
HOXA2
HOXB2
HOXB2
HOXB1
HOXB1
HOXD1
HOXD1
HOXA1
HOXA1
DBD MethylPlus GACT
TCAG
CTGA
GATTC
TAC
ATGC
ATGC
DBD No CpG TCGATCAG
ATCGAT
TGCA
TGAC
AGT
CTGA
DBD No CpGGCTAGCAT
TCACTG
ACGTTAGCAGTCATGCCGTA
DBD MethylPlus GACT
TCAGCTAG
GACTCGATACGATGCATGC
DBD No CpG GTCA
TCACTATTGACAGT
DBD MethylPlus GACT
TCAG
CTGA
GATCATACGATGCATGC
FL No CpG GCATGCTA
TCACTGACGTTA
TAGAGTC
AGTC
CGTA
FL MethylPlus GACT
TCAG
CGTA
GATCATAGCATGCATGC
DBD No CpG GCAT
CTACTGACTTTGAACAGT
DBD MethylPlus GACT
TCAGCGAT
GATAGCTACGAGTCATGC
FL No CpGGCATTCACGATTGCAGCCGTA
DBD No CpG GCTA
TCACATTGAGCAT
DBD MethylPlus GACT
TAGCCGTA
AGC
TCAG
TACG
AGTC
AGTC
FL MethylPlus AGCT
TCGA
CAGT
AGCTCGATACGACGTATGC
DBD MethylPlus GACT
TCAGCTGA
AGCTTCAGTACGAGTCAGTC
FL MethylPlus GAC
TCGACGTA
AGTACTACGATCGAGTC
FL No CpG GCTA
TCA
ACGATTGCACGAT
DBD No CpG GCTA
CTAACGTACTTGCAGGCAT
DBD MethylPlus AGCT
TCAGCTA
AGCTCATACGATGCAGTC
DBD No CpGGTCA
TCCAGTACTTGCAGGCAT
FL No CpGGACT
TCA
CAGT
AGTTCAAGTGACT
FL MethylPlus AGCT
TCAGCTA
AGCTTCTACATGCAGTC
DBD MethylPlus AGCT
TCGACTG
AGCTCAGTACGAGCTGATC
FL No CpGGACT
TCAG
CATG
AGTTCAGTGACT
FL MethylPlus GACT
TCGACAT
AGTCATACGATGCAGTC
FL MethylPlus AGCT
TCAGCAT
AGC
TCG
TAC
ATCG
AGTC
FL No CpG GACT
TCA
CAGT
AGTTGCATGGATC
DBD No CpG GTAC
CTACTG
ATGCTTAGCAACGT
DBD MethylPlus GACT
TCAG
CTGA
GAC
TAGC
TACG
ATGC
ATGC
FL MethylPlus GACT
TCAG
CATG
GATCTC
TACG
ATGC
ATGC
FL No CpGGTACTCAG
ACTG
ACTG
TGAC
TGAC
AGTC
CAGT
DBD No CpG GATC
CTAACTG
ACTGTTAGCACAGT
DBD MethylPlus GACT
TCAG
CGTA
GACTCAGTACGAGTCATCG
FL No CpG CTGATC
ACATTGAGCGTA
FL MethylPlus GACTGCACAGTCGTACAGGATC
DBD MethylPlus GACT
TACG
CATG
AGCTCAGTAGACAGTC
DBD No CpG CTGA
TCA
ACGATGCTGCAAGTCTGA
DBD No CpG GCTATCACATTGAGCAT
FL No CpG GCATTCACAGTTAGGCAT
DBD MethylPlus GACT
TAGC
CATG
AGCTCAGTACGATGAGTC
FL MethylPlus GACT
TGAC
CATG
AGC
TCGA
TACGATC
GATC
DBD No CpG GCTA
TCACGATTGAGCAT
DBD MethylPlus GACT
TGAC
CATG
AGC
TCGA
TACGATG
AGTC
DBD MethylPlusAGCT
TGACGATGTCAGACGCATG
DBD No CpG GCTCACGATGTCGAGGCTA
DBD No CpG GCTA
TCGA
ACGATCTGCAAGCGAT
DBD MethylPlus GACT
TACGCAT
GACTCATACGAGTCACGT
FL No CpGGCTATCACGTATGTGCAAGTCGAT
FL MethylPlus AGCT
TGCA
CATG
AGCTCAGTACGAGTCAGTC
DBD TCGATCACTATGCTGCAAGCTGA
DBD GTCAGCTA
TCGA
ACTG
AGCTTAGCATGCAGTCCGTA
DBD GCTA
TCACGTATTGACAGT
FL GACTGTTCGACACTGTACAGAGCTCGAT
DBD GCTA
CTGACGTATCGTTGAACGAT
FL GCATTCACATTGCAGCGTA
DBD GCTA
TCACGATTGACGAT
FL GCAT
TCACGACTTGCACGAT
DBD GCTA
CTA
ACGTATTGCAGCGAT
DBD GACT
TCCAG
AGTGTCGAGCGACT
DBD GTCA
TCACGATTGCAGGCAT
FLAGCT
TCCAAGTTAGGATC
FLGACTTCA
CAAGTTAGAGCT
FL AGCTTCCAAGTTGAGGACT
DBD GTCA
CTACGATTGAACAGT
FL GTACTCACTACTGTGACAGCATG
DBD GACT
CTACGATTGAACAGT
FL CTGATCACATTGAGCGTA
DBD CTGA
TCA
ACATTGCAGTCGTA
DBD GCTA
TCA
ACGATTGCAGCAT
FL GCATTCACGATTAGGCAT
DBD GCTA
TCA
ACGATTGAGCAT
DBD GCA
TCACGATTGCAGCACGT
DBD GCTATCA
ACGATTCGAGCGAT
FL GCTATCACGATTGCAGCGTA
Homeobox TFs
13
Methyl Control
HOXB9
HOXB9
HOXA9
HOXA9
HOXD9
HOXD9
HOXD9
HOXD9
HOXC9
HOXC9
HOXD10
HOXD10
HOXD10
HOXD10
HOXA10
HOXA10
HOXA10
HOXA10
HOXC10
HOXC10
HOXC10
HOXC10
HOXD11
HOXA11
HOXA11
HOXC11
HOXC11
HOXC11
HOXC11
HOXC12
HOXC12
HOXD12
HOXC13
HOXC13
HOXA13
HOXA13
HOXA13
HOXA13
HOXD13
HOXD13
HOXB13
HOXB13
CDX4
CDX4
CDX1
CDX2
CDX2
DBD MethylPlus GACTGCGGATATGAGCACGACTGTCGA
FL No CpG GATC
CTCAGT
AGCTTACTAGCATCACTGCAGTGCTA
FL MethylPlus GACTCAG
CAT
GATATCGATCATCGTCAGGCTA
DBD No CpG GACT
CTA
ACTG
AGCTTA
ATGC
AT
ACTG
ACTG
CGTA
FL MethylPlus GACTCAGCGATATATACTGATCGCTAG
FL No CpG GACT
CTACTAGCTTAATCATACTACTGCTAG
DBD MethylPlus GACTCAG
CAT
GATCATATATCGATCGCTGA
FL MethylPlus GACTCACA
GATATATATCATCGCTAG
FL No CpG GACT
CTACTAGCTAATCATATACTGCTAG
DBD No CpG GTA
TCACGATAATAAACTGCTAG
FL MethylPlus GACTGACTCACGATCATACACGATCGTCAG
FL No CpG GATCGAC
TCACATAATAATACGCATG
DBD MethylPlus GACTCCGATATAAATCGCTAG
DBD MethylPlus GCATGACTCCGATATAATCATCGCTAG
DBD No CpG GACTGACT
TCACTGAGTAATGATACACTGCTAG
FL MethylPlusGCTAGACTTCACAT
GATGCATGCATCGACTGACTGCTGA
FL No CpGGCTA
GACT
CTACTG
AGCTAATGCATCACTACTGCTGA
DBD No CpG GCATGACTTCACATAATACAACTGCGTA
FL No CpG GATCGTCACATAATACAATCCTAG
FL MethylPlus GCATGACTCGATATAAATCGCTAG
DBD MethylPlus GCATGACTCGATATAACATCGCTGA
DBD MethylPlusGCTAGACTTCAGCTAGATCATGCATGACTGATCGCTAGTGACTAGCTAGCATGCTCAG
DBD MethylPlusGACTGACTCACTGATATGCATACTATCGCTAG
DBD No CpGAGTCGCTA
CTACGT
AGTTATATATCAGTCTCAG
FL MethylPlusGCAT
GACT
TCAGCTA
GATTCATCGATGACTGATCGCTGA
DBD MethylPlus GCAT
GACTCACTAGATATCATACTGATCGCTAG
DBD No CpGGATC
GCAT
TCCATG
AGCTTATCAGTACTATCGCATG
FL No CpGGTACGCAT
CTAG
CAGT
AGCTTCATCGATACTGACTGACTG
DBD No CpGGACTGACT
TCACGAGCTTCATCGATGATACTGACTG
DBD MethylPlusGCAT
GACTCAGCTAGATCATGATGATCGACTGCTAG
DBD MethylPlusGCTA
GACTCACATGATATCATCATCGATCG
DBD MethylPlus GCTACGATCGTAAAATCGCTAG
DBD No CpGACGTCGAT
CTA
ACTAGTTATATATCACTGCATG
DBD MethylPlus GCATCGATACGCTGATCGATATACTATCGCTAG
FL No CpGAGCTCAGT
CTATCACTATAACACGTCTAG
FL MethylPlus GCTACGATTCGACATGATCATATACATCGCTAG
DBD No CpG AGCT
CGAT
CTAG
ACTATGTATGATACTGACTGCATG
DBD MethylPlus GCATCGATCAGCTGATCGATATACTATCGCTAG
DBD MethylPlus GCTACGATCGTATAAATCGTCAG
FL MethylPlus GCTA
GACTCACTGATACGATCACTACTGCGTA
FL No CpG GTCAGCAT
CT
ACTATACATACTACTGCGTA
DBD MethylPlus GTCAGATCGATGAAAATCGCTGA
DBD MethylPlus CGTA
GAC
TCAG
CTG
GATATCGATCGACTGCTGAGCATCGTA
DBD GACTCCGACTATCAACTATCGTCAG
DBD GATC
CTA
ACTG
AGTCTATGATACGACTGTCAG
FL GAC
CTCAGT
AGCTTCTACGATCGACTGCAGTCGAT
FL GACT
TCAGCATG
GAC
TC
ATCG
ATCG
ATCG
CTAG
GCAT
DBD
GACTCCGATATAAATCGTCAG
FL GACTCACAGATATATATATCGCTAG
FL GACT
CTGACTGAGCTA
ATATAACTGCTAG
DBD
GATC
CTACTGATATAAATCGACTG
FL GACTCCGATATAAATCGTCAG
FL GATC
CTACTGATAATACAACTGCATG
DBD GAT
CTACGTAGTAATAACTACTGCTAG
FL GACT
GACTCCAGATGATGAACATCGCTAG
FL GATC
GACT
TCAG
ACGTAG
TAG
ATAATACTGACTG
DBD GACTCCGATATAATCATCGCTAG
DBD GACT
GACTCCGATATAATATCGCTAG
DBD GATCGACTTCACGTAGTAATAAACTGCATG
FL GTACGACTCAGCATGATTATATCATCGACTGCTGA
FL GCATGACT
CTACGT
AGCTATCATACTACGTCTAG
DBD GCATGACT
CTACTG
AGCTTATAACGACTGCTGA
FL GATCGATCTCACAGTAATAAACTGCTAG
FL GCAT
GACTCGATATAATATCGCTAG
DBD GCAT
GACTCACATGATATATATCACTGCTGA
DBD GCAT
GACT
TCAG
CTA
GATGATGCATGACTGATCGCTGATGACTAGCTAGCATGCTCAG
DBD GACT
GACTTCAGCTAGATCATGATACTGATCGTCAG
DBD GATCGCAT
CTAG
CAGT
AGCTTATGCATCACTATCGCTAG
FL GCAT
GACTCAGCTAGATATGCATGATCATCGCTAG
DBD GACT
GACTCAGCTAGATATATATCATCGCTAG
DBD GATCGACT
TCCATG
AGCTATCATATATCGCATG
FL GATC
GCAT
CTA
CATG
AGCTTGATCATAGTCATCGCATG
DBD GATCGAC
TCACGT
AGTCATCAACATCGTCAG
DBD GACT
GACTCCATGATATATGATCATCGCTAG
DBD GCTA
GACT
TCAG
CT
GATATATCACTGCTAG
DBDCGAT
CGATCT
ACTGATACAAACTGCTGA
DBD GCTACGATCCTAGATATATACTACTGCTAG
DBD CAGT
CGACT
ACATAGAAACTGCATG
DBD GCTACGATGCTGATGATAACACTGCTAG
FLCATGCGTA
CTA
ACTG
ATGTATAGTCATCACTGCATG
FL GCTACAGTTCAGCTAGATCATGATACTGATCGCTAG
DBD CGAT
CGACACAGTAAAGACACGCAGT
DBD GCTACGATTACTGATATAACACTGCTAG
DBD CAGTCGTACTA
ACTGAGTTATAAACTGCTAG
DBD CGTACGATCCTAGGATGATAAACTGCTAG
FL
GTACGACT
CTACATAAACACTGCTGA
DBD GTACGACTCAATAAAACTGCTGA
DBD
GACT
CTCATG
AGCTTATCGATCGACTGCGTADBD
GTCA
GACT
TCGA
CTGA
GATATGCATCGATCGCTGA
No CpG
No CpG
No CpG
Homeobox TFs
No CpG
14
Methyl Control
GSX1
GSX2
MSX2
MSX2
MSX1
MSX1
MSX1
MSX1
MNX1
MNX1
GBX2
GBX2
GBX2
GBX2
MEOX1
MEOX1
MEOX2
MEOX2
EVX2
EVX2
EVX1
EVX1
VENTX
VENTX
EN1
EN1
EN2
EN2
NANOG
NANOG
DLX2
DLX2
DLX5
DLX5
DLX5
DLX5
DLX3
DLX3
DLX3
DLX3
DLX4
DLX4
DLX4
DLX4
DLX1
DLX1
DLX6
DLX6
BARHL1
BARHL1
BARHL2
BARHL2
BARHL2
BARHL2
BARX2
BSX
BSX
DBD MethylPlus CAGT
TAGC
CTAG
GATC
TCA
TCAG
ATGC
AGTC
DBD MethylPlus CGAT
TAGC
CTA
GATCTCTCAGATGAGTC
DBD No CpGGCTACTAATTAAGTC
DBD MethylPlus CAGT
TAGC
CTAG
GATCAGTACGAGATCG
DBD No CpGGCTA
CTAAGCATTCAATGGCAT
DBD MethylPlusACGT
TGAC
CTA
GATCAGTACGAGCTTCAG
FL No CpG CGAT
CTAG
AGCT
ATGCTTCAGATGCAGT
FL MethylPlusCAGT
TAGC
CTA
GATCATAGCACGTAGCT
DBD No CpG GCTA
TCAACGATTGCAGCAT
DBD MethylPlus GACT
TAGC
CAT
AGTCATACGATAGTC
DBD No CpGCGTA
CTAACGATTCGAGACT
FL No CpGCGTA
CTAGAGCACTTCAATGGACT
FL MethylPlus CAGT
TGAC
CATG
GATCAGTACATGCGATC
DBD MethylPlus CAGT
TGAC
CTAG
GAC
TCGA
TACATGC
AGTC
FL Little effect GACT
TAGC
CAT
AGC
TAG
TCAG
AG
AGTC
FL No CpG GTCA
TCAG
ACGATTGCACGTA
FL Little effect GACT
TAGCCAG
AGCTATCAGAGTCAGTC
FL No CpGGTCA
TCA
ACGT
ACTTCGAAGCGAT
DBD No CpGCGTATCACGATTGCAGCTA
DBD MethylPlusCGAT
TAGCCAT
AGTCATACAGATC
DBD No CpGGCATTCACGTATTGCAAGCTA
DBD MethylPlusGACT
TAGC
CAGT
AGCTCAGTAGCATCGTAC
FL No CpGCTGA
GCTA
TCACGTACGTTGCAGTGATCCTGA
DBD No CpG CGTA
CTAGCATTCGAGGCAT
DBD MethylPlusCAGTAGCAT
GAC
TC
TACGAGGCTA
DBD MethylPlusACGT
TAGC
CTAG
GATCGATACGAGCAGTCTCGA
DBD No CpG CGTA
TCAGATTCAGCAT
DBD No CpG TGCATCAG
AGACGTGCATGCAGACGTA
DBD MethylPlus TACG
TCAG
AGTC
AGTC
CTG
GTAC
ATCG
DBD No CpG GCAT
TCAATTATCGA
FL No CpG GCAT
TCAATTATCGA
DBD No CpG GCAT
TCAATTATCGA
FL No CpG GCAT
CTACGACTTGAGCTGA
DBD MethylPlusAGCT
TCGA
CATG
AGTC
TCA
TAC
ATGC
TAGC
FL MethylPlusGCAT
TGAC
CAT
AGTACGTACAGCTACG
FL MethylPlus GACTTAGCCAG
AGTCAGTACGATCGATCG
FL No CpG GCAT
CTACGTATTGCACTGA
DBD No CpG GCAT
CTAACATTGATCGA
DBD MethylPlus AGCTTAGC
CATG
AGTCAGTAGCAATGC
FL MethylPlus GCAT
TCGA
CATG
AGTACTACATGTAGC
DBD MethylPlusGACT
TCGA
CTAG
GATC
TCA
TAC
ATGC
TAGC
FL No CpG GCAT
TCAATTATCGA
DBD No CpG GCAT
CTACGATTGATCGA
DBD No CpG GCAT
TCAATTATCGA
FL No CpG GCAT
CTAATTATCGA
DBD MethylPlusGCAT
TCGA
CATG
GATCATACATGCTAGC
DBD No CpG GCAT
CTA
ACGTACTTGCATCGTA
DBD No CpGCGTATAAATAGTGACGACGAT
DBD
MethylMinus
CTAGTAAATAGTGACGATCGATTCGA
FL
MethylMinus
CTGATAATAGTGACGACGTA
FL No CpGAGTC
ATGC
ATATACTGCTAGCAGTAGTAGCTCATCAGT
DBD MethylMinus CAGT
TAGCCAGT
GATCATACGAGTCATCG
DBD No CpGGCTA
CTACGACGTTGCACGAT
DBD CTAG
TCGA
ACTGAGCT
TCGA
TGAC
AGCAGT
DBD GCA
TCAG
ACGT
AGTCTGAGTGATC
DBD CGTA
CTAATTAAGCT
DBD GCTA
CTAGAGATTGAGCGAT
FLCGATCTAGCACGTTCGAAGCCATG
DBD GCAT
TCAGCATTGCAGCTA
DBD CGTA
CTACGACTTGCAGCAT
FL GCTA
CTAGATTAGACT
FLAGCTGACCAGTCGATACGAGCATCG
FL GTCA
TCGACGATTGCACGTA
FLGACT
TAGCCAAGTACGTCAGACGATGC
FL GTCA
TCGACGATTCGACGTA
DBD CGATTCACGATTGCAGCTA
DBD CGATTCACGATTGCAGCTA
FLGCTA
GCTA
TCAGCT
ACGTTGCAGTCGACTCTGA
FL CTAG
GACT
ATCGTAGTGCAGTGACCTGAGTAC
DBD GCTA
CTAGATTCGAGGCAT
DBD CGTA
TCAATTAGCAT
DBDTGCATCGA
AGATCGGCTAGACTCGTA
DBD GCAT
CTAAATTACTGA
FL GCAT
TCAATTATCGA
DBD GCAT
CTA
ACGATTACTGA
FL GCAT
CTAACGATTACTGA
FL GCAT
TCAGATTACTGA
DBD GCAT
CTA
ACGTACTTGCACGTA
FL GACT
TCAATTATCAG
DBD GCAT
CTA
ACGATTGCATCTGA
DBD GCAT
CTAACGATTGACTGA
FL GCAT
CTAATTACTGA
DBD GCAT
CTAG
AGCATTGCATGCGTA
DBD CGTATCAGATAGCTCGAGACGAT
DBD CGATTAATGCACATGCCTGATGTAC
DBD CTAGTAATAGTCGAGACGTATCGA
FL CTGATAATAGTCGAGACGAT
DBD CTAGTATAATGCTGTAGATCTCAG
FL CATGTATAATGCTGATGACT
FLAGTC
ATGC
ATCATGACGTCTAGCAGTAGTTCATGCCGAT
DBD CAGT
TAGCCGATGCATCAGAGCACGT
DBD GCTA
CTGA
AGCACTTGCAGCGAT
MethylMinus
MethylMinus
No CpG
No CpG
Homeobox TFs
15
NKX2-8
NKX2-8
NKX2-8
NKX2-3
NKX2-3
NKX2-3
NKX2-3
NKX2-5
NKX2-5
NKX3-2
NKX3-2
NKX3-1
NKX3-1
NKX6-2
NKX6-2
NKX6-3
HMX2
HMX2
HMX1
TLX2
TLX3
TLX3
LBX2
LBX2
LBX2
EMX1
EMX1
EMX2
VAX2
VAX1
NOTO
UNCX
ALX1
ALX3
ALX3
ALX3
ALX3
ALX4
ALX4
ARX
VSX2
VSX2
VSX2
VSX2
VSX1
VSX1
VSX1
VSX1
RAX
RAX
ISX
ISX
ISX
ISX
FL MethylPlus GCAT
AGTC
TACGACTACGAGCATTCAGCTTCGATCAGGATCCATG
FL No CpG AGCT
CGAT
CTATGCCTGTCGCAATGGACT
FL MethylPlus CGAT
TAGC
CGTA
GCATGCA
TCAG
GCAT
ATCG
AGCT
DBD No CpGACGT
CGATCTATCATTCGACTACTGCGAT
DBD MethylPlus GAC
TGACCGT
GAC
TAGC
TCG
GACT
ATCG
GCAT
FL No CpGCAGT
CGAT
CTACTGTCGACTACTGCGAT
FL MethylPlusGCAT
TGAC
CGTA
GAC
TAGTC
GAC
ATC
GCAT
FL No CpG ACGTCGATCTATCTTCGACTATGCCGAT
FL MethylPlus CGATGAC
CGAGATAGC
TAC
GACT
ATGC
GCAT
DBD No CpG ACGT
CGATCTAG
ATCCATGACTCAATCGAGTCCGTA
DBD MethylPlus CGAT
TAGCCGTA
GACTCGA
TAGC
AGC
ATGC
DBD No CpGAGCT
CGATCTAATCCATTCATCGAGTCCGTA
DBD MethylPlus CGAT
TAGC
CGAT
GACTCAG
TAGC
AGC
ATGC
FL No CpGGCAT
TCAG
CAGTAGTTCAAGATCG
DBD No CpGGTAC
TCACTGATTGCAAACTG
DBD No CpG GCATTCCTGAAGTTCAGATCGATCG
FL No CpG ACTG
CGTACGAACATGTTCAATGATGCCTAG
DBD No CpGCGATCTAAGCAGTTTCAAGTCAGTCCGAT
DBD No CpG CGATCTAGCATGTTCAAGTCAGCTCGTA
DBD No CpGTCGA
CTAG
AGTCACTTATGACT
FL No CpG TCAG
ATCG
ATGC
TACG
TAGC
GACT
GTCA
TAGC
TCAG
ATCG
ATCG
ACGT
ATGC
TCGA
TCAGCTA
ATCG
ACGTTAC
TACG
AGCT
DBD No CpG TCGAACGTATC
TAGC
TGAC
GATC
ATCG
TACG
TCAG
ATCG
TACG
ATGC
ATGC
ATGC
AGTC
AGTC
GTACCTGA
ACGT
ATG
TCAG
TAGC
AGTC
DBD MethylPlus CAGT
TGAC
CTA
GACTTAAGTCATGC
DBD No CpG CTGATCAG
CATG
AGCT
TCG
TCA
ATG
AGTC
TACG
TACG
AGTC
TGAC
DBD No CpGAGCT
CTAG
TCA
ACTG
ACGTC
TCGA
AGT
AGTC
CTGA
FL No CpG CGTATCACATTGAGCAT
DBD No CpGGCTA
TCACGATTGAGCAT
DBD No CpG CTGA
TCA
ACTG
AGCT
TGCA
TGAC
AGT
CTGA
FL No CpGCGTA
TCACATTGAGCAT
DBD No CpGGCTA
TCA
ACTGACTTGCAGCAT
DBD No CpG CTGA
CTAG
ACTG
ATTATGCAATGGCAT
DBD MethylPlusCATG
GATC
CAGT
GATCAG
TCGA
AG
AGCT
FL No CpG TAATATTCACTGGACAGTTATFL No CpG C
GTA
TCAG
ACGTATTCGAAGTCCAGT
DBD No CpG CGTA
TCGA
ACGTACGTCTCGAAGCTCAGT
DBD MethylPlusCGAT
TGAC
CAGT
GATACGTAGCAGAGTC
FL MethylPlus CAGT
TAGC
CAGT
GAC
TCAG
TACGAAGTC
DBD No CpG CGTA
TCGA
ACGTACTTCGAGCTCAGT
DBD MethylPlusCATG
TGAC
CAG
GATCAGTAGCAGCACTG
DBD No CpG CTGA
TCAG
AGTCACGTTCGAAGTCACGT
DBD No CpG CTGA
TCAG
ACGAGTTGCAGTCGTA
DBD MethylPlusCTAG
TGAC
CAGT
GATCGATACAATGC
FL MethylPlusCGTATGCA
CATG
GAC
TC
TACATG
GTAC
FL No CpG GCAT
CGTA
TCAAACTTCAGATGCCTGA
DBD No CpG CTGA
TCGA
ACGTAGCTCGTGCAAGTCCGTA
DBD MethylPlus CTAG
TGAC
CATG
GACTCAGTACGAGATGC
FL No CpG CTGA
TCAG
ACTGACTTCGAAGTGCAT
FL MethylPlus CGTATGAC
CATG
GATCATACGAATGC
DBD MethylPlusCGTA
TGCA
CTAG
GACT
TCA
TAC
ATG
AGTC
DBD No CpG CTGA
TCAG
AGCTATTCGAAGTCCGTA
DBD No CpG CTGA
TCAATTAGAGTC
FL No CpG CGAT
TCACATTGAGCAGCT
FL MethylPlus CATG
TGAC
CTGA
GAC
TCGA
TACACGT
AGTC
DBD MethylPlus CATG
TAGC
CTAG
GACT
TCAG
TAACAGTC
FL AGCT
CGAT
CTATCATGTCGCATATGCGACT
DBDACGT
CGATCTATCCTCGTCAGACTACTGCGAT
FLCGAT
CGAT
CTACTGTCGACATCGCGAT
FLACGTCGATCTGATCATGATCGACTATGCGCAT
DBD ACGT
CGATCTATCCATTTCACTGAGCTCGAT
DBDACGT
CGATCTAATCCATTCATCGACGTCGTA
FL GCAT
TCGA
CAGTATTCGAGCATCG
DBD GTCATCACGATTGCAACTG
DBD CGAT
TCCTGAATTCAGATCGATCG
FL AGTC
CGTACAGTAGCATGTTCAATGATGCCATG
DBD GCATCAAGCCAGTTGTCAGTCACGTCTGA
DBDGCATCAGCATTGTCAGTAGCTCGAT
DBDCTGA
TCAGAGATTAGACT
FLGTACAGCTATTACGTGACGACTCTGATGCACGTATGACAGTCACTGACTGGCATACGTGCATCGTAACGTATGCTCAGTCAGCATG
DBD TGCAAGCT
AGTC
TACG
TGAGACCGTACTGAGCATCTAGGTACAGTCTAGCTACGATCGAGTCGATCACGTGCTACATGACTGATCGTAGCTCGAACGT
DBD CAG
TGAC
CTGATCGTAAGATGC
DBD CGAT
TCAG
ACTG
AGC
TCAGTCAGAGCTTCGTCGAAGCTGCTA
DBD CGATCTCAATTAAGCTCGTA
FL CGTATCAACTGATTGAGCAT
DBDCGTATCACATTGAGCAT
DBD CTGA
TCA
ACAGTTGCAGCGTA
FLCGTA
TCACATTGAGCAT
DBDGCTA
TCA
ACTATTGAGCAT
DBD CGTA
TCAG
ACGATTGCATGACT
DBD TGCA
TCGA
AGCTAGCTCGTCGAAGTCGTAC
FL TAATATTATCGGAATTAFL C
GTA
TCAGACGATTGCAGCTACGT
DBD CTGA
TCAGAATTAGACGT
DBD CGTA
TCGA
ACGTATTCGAGCTCAGT
DBD CTGA
TCGAAGATTCAGCTAGCT
DBD CTGA
TCAACATTGAGTGCTA
FL GCA
CGTA
TCAATTCAATGCCTGA
DBD CTGA
TCAG
ACGATTGCAGTCCGTA
FL CGTA
TCAG
ACTGACTTCGAGTCCAGT
DBD CTGA
TCGAAATTCAGCGAT
DBD CTGA
TCAATTAGAGCT
FL CGTA
TCAATTAGAGCT
Methyl Control
Homeobox TFs
16
Methyl Control DRGX
PHOX2B
PHOX2B
PHOX2A
PRRX2
PRRX2
PRRX2
PRRX2
SHOX
SHOX
PITX2
PITX2
PITX3
PITX1
PITX1
OTX1
OTX1
OTX2
CRX
DMBX1
GSC2
GSC
GSC
MIXL1
MIXL1
PROP1
PROP1
PROP1
PROP1
DUXA
ESX1
ESX1
HESX1
RHOXF2
RHOXF1
HMBOX1
ARGFX
ARGFX
0.0 5
DBD No CpG CTGA
TCAG
AGCTACTTCAGAGTCCGTA
FL No CpG TACG
AGTATCGATCGAATCGGACTAGTCTTCAGATGC
DBD No CpG CGTA
TCGA
AGCTAGTTCGAAGCTCAGT
DBD No CpGGCTA
CTGA
AGCT
ACGTTCGAATCGAT
FL No CpG CTGA
TCAGAGATTAGTAGTC
FL MethylPlus CATG
TGAC
CTAG
GAC
TCAG
TACG
AGTC
ATGC
DBD MethylPlusCGAT
TGACCGA
GACTACTCAGAGCGCAT
DBD No CpGCGTA
CTGA
AGCACTGTCGAGGCTA
DBD No CpG CTGA
TCAG
ACTGATTCGAAGTCACGT
DBD MethylPlus CGAT
TGAC
CTAG
GACT
TCA
TAC
AT
AGTC
DBD No CpG CTAGTAATGCCTCATG
FL No CpG CTAGTAAGATGCGATCTAGCATG
DBD No CpG CTAGTAATCTCCTAG
DBD No CpGCTGATAAGATGCGACTGAGACT
FL No CpG CTAGTAATCCTCATG
DBD No CpG CGTATAGATGCGATCTGACTGA
FL No CpG CTAGTAAGTATGCATGCTAGCTGACTAGTCAG
FL No CpG CTAGTAATGCATGCTAGCGTA
FL No CpG CTAGTAATGCTGACTAGCGTA
DBD No CpG CTAGTAGATGCAGCTGACGTA
DBD No CpG CATGTCAAGCTATCGACGATCTAGCGTA
FL No CpG CTAGTAAGTATGCTAGCTAGCGTA
DBD No CpG CTAGTAATCTACTAGCTA
FL No CpG TAC
AGATCATCGATACGAGCTAGTTTCATG
FL MethylPlus TAAGTCTCGAGTACAGATTAFL No CpG T
AAATCTCGAGACTGCATAGTTATFL MethylPlus TAATTCGGATCAGTGATACTADBD No CpG T
ACG
AGTATCGATCGAGACTGCATAGTCTCGATCAGATGC
DBD MethylPlus TACATGATGTCACGTATGACCATGGATATAT
DBD No CpG TCAG
AGATCGATCGTCGAACATCAGT
FL No CpG CTGA
TCA
AGCATTCGAGCGAT
DBD No CpG CTGA
TCAATTAGGCAT
FL No CpG CTAG
TCAG
ACGACTTGCAGCCATG
FL No CpG CTAGTAAGATGCGACTACTAG
FL No CpG GCTAGATGACTCTAATAGTC
DBD No CpG ACGT
CTGTAAGGTGTACGATGAGCT
DBD No CpG TGACCTAGTCAGACGATTCTGCAGCGATCACTG
DBD No CpG TCAGTACGAGCTAGCTTGCACTGTCGAACGATTCGAGCTGATC
DBD CTGA
TCGA
AGCATTCGAGTCGAT
FL TACG
AGTATCTCGAATCGGACTAGTCTTCAATGC
DBD CGTA
TCGA
AGCATTCGAGCTCGAT
DBD GCTA
CTAG
AGCAGCTTCGACGTGCAT
FL CTGA
TCGAACATTAGAGTC
DBDACTG
GTACCGGATCATAGCAGCACGT
DBD CGTA
CTG
AGCATTCGAGGCAT
DBD CTGA
TCAGACTGATTCGAAGTCACGT
DBD CGTATAAGTATGCGATCTGACATGCTAGTAGATGCGACTGACGATACTGTAAATGCTCTGACAGT
DBD CTGATAATGCTACAGCAGT
FL CTAGTAATGCATCTGACATG
DBDCATGTAGATGCGCGTAGCTA
FLTCAGTCAAGATGCTGCTGAGCTACTAGTACG
FLCATGTAGTATGCGTACTGACGAT
FL CATGTAGATGCGCGATGCTA
DBDCGATTAGATGCGACGTAGCTA
DBDCTAGTAATGCAGTGACCGTACTGAGTCA
FL CATGTAATCTAGCGTACGTA
DBD CATGTAAGATGCTGACTGAGCTA
FL TACG
AGTATCAGTCGACGATAGCTAGTCTTCAGATGC
FL TACGAGATCTCGAAGTCGACTAGTTTCATGC
DBD TACG
AGTCATCAGTCGAGATCGCATAGTCTTCAGATGC
DBD TCA
AGATCGCTGTCGAGATGACGA
FL CTGA
TCAG
AGCACTTCGAGTCGTA
DBD CTGA
CTAG
AGCACGTTCGAAGTCGTA
FL CTGA
TCATGCATTGAGCATCG
FL CTAGTAGATGCGACTGCTAG
FL GCATGATGTACTCTAATGCAGTC
DBD AGCT
CGTATACG
AGCGTGTACGAGTCCGAT
DBD TGAC
CTAGTCAGACATTCAGTCAGTCACTG
DBD TCAGTACGAGTCAGCTTGACTCGATCAGAGATTAAGTCGATC
Homeobox TFs
17
Methyl Control HSF1
HSF1
HSF4
HSF2
HSF2
HSF5
HSF5
HSFY2
HSFY2
HSFY1
HSFY1
0.0 5
FL Inconclusive GATCGTCAATCGATCGCTGAGACTTACGTGACCATCGAAGCTGTCAACTGATGCCGTA
DBD Inconclusive AGTCGCTATCGATCGCTGAGACTTACGTGACCGATCGAAGCTGCTAATCGATGCCTAG
DBD Multiple effects GATCGCTA
ATCG
ATGC
CTGA
GACT
TAGC
TAGCCGA
TCAG
AGTC
GCTA
ACTG
ATCG
CTGA
DBD Multiple effects GATCGCTATCATCGCTGAGACTTACGTGACGATCGAAGCTGTCAACTGATCGCGTA
FL Multiple effects GATGTATCATGCCGTAGACTTACGTGACCTAGTCAGATGCTAACTGATGCGCTA
DBD MethylMinus ATCGACCAGCTTGCTAGCAGTTGATCGTACACTGAGCTTCAGGCTTCGTGAC
DBD Inconclusive TCAG
GACGAGAGTTCGGATCTCAGTCAGGACTCAGTGCTAGATCATGCCATGCGATCTGACTGAAGTCAGCTCGATAGTCATCCTGAGTC
DBD MethylMinus AGTC
TAGC
TAGC
CGATGTCATCATGCTCAGCGTAAGTCTACGTAGCAGGCTACGTATCGTCAG
DBD MethylMinusGACTCGAT
AGCTCATCTCGATGCATCATCGCGATAGCTCATCCTGATGCTACGTAGC
DBD MethylMinus AGCTCGAT
AGCTCTCTCGATGATCATCGCGATAGCTCTCCTGAGTCTACGTACG
DBD MethylMinusAGTC
TAGCTGCACGAGCTAGTATGCCTAGCGTAGATCTACGTACAGGCTACGTATCGCTAG
FL GACTGATCATCGCTGAGACTTAGCTGACCTGCAACGTGCTAACTGATCGCGTA
DBD GACTGCTAATCGATCGCTGAGACTTAGCTGACCGATGCAAGCTGCTAATCGATCGGCTA
DBD AGCTGTCA
ATCG
ATCG
CTGA
GACTTAGC
TGACCGTGCAACGTGCACTGATCGGCTA
DBDCGATGCTAATCGATCGCTGAGACTTAGCTGACCGTGCAACGTGCTAACTGATCGCGTA
FLAGCTGACTATCGATCGCTGAGACTTAGCTGACCTAGTGCAAGCTGTCAACTGATCGGCAT
DBD ATCG
AGTC
CTAG
GAC
TCAG
TCGA
CGAT
TGCA
AGCTGTAC
ACGT
AGCT
CTGCATTCGATGAC
DBD TCGA
CGATGCTAAGCTAGTCCTGGATCTCAGTCAGGACTCGATGCTAGCATCGATCATGCGATCGTACTGAATCGAGCTCGTAGACTCAGTAGCAGCGTAAGCT
DBD GATC
TAGCTGAC
CAGGTCATGATGCCTAGGCTAGATCTACGTACCAGGTCACTGATCGCTAG
DBD GACT
CGAT
GACT
TCAGTACGTCATGATCGATCGCGATGACTTCAGTACGGTCATCGATCGTACG
DBDGACT
CGAT
GACTCATCGTCATGATCATCGCGATGACTTCATCGCTATGCATCGTACG
DBD GATC
TAGCTCGA
CGAGTCAATGCCATGGCTAGTACTACGTCAGGCTAGCTATCGCTAG
HSF TFs
Methyl Control IRF3
IRF3
IRF7
IRF8
IRF8
IRF4
IRF9
IRF2
IRF5
IRF5
IRF6
IRF6
0.0 5
FL Inconclusive ACTG
GCTA
GATC
AGTC
AGTATGC
GTCA
GCTAGAAGTATGAT
CGTA
GTCAGAACGTATCGATCCGTAATGC
DBD Inconclusive GTCA
CTA
TGACGCATTATATCCCGATTACGGCTAGAAATATCCAGTCTAGGAACGTATCGATCGCGAT
DBD MethylMinusATCG
GTACGATCAGCATGATCGGACTTCAGGACAGCTAGTATCGACTTCAGGATC
FL Inconslusive AGTC
CTAGGATCACGTATGATCCGATTCAGGAACGTATGCATCCGATTCAGAGTC
DBD InconclusiveAGCTCTAGGATC
ACTG
ATGC
ATC
CGAT
CTAG
GATC
ACTG
ATGC
ATCG
CGAT
TCAG
AGCT
FL Multiple effectsAGCT
TCAGGATC
ACGT
ATGC
ATCG
CGAT
TCAG
GATC
ACGT
ATGC
ATC
CGAT
TCAG
AGTC
FL Multiple effects AGCT
CTGAGATCACGTATGATCGATTCAGGATACTGATGATCCGATTCAGATGC
FL MethylPlus CTAGGACT
AGCT
ATGCATG
GCAT
CTGA
GAAGCT
ATGC
ATGC
GCAT
FL Little effectCGAT
CTAG
GACT
ACGT
ATGCACTCGATCTAGGATACGTATGCATCCGATTCAG
DBD Little effectCAGT
CTAG
GACT
ACTG
ATGCACGTCGATCTAGGACTACGTATGCATCGCGATTCAG
DBD MethylPlus AGTCGCTATCTCTGTACGCATTACGTAGCATCGTAGCGCATTCAGGAATAGACGTCAG
FL MethylPlus AGC
CGATCTGACACTTACACGCGCTAG
FL ACTG
GCAT
GATC
AGTCAGTATC
CAGT
GCTAGAAGTCATGATCGTACTGAGAAGCTATCGATCGCGATTACG
DBD TGAC
CTAG
AGCTGCTATATACTCAGCTGCATCGATCGTAGAAGTATATCGATCGTAGATACGTATCGACTGCGATTCAG
DBDCATGCTGA
GCATAGCTATGCATGCGACTCTAGGATAGCTATGCATCGCAGTTCAGAGCT
FLTACGCTAGGACTACGTATGATCGATCTAGGAACGTATGCATCCGATTCAGAGCT
DBDATCGCTAGGACT
ACGT
ATGC
ATCG
CGAT
CTAG
GAT
ACTG
ATGC
ATCG
CGAT
TCAG
AGCT
FLCATGCTAG
GATC
ACGT
ATGCATC
CGAT
CTAG
GAT
ACGT
ATGC
ATCG
CGAT
TCAG
AGCT
FLATGCCTGAGAACGATATCGATCTAGGAACATGATCCGATTCAGAGTC
FL CTAGGACT
AGCT
ATGCATG
GCAT
CTGAGAAGCT
ATGC
ATGC
CGAT
FL CTAGCTAG
GACT
ACGT
ATGCACGTACTAGGATACGTATGCATCGATTCAG
DBD CAGTCTAG
GACT
ACGT
ATCGACTGCGTACTAGGATCACGTATGCATCGCGATCTAG
DBD AGCTGCTATTACTCCTGTACGATCTACGATGCATCGATGCGCTACTAGGAAGCTAGACGTATCGA
FL AGCT
CTAGCGTGATATATGAGCGTCAG
IRF TFs
Methyl Control SRF
MEF2C
MEF2D
MEF2B
MEF2B
0.05
DBD No CpG CACGATGTACGATCTCATTCAGGAGTFL No CpG C
ATG
CTG
ATCG
ATGC
ATTAC
TACG
TAGC
AGCTGTA
DBD No CpG CACT
ATGC
ATGC
ATTA
TACG
TAGC
GAGT
DBD No CpG CAG
CT
ATGC
ATGC
ATGC
TACG
TAGC
TACG
GAC
GT
FL No CpG TCAGGACTACGTACAGTCCTATGCTACGATCTACTACGTGCAGATGTAC
DBD CAGT
CT
ATGC
TAC
GATCTACATGTACGGAGTCA
FL CACATCGATGCATTATACGTAGCGAGT
DBD CACT
ATCG
ATGC
ATTAGTAGTACGGAGT
DBD CACT
ATGC
TACG
ATG
TAC
TACG
TACG
GACG
FL TCAGGCTACTCAAGTCCCTATGCTACGATGCTACTACGTGCAGAGTAC
MADS TFs
18
Methyl Control NFIC
NFIB
NFIX
0.01
FL No CpGGCTATCAGTGGGCAGATCCTAGGCTAGATCTCAGGTCCACAGTCCGTA
FL No CpGGCTATCAGTGAGGCATGAGTCCTAGGTCAGTACTCAGGTCCACTAGTCGCAT
FL No CpG GCTATCAGTGAGGCAAGTCCTGAGCTAGTACTCAGGTCCACTAGTCGCAT
GCTATCAGTGGGCAAGTCCTGAGCATGACTTCAGGCGCAAGTCCGTA
GCTATCAGTGCAGGCAGTAGTCCTGAGCTAGTACTCAGGTACCACGTAGTCGCTA
GCTATACGTGCAGGCATAGTCCTGAGCTAGTACTCAGGTCCACTGGATCGCTA
NFI TFs
Methyl Control NR5A1<SF1>
NR5A2<LRH1>
NR5A2<LRH1>
NR5A2<LRH1>
NR3B3<ERR3><ESRRG>
NR3B1<ERR1><ESRRA>
NR3B1<ERR1><ESRRA>
NR3A1<ESR1>
NR3A1<ESR1>
NR3C1<GCR>
NR3C2<MCR>
NR1D1<THRAL>
NR1D2<RVR>
NR1C2<PPARD>
NR1C2<PPARD>
NR1F3<RORC>
NR1F3<RORC>
NR1F2<RORB>
NR1F2<RORB>
NR6A1<RTR>
FL No CpGGCTA
TCGACGTA
AGTAGTCGTCGTCAGCTGAAGTCCTAG
DBD MethylPlus TCGA
CGAT
AGTC
AGCT
GTCAGCATCAGCTGAGACTAGGACTAGTCCGTACATGTCGATCAGGCTAAGCT
DBD No CpGCTGATCAG
CGATAGAGGGTCAGCTAGTCTAG
DBD No CpG TCAG
GACT
AGTCCCATCATCAGCATAGCTGCTATCGACGTAAGTAGTCGTGTCAGCTGAAGTC
DBD No CpG GCTA
TCGA
CGATAGTAGCTGTACGCATTGACCTGAAGTCTAG
DBD No CpGGCTA
TCGA
CGATAGTAGCT
GTAGTATGACCTGAAGCTAG
FL No CpG GCTA
TCGA
CGATAGAGTGTGACTGAGTCAG
DBD MethylPlus GATCAGCGTGTACCGTAGCTGACGTAGACTCTGCATGCCCATCGATCAG
FL MethylPlusGACT
AGCT
GTAGATGACTGAAGCCAGTCGTAGTCATCGACTACTCTACAGTTCGATGCA
DBD MethylPlus AGCTGATCTAGCACTCGTAGTCTGCATAGCAGTCTCAGATTAATCGCATGTCAG
DBD MethylPlus GACTGTAC
TAGCAGTCCTGAGTCTCGAGTCAAGCTTCAGGATCAACTGCATGCTGA
DBD No CpGGTAC
ATGC
TAG
GTACTGCA
GACT
GTGATGCCTAGCATTCGAAGGTGTGCACTGAGGATC
DBD No CpGGATC
ATGC
TAG
GTCA
TGCA
GACT
GTAGTAC
TGCA
CTAG
AGT
GCATTCGA
GACT
GTAGTATGCACTGAAGTGTCA
DBD No CpGAGTCGATC
GAGTAGTATGCCTGAAGAGTAGGGTTGCCTGAAGTCAG
DBD MethylPlus ACTG
GACT
AGCT
GTCA
GTCA
TCGACTGA
GATCTCAG
GATC
ACGT
CAGT
CGAT
TCGA
CTGA
TGAC
DBD No CpG TCGA
AGCT
GTCA
GCTA
TGCACTAGTCGGACTACGCGACGATTCAGCT
DBD No CpGTAGCATGC
ATG
GTCATGCA
AGGTGTGCCTAAGCATTGCAGGTGTGCACTAGACTG
DBD No CpG TAGCATCG
ATGC
GCTATGCA
AGCGTGTTGCCTAAGTGCATTGCAAGGTGTACTGCACTGAAGTCGAT
DBD MethylPlus TAGCATGC
ATGC
GCTA
TGCA
AGCTGTCAGATCTGCACTGGACTCAGGAACGTCTGACATCGACGTGCATTAGCTAGCATCG
DBD No CpG GTCA
TCGA
CGTAAGTC
AGTCGTA
TGAC
TCGA
CTGATGATGCGTACGTACTGCACTGAAGTCACTG
FLGTCA
TCAGCGTA
AGATGCGTGTCAGCTGAAGTCCTAG
DBD TCGA
CGAT
AGCT
ATCG
GCTAGACT
TCAG
CTAG
AGTCAGGATCAGTCCTGACGATTCAGTCGAGCTAAGTC
DBDTGCATCAG
CGATAGAGGGTCAGCTGAGTCTAG
DBD TCAG
GACT
AGTCCCATCAGTCAGGCTAAGCTCGATTCGACGATAGTCAGCTGTGTCAGCTGAAGTC
DBD GCTA
TGCACGATAGTAGCT
GTACGATGACCTGAAGCTCTAG
NR3B2<ERR2><ESRRB> DBD No CpGTGCA
TCGA
CGATAGACGGTCGTAGCCTGAAGTACGDBD
GTCA
TCGA
CGATATAGGTCAGCATTGACTGAAGTTCAG
NR3B3<ERR3><ESRRG> FL No CpG GCTA
TCGA
CGATAGT
AGC
GTAGATGACTGAGTCCTAGFL
GCAT
TGAC
CGATAGAGCGTGTGACTGAGCTAG
DBDGCTA
TCGA
CGATAGT
AGC
GTCGTGACTGAGTCTCAG
FL GCTA
TGCACGATAGACGTGTGCTGACCGTAGTCAG
DBD AGCTAGCGTAGATCGACTAGGCTAGATCTCGACCCATCGTCAG
FL AGCT
AGCT
GTACGATTGCACTGAGTCTAGCGTAGATCTCAGACACTGCATCATTCGATCGA
DBD AGTCGACTAGCAGTCATATGTCAGTACGAGTCTCGGCTAGATCGCATGTCAG
DBD GACTGTAC
TCGAAGTCCTGAAGTCCTGACGATGACTTCAGGACTCAGAGCTCATGCTGA
DBDGTAC
ATCG
TAG
GCTATGCA
GACTGTAGATGCCTAGCATTGCAAGCGTGTGCACTGAGTGATC
DBD TGAC
ATGC
TAGC
GTACTGCA
GACT
GTA
GTAC
TGCA
TCAG
ATG
GCTATGCA
GATC
GTAGATCTGACCTGAAGTCTGAC
DBD ATCG
GACT
GACGATGTATGCCTGAAGAGTCAGGTAGTATGCCTGAAGTCACTG
DBD ATCG
GATC
AGCT
GCTA
GTCA
TGCA
CGAT
AGCT
TCAG
GACT
AGCT
CAGT
CTAG
TCA
TCGA
TGAC
DBD TGCA
AGTC
GTCA
GTCA
TGCACTGA
AGTCTCGGACACGTCTAGCAGTCGAACGT
DBDATGCATGC
ATGC
GCTATGCA
AGC
GTAGTATGCACTAGAGTGCATTGCAAGCTGTCAGATCTGCACTGAAGTCCAGT
DBDTAGCATCG
ATGC
GCTATGCA
AGC
GTGTATGCACTAATGGCATTGCAAGCTGTACGATCTGCACTGAAGTCGTA
DBD TAGCATCG
ATGC
CGTATGCA
AGC
GTACGATC
TGCACTGAGTCTCAGACACGTCTGACATCGACGTGCATTACGTAGCATCG
DBDGTCA
TCGA
CGTAAGTCACGTGTACTGACTCGCTGAATGACTGGTACGTACTGCACTGAAGTCATGC
Nuclear Receptor TFs
19
Methyl Control NR1B3<RARG>
NR1B3<RARG>
NR1B3<RARG>
NR1B2<RARB>
NR1B2<RARB>
NR1B2<RARB>
NR1B1<RARA>
NR1B1<RARA>
NR1B1<RARA>
NR2C2<TR4>
NR2C1<TR2>
NR2C1<TR2>
NR2F6<ERBAL2>
NR2F6<ERBAL2>
NR2F6<ERBAL2>
NR2F6<ERBAL2>
NR2F1<TFCOUP1>
NR2F1<TFCOUP1>
NR2F1<TFCOUP1>
NR2F1<TFCOUP1>
NR2E1<TLX>
NR2A1<HNF4A>
NR2A1<HNF4A>
NR2A1<HNF4A>
NR2A1<HNF4A>
NR2B1<RXRA>
NR2B3<RXRG>
NR2B3<RXRG>
NR2B2<RXRB>
NR2B2<RXRB>
NR4A1<GFRP1>
NR4A1<GFRP1>
NR4A2<NURR1>
NR1A2<THRB>
NR1A2<THRB>
NR1A2<THRB>
0. 05
FL No CpG AGTC
AGCT
GTC
GTTGACGAGCATGGACT
DBD No CpG GATC
AGCTGTA
GTTGAC
CGTA
AGCTAGTC
AGTC
AGCTGATGTTGACCTGAAGTTAGC
DBD MethylPlus AGTC
AGCTGTAC
GTATGACCTAGATTCGAACTGCAGCATGTCGATCAG
FL No CpG ACGT
ATCG
AGTC
AGCGTGTTGACCTGAGCATG
FL No CpG AGTC
AGCTGTAC
GTATGACCTGAAGCTATCGAGTCAGCTGTACGTATGACCTGAAGTCCATG
FL MethylPlus AGCT
AGCT
GTCA
GTCA
TGCACGTA
GATTCAGACTACTGCAGTCATGTCGATCAG
DBD No CpG GATC
AGCT
GTCA
GT
TGAC
CGTA
AGTC
ATCG
GATC
AGCTGTCA
GTAC
TGAC
CGTA
AGTC
CATG
DBD MethylPlus AGTC
AGCT
GTCA
GTCA
TGACCTGA
GACT
TCAG
GACT
ACGT
CAGT
CATG
TCGA
TCAG
DBD No CpGAGTCAGTC
AGCGGTTCAGCATGGCTA
DBD No CpG GATC
AGGTGTTGCTGAGATCG
DBD No CpG AGTC
AGTC
AGGGTCTAGACTG
DBD MethylPlus GACT
AGTC
GTCA
GTAC
TGCACTAG
AGTCAGACTACTGCATGCAGTCAGCTGA
FL No CpG GATC
GACT
GTACGTA
TGCA
CTGAAGTC
AGTC
AGCT
GTAC
GTAC
TGCA
CGTAAGTC
GTAC
FL MethylPlus AGTC
AGCT
GTAC
GTA
TGCA
CGTA
GACT
GCTATCGA
GACACGT
CAT
CATG
TCGA
TCGA
DBD No CpG GATC
AGCGTCAGTTGCCTGAGATGCAGGTAGATGCTGAGTCTACG
DBD MethylPlus AGTC
AGGTAGTATGCCTGAGCGCTATCGGACACGCATCATTCGTCAG
FL No CpGGATC
AGCT
GTAC
GTA
TGC
CTG
AG
ATGC
AGCTGTGTATGCACTGAGTCCATG
FL MethylPlus AGCT
AGCT
GTAC
GATC
TGCA
CTGA
AGCT
CGATTCGA
GACACGT
CATG
CATG
TCGA
TCAG
DBD No CpGAGTC
AGCT
GTA
GTA
TGCA
CTG
AGT
ATGC
AGTCGTAGTATGCCTGAGTCATCG
DBD MethylPlus AGTC
AGCT
GTAC
GTAC
TGCA
CTGA
GACT
TCGATCGAGACTACGTCATGCATGTCGATCAG
FL No CpG AGTC
AGTCAGCT
AGCTGATCGCTAGACGT
DBD No CpG GATC
GACGTGTATGACCTGAGATGAGGGTATGCTGAGTCATCG
DBD No CpG GACT
GACTGGTATGCACTGAGATGAGTCGTTGCTGACTAGTCCATG
DBD No CpG GACT
GATCGTA
TGA
CATGCTAGAGATAGCGGTATGCCTGAAGTCCATG
DBD No CpG GACT
AGTCGTCATGA
CATGCTAAGAGTAGTCGTGCTGACTAGTCCATG
DBD No CpG GACT
AGGATGTATGCCTGAAGAGTAGGGTTGCCTGAAGTATCG
FL No CpG GATC
GACT
GTAC
GTAC
TGCA
CGTA
AGAGTC
AGCT
GT
GTA
TGCA
CGTA
AGTC
ATGC
FL MethylPlus GACT
AGCGTAC
GTATGC
CTG
AG
CTAGATCACGTCATGCAGTTCGACTGA
DBD No CpG GACT
GACT
GAT
GTA
TGCA
CGTA
AGAGTC
AGGATGTATGCCTGAAGTCTACG
DBD MethylPlus GATC
AGTC
GTAC
GTAC
TGCCTGA
GATCTCAGACTACGTCATGCATGTCGACTGA
DBD No CpGTGACATGATAGTGTTGCCTAGACTG
DBD No CpGTGCAATGATAGTGTATGCCTAGCTAG
DBD No CpGGTCAAGTCATAGTGTTGACTAGTCAG
DBD No CpG GATC
GACT
GTAC
GTAC
TGCA
CTGA
AGTAGTC
AGCT
GTA
GTAC
TGCA
CTGA
AGTC
GTCA
DBD MethylPlusAGCT
GACT
AGCT
GTAC
GTAC
TGCA
CTGA
GATCTCGAGACTACGTCATGCATGTCGATCGATGAC
FL No CpG GTACTCGCAT
ATGCCACTCCTGAAGCTATGCTCGAGACTAGGCGTTAGCCGATAGCATG
FL GATC
AGCT
GTCGTAGCAGCATGGACT
DBD AGTC
AGCTGTA
GTATGACCTGAAGTATGCAGTCAGCTGATGTTGACCTGAAGTACTG
DBD AGTC
AGCT
GTAC
GTAC
TAGCCTGA
AGTCTCAGGACTATCGCATCATGTCGATCAG
FL AGCT
ATCG
AGTC
AGCGCAGTTGCGTAAGACTG
FL AGTC
AGCT
GTAC
GTTGCACTGAAGTATCGAGTCAGCTGTACGTCTGACCTGAAGCATG
FL AGTC
AGCGTCA
GTAC
TCGACTGA
AGTTCAGACTACGTCATCTAGTCGATCAG
DBD GACT
AGCT
GTAC
GTCA
TGCA
CGTA
AGTC
ACTG
GACT
AGCT
GTAC
GTATGAC
CGTA
AGTC
CGAT
DBD GATC
AGCT
GTCA
GTCA
TGCACGTA
AGT
TCA
GACT
ACTGCAT
CAGT
TCGA
TCAG
DBD ATCG
AGTC
AGCGGTTGCACATGGCAT
DBDGACT
AGCGTC
GTTGCTGAGTACG
DBDCATG
GATC
AGCTGTGTGCGAGCTAG
DBDGACT
AGCT
GTCA
GTAC
TAGC
CTGA
AGT
TCGCATACTGCAGTCAGTCAGCTGA
FL GATC
GACT
GTAC
GTAC
TGCA
CTGAAGTC
AGTC
AGCTGTCA
GTAC
TGCA
CTGA
AGTC
GTCA
FL GACT
AGCT
GTAC
GTA
TGCA
CGT
AGCT
GCATTCGAGACACGTCATGCATGTCGATCGA
DBD AGTC
AGCGTAC
GTACTGCA
CTGAGATGCAGGTAGTATGCCTGAGCTACTG
DBD AGTC
AGCGTAGTATGCACTGAGTCCGTATCGAGACACGCATCATTCGTCAG
FL GACT
AGCT
GTAC
GTA
TGC
CTGAG
AGTCAGGGTATGCCTGAGTCCATG
FL AGTC
AGTC
GTCA
GATC
TGCA
CTGA
AGC
TGCATCGGACTACCTCAGTTCAGTCAG
DBD GACT
GACT
GTAC
GTA
TGCA
CTGAGT
AGTC
AGCTGTAGTATGCCTGAGTCGACT
DBD GACT
AGCT
GTAC
GTAC
TGCA
CTGA
AGCT
GCTATGCAGACTACGTCATGCAGTTCAGTCGA
FL ACTG
AGTCAGCT
AGCTGTCGCAGACTG
DBD GACT
GACTGGTACTGACCTGAAGCAGAGCGCGTATGCCTGAGTCACTG
DBD GACT
GACTGGTACTGCACTAGTATAGTCGTCTGACCTGACTAGAGTCACTG
DBD GACT
GACTGTAC
TGA
CTAGCTAGAGATGAGGGTATGCCTGAAGTCCATG
DBD GACT
AGTCGCATTGCCATGCAGAGCACGTATGCGTTGCTAGCTAGTCACTG
DBD GACT
GAGAGTATGCTGAGAGTAGGGTTGCTGAGCTAG
FL GACT
GACT
GTAC
GTA
TGC
CTGAAG
AGTC
AGCGTAGTATGCCTGAAGTCATCG
FL GACT
AGCGCGTCATGACCTACTCGACTACTGCATGCGATTCGACTGA
DBD GACT
AGCT
GATC
GTATGCCTGAAGAGTCAGGTAGTTGCCTGAAGTCCATG
DBD GACT
AGCT
GTAC
GTCA
TGCA
CTGA
AGCT
TCAGACT
ACGT
CATG
CATG
TCAG
CTGA
DBD TGCAATAAGTGTCAGCATG
DBDTGCAATGCATGAGTGTGCCTGAAGTACTG
DBDGTCAATGCATGAGCGTGTATGCACTGAGCCTAG
DBD GACT
GACT
GTAC
GTA
TGCA
CTGAAG
AGTC
AGCGTAGTATGCACTGAAGTCTCGA
DBDATCG
GACT
AGTC
GTCA
GTAC
TGCA
CTGA
AGTCGAGACTACTGCAGTCATGTCGACTGATGAC
FL GATCTCAGGCATATGCCACTCGCTGAAGCTTACGTCGAGACTAGCGGTTACGCGTAAGCTAG
NR1I2<PXR>
NR1I3<CAR>
DBD MethylPlus
FL MethylPlus
AGTC
CTAG
GACT
ACTG
ACC G
ACT
ACTG
ACCTTCCTGA
AGTC
CT
TCACTGA
ACGT
AGTC
TCG
GAAACCTCTACGTACG
DBD
FL
AGTC
TCGA
GAT
ACGT
ACCAG A
CGT
ACGCT
TCGA
CTGA
AGTCTCA
TCAG
CGTA
GACT
AGTCTCGATC
GAACTGACCTCTCAGTACG
GATCTCGCTAATCGCTGCGTTCGATCGAAGCTCGTAGACTGGTATCCTCATGTCTCGAGCG
ATC
TCG
GAC
ATCGTA
CGTA
TGA
CTG
AGT
CTGA
GACT
TCGTATCGCTGATCTGAGNR1A2<THRB> FL MethylPlusFL
Nuclear Receptor TFs
20
Methyl Control CUX1
CUX2
ONECUT2
ONECUT2
ONECUT2
ONECUT1
ONECUT1
ONECUT3
0.0 5
DBD MethylMinusGTAC
TCGAAGTACGTCGGAGTCTAGAGCT
DBD Inconclusive CGTA
TCAG
GATC
AGTTCCTAGATAGTCTCAGTCAGGATCGTCA
FL MethylMinus TGACTATGCTGCTCGTCAATCGTTCTAGCTGAC
DBD MethylMinus TGACTCATTCGATTCTGAC
FL MethylMinus TGACTATTCGATCCGTGATCA
FL MethylMinus TGACTATTTCGACTCTCGTGACTTCGA
DBD MethylMinusTGACTCATTCGATTCGTAC
DBD MethylMinusTGACTCAGATTCGGATCTCGATGAC
DBDGTCA
TCGAAGTCTCAGCTGGATAGTTCACTAGAGCT
DBD CTGATCAG
GATCAGTCTCAG
CTAG
GATC
AGCT
TACG
TCAG
AGTC
GTAC
FL TGAC
TGACATCGCTGTACTTTCGATCTGAC
DBDGTAC
TCAGATGCTACGCTGAGACTAGTCAGCTGAGTAC
FL GTACTACGATCTGATCTGCTGCTATCGA
FL GTACTCAGATCGATCTGCGCTAGCAT
DBDGCAT
TCGAAGTCTGATCCTAGGCAT
DBDGTCA
TCGAAGTACTGATCTCAGGCTA
CUT TFs
Methyl Control PAX4
PAX4
PAX4
PAX4
PAX6
PAX6
PAX7
PAX7
PAX7
PAX7
PAX7
PAX7
PAX3
PAX3
PAX3
PAX1
PAX9
PAX8
PAX2
0.0 5
DBD No CpG TCGA
ACTGATGCTAGC
TCGA
AGCT
GACT
CGTA
TCGA
AGCTACGT
TAGC
TGAC
AGCT
DBD Little effect GACT
ACTG
TCGATCGA
TAGC
CTAAGCTCTAGACGATCGTCAGCTAAGCTACGTTCGAGTACCAGTAGCTCTGAACTG
DBD Little effect TACG
TGAC
TCAGACGT
CTGACGATCGTCAGCATAGCTACGTTCAGGTACCAGTAGTCCTAGATGC
DBD Little effect TGAC
TCAG
AGCT
CTAG
GACT
CGTA
TACG
ACTGATCGTCGTCAGATGCGACT
DBD MethylPlus TGAC
CTAG
AGCT
CTAG
GAC
CGTA
ATCG
TCAG
GCTA
AGCT
CAGT
TCAG
GATC
CAGT
AGTCCTGA
AGTC
FL MethylPlus TGAC
CTAG
AGCT
CTGA
GAC
CGAT
ATCG
TCAG
CGTA
AGCT
CTAG
TCAG
GAT
CAGT
ACTG
CTGA
ACTG
DBD MethylPlusTCGA
CGTAGTATACGCTAGAGCTAGATGCATTACGTACGAGCTTACGTCAGATGCAGTC
DBD MethylMinusAGTCTAGCAGCTATCTCAGTCGAGACTAGCTTAGCTCGAATCGTGAC
DBD Multiple effects CTGA
GACT
AGTCTAGC
TCAG
ACGTGAT
TCAG
CTAG
AGT
CTAG
GAC
GCT
TCAG
TAGC
FL MethylMinusACTGTGAAATTCGATTATCTGAC
FL Multiple effects CTGA
GACT
AGTCTCGA
TCGA
ACGTGTTACCTAGAGTCCTGATCCGTCAGTACG
FL MethylPlus TCAG
CGTAGTTACTAGCTGCGTCAGTACGAGTCTAGCTCAGATGCAGTC
DBD MethylPlus TCAG
CGTAGTACTACGCTAGAGCTCTAGACTCGTCAGATCGAGTCTAGCTCAGATGCAGTC
DBD MethylMinusCATGTAGCAGCTAGTCAGTCGAGACAGCTTGCATCGAATCGTGAC
DBD Multiple effectsTCGA
CTAG
AGCT
ATGCTCAG
TCGA
AGCTGTATACGCTAGAGTCCTAGGATGCTTCAGTACG
DBD MethylPlusCTAG
CGTAGTATACGCTAGAGCTCTGAGACGTACGTCAGCATAGCTCGTATCGAGTACCAGT
DBD MethylPlusTCAG
CGTAGTAC
TACG
CTAG
AGTCTAGACGTACGTCAGCATAGCTGCATCTAGGTACCAGT
FL MethylPlusTCAG
GCTAGTACTACGCTAAGTCTAGACGTACGTCAGGCTAAGCGATCTAGGATCACGTATCGCTGAAGTC
DBD MethylPlusTCAG
CGTAGTCTACCTAGAGCTCTGGACCGATCGTCAGCATAGCGTATCAGGATCCAGTATCGCTGAATCG
DBDATCGAGCTAGTGATCGACGGCATGTCAAGCTCTAGTCAGGCTAGCATCTGATCGAATGCTATCGAGTC
DBDCGATAGCT
TCGA
TCAG
TACTAACTGACCGTATCGTCGACGATAGTCAGCTTCAGACTCATGGATCCTGAACGT
DBD TCAG
TAGC
CTAG
ACGT
CTGACCGTATCGTCAGGCATAGCTACGTTCAGGTACCAGTAGCTCTAGACTG
DBD TAGC
CTAG
AGTC
CTGA
GA
CGTA
TGCA
ACGTATAGTCGAAGTCGACT
DBD TGAC
CTAG
AGCT
CTAG
GAC
CGTA
ATCG
TCA
GCTA
AGCT
CGATTCAG
GATC
CAGT
AGCT
CTGA
ACTG
FLTGAC
CTAG
AGCT
CTAG
GACT
CGAT
ATGCTCAG
GCTA
AGCT
CAGT
TCAG
GATC
CAGT
GACT
CTGA
AGCT
DBD TCGA
CGTAGCTGCTGAACATGGATCGTATCAGTACGAGCTGCTCAGAGTCAGTC
DBDGACTTAGCAGCTATCATCGGCAAGTCTTCGAATCGCTGA
DBD CTG
GACT
ACGTGTCGCAGGCTTCGACTGAACGTCAGGATGCTACGCTGA
FLAGCTTAGAATCTGATTATCTCAG
FL CTGA
GACT
AGTCTCGA
TCGA
CAGTGTACCTAAGTCTAGAGCTATACGTGAC
FLTCAG
CGTAGTTACTGACTGACGTCAGTACGAGCTTGACTCAGATGCGACT
DBD CTGA
CGTAGTTACG
CTGAAG
CTA
GA
CGTATCAG
ATCG
AGCTTACG
TCAG
ATGC
AGCT
DBDCATGTGACAGCACGTCTCGGACAGCTTGCATCGAATCGGTCA
DBDGCTA
CTGA
AGCT
ATGCTCAG
TCAG
ACGTGTACTACGCTAGAGTCCTAGACTGCTTCAGTCAG
DBD CTGA
CGTAGTCA
TCAGCTGA
AGC
CTAGGA
CGAT
TACG
TCAG
GCTA
AGCT
CGATTCAG
GTAC
CAG
DBDCTGA
CGTAGTAC
TACG
CTAG
AGTC
CTAG
GAC
CGATATCG
TCAG
GCAT
AGCT
CGAT
TCAG
GTAC
CAGT
FL CTGACGTAGTACTCAGCTAGAGTCCTGACGATCGTCAGCTAGCCGATTCAGGATCCAGTGCTACTGACATG
DBD CAGTCGTA
GTA
TCAG
CTAG
AGCT
CTGA
GACT
CGTA
ATCG
TCAG
GCTA
AGCT
CGAT
CTGA
GATC
CAGT
CGAT
CTGA
ACGT
PAX TFs
21
Methyl Control POU4F1
POU4F1
POU4F3
POU4F3
POU4F3
POU4F3
POU5F1
POU5F1
POU5F1
POU2F3
POU2F3
POU2F2
POU2F2
POU2F2
POU2F2
POU2F2
POU3F1
POU3F1
POU3F1
POU3F1
POU3F1
POU3F4
POU3F4
POU3F4
POU3F4
POU3F4
POU3F2
POU3F2
POU3F2
POU3F2
POU3F2
POU6F1
POU6F1
POU6F1
POU6F1
POU1F1
POU1F1
POU1F1
0. 1
DBD No CpG AGCTTCTCAGACTGATCGTACTAGCATCGGTACTGAAGTACG
DBD No CpG TCAG
CTAG
AGCTTCGTACCAGTAGTCTCGAGATCAGTC
DBD No CpG AGTCTCTCAGATCGATCGTACGTACGATGTGTACTAGAGCTACG
FL No CpG AGCTTAGCTACTATCTATGCATTGTACTGAATACG
FL No CpG AGTCTAGACTCATGATATAGCATCGTCGTACCTGAAGTTGAC
FL MethylPlus AGCT
TCAGTACG
ATGC
AGTC
TAGCTAATGACGTCTGATCTAGAGCTATGC
FL No CpGGACT
AGTC
TAGCTAATGCTGTAAATCAGTCAAGTCGACTGCTA
FL MethylPlus TAGC
TACGATCGTCGATCGCTAGAGCTAGCATGCATCG
DBD MethylPlusAGTC
TCAG
AGTC
TGCA
GTAC
CTA
GTAC
CTAGATG
TCAG
AGCT
TCAG
DBD No CpGATGC
TCAGAGTTCGAGTACTGAATGCAGTCATGCTAGCGTCA
DBD No CpG CAGT
TAGC
ACGT
AGTC
TAGC
TCAG
ATG
TCGA
GTCA
CTA
ATGC
ATGC
DBD MethylPlus ATGC
TCAGATCTGATCTAGGATCCGACTGAGCTACG
DBD No CpG TAGCTCGATGCTGATAATTGCA
DBD No CpG TACG
TACG
GATC
CATG
ATGC
TAATG
TCA
GTC
CTGA
ATGC
ATCG
DBD No CpG TACG
ACGT
ACGT
TACG
TGAC
ATCG
CTGA
CGAT
CAGT
GCTA
TCAGTAGC
ACTG
ATGC
TCGA
TGA
ATGC
DBD No CpG TAGCTACGATGCTGAATAATGTCAATGCGACT
DBD MethylPlusTACGTAAATGCTGACTAGAGTGTCATGATTCAG
DBD MethylPlus ATCGTAAATGTCATGCGTCATTGTACTGATCTCAG
DBD MethylPlus TAGC
TACGAGTTCGTACCTGACTCATGAGCTTCAGATCGATCG
DBD No CpG TAGCTAATGCTGATAATGTCAAGACT
DBD MethylPlus TACGTAATGTAGTCAGCTGCAGATTCAG
DBD MethylPlus TACGTAAATATGATAAGTGTCAGATTCAG
DBD MethylPlus TAGC
TCAGATTGCCAGCCTATAGCATGCATCG
DBD No CpG TAGCTACATCGCTGAATAATGTCAAGTGACT
DBD No CpG TACG
AGCTACTG
TGCA
GTCA
ATCG
GTCA
GACT
TGCA
GCTA
CGTATAGC
ATGCACGT
TGCA
TGCA
ATGC
DBD MethylPlusTGAC
TACGAGCTTCGAGTACCTGATCATAGCTTCAATGCATCG
DBD MethylPlus TAGCTAAATGTCAGTCAGTCTGGACCGTGATTCAG
DBD MethylPlusTACGTAATTGTAAGTGCGTCAGATTCAG
FL No CpG TAGCTCA
ACGATGGTAGTAGCTTAGC
FL MethylPlusAGTCTACAGTCATCGTCAATGCTGCAGTCTCAGATCCTGAGATCTGCA
FL No CpG TAGC
TACGAGTCTCAGGATCTCAGTAGCAGCTATTGCGTACAGTCGTCAGCTA
FL No CpG TGA
CATGACG
TCAG
TCG
AGTC
CAGT
ACGT
CGTACAGT
TAGC
CATAGC
TAGC
TCAG
AGTC
DBD MethylPlusTAGCTACAATCGTCAAGTGTCAATGGTACGGATCTCAG
DBD MethylPlus TAGCTATATTTAATGTCGATCAG
DBD No CpG ATGCTACGAGCTCAGCACTGATAATTGCAAGGACTCGTA
DBD ATGCTCAG
GATC
CATG
AGTCTAGC
TACG
AGTC
TCG
GTAC
CTAGAGC
TCAG
DBD ACGTTCGA
GTCA
ACTG
ATCG
TAGC
TACGATGTCGAGTACTAGAGTCTCGA
DBD AGTCTCGAGATCCATAGCTAGATGCATGACGTACCATGAGTTCGA
DBD AGCTTTGACACTGATCTCTAGCACTCGTCTAGAGTACG
FL AGCTTAGCTACTATATGCATGTACTGATGAC
FL ACGTTGACGACTCATGAGCTTCGATGCATTAGTACCTGAACTCAG
FLAGCT
AGTC
TAGCTACATGCTGTAAATATGCAATGCAGCTGCTA
DBD GTCA
TGCAAGTCGCAGTAAGTCAGTCTCGGCAT
DBDCGTA
TGAC
ACGT
ACGT
TACG
TCGAAGT
TCGAGTAC
CTGA
AGTC
TCAG
DBDGCTATCAGATGCACGTCAGGTACTCAGAGCTCAGGTCTGAGTC
DBDGTAC
TCGAAGTCGAGTCTGAATGCAGTCAGTCTGACGTCA
DBD ATCG
TACG
GACT
CATG
AGTC
TAGC
ATGC
TCGA
GTAC
CTGA
AGTC
TACG
DBDGTCA
CAGT
AGCT
TGA
TAGC
ATG
TGAC
GCAT
CAGT
TACG
AGTC
ACGT
TCG
GCTA
ACTG
DBD TCAG
ACTGATGC
TGCA
TGCA
AGCT
GACT
CGTA
GCTA
GCAT
CTGA
TCGA
ACGT
ACGT
TCAG
TCGA
AGT
DBDTAGC
TCAGAGTTCAGGTCACTGATAGCAGTCATGCTGCAGTCAAGCTGCAT
DBDCAGTTCAG
ACGTAGC
TAGC
TGAC
TAGC
AGTC
TCGA
GTAC
CTGA
AGTC
ATCG
DBDACTGTACG
AGCT
ATGC
TCGA
GTCA
AGTC
GTCA
AGCTTCGA
GATC
CTGA
AGTC
TGCA
DBDTGACTACGAGCTCGCTGATAATGATGCAGTCAAGTCGCAT
DBD CAGT
ATGC
TAGC
TAGCAGCT
TCAG
GTA
CTAG
AGTC
ATCG
GACT
CTGA
DBDTAGCTACAGTATGCTCGAGTCAAGTCGTCAAGTCTCGAGTACCTGAGTCTCGA
DBDGTACTCAGAGTCAGCTAGCTGACTACGAGTCTCGGTACTAGAGTCTCGA
DBD GTATACGAGTTAG
GTCA
CTG
GAC
CTGA
AGC
TCA
ACG
ATGC
DBD TAGC
TACGAGTCAGGACTGAATAGTCATGCAGTCAATGCGCAT
DBD TCG
AGCATG
TAG
TGCA
ACTG
GTAC
CGTA
ACGT
TAGC
AGCT
CATGTAC
ACTATCG
TACG
TGCA
ACT
DBD TAGC
TACGAGTC
TCAG
GACT
CTG
GACTCTATC
TCG
ATGC
ACTG
DBDATCGTACGACACGTCGGTCAATGCGTCAAGTCTGCAGTACTAGTCTAGC
DBDCATGTCAACGAGTAGTGATACGAGCTCGGTCTAAGTCTCAG
FL AGTCTCA
AGCATGGTCAATCGTCAGCATTAGC
FLAGCTTACG
AGTCATTCAGGTCAAGTCGTCAAGCTTCGAGACTCTGAAGTCCGTA
FL TAGCAGTC
TCG
GACT
CTGA
ATGC
ATCG
ACGTGATC
CAGT
ATCGTAGACTG
FL CATGAGTTAGCACTGCAGCTACGTATGCACGATCATGGATCCGTAACGTTGCATGCAGTTCGAGTCA
DBDTGACTACGAGCATCGTCAAGTCGTCAAGTCTGTACTGAGTCTCAG
DBD TAGCTGCAAGTCACTTACGTAGTACGATGCGTCTAAGTCTCAG
DBDTAGCTACGAGTCAGGTACTGAATAGTATAGCGTCAATCGGCATGCTA
DBD No CpG
No CpG
POU TFs
22
Methyl Control RFX7
RFX5
RFX5
RFX3
RFX3
RFX2
RFX1
RFX4
0.05
DBD No CpG CGTAGTAGCTCAGATCTGATCGAAGTCTCGA
DBD MethylPlusGCTAGACTTGCATCAGGATCCTGATCGAAGTCGTACGCATCGTAGATTCAGTCAGGATCCTGATCGAAGTCGTAC
DBD Little effectACGT
CTAG
GACT
GACT
CTAG
AGTC
ATGC
CGTA
CGAT
GCAT
TAGC
TCAG
GATC
CGAT
CTGA
AGCT
TCAG
DBD No CpG CGTAGATCTCAGATCCTGCTAGTTCAGGAGACCTAGAGTAGCTGCAT
DBD No CpG CGTAGCTGTCGACCTCTGATAGAGTGCTGAGAGCCGAT
DBD No CpG CGTAGATCTACGATCCTGCTAGTTCAGAGACCTAGATGACTGCAT
DBD No CpG CTGAGATCTACGATCCTGCTAGTTCAGAGACCTAGATGACTGACT
DBD No CpG CGTAGTTACGATCTCTAGTCGAGACTAGATGACGCAT
DBD CGTGCTCTCGATCGTATCGAGTCTCAG
DBD CGTAGACTTGCATACGGATCCTGATCGAAGTCTGACGCATCGTAGATCGATACGGATCCTGATCGAAGTCTGAC
DBDACTG
TCAG
AGCT
GACT
CTAG
ATGC
ACTG
CGTA
CGATGCAT
TAGC
TACG
GATC
CGAT
TCGA
ATCG
TAGC
DBD CGTAGATCGTCAGATCCTGCTATGCTACGGAGACCTAGAGTAGCTGCAT
DBD CGTAGTTCAGATCCTGATACGAGCTGCTAGTAGCTGCAT
DBD CGTAGATCGTACGGATCCTGCTGATGCTACGGACGACCTAGATGCAGCCTGCAT
DBD CGTAGATCTACGATCCTGCTAGTTCAGAGACCTAGATGAGCTGCAT
DBD CGTAGATTACGATCCTCTAGTCAGAGACTAGATGACTGCAT
RFX TFs
Methyl Control NFKB2
NFATC4
NFATC4
NFATC3
NFATC3
NFATC3
NFATC2
NFATC2
NFATC1
NFATC1
NFAT5
0.1
DBD No CpG ATGCGACTGGTGATCAGTCATCGGTACCTAGACTCACGTATGAC
DBD MethylPlus ATCGAGTC
CTGGACAACTGACTGTACG
DBD MethylPlus TGAC
TGACTGCA
TGACCGCATGAGTTCGTCGATCATCGATCGACTGACGT
DBD MethylPlusAGTCAGTC
CTGGAAACTACGTTACG
DBD MethylPlus TGCATGACTGCATCGACGTCATGGATCTGTCGCTACTACGTACTGACTG
DBD MethylPlus AGTC
CTAGGTGCTATGCACACTGACGTATCGTCGACGTAAGCTTAGCTGCATGACTGATCGACGCGGATCTCAG
DBD MethylPlus TGCATGACTTGCCCGACTGGAAACTGACTG
DBD MethylPlus TGACTGACTTCCGATCTCAGTACGATGCAGTCCTAGGGAAACTGACTG
DBD MethylPlus TGACTGACTTCCCGATCTAGGACAACTGACTG
DBD MethylPlus TGACTGACTTGCCGATCTCAGTACGATGCAGTCCTAGGGACAACTGACTG
DBD MethylPlus AGCT
CTAGGGCTACTGAGCTATGCAGTCGTACTCAGACTGCGTGCAT
DBDAGCTGTAGTGTGATAGTCATCGGTACCTAGACTCACGTGTAC
DBD AGCT
AGTC
TCAGGACAACTGACGTTACG
DBD TGCA
TGCA
TGAC
TGAC
CGTA
CAGT
AGC
TCA
GTAC
GCTA
ATCGACT
ACTG
CAGT
DBD AGCTAGTC
TCAGGGAAACTGACGTTACG
DBD TGCATGACTGCA
TGCACGTCGATAGCTTCGAGTCGCATACGTAGCTACTGACTG
DBD AGTC
TCAGGTGTCAAGTCAGTCACTGACGTATCGTAGCGTACATGCTACGTGACTGACTCAGTCGACGTACAGTCTCAG
DBD TGACTGACTGCATACCACTAGAGTCGATGTACGATGCACTGACTG
DBD TGACTGACTTCCAGTCTCAGTCAGAGTCAGTCTCAGGGAAACTGACTG
DBD TGACTGACTTCGCAAGTCGCGACAACTGACTG
DBD TGACTGACTTCCAGTCTCAGTCAGAGCTAGTCTCAGGGAAACTGACTG
DBD GACT
TCAGGGTCAGCTACGTATGCGACTGTACTCAGACGCGGCAT
RHD TFs
Methyl Control SKOR1
SKOR2
GMEB2
GMEB1
0.1
DBD No CpGTCGAATGC
ATGC
CAGT
TGAC
GTTGAATTAACCTGA
DBD No CpGTGACATGC
AGCT
CAGT
TGAC
GTTACATTAAACTGCTA
DBD MethylMinus TGCA
TGCA
AGCT
CTAGGAC
TCGA
AGCT
CAGT
CGTA
GTCA
TCGA
AGCTCTG
GATC
TCGA
ACGT
ACGT
FL MethylMinus TGCA
TGCA
AGCT
CTA
GTAC
TCG
AGCT
AGCT
TCGA
TCGA
ACGCGTGTTCGAATCGACGT
DBDATGCATGC
AGTC
CAGT
GTAC
GTTGAGACGTGCATCGAGACTGGCTA
DBDTGCAATGC
AGTC
CGAT
TGAC
GTATAATTAACTGTCA
DBD CGTA
TCGAAGTCGATCAATGCCGATGCAGCTATACGAGTCCTAGTCAAGCTGCAT
FL TGCA
TGCAAGTC
CTGATTCGACGTACGTATGCTGCATGCAAGCTAGATCAGACTGACGT
SAND TFs
23
Methyl Control TBX21
EOMES
T
T
TBX19
TBX20
TBX20
TBX20
TBX20
TBX18
TBX15
TBX1
TBX2
TBX3
TBX6
0.05
DBD No CpG AGTCAGTC
GCTAGTCGGTCAGGTCAAGTATCG
DBD No CpGAGTC
AGTC
GCTAGTCTCGAGTCAGGTCAAGTCATCG
DBD No CpGAGTCAGTC
CGTAGATC
TCGGTCAGGCTAAGTCATCGATGCTACGTGACTCAGCAGTAGTCCAGCTAGCGATTCAGCTAG
DBD No CpG TGACTCAGCAGTAGTCCTGAGCTAGCGATTCAGAGTCGCTAGATCTCGGATTCAGGTCAAGCTACTG
DBD No CpGATGCAGTC
CTGAGATC
TCGGATCAGGTCAAGTCACTGATCGTGACTCGACAGTAGTCCTAGCCTAGCGATTCAGTACG
FL MethylPlus AGTC
AGTC
GACTGTC
TCAGATCAGGTCAAGTGATCGCATGTCTCAGTCAGGTCAAGTTAGC
FL MethylPlus TAGCTCCAGTATGCAAGTCGACTGTACATCGAGCTGATTCGAGTCTCAGTCAACTGATCG
DBD MethylPlus AGTCAGTC
GACTGCTTCGGTCAGGTCAAGATGCCGATGTCACTGGATCAGGTCAAGCATCG
DBD MethylPlus ATGC
AGCT
GCTAGCTCGGTTCAGGTCAATATCGATGCTAGCTCAGTAGTCCAAGCCCGTATCGATACG
DBD No CpGATGC
AGTC
AGTC
GCATGATTCGAGACTACGGTCAAGTCATGCAGCT
DBD No CpG AGTC
AGTC
GCATGTTCGAGTCAGGTCAAGTCATGC
DBD No CpG GTAC
GTACATGCGTCAGACT
TCAGATCAGGATATCGAGTCTAGC
DBD No CpGAGTC
AGTC
GCATGACTTCGAGTCAGGCTAAGTCACTG
DBD No CpG GATCAGTC
GCATGTCGTCAGTCAAGTATGC
DBD No CpGAGTC
AGTC
GCATGCTATCGAGATCTCAGGTCAAGTCATCG
DBDGATC
AGTC
GCTAGTTCGGTCAGGTCAAGTCATCG
DBDGATC
AGTC
GCTAGTCATCAGTCAGGTCAAGTCATCG
DBDGATCAGTC
GCTAGATC
TCGGATCAGGTCAAGTCATCGATGCTACGTGACTCGACAGTAGTCCTAGCTAGCGATTCAGTCAG
DBD TGACTCGCAGTAGTCCTAAGTCTAGCGATTACGATGCGCTAGATCTCGATTCAGGTCAACGTACTG
DBDGATCAGTC
CGTAGATCTCGGATCAGGTCAAGTCACTGATCGTGACTCAGCGATAGTCCTAGCCTAGCGATTCAGTCAG
FLAGTC
AGTC
GACTGTCATCAGGTCAGGTCAAGTCGATCGACTGTCATCAGGATTCAGGTCAAGTCATGC
FL TGACTACCAGTAGTCCTAAGCGATCTGATACGATGCGACTGCTATCGGATCAGTCAACTGATCG
DBD GATCAGT
GATCGTCTCGTACGGTCAAGTAGTCGCATGTCTCAGTCAGGTCAAGTATGC
DBDGATCATGC
GATCGCTCGGTCAGGTCAAGATCGTACGTAGCTCCAGTAGTCCAGCCGCTAGTCAGCTAG
DBD GATC
GATC
AGCT
GACTGATCAGACTTGACGCATATGAGTCAGCT
DBDAGTC
AGTC
GCTAGTC
TCAGGTCAGGTCAAGTCAGTC
DBD GTCA
AGTC
AGTCGACTGCTTCGGTCAGGTCAAAGCTAGCT
DBDGACT
ATGC
GCTAGCTCGAGATCGAGCTAGATCGCTA
DBD GATC
AGTC
GCATGCATCAGTCGAGCTAAGTCAGCT
DBD GATC
AGTC
GCATGCATCAGTCAGGTCAAGTCATGC
TBX TFs
Methyl Control GCM2
GCM1
RUNX2
RUNX3
YBX1
LIN28B
SMAD5
TEAD1
TEAD2
MYBL2
0. 1
FL Inconclusive AGCTGACATGGTAGGTCAAGTC
DBD Inconclusive AGCTGAGACTGTACGGTCAAGCT
DBD MethylMinusCGTA
ATCG
AGTCACGTCACTAAGTCCAAGCTAGTCATGCATGCACGCACAAGTCCAAGCTAGTCACGT
FL MethylMinus CTAG
ATC
AGCAGCCAAGTCAGCAGTATAACAGCAGCTCTGAACGTAGCTACTG
DBD No CpG TCAG
GATC
TCAG
ATCG
CATG
CTATGTCACA
FL MethylMinus CAG
GACT
CAG
GTA
AGTC
TAGC
AGCT
TACG
AGCT
AGCTCTAG
AGTCGATCCTGA
GTAC
DBD MethylPlus CTAGGTTAGCCATCGAAGGCATACTGCTAGTC
FL No CpG CTGA
GATCCAATTAGCGACTAAGTC
FL No CpG CTGA
GACCATTAGCGCTGATGCTACG
DBD MethylMinus TGAC
TACG
AGT
AGTCTCGGATCATCAGATGCACTG
FL AGCTTCGACATGGTAGGTCAGGATC
DBD AGC
TGCA
GAC
CGATGTAGCTAGTAC
TCGA
GACT
DBD CTAG
TACG
AGCTACGTCACATGATCCAAGCTAGTCATCGATGCACGTCAGTCGAGATCCATGAGCTAGCTCAGT
FL CTGA
ATCG
AGTCACCGACAGAGTCATGAACCAGCGACAGAGTCGACT
DBD TCAG
GATC
TCAG
ATCG
CAT
CTATTCAC
FL CA
GATCAGTAAGTTAGCAGTTAGCAGTCAGCTCTAGTCGACTCGGATC
DBD TCAGGACTGACCAGTGCACGGCAACTGCTAATCG
FL CTGA
GATCCAAGTTAGCGACTGAGTC
FL CTGA
AGCAATTAGCCTATGCTACG
DBD TGAC
TAGC
AGTATGCGCGTCATCAAGTCACGT
Other TFs
24
Methyl Control ZNF385D
DPF1
ZBED1
MBNL2
ZNF821
ZBTB2
OVOL2
OVOL2
OVOL1
ZBTB33
ZNF597
ZNF704
ZNF281
ZNF740
ZNF740
PRDM4
PRDM4
BCL6
BCL6
BCL6B
BCL6B
ZNF32
ZNF396
ZIC1
ZIC1
ZIC3
ZIC3
ZIC4
ZIC5
GLI3
GLI2
GLIS1
GLIS2
EGR2
EGR3
EGR1
EGR4
ZBTB7B
ZBTB7A
DBD Little effect TCAG
CTGA
GTCTCAG
CTGGCACTA
GAC
ATGC
CAGT
GACT
AGTC
DBD No CpG GTCA
CAGTCATGTAGGCTAGACTTGCAGATCACTG
DBD MethylMinus ACGTTCGA
AGCTAG
CGT
GATC
CTAG
GTAC
ATGC
TCAG
AGTC
TGCA
FL MethylMinus TAGC
TCAG
GTCACTGA
TCAG
TACG
CTAG
GACT
CTAG
TCAG
TCAG
CTAG
FL MethylPlusACTGGATC
GTAC
AGCT
CTGA
AGT
GATCACCTAGATCGTACACTAGATCGTCA
DBD MethylMinus GTAC
TAGCTACG
TACG
CATCGGCGTTGAATGACTGTCAG
DBD MethylMinus ATGC
TAGC
ATCGCAGCTGAGTCTAGTCTCGATAGCTCAGATGC
FL MethylMinus AGTC
TAGC
ATCGCAG
CATGGTCTAAGTCTCGATAGCTCAGGTAC
FL MethylMinus AGTC
AGTC
ATGC
ATCCCATGTTATCGATGACTCAGGCTA
DBD MethylPlus AGCT
GACGCGATCATACTGTACGTCATTGACATGACCAGTAATTCAGAGCT
FL Inconclusive GATC
GTAC
CATG
GCAT
GTACACATTCGATAGCTCGATCGTAC
FL MethylMinus CTAG
GACTCGTCGAGCACGTCAGGCTCTGAGATC
DBD No CpG GATC
CAGT
CAGTCAGT
CAGT
TAGCAGT
CAGT
CAGT
CATGCATG
GATC
FL MethylPlus CTGA
CTAG
GACTCAGTCATCATCACACATCCGATACGTCTAG
DBD MethylPlus CTGA
TCAG
GTACCGATCTG
CGTACAT
CTAGCTACA
CGT
ACTG
CTA
DBD MethylPlus CTGA
GATC
GATCTAGATGTTGTCTGACTAGGTAGCATTGACTGCAACGTCTC
DBD MethylPlus CTGA
GAT
GATCTA
GATGTTGTCTAGTCATGTCGTACCGATTCAGCTGACAGTCTCAGT
DBD MethylMinus ATGCTCAG
GATC
CATG
TAC
TCAGTACTTCGAATGATGTCAATGCATGCTCAGTGAC
DBD Multiple effects AGCT
CTGAGATCTCAGATCGATCGTACTTGCAACTGATGTCAATGCATGCTCAGTAGC
DBD MethylMinusTCAGTCAGGATCCTATACTCAGTCTTCGAAGATGTCATGATTACGTGAC
DBD Multiple effects AGCT
CTGAGTCATCATCTCTTGCAGAGTAGATTACGTAGC
FL MethylPlusAGCT
CTGAGACTACGACTGATCGCTGACAGTCTGAGATCATGCTCGAACGTCTGACGTA
FL MethylMinus CAGT
TCGTCCAGTCGAAGTCATGCATATATGC
FL Inconclusive GTCA
AGCCATCATCATCCATCGACTTGCAGTAGTCATG
DBD Inconclusive GTCAGCCACATCATCCATCGACTTCGAGTAGTCATG
DBD InconclusiveACGTGTCA
AGCCACACATCCATCGACTGCAGTACGGTCATG
FL Inconclusive GTCA
AGCCACATCATCCATCGACTGTGGTGCATG
DBD Inconclusive GTCA
AGCCATCATGCATGCACAGTTCAGACTGATGCAGATACGGTCCATG
DBD InconclusiveAGCTGTCA
AGCCACATCATCCATCGACTGTGCAGTAGCGTCACTG
DBD Multiple effects AGCTGTAGCCCACTCCACTAAGCATGGACTTAGCATGCGCTA
DBD Multiple effects AGCTGTCAACGCCACTGCCACTAAGCATGGACTTAGCTACGGCTA
DBD MethylMinus GTCA
AGCCCCTACCACTAGTCGTAGATCGATCATCGGCTACATG
DBD MethylMinus AGCCACCTACCACTAGAGTCCTGAGACTAGTCATGCGCTACATG
FL Little effectTCAG
CATCGATCCCTACGATCTAGCTCTAG
FL Little effectCATG
CATCTGATCCACCTACCAGATCCTGAAGCTCATG
DBD Little effect CTAG
CATGCTAG
GATCCATGCAGTCTGAACTGCTGATCCTAGACGTCTAG
DBD MethylPlus CTAG
CATGCTA
GATCCCCTGACGTCGATCCTGAAGCTCATG
DBD MethylMinus AGTC
CAGT
GCTA
ACTGCTCAACCTCGTAGACT
DBD MethylMinus GATCAGGCACTCGCAACCAGCATGACTACTG
DBD CATG
CTAGGATTACGCTGGCATCATGGACTAGTCATGGATCGTAC
DBD TGCA
CAGTCATTAGGTCAGACTTCGAGATCACTG
DBD CAGTTAGCAGTCGACTGACTATGTGCA
FL TACG
CTAG
GCATCTA
TCAG
TACG
CTAG
GCATCTAG
TCAG
TCAG
CTAG
FL CATG
GACTGTCAACTG
CTAG
AGCT
GATCAGCCTAGAGCTGTACACGTCTAGAGTCTGCA
DBDGTAC
TCGA
TCAG
TCAG
CATGCGGCGTTATGCACTGCATG
DBDATGC
TAGC
ATCGCAGCGTGTCGTAAGTCTCGATACGTCAGGATC
FL GATC
TAGC
ATCGCCGGTCTAGTCGAGTACTCAGGCTA
FL ATGC
AGTC
ATGC
ATCCCGTTATCGATCGATCAGGCTA
FL GCAT
GTAC
CAGT
CGAGTACACATCTCAGTATCAGTACTGAC
FL CTAG
GACTCGACGTGCACGTCAGGTGCCTGAGATC
DBD GCTACTAGCAGTCTCATGTACCACTAGCTGACATACTG
FL CATG
CTAG
GACTCATG
CAG
CATG
CATG
CATGCAGTCGTCAGTACTGCTAG
DBD CTAG
TCAG
GACTCGATCAG
CATGCATCATG
CATG
CATG
CAGT
ACTG
CTAG
DBD CTGA
AGTC
AGTC
CTAG
ATCGGTTCTGCTACTATCGACTGGTCAGTACCATGCTAGCAGTCATGCTCATG
DBDATCGTCAGGATC
CATG
TACG
TGCATACTGTCAATCGGATCGTCAAGTCATGCTCAGTGAC
DBDAGTC
CTGAGATCTCAGATCGATCGTGCACTGGTCAATCGGACTGTCAAGTCATGCTACGTACG
DBDGTCA
TCAGGATC
CTA
TAC
TCAGTCTGTCATGATGTAGTATTACGTGAC
DBD GACT
CTGAGTCAACTGATCGTCGTCATGAGTAGTATTACGTGAC
FLAGCT
TCGAGATCTACGATCGATGCCTGACAGTTCGAGATCAGTCTCGAACGTCTGACGTA
FL GCATTCGTACCACGTAATGCATATGCTA
FL GTCA
AGCCATCATGCATGCCACTGACTTCAGGTCAGGTCCATG
DBD GCTA
AGCCATCATGCATGCCAGCTAGGACTGTCAGGACTAGGTCCATG
DBD ACGTGTCA
AGCCCCACCCTGACTGGTCAGGTACTG
FL GTCA
AGCCCACATCCCTGACTGTGACGTCAGCAT
DBD CTGA
AGCT
CATG
CAGT
CATGCAGTCAGTCTAGACTCTGATCGAGATCCTAGGTCACTAG
DBDCAGT
GTCA
AGCCACAGTCAGTCCACTGACTGTCGAGATCAGGTCACATG
DBDACGTGTCAACGCACACTGCCACATAGCATGGCATTAGCCTAGGCTA
DBDACGTGTCAACGCCACTGCCACATAGCATGGCATTAGCCTAGGCTA
DBDCTGA
ACGT
CTACAGCTAGCGTCAGCTGAAGCTCGATGACTATGCCATGGCTACATG
DBD AGCCACGCTACGACATCTAGATCTGACTATGCCTAGGCTACTAG
FL CTAG
ACTGCTGAGATCCCACTAACCGATCCTAAGCTCATG
FL CATG
ACTCGATCCCCTACCAGATCCTAGTCCATG
DBD CATG
CATGCTAG
GATCCATCATGCTAGACGTCTGGACTCTAGACGTCATG
DBD CTAG
CATGCTA
GATCCCCTACGCGATCCTGAGCTCATG
DBD GATCCGTGATCACTCTCAACCACGATGCAT
DBD GTAC
CGAT
GATACTCCACCTACTAGGACTACTG
Zinc finger TFs
25
Methyl Control
KLF17
KLF17
KLF5
KLF3
KLF3
KLF12
KLF12
KLF6
KLF4
KLF2
KLF14
KLF16
KLF13
KLF13
SP1
SP3
SP9
SP8
SP2
KLF10
KLF11
KLF15
KLF15
YY2
YY1
YY1
ZFP42
ZNF784
ZSCAN4
ZBTB18
ZNF296
ZNF460
ZNF177
ZSCAN9
ZSCAN23
ZNF250
ZNF140
ZNF345
ZNF660
ZSCAN16
ZSCAN16
DBD MethylPlusTACGGACT
CATGCTAG
ACGTCTAGATCCACAGCTATAGCTACG
DBD Little effect CATG
ACGTCAGT
CGAT
ATCG
CTAG
GCAT
CATG
ATGCCGAT
CAGT
CTAG
CATG
TCAG
TCAG
DBD Little effect GACT
CATGCTAG
ACGTCTGATCCTAGCAGTCTAGTACG
FL MethylPlus GACT
AGCCGACGACCATACTGACTCCCTAGTC
FL Little effect GATC
GACT
CGAT
CTAG
AGCT
CAT
GATCCATGCAGCTAGATCG
FL MethylPlus AGTC
GATC
CGTACGGACTACTCGACTCTCTCTGATCG
FL MethylPlus GTCA
GACT
CATGCGAACGTCGACCCCTATCG
DBD MethylPlusTCGAGACT
CATG
CGA
AGCCGACCCTGAATCG
DBD Little effect CTGA
GACTCTAG
CAGT
ACGTCTG
GATCTCAGCTGATCG
DBD Little effectCGAT
AGCT
CAGT
CGTA
ACGTCGACTCGCGATCTGACTG
DBD MethylPlus CTGA
GACT
CATGCTAG
ACGTCATGATCTCACTACATGCTAGCTAG
DBD MethylPlus GACT
CATGCTAG
ACTGCGATCCCTAGCTACATG
DBD MethylPlus CTGAGACT
CATGCGAT
ACGTCGATCCCTCATGCTAGCTAG
FL MethylPlusCTGAGACT
CATGCGAT
ACGTCGATCCACTCATGCTAGCTAG
DBD MethylPlus TCAG
ATCG
AGTC
GACT
CATG
CTGA
ACGTCTAGATCCCCTACTGCTAGTACG
DBD Little effectCGTAGATC
CATG
CTAG
ACCGATCTCCTACTGCTAGCTAG
DBD Little effect GACT
CTAG
CATG
ACTCTGATCTGCAGCTGACTGCTAGCTAG
DBD Little effect GATC
CATG
CAGTACTCGATCTCGCTGACATGCTAGCTAG
DBD MethylPlusATCGTCAG
ATCG
ACTG
GCAT
TCGA
CAT
CTGA
CATG
GTCACTGACAGCTAGCATGCTAGTACGTCAG
DBD MethylPlus GACT
CATGCGAAGCGACCCTCATGCTAGGCATCATGCACGACCCTACATGCTAG
DBD MethylPlus GACT
CATG
CATG
ACGTCAT
GATCCCCTCATGCTAGGCTACATGCTAGACGTCTGATCGCGACTAGACTGCTAG
DBD MethylPlus GATC
CATG
CGAT
ACGTCAGATCCATCCTAGCATGCTAGCTAG
FL MethylPlus GAT
CAT
CTAG
ACCGATCCCTCATCTAGCTAG
FL Multiple effects GATC
GTACCATGCGATGTACCATTCGATATGATCAGTC
FL MethylMinus CGAT
GTAC
CATGCACTTCAGTGATTGAGATCGATCCTGAAGTCATGCTAGCTAGCTCAGGATCTAGCTGATCGA
FL Inconclusive GATC
GTAC
CATG
GCAT
GTAC
CATGCATTCAGTAGCTGTACGTAC
DBD Multiple effects TGACGATCGATCTGAGACGCACATACTGTTGTACGTAC
FL MethylPlus GCAT
TCGAACGCATGCTAGTCAGACGCTACTGAGTCATCAG
DBD InconclusiveCGAT
TCAG
GACACACTAGCATGCATAGGTCAACTGACTGAGACGTTACG
DBD No CpGAGTC
TAGC
TGAC
CAGTCATGCACTGTGCAGTCAGGTACCGTA
DBD No CpG TCGA
AGCT
GCAT
TGCA
GCT
GAC
ATGC
CAG
AGT
GCTA
TCGA
DBD MethylMinus CGAT
ACGT
ACGT
CATG
GTCACTAG
CATG
CGAT
CAGT
CAGT
CTGA
GCAT
CATG
DBD Inconclusive CGTATGCA
TACGGATAGTCTTGCAACGTGATCGACTGTCAGTCACAGTACGTCAGTAGTGCATTCCGATTTGAC
DBD No CpG AGCT
AGCT
GTACGATACATAGATAAGACTATGTGCACATGACGTCTAG
DBD No CpGAGCTTCAG
CTAGAGCTGGACTCGCATACAGTCTCAAGCCAGCTACTGAGTC
DBD No CpGAGTCTCGAAGCT
GATCGACCTAG
CTAG
TCGA
AGCT
TCAG
DBD Little effect ATCG
GACCATGAGTTCCTAGACATCCTAGCT
DBD Multiple effects TCGA
TCAGGACAAGAGCACGTCTGAGACTATCGAGCTCTGAATCGAGCTCTACGGTCTGCAAGCTCTAGCTGA
FL No CpG ACGT
TCAGTGCACTTTGACACGTCTGACTCAAGCTCTAGCTAGCTTACGAGCTCTAG
DBD No CpG AGCT
AGTC
GATCTCGGTTAGTATCATGAGCCATCCTAGC
FL No CpG AGCTAGTC
GTACTCAGGTTGAAGTATGCATCGAAGCCATCCGTATCG
DBD CATG
ACTGCAGTCAGTATCGCTAGACTCATGATGCCGATCGACTAGCAGTTCAGTCAG
DBDAGCT
CATGCT
ACTCTA
GATCCTGA
CAT
CTAG
CATG
FL
GATC
AGCT
CGATCTAG
AGCT
CAT
GATCCACCTATCG
FL GTAC
AGCTCATCA
ACGCTGACTCTCGCTGATCG
DBDGCTA
GACT
CAGT
CAGT
ACGTCTGACCGACATGACTG
DBDCGAT
AGCT
CAGT
CATG
ACGTCTA
GATCCTCATGCTGAACTG
DBDCGAT
AGCT
CAGT
CATG
ACGTCTGACTCGTCGACTGAATCG
DBDGCAT
AGCT
CATGCTAG
ACGTCATGGATCCTACGACTAGCATGCTAGCTAG
DBDGACT
CAGTCATG
ACGTCTGACTCTAGCAGTCTAGCATG
DBDCGAT
GACT
CAGTCATG
ACGTCAGATCCACAGCTCATGCTAGCTAG
FLCAGT
GACT
CATGCATGACGTCGATCCCTCATGCTAGCTAG
DBD TCGA
ATCG
AGCT
GATCATCTACCGATCCCTACTCTAGTCAG
DBDGCTAGACT
CATGCTAG
ACCGTACCCTACTGCTAGCTAG
DBD GACT
CATG
CATG
ACTGCGTGACTCATCTCTAGCATGCTGACTAG
DBD GACT
CATGCTAG
ACTGCTGGATCCTACGACTGACTGCTAGCTAG
DBD CAGT
TCGA
ATCACTG
GCAT
CTAGCA
CAGT
CGTA
GACTCTCGTACTAACGTCTATCATCAG
DBD GACT
CATGCATG
AGCCATAGTCCCTCATGCTAGGCATCATGCATGACGCTAAGTCCCCTCATGCTAG
DBD GACT
CAGT
CATG
ACGT
CTA
GATCCCACTACTGCTAGGCATCATGCATGACGTCTGATCCTCGCTACTGCTAG
DBDGACT
CATG
CATG
ACTGCTGCATCTAGCAGTCTGACATGCTAGCTAG
FL GACT
CATG
CATG
ACTG
CTAG
GATCCTAG
CATG
CTAG
CATG
CTAG
CTAG
FLGTAC
TGACCATGCGAGTCCATTCGATATGATCATGC
FL CGAT
GATC
CAGTCACTCTGATGATTGACGATCGATCCTGAATGCATGCTACGTAGCCTAGGATCTCGAGCACTGATGCA
FL GCAT
GTAC
CAGT
CGAT
GATCCAGCATTCAGTGATAGCGTACGTAC
DBDTCGAGATC
GATC
CGTA
AGCTGATCATGCATTCACGTTAGCTAGTACGTCA
FL GCAT
TGCAACTACTGATCAGAGCTCTACGTAGTACCTAG
DBDGCAT
TCAGGACCTACACGCTAGCGATCAGTTGACGTCAATCGACTGAGCTAGCTTACG
DBD AGTC
TAGC
TGAC
CAGCATGCACGTTGGTCAGTGACCGTA
DBDTGCA
AGCT
GCAT
TCAGCGTCATCCGATAGCTCGTATCGA
DBD CGAT
AGCT
ACGTCTGTCCCCCACCGACTACTG
DBD CGTATCGA
CTAGGAT
AGTCTGTCAACTGAGTCGCATGTACGTCACATGAGCTCAGTAGCTGCATTCACGATTCTGAC
DBD AGTC
AGCT
GTACGATACATAGATAAGACATGTGCACTAGACTGCTGA
DBDCGTATCGACTGA
AGCT
TGAGACTGCATACAGTCTACGAGCCTAGCTACGTAGTC
DBD CGAT
TCAG
ATCG
GCTAGCT
CT
CGTA
TCG
AGTC
CTGA
DBD ATGC
GACCATAGTTCACTAGACATCGACTACGT
DBD TCGA
TACG
GACAG
AGTAGCACGTTCGAGACTGACTAGTCCTGAATCGAGCTCCTGAGCTTGCAAGTCCTAGCTGA
FL AGCT
TCAGTGAACTTTGACACGTCTGACTGCAAGCTCTAGCTAGCTTACGAGTCCTAG
DBD AGCTAGTC
GTACTCGTTAGATCATGAGCCATCCTAGC
FLACGTAGTC
GTACTCAGGTTGAAGTATGCATCGAAGCCATCCGTTACG
Zinc finger TFs
26
Methyl Control
ZNF501
ZNF713
ZNF713
ZNF454
ZNF454
ZNF23
ZFP1
ZNF12
ZNF343
ZNF684
ZSCAN31
ZFP41
ZSCAN29
ZNF75A
ZNF75A
ZNF263
ZNF449
ZNF449
ZNF282
ZNF771
ZNF771
ZNF787
ZNF787
ZSCAN5
ZNF384
ZNF274
GFI1
GFI1B
ZBTB14
ZBTB14
MTF1
PRDM1
ZNF410
ZNF174
ZNF76
FL MethylMinusCAGT
GCAT
GACT
CGAT
GCAT
ACTG
CTGA
GCAT
CTAG
GACT
ACTG
ACTG
CATG
ACGT
CATG
DBD No CpG TAGC
AGCT
GAAACAGAAATGACCAATAGTGAAATGCAGTCGCAT
DBD MethylPlus TACG
ACTGGAACTGAGAACGATTCGCACATCGATGAACAGCTAGTCCGAT
DBD Little effect TAGC
GAT
GACCGTGTACCTACAGTAGCGTAGACGAGACCTCTAGATCG
DBD Little effect TAGC
GATC
GACTCTAGCTCATGTAGCATGGTACTGACTAGATCG
DBD MethylPlusGTCA
GTCA
GTCA
GTAC
CAGTGATCCGTAGTGCTCAGCAGTAGCTGAGTACGCGCATTGACGATACG
DBD No CpG CTGATACG
TAGC
TCAG
TCGAAGCTTCGATCGCAGTCCTAATCGGATCCATGTACG
DBD MethylPlus GACTGATGTACGCATACGTTCGATCCGTTACTGACTTCAGTTCAGATCGGTACCGATGATCTCGAAGCT
DBD CGAT
CTAG
GACTTCACGTCTGACTGAGATCCTAGGACTGCATCTAGACTGGACT
FL MethylPlus AGTC
TCGAAGCT
CTGA
ATCG
GCATTGACGATCTAGAGTCCGTACATGCTAGCTTACGTCAGTGACAGCT
FL MethylPlus GATC
CTGA
ACGTATAGCTATCGAGCCTACATCCTGACTATGACGTACCTAGCATG
FL Inconclusive CTGAGACATGTCAGACTACTCCTCCAAGCTCTAGAGCT
DBD CATG
CATG
GACT
TCAGATCTAGAGGACTACTGCTAGATGACCTGATCATCCTAGAGCTAGACGTGACT
FL No CpG ATCGGTCCGATCTTCGATCCACACAGCTCTAG
DBD No CpG CATGGTAC
CGAT
TCATTCGATCTCATCATCCAGCTCTAG
DBD No CpG CGATGCAT
TC
GCAT
CAGT
TCACGA
CAGT
CATG
CTAG
DBD Little effect GACT
TAGCCAGGACTGAATCGGTACCGATCATGACTGGACTCGAACTGTGAC
DBD MethylMinus ACG
CAG
GCTCGCGTCATACTACTCCGAT
DBD No CpG TCAG
TACG
TCGACGATCTCTACTCTGAGCTACGTCATACTGCGATTGAC
DBD MethylPlusTCAGGATCCTAGGATCCATCAAGCACGCCAGTCAGTCGATCCTAG
FL MethylPlusTCAG
GATCCTAG
GACTCAGTCAAGCTACGTCGTCTGAGCCTGATCAGGACTCATG
FL No CpG GATC
ACGT
TCGAGC
CGTA
ACTG
CTGA
GTAC
TGCA
ATCG
CGAT
CTAG
GCATTCGGTA
CAGCTTCTAGAGTC
FL No CpG TACG
GATC
CATGCATCTAGGATCTACGTACTGCTACAGTCTAG
DBD No CpGCAGT
TCAG
GTAC
TAGC
CGATCACTAGCTAGCATGCATGCATGCTAAGCTACAGCTTGACCATGCTAG
DBD No CpG TGCATGCATGATTCAGTCAGTCAGTCGAAGTCGATCGTCAAGCTTGCATGACATGCAGTCAGTCAGCTACTACGACGTACGT
DBD MethylPlusATGC
GACT
TCGA
AGTTGAGATGGCATTGATCACTCTGATCCTGATGAC
DBD MethylMinusGTCA
ACTGAATCATCGATAGCGATCTAGAGTCTCAGTCGATCGACGTAATCTAGTACAGTCAGT
DBD No CpGTGCA
ACGTATATCCATCCGATTACGGATCCTAGAGTCTCAGTCGATCGACGTAATCGCTAGTACGCATGACTG
DBD MethylMinus AGCTCGA
GTC
CATG
GAT
CAGT
GAT
TCGGTCTACTGGATCAGTCACGTA
FL MethylMinus GCATGGCCGGACAGTCGCCACTGCATTGGTAG
DBD Little effect CGTA
TCGATGATCGATGCAGCCAACTCGCTGTACCTAGCGTACTAGTGCA
DBD No CpG AGTC
AGTC
GTAC
TGCAGAACTAGTCAGTCGCTGCGATCGATC
DBD No CpG ACGT
CTAATGTGACCATGCCATAGTGAAGTAGTCTCAG
DBD MethylPlusTGCAGATC
CGTACATGACTAGTCTATCTATCGCTGAGTACGATCATGCATG
DBD InconclusiveACTG
TCAG
TACG
ATCGCCCACTGAACGAGCTGCTACATCTCAGTCAGGATCCGTAGATCCAGT
FL CGAT
GCTA
GCAT
CGTA
GCAT
ACTG
CTAG
GACT
CTAG
GCTA
ATCG
ACTG
CAGT
ACGT
CATG
DBD TACGACGT
GAAACAGAAATGACCATATGATCGAAATGCAGTCGCAT
DBDTAGC
CATGGAACTAGGAACGATTCGGCCTATCGAGAAAGAGTCGCAT
DBD TAGC
GAGACCGCACAGTAGCGTCGTACCGCTCTATCG
DBD TAGC
GATCGACAGCCGGCGTCTGCTAGATCG
DBDGTCA
GTCA
GCAT
TGAC
CGTA
GATC
CGTAGAGATCCAGTCGAAGTTGCGTGATGTACTCAGGACTATCG
DBD CTGATACG
TAGC
TCAG
TCGAAGCT
TCG
ACTG
CATGCTGACTGAATGCGATCCATGTCAG
DBD GCATGTAGTACGCATCATGTCGACTCTGTACGTCGCATTTCATGTCAACTGGTACCAGTAGTCTCGAACGT
DBD CGAT
CTAG
GATCCTTCACTGCGTACGTAAGTCCTAGGACTGACTCTAGACTGCGAT
FL AGTC
TCGAAGCTCTGA
ATGC
GCTATGCA
CGAT
CTA
ATGCCGTACAGT
CTGACTTACGTCAGTGACAGCT
FL GTAC
CTGA
ACTATAGCTATGAGTCCTCTACGTATCAGGACTAGTACTGACCTAGCATG
FLCTGAGACATGTCGAACTGACTCCTCCAGACTCTAGAGCT
DBD CATG
CATG
GACT
CTGA
GATCTAG
AG
GACT
ACGCTGGATGACCTGATCACGCTGAAGTCCTAGAGCTGACT
FL ACTGGTCCGATTCTGCTCTCGCGCATCGACAGCTCATG
DBD CATGGTCA
CAGT
TCAGTTCGATCTCATGCACGTCAACGTCATG
DBD CAGTGCAT
TC
GCAT
CAT
TCACTCAGCATGCTGA
DBD GACT
TACGCTAGACAGAATCGGTCACGACATGATCGGACTCACTGGTAC
DBD GACTCTGAGC
CGAT
CGA
CG
ATCGACCGCAGT
DBDTACG
TACG
TCAGCAGTCACTAGACTGCTGAAGCTACGCTACTGCGATGTCA
DBDTAGC
GATCCTGAGATCCATCAAGCACGCCAGCTCAGTCGATCTCGA
FLATGC
GATC
CTAG
GATCCAGTTCAGAGCTACGTCGTCTAAGCTTCGATCAGGATCTCGA
FL GATCACTGTGC
GATCCATACTGCGTACGTATAGCATGCCATGCGATGCATTAGCGATCCACATTCAGCTGAGACT
FL TAGC
GATCCAGCGATCGCG
AGCT
GAT
TCAG
TGCA
TGAC
ACGT
CGTA
CAGT
CTGA
DBDCAGT
TCAG
GTAC
TAGC
CGAT
CAG
CTAG
CTAG
CAGTCATG
CGATCTAAGCTATAGCTTGACCATGCTGA
DBD TGCA
TCG
TCG
TCAG
TGCA
CTGA
CATG
GCTA
TGAC
CTAG
ATGC
GCAT
TGAC
GACT
GCTA
AGTC
GACT
AGCT
ACGT
ACG
AGC
ACGT
DBDGATCGACT
TCGA
AGTTGCAGAGTGCATTGATCACTCTGATCCTGATGAC
DBD CTGA
ACGTAATCATCGATGAGATCCTAACTGCATGCTGATCGACGTAATGCTAGTACAGTCAGT
DBDTCGAACGTAATCATCCGATAGCGATCCTAGATCGCTAGCTGATGCACGTAATGCCTAGTACGCATGCAGT
DBD AGTC
TCGA
GTCACATG
GATCCGATGACTCGAGTACCAGTACGTCTAGATCTCAGGTCAAGCT
FL AGTC
TCAG
GTCACGACGTCGGTCACCTGTCAGTACATGC
DBDCGTATCGATGATAGCTGCAGCCACGCGGATCCTAGCGTATCAGTGCA
DBDATGC
AGTC
GATC
GTCAGACACTGAGTCAGCTGTACTGCAGATCTGAC
DBD CAGT
CTAGATGTAGCCATGCCATAGCTGAAGTAGTCCTAG
DBDGTACGTAC
CGATCGATGACTAGCTCGCTAAGTCTATGCATCGGTCGATCATACTG
DBDCATG
CTAG
TCAG
ATCGCATCCAGCTCTGAACGTAGCTTGCAGCATCACTGCTAGCTAGGATCCGTAGATCCAGT
Zinc finger TFs
Multiple effects
Multiple effects
27
Methyl Control SNAI2
SNAI2
SNAI1
SNAI1
SNAI3
SCRT2
SCRT1
OSR2
OSR1
ZNF444
ZBTB22
ZBTB43
HIC1
ZBTB37
ZBTB12
ZBTB12
ZBTB26
ZNF580
ZNF580
ZNF580
ZNF524
ZNF276
ZBTB45
ZBTB20
ZBTB32
CPSF4
XPA
BCL11B
ZSCAN1
0. 1
DBD MethylPlus AGTC
AGTCAGAGTGCTGAAGTC
FL MethylPlusGATC
AGTCCAGAGTGATCTGAGATC
FL MethylPlus AGTC
GATCCAGAGTGACTGAGATC
DBD MethylPlusGATC
GATCAGAGTGCTGAAGTC
FL MethylPlus AGTC
AGTCCAGAGACGTGGACTGAAGCT
DBD MethylPlus ATCGGTCAGACAGAGTGATC
DBD MethylPlusTACGGTACCTGAAGTCAGTCATGATCGTATCAGATC
DBD Inconclusive TCAGGACCTGA
TCA
ATCGCAGT
TCGGTATGACGTAC
DBD Little effect TCAGGACTCTTCATCGCTATCGATCTCGAGTAC
FL MethylPlus CGTA
CTGA
GACT
TACGCAGTCACTACCATTCACTACCATCTACAGCATG
DBD No CpG TCAG
TGACACCTACGATCGATGCAGCTAGATGCGTGGACTAGTC
DBD No CpG ATCGGTACTGCCGCTAATCGTCAGAGTCATCGATCGGATCGATCCTAGACTGGCTCTGAACGTATGAC
DBD No CpG CTGA
AGTCTGCGCACTACGTCTAGCGTA
DBD MethylPlus TACG
CTAG
AGCT
CGTA
CGAT
GACT
CTGA
GACT
CATG
TCAG
CTAG
AGCT
CATG
CGTA
GACT
CTGA
GACT
DBD Little effect AGTCGTACCTGCGTGATCGATCCGACGCATTCGACGTA
DBD MethylMinus TAGGACGATCACATACGCCATGCTAGCATTGCCTAGGTACCTGA
FL No CpGGACT
ACTGTAGCGATCAGTCGAACATGCACTGAGCTATGC
DBD No CpG CAGT
CTATCA
ACTGCATGCTCTAGTCAGCTAGGACTCAGTCTAGTCAACTGCACTCTAGTCAG
FL No CpG CAGT
CATG
TACGATCG
CTAGCAT
CATG
TCAG
CATG
CATG
CAGT
CAGT
CATG
TACGATCGCATGCAGTCTAGTCAG
FL No CpGCTGA
AGCTTATATCGTGTAACTGAATAGTAGCAGTCTCAGTAACTCCATGTCAGAGTC
FL MethylPlus CATGCTGATAGCCTGCACGTACACGACGATCCTAG
DBD No CpGACGT
TGCA
TAGATAGGA
GACT
TAGC
GACTGTACGACGTGACATGCGCTATAGCAGCGTAACGTCTGACTTCGTAATGCACTGGCAT
DBD No CpG TGACCTAG
ACGT
CTAG
CGATTCGAGTCAGAGGTCACAGT
DBD MethylPlus TAGC
TCAGAGTC
ATGC
TCG
GCAT
TCGAGTTCAGAGTCGTCAACGT
DBD No CpG TCAGGATTCGACTAGTGTAGAGTCATCGTCAGATCGTCAGTAGCTAAGTC
FL No CpG CATGCATG
CATG
TAGCCATGCATGATGCCGATCAGTATGCCATCGATCTACTATAGCCTACATCATGCTACAGAGTCCTACAACGTATGC
FL No CpG CGTA
CGA
AGCTCTCGT
TCGA
CTAAGCTACGCTGA
DBD Little effect GCTCGATACGACCTGATCAGAGTCACTGCATGGACTCTTAACTAGCAT
DBD InconclusiveCGAT
TCAG
GACCACACTAGCAGTCATTAGCGTCAACTGACTGAGCTACGTTACG
DBD AGTC
AGTCAGGTGGCTAGTC
FL AGTC
AGTCCAGAGTGACTGAAGTC
FL AGTC
GATCCAGTAGTGACTGTGAGACTGAAGTC
DBDGATC
GATC
CATG
ATCG
GACTGATGGATCTGAAGTC
FL AGTC
AGTCTAAGGATCGCTGGATCTGAAGCT
DBDATCGGTCACTATCACAGAGTGTAC
DBDATCGGTCACTATCGACAGAGTCGATC
DBD TCAGGCATCAT
TC
ATCGCGATCAGGATCTGCATGAC
DBD TCAGGACTCTTCATCGCATCGATTCGATGAC
FL CGTACTGA
GACT
TACGCTGACACTCTCATCACTCACCTACTCATG
DBD TACG
TGACCACGCTTACGATCTCGAATCGAGCTTACATGCGTGGAACTGATGC
DBD ATCGGATCTGCTCATCGTCAGATCGATCGATCGGATCGATCCTAGATCGACTGAGCTAGTGCA
DBD CTGA
GACTGCGCAACTACTGCTAGCGTA
DBDATGCTGACGTACCGCATGACTACGAGCTGACTGACAGTGACCGATCATGGATCATGCTCAG
DBD AGTCGATCTGGAGTCAGTCCGCGCATCTGACAGT
DBD GCATGGCCATGCGTACGTAGTGCCTAGGTCATAGC
FLAGTC
ACTGTGACTCGAGTCGAAATGCATCGAGCTAGTC
DBD CGAT
CAG
TCG
ACTCAGT
CAGT
CATG
TCAG
CTAG
AGTC
CAGT
CTAG
TCGA
ACTGCAT
CAGT
CTAG
TCAG
FL CAGT
CTAG
TCAG
ACTG
CATG
CATG
CTAG
TCAG
CATG
CTAG
ACTG
CAGT
CTAG
TCAG
ACTGCAT
CAGT
CTAG
TCAG
FL TCGA
GACTTTATCGTGTAACTGAAGTTAGCATGCAGTCTCAGTAACTCCTAGTCAGATGC
FLACTGCTGATCA
CTGA
GCAT
AGCTACGTCTACTGCTGAGTCATGCA
DBD GCTATAGC
TAGC
ATGC
AGCT
GATC
GACT
TAGC
ACGTGCTATACGACGTTGACACTGGTCATACGCAGTCGTAATGCCTAGCTAGTCGATACGATGCATCG
DBD TGCA
CTAG
AGCTCTGA
CGATTCAATTCAAGTGTCAACGT
DBD TGAC
TCGA
AGTC
ATGC
TCG
GCAT
TCAGTTACAGTCGTCAACGT
DBD TACG
GATTACATGTAGTCTAGCTCAGACTGTACTAATGC
FL CATGCAGTCAGTATGCCTGACAGTAGTCCATGCTAGAGTCCTACAGCTAGCTAGAGTCCAGCAGTCAGTCTGACAGTAGCTCAGCGAACGTAGTC
FL CGAT
CGTA
ACGTCACGATTGACCTAACGTCACGTCTAG
DBD GTCAGTCACGACCGATCTGATACGGATCATCGATCGGACTCTATCACCTGACCAGTDBD
ACGT
TCAG
GACACACTAGACGTCATGTGACGTCAACTGACTGAGCACGTATCG
Zinc finger TFs
28
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