Yellow Fever

March 29, 2012

Aaron Dinerman

Yellow Fever in Today’s World

• 200,000 Cases/Year

• 30,000 Deaths/Year

Symptoms/Presentation

• Phase 1

• Phase 2 (Variable)

• Phase 3 (Variable; 15% of Patients reach this point)

Yellow Fever originated from Africa….

First Recorded Outbreak: 1648

“Xekik” = “Black Vomit”

Worldwide Spread

“Yellow Jack”

Wilmington, NC and Yellow Fever

The Walter Reed Commission of 1900 and “The Mosquito

Hypothesis”

THIS GUY, AGAIN.

BUT….

Yellow Fever ≠ Malaria

A Capsid Flavivirus with an Envelope

“Flavus” = Latin for “Yellow”

Note the different binding domains for the various cleaved proteins (early virus assembly)

The Viral Life Cycle: Overall Body Effect

Epidemiological Cycles

Detection/Diagnosis

Prevention/Vaccination

Protease Inhibitors as a Possible Therapeutic Drug?

This approach is like that of the HIV protease inhibitor paper

Sources

• http://ncpedia.org/history/health/yellow-fever• http://www.infectionlandscapes.org/2011/07/yello

w-fever.html• http://www.who.int/mediacentre/factsheets/fs100/

en/• http://en.wikipedia.org/wiki/Yellow_fever#Histor

y• http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH

0002341/• http://vir.sgmjournals.org/content/88/8/2223.full.p

df• http://www.med.yale.edu/micropath/pdf/

Lindenbach2007.pdf