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Indianapolis ● Chicago ● San Juan www.hollandapt.com
800-800-8464
XDM Quad™ Single-Use Mixing System
DATA SHEET
The Xcellerex XDM Quad Mixing System is designed for convenient and
effi cient mixing of buff er, media, product, and other process fl uids. The single-use
system eliminates the hassle of time-consuming and costly steam-in-place (SIP),
clean-in-place (CIP), and cleaning validation. The result is more effi cient processing
and rapid batch-to-batch turnover time.
The XDM Quad is comprised of a full-featured and integrated rigid containment
system complete with motor and controls, and an irradiated USP Class VI, single-
use LDPE fl uid contact layer bag equipped with a disposable bottom-mounted
impeller. The engagement between motor and disposable impeller is via a robust
magnetic coupling, and agitation is driven through stainless steel bearings within
the impeller, imparting high torque and rapid mixing to the system.
The system delivers fl exibility with the availability of two standard
www.xcellerex.com • 1-866-Xcellerex
The XDM Quad Mixing System is available in 100L , 200L, 500L and 1000L sizes.
Key Features
• Powerful integrated magnetic agitator with compact VFD and DC motor
• Optimized, disposable impeller
• Square confi guration off ers enhanced mixing effi ciency through natural baffl ing eff ect, workable heights, increased level of safety from lower center of gravity, and compact storage capability
• Bottom is slanted on two planes for extremely low bag hold-up volume
• Handles and casters for ease of mobility
• Fitted square bag minimizes bag wrinkles
• In-line sensing and sampling capability via mixer window and bag probe ports, sampling port and thermowell for non-invasive temperature sensing
• Integrated holders for 50ml conical buff er tubes
• Integrated supports for bag tubing lines
• Bags have integrated 3” Tri-clamp port for powder addition
• Translucent lid is included for protection of bag and is equipped with securing feature for bag powder addition port and hopper
• 500L and 1,000L systems equipped with removable door for easy bag loading
• Two bag types: BASIC and PLUS (additional lines, probe ports, and connections)
• System also available in either polypropylene or jacketed stainless steel (for heat-ing and cooling applications
• Fully wash-down rated
bag types that include varying numbers of tubing lines and
connections, and sampling and sensing capabilities to accom-
modate a wide array of applications. Key features of the bag
and rigid container also permit seamless transitioning between
powder-liquid and liquid-liquid mixing applications. The XDM
Quad Mixing System is also available in either polypropylene
or jacketed stainless steel (for heating and cooling applications).
SYSTEM SPECIFICATIONS
100 Liter 200 Liter 500 Liter 1000 Liter
DIMENSIONS Container Interior (LxWxH) 20” x 20” x 20” 25” x 25” x 25” 33” x 33” x 33” 41” x 41” x 38”
Container OAL (LxWxH) 29.5” x 27.5” x 40” 34.5” x 32.5” x 40” 43” x 40.5” x 48” 50.5” x 48.5” x 53”
Slope to Drain ~0.5” per foot Cross-Section
Caster Dimensions (ø x W) 4” x 2” 4” x 2” 4” x 2” 4” x 2”
WEIGHT System Weight (empty) 143 lbs. 183 lbs. 304 lbs. 400 lbs.
MATERIAL OF CONSTRUCTION Container Polypropylene
Lid Acrylic
Casters SS / Polyurethane (Non-Marring)
Motor / VFD White Epoxy Paint
Option 304 SS, Dimple Jacketed Version for temperature control
MOTOR/VFD Type DC Motor
HP 1/4 1/2
Watts 225 450
RPM 180
Electrical 115V or 230V: (50/60 Hz)
Functionality Start/Stop, Forward/Break/Reverse, Run/Jog, Speed Potentiometer (0 – 100%)
Power Cord 10 ft. (North America only)
Washdown Washdown rated motor and controller
HOPPER Dimensions (ø x H) 10” x 8”
Material of Construction Polyethylene
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XDM QUAD OPTIONS & ACCESSORIESThe following options are available for all XDM Quad Mixing Systems:
Hopper for powder addition (locks onto 3” tri-clamp powder addition port)
Probe sheath assemblies (for aseptic insertion of traditional pH and conductivity probes)
pH probe
Conductivity probe
RTD probe
Level indication (fl oor scale or load cells)
Temperature Control Unit for heating and cooling of jacketed stainless steel system
See last page for order codes.
www.xcellerex.com • 1-866-Xcellerex
XDM QUAD MIXER SYSTEM DETAILS
Motor controller (fully washdown rated)Motor controller (fully washdown rated)
Convenient buff er tube holders (4)Convenient buff er tube holders (4)
DC motor and magnetic drive (fully washdown DC motor and magnetic drive (fully washdown
rated)rated)
Probe port window with support barProbe port window with support bar
Notches for supporting bag tubingNotches for supporting bag tubing
Handles for ease of mobilityHandles for ease of mobility
Detail of probe port window and support bar for inline sampling Detail of probe port window and support bar for inline sampling and sensing, such as pH, conductivity and temperature.and sensing, such as pH, conductivity and temperature.
Removable lid with integrated support for powder Removable lid with integrated support for powder addition port and hopper addition port and hopper
Hopper and 3-inch triclamp for easy powder Hopper and 3-inch triclamp for easy powder additionaddition
Removable door for easy bag installation and Removable door for easy bag installation and removal (500L and 1000L only)removal (500L and 1000L only)
Mixer bottom is slanted on two planes toward Mixer bottom is slanted on two planes toward
drain for minimal holdup volume; Magnetic drain for minimal holdup volume; Magnetic
impeller drive is easily accessibleimpeller drive is easily accessible
BAG ASSEMBLY DETAILS
XDM Quad Mixing Systems are available with two standard bag assembly types: BASIC and PLUS
BASIC
Top ½” ID C-fl ex inlet line, 4FT, with pinch clamp, plugged
Top 3” tri-clamp powder addition port, capped
Bottom outlet ½” C-fl ex line, 6FT, with pinch clamp, plugged
In-line (side) 1/8” ID C-fl ex line, 6”, with needleless syringe swabable valve sample port (Luer Lock connection), with pinch clamp
PLUS
Top ½” ID C-fl ex inlet line with female MPX quick connect and male MPX plug, 4FT, with pinch clamp
Top ¾” ID C-fl ex inlet line, 4FT, plugged
Top 1/8” ID C-fl ex addition line, 3FT, with needleless syringe swabable valve sample port (Luer Lock connection), with pinch clamp
Top 3” tri-clamp powder addition port, capped
2 x in-line (side) female Kleenpack Connector ports
In-line (side) thermowell for non-invasive temperature sensing; compatible with 1/8” diameter RTD up to 6” long
In-line (side) 1/8” ID C-fl ex line, 6”, with needleless syringe swabable valve sample port (Luer Lock connection), with pinch clamp
Bottom outlet ½” C-fl ex line, with male MPX quick connect and female MPX cap, 6FT, with pinch clamp
www.xcellerex.com • 1-866-Xcellerex
SINGLE-USE BAG SPECIFICATIONS100 Liter 200 Liter 500 Liter 1000 Liter
DIMENSIONS Dimensions (LxWxH) 20” x 20” x 19” 25” x 25” x 24” 33” x 33” x 32” 41” x 41” x 37”
VOLUME Maximum 125 L 246 L 571 L 1019 L
Nominal 100 L 200 L 500 L 1000 L
Minimum (Mix) 28 L 44 L 76 L 117 L
Hold Up < 20 mL < 20 mL < 20 mL < 20 mL
FILM Fluid Contact Layer LDPE (USP Class VI)
IMPELLER # of Blades 3
Diameter 7.5”
Blade Height x Width 4.2” x 2.5”
Blade Pitch 57º
Material of Construction Molded HDPE impeller with 316 SS bearing
TEMPERATURE RANGE 2º – 80ºC
POWDER PORT Dimensions 3” TC
STERILIZATION Gamma Irradiated
The XDM QUAD disposable impeller is welded
to the bottom of the bag assembly.
0%
20%
40%
60%
80%
100%
0 20 40 60 80 100
Minutes
% D
isso
lved
75% Corn Syrup, 274 cp
85% Corn Syrup, 561 cp
90% Corn Syrup, 1000 cp
1% NaCL in Corn Syrup, XDM200
The XDM Quad demonstrates eff ective mixing even at high viscosities
6g/L NaCL, XDM500
The XDM Quad demonstrates rapid mixing of common salt solutions.
9.0
9.5
10.0
10.5
11.0
11.5
0 60 120 180 240 300
Time (seconds)
Co
nd
ucti
vit
y (
mS
/cm
)
APPLICATIONS AND PERFORMANCE DATA
DMEM/F-12 Medium, XDM500
www.xcellerex.com • 1-866-Xcellerex
The XDM Quad demonstrates eff ective mixing of common cell culture media.
0
1
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9
10
0 60 120 180 240 300
Mix Time (Seconds)
Co
mp
on
en
t C
on
cen
trati
on
L-Gln (mmol/L)
Glucose (g/L)
0
10
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30
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60
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90
100
0 60 120 180 240 300
Mix Time (Seconds)
Co
mp
on
en
t C
on
ce
ntr
ati
on
[m
mo
l/L
]
Na+ (mmol/L)
0
1
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0 60 120 180 240 300
Mix Time (Seconds)
Co
mp
on
en
t C
on
ce
ntr
ati
on
[m
mo
l/L
]
K+ (mmol/L)
0
50
100
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200
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350
400
0 60 120 180 240 300
Mix Time (Seconds)
[mO
sm
/kg
]
Osmo (mOsm/kg)
VIDEO DEMONSTRATION
Base & Acid Addition /
Phenolphthalein Dye Test, XDM500
A video demonstration of this
mixing test is available at www.xcellerex.com/mixerdemo
SODIUM TREND
OSMOLARITY TRENDPOTASSIUM TREND
GLUCOSE & L-GLN TRENDS
Buff er and Media Prep pH adjustments
Resuspension
Chromatography pooling Viral inactivation
UF/DF Formulation
Product Mixing
XDM QUAD
APPLICATIONS
Indianapolis ● Chicago ● San Juan www.hollandapt.com
800-800-8464
Product Code Size Type
888-0164 100L Basic
888-0154 100L Plus
888-0165 200L Basic
888-0155 200L Plus
888-0166 500L Basic
888-0156 500L Plus
888-0167 1,000L Basic
888-0157 1,000L Plus
Ask about our made-to-order bags for UF/DF.
XDM Quad Bag Assembly Ordering Codes
To order XDM Quad systems,
bag assemblies or components,
please call
1.866.XCELLEREX
(1.866.923.5537)
Xcellerex, Inc. Toll Free: 1-866-Xcellerex170 Locke Drive Tel: 508-480-9235 Marlborough, MA 01752 [email protected] www.xcellerex.com
rev. xdmQ022209
TM
Product Code Size Type
XDM-Q100 100L Standard Polypropylene
XDM-Q200 200L Standard Polypropylene
XDM-Q500 500L Standard Polypropylene
XDM-Q1000 1,000L Standard Polypropylene
XDM-Q100-T 100L Jacketed Stainless Steel
XDM-Q200-T 200L Jacketed Stainless Steel
XDM-Q500-T 500L Jacketed Stainless Steel
XDM-Q1000-T 1,000L Jacketed Stainless Steel
* Various electrical requirements can be accommodated. Please specify at time of order.
XDM Quad System Ordering Codes*
ORDERING INFORMATION
Product Code Description
888-0138 Probe Sheath Assemblies
XDM-Q-HH Hopper (includes fi tting for fastening to 3” tri-clamp port)
XDM-Q-PB PH Probe
XDM-Q-CB Conductivity Probe
XDM-Q-RTD RTD for Temperature Measurement
Accessory Ordering Codes
For information on Xcellerex’s other innovative single-use technology, including XDR single-use bioreactors and the FlexFactory biomanufacturing platform,
please visit www.Xcellerex.com
