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CFI Global Consultation – Meeting 1Wellcome Trust, London, 16-17 April 2015
Carel IJsselmuiden
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Core teamTWGCOHRED BoardJack WattersPfizer, Sanofi, Celgene, Wellcome TrustYou
The team
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• Our missionAchieving and sustaining global health is crucially
dependent on the capacity of low and middle income countries to use science and innovation to solve their own priority health and development problems – both on their own and in partnership with high income countries and their researchers, innovators and institutions
• FRC – Fair Research Contractingwww.cohred.org/frc
• ISEAL Alliance– http://www.isealalliance.org
How did we arrive at the CFI ?
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http://grandchallenges.org / accessed 15 April 2015
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APAME
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Olalekan A Uthman et al. BMJ Open 2015;5:e006340
Trends in the WHO/AFRO health research article outputs indexed in PubMed (2000–2014; AAPC, average annual percentage change). *AAPC is significantly different from zero (0), p=0.0001.
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Main recommendations from the Dakar Forum: (2)
5) Promote the strong and effective support of policymakers and various stakeholders, to develop the capacities of African scientists to conduct research and design interventions addressing the challenges related to the outbreak of Ebola as well as similar health threats; and
6) Strengthen the capacity of health, research, and governance bodies in the subregion.
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Research & Innovation for Health
HealthSocial & Political Development
EconomicDevelopment
Health System
Health Research
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CFI – Research & Innovation for Health
• Research = knowledge generation
• Innovation = transforming knowledge into practical and scalable solutions
– Link between R & I is ‘automatic’ in private sector, not so in public sector – but is essential for impact – so has to be part of the CFI
• e.g. ‘translation research’ ‘implementation science’
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• Insecticide-treated nets made in Tanzania exported to other African countries.
• 30,000,000 olyset nets (50% of the worlds production) made by A - Z company Tanzania
• Tanzania’s worth of export of nets have increased from Tsh 65bn in 2008 to 105bn in 2010
• 7000 people employed in the industry
Health: products
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Research & Innovation Partnerships
• Partnerships are key to growth of research and innovation
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COHRED Fairness Index - CFI
an actively managed certification system to optimize
the ability to engage in and sustain fair research and innovation partnerships
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Creating the CFI - rationale
• Raising Awareness– e.g. Costello & Zumla (2000)
• Establishing principles of best practice– e.g. KFPE : 11 principles, 7 questions
• Creating practical tools– e.g. Fair Research Contracting (FRC)
• Actively managed certification system– e.g. the COHRED Fairness Index
• Generating legal obligation– e.g. the Nagoya Protocol
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CFI – what can it measure ?
1) Assess conditions essential to fairness in research and innovation
– rather than partnerships themselves
2) Assess partnerships directly – given the complexity of doing so means this is not for the early phase of the CFI
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CFI – what is the ‘unit of application’ ?
1) Project / Program
2) Institution
3) Country
4) Partnerships
Measuring conditions essential to fairness in partnerships
Measuring partnerships directly
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CFI – what does it measure (2) ?
• DOMAINS / Objectives– are likely to be the same across the 4 levels
• INDICATORS – are likely to vary for each level
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COHRED Fairness Index
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CFI – example of Indicators at 4 Levels
If the DOMAIN is ‘proper financial management’ – then
• Projects/Program: – Co-PI’s have full transparency and decision power, from the beginning
• Institution:– There is a competent research administrator or accredited outsourced
auditor
• Country:– Enforceable Policy requiring that research is contracted institutionally, and
that institution use accredited auditors
• Partnership: – Joint financial audit, conflict resolution mechanism that is ‘neutral’,
reasonable F&A sharing; IP sharing
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CFI – who would benefit ?
In the DOMAIN of ‘proper financial management’
• Research institutions :• Research sponsors :• Business :• Researchers :• National development :• Global health research :
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CFI – boundaries
• What should NOT be included in the CFI – what should be its boundaries ?
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CFI – the concept
1) Widely agreed upon, measurable set of best practices
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CFI – membership of TWG
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CFI – participation in today’s meeting
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CFI – the concept
1) Widely agreed upon, measurable set of best practices
2) Enabling users to (gradually) improve their own practices
3) Independent verification 4) Certification
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CFI – Governance & Management
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CFI – what standards ?
The CFI – Technical Advisory Group will:
1. Examine existing, related standards, guidelines, best practices and take what aspects are relevant to the CFI
2. Design new standards where there are none, particularly around ‘fairness’
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CFI – some reasons to use it
1. Early Adopters – it matters who these are 2. Pressure – from one of the partners in the
partnership3. Collaborating PI’s – want fairness4. Institutional / National Policy – efficiency,
grow system capacities5. Reduce Reputational Risk – all parties6. …
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CFI – Business Model & Financing
• Sustainable funding – ‘user pays’
• Development of Financing– Phase 1 : to 31 October 2015 :
• COHRED internal resources plus support from Pfizer, Celgene, Sanofi, Wellcome Trust
– Phase 2 : up to end 2018 : • needs 3 years of external support
– Phase 3 : 2019 onwards : • user-base should be able to sustain costs
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CFI – Business Model & Financing
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CFI – possible evolution - 1
TIME we are busy with a process not just a product
• Global Reporting Index …• Forest Stewardship Council …
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CFI – possible evolution - 2
1) From High – Low & Middle Income partnerships >> all partnerships
2) From “Research and Innovation for Health” >> all science & innovation
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CFI – This meeting - process
Create more opportunity to contribute:
• Panels, discussions, networking• Notes to send us afterwards• Help to arrange a CFI workshop where you are• Email Najia, contact other COHRED staff, board• Tweet it• …
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• September - November 2014: Technical Working GroupI
• 22 January - 27 March 2015: Global Consultation III
• 16-17 April 2015: CFI Stakeholder MeetingIII
• 18 May - 31 July: Global Consultation IIIV
• October 2015: Launch of the CFI V
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• Today– AM : Need for CFI / Domains
• Lunch : networking
– PM : CFI – moving towards practice: going global• Cocktail : Forum 2015
– Dinner : Sustainability & Endorsements• Tomorrow
– AM : Implementation, Endorsement, Early Adopters
CFI – Meeting Programme
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CFI – Outcomes of this meeting
1) Confirm need for a “CFI”2) Outline ‘Domains’/Objectives that need to
be included3) Indicators4) Financing & Sustainability5) Endorsement, early adoption,
operationalisation6) Any other help you can offer
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