Wound Healing-ms 1

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    WOUND HEALINGMS-1

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    Regeneration

    Repair

    Restitution

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    Cells Labile

    StablePermanent

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    Granulation Tissue

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    Angioneogenesis/Neovascularization

    Migration and proliferation of fibroblasts

    Deposition of ECM

    Remodelling

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    Components of the ECM

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    As BM and Interstitial matrix

    Collagen,Elastin

    Fibronectin,Laminin Proteoglycan,hyaluronan

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    Molecular events in cell growth

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    Intercellular signalling-

    auto/para/endocrine

    Cell surface receptors

    Signal transduction system

    Cell transcription

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    Growth Factors

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    TGF EGF PDGF

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    Cyclins and Chalones

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    Contact inhibition

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    Reduction in material

    Reduced GF

    Increased inhibitors

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    HEALING BY -

    First intention

    Second intention

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    Wound contraction vs contracture

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    Factors affecting wound healing

    Favourably

    Adversely

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    Complications of healing in

    Skin Intestine Brain

    Urinary tract Liver Bone

    Myocardium Lung Kidney

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    Wound strength

    Wound failure

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    FRACTURE HEALING-

    Process

    Factors affecting

    Complications