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Worldwide Laboratory Based
Influenza Surveillance
Linda C. Canas
Brooks AFB
San Antonio, TX
ANNUAL MESSAGE
SELECTEDISOLATES
Epidemiology andLaboratory personnel provide:-Program Oversight-Annual Guidance Letter
USAF Surgeon General’s Office (EA)
Sentinel Sites
Brooks AFB Virology Laboratory
-Isolation and Identification
Disease Surveillance, Disease Surveillance, Results AnalysisResults Analysis
CDCSubmitting Sites
Vaccine Decisions
SUPPLIES
DoD Global Influenza SurveillanceDoD Global Influenza Surveillance................................................................ IN ACTIONIN ACTION
COLLECT/SHIP SPECIMENS
USAF Surgeon General’s Office, DoD GEIS
REPORTS
INPUT
Impr
ovem
ents
PATIENTRESULTS
2000-2001 Sentinel Sites2000-2001 Sentinel Sites
All Sites
0
100
200
300
400
500
600
700
800
900
0
100
200
300
400
500
600
700
800
900 All SpecimensReceived
1999 - 2000
2000 - 2001
North America
0
10
20
30
40
50
60
70
80
Sep-99O
ct-99Nov-99Dec-99Jan-00Feb-00M
ar-00
0
10
20
30
40
50
60
70
80
Sep-00O
ct-00Nov-00Dec-00Jan-01Feb-01M
ar-01
Influenza A
Influenza B
1999 - 2000 2000 - 2001
Pacific Rim Japan Korea Singapore Guam Hawaii
0
10
20
30
40
50
60
70
80
90
Sep-99
Oct-99
Nov-99
Dec-99
Jan-00
Feb-00
Mar-00
0
10
20
30
40
50
60
70
80
90
Sep-00
Oct-00
Nov-00
Dec-00
Jan-01
Feb-01
Mar-01
Influenza A
Influenza B
1999 - 2000
2000 - 2001
EuropeUK Germany Turkey Italy Spain
0
2
4
6
8
10
12
14
Sep-99
Oct-99
Nov-99
Dec-99
Jan-00
Feb-00
Mar-00
0
2
4
6
8
10
12
14Influenza AInfluenza B
1999 - 2000
2000 - 2001
South AmericaArgentina Ecuador Peru
0
3
6
9
12
15Influenza A
Influenza B
0
3
6
9
12
15Influenza A
Influenza B
Nepal and Thailand
Influenza Subtypes by Region2000-2001 Season
0
10
20
30
40
50
60N
OR
TH
AM
ER
ICA
PA
CIF
ICR
IM
EU
RO
PE
SO
UTH
AM
ER
ICA
NEP
AL
AN
DTH
AIL
AN
D
B/Beijing-like
H1N1
H3N2
B/Beijing-like Subtype by Region
0
10
20
30
40N
OR
TH
AM
ER
ICA
PA
CIF
ICR
IM
EU
RO
PE
SO
UTH
AM
ER
ICA
NEP
AL
AN
DTH
AIL
AN
D
1999-2000 Season
2000-2001 Season
H1N1 Subtype by Region
0
10
20
30N
OR
TH
AM
ER
ICA
PA
CIF
ICR
IM
EU
RO
PE
SO
UTH
AM
ER
ICA
NEP
AL
AN
DTH
AIL
AN
D
1999-2000 Season
2000-2001 Season
H3N2 Subtype by Region
0
20
40
60
80
100N
OR
TH
AM
ER
ICA
PA
CIF
ICR
IM
EU
RO
PE
SO
UTH
AM
ER
ICA
NEP
AL
AN
DTH
AIL
AN
D
1999-2000 Season
2000-2001 Season
Influenza A Subtypes by Season
12
74
88
26
0%
20%
40%
60%
80%
100%
19
99
-2
00
0S
easo
n
20
00
-2
00
1S
easo
n
H3N2
H1N1
Isolate PAN/2007A/Ecuador/3002/00 97.9A/Peru/2950/00 98.8A/Ecuador/2989/00 98.8A/Peru/2942/00 98.5A/Peru/2955/00 98.2A/Peru/4077/00 97.6A/Ecuador/4087/00 97.9A/Peru/5995/00 98.5
Isolate NC/20/99 Bayern/795 BJ/262/95A/Peru/2940/00 97.5 94.5 96.4A/Ecuador/2985/00 97.4 94.3 96.3A/Ecuador/3003/00 92.7 97.3 93.7A/Alaska/6442/00 91.4 96.1 92.6A/Argentina/6037/00 98.0 93.8 96.1A/Germany/6617/00 98.5 94.4 96.1
Isolate Yam/166/98B/Alaska/3341/00 98.60B/Ecuador/4085/00 99.10B/Kadena/4757/00 98.60B/Kadena/5595/00 98.60B/Alaska/5846/00 97.10B/Alaska/5847/00 97.40B/Alaska/5848/00 97.40B/Alaska/6467/00 98.00B/Alaska/6468/00 97.70B/California/6828/00 96.20B/Washington/6786/00 96.80B/California/6870/00 96.80
Flu Flu BB
H1N1H1N1
H3N2H3N2
% Nucleotide Homology of HA1 to Reference Strains% Nucleotide Homology of HA1 to Reference Strains
Summary for 1999-2001Summary for 1999-2001
• 99-00 Influenza Season99-00 Influenza Season – Predominately H3N2 worldwide and U.S.A.Predominately H3N2 worldwide and U.S.A.
– Panama 2007 strain included in vaccine.Panama 2007 strain included in vaccine.
– Early detection of Peru strains incited the NC/20/99 vaccine Early detection of Peru strains incited the NC/20/99 vaccine component.component.
– Molecular and immunological descriptions of these Peru strains Molecular and immunological descriptions of these Peru strains being prepared for publication with CDC.being prepared for publication with CDC.
• 00-01 Influenza Season 00-01 Influenza Season – Predominately H1N1 and B.Predominately H1N1 and B.
– Nepal isolates currently being analyzed.Nepal isolates currently being analyzed.
