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WORKSHOP SESSIONS DAY 2（October 29［Mon］）

WORKSHOP SESSIONS DAY 2（October 29［Mon］）WorkshopRoom 1（1F Terrsa Hall） Day 2　October 29 [Mon]　14：45～15：21

Data analysis and mathematical model 1Chairs：Shingo Iwami（ Department of Biology, Faculty of Sciences, Kyushu University）

Shinji Nakaoka（ Faculty of Advanced Life Science, Hokkaido University）

W2-1-01 A retrovirus testing pipeline for production of recombinant protein therapeutics in CHO cellsKeisuke Yusa1），Yosuke Maeda2），Yoji Sato1），Yuzhe Yuan3）

1）Division of Cell-Based Therapeutic Products, National Institute of Health Sciences，2）Department of Microbiology, Faculty of Life Sciences, Kumamoto University，3）Graduate School of Science, Technology and Innovation, Kobe University

W2-1-02 Establishment of a model for the quantification of hepatitis B virus cccDNA dynamicsYusuke Kakizoe1），Masashi Iwamoto2），Miles P Davenport3），Koichi Watashi4），Shingo Iwami4）

1）Mathematical Biology Laboratory, Systems Life Sciences, Graduate school of Kyushu University，2）Mathematical Biology Laboratory, Department of Biology, Graduate school of Kyushu University，3）Infection Analytics Program, Kirby Institute, University of New South Wales，4）Department of Virology II, National Institute Infectious Diseases

W2-1-03 A comparison between HCV JFH-1 and Jc1 strains by quantitative analysis of infection dynamicsShoya Iwanami1），Hirofumi Ohashi2），Yusuke Asai3），Koichi Watashi2），Shingo Iwami4）

1）Graduate School of Systems Life Sciences, Kyushu University，2）Department of Virology II, National Institute of Infectious Diseases，3）Graduate School of Medicine, Hokkaido University，4）Department of Biology, Faculty of Sciences, Kyushu University

WorkshopRoom 1（1F Terrsa Hall） Day 2　October 29 [Mon]　15：21～15：57

Data analysis and mathematical model 2Chairs：Akira Sasaki（ Department of Evolutionary Studies of Biosystems, The Graduate University for Advanced

Studies）Hironori Sato（ Pathogen Genomics Center, National Institute of Infectious Diseases）

W2-1-04 Dynamics of HIV-1 coinfection in different susceptible target cell populations during cell-free infectionYusuke Ito1），Fabrizio Mammano2,3,4），Shingo Iwami5）

1）Mathematical Biology Laboratory, Graduate School of Systems Life Sciences, Kyushu University，2）INSERM, U941，3）Univ Paris Diderot, Sorbonne Paris Cité, IUH，4）Institut Universitaire d'Hématologie, Hôpital Saint-Louis，5）Mathematical Biology Laboratory, Department of Biology, Faculty of Sciences, Kyushu University, Japan

W2-1-05 Quantification of antiviral effects of IFN-α on HIV cell-free and cell-to-cell infection based on experimental-mathematical investigationRyuichi Kumata1,2），Yusuke Kakizoe3），Naoko Misawa1），Shingo Iwami4），Kei Sato1,5,6），Yoshio Koyanagi1）

1）Laboratory of Systems Virology, Institute for Frontier Life and Medical Science, Kyoto University，2）Faculty of Science, Kyoto University，3）Systems Life Sciences, Graduate School of Kyushu University, Mathematical Biology Laboratory，4）Department of Biology, Faculty of Sciences, Kyushu University，5）Division of Systems Virology, Department of Infectious Disease Control, Institute of Medical Science, The University of Tokyo，6）CREST, Japan Science and Technology Agency, Saitama, Japan

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The 66th Annual Meeting of the Japanese Society for Virology

W2-1-06 Development of a quantitative simulator of HTLV-1 proviral integration sitesMitsuaki Takaki1），Jun-ichiro Yasunaga2），Ryo Yamaguchi3），Masao Matsuoka2,4），Shingo Iwami5）

1）Graduate School of Systems Life Sciences, Kyushu University，2）Institute for Frontier Life and Medical Sciences, Kyoto University，3）Department of Biological Sciences, Tokyo Metropolitan University，4）School of Medicine, Kumamoto University，5）Department of Biology, Faculty of Science, Kyushu University

WorkshopRoom 1（1F Terrsa Hall） Day 2　October 29 [Mon]　15：57～16：33

Data analysis and mathematical model 3Chairs：Takaaki Nakaya（ Department of Infectious Diseases, Kyoto Prefectural University of Medicine）

Yoshiyuki Suzuki（ Graduate School of Natural Sciences, Nagoya City University）

W2-1-07 Genome-wide expression analysis for endogenous viral elements in mammalian genomesSo Nakagawa1,2），Mahoko Ueda2）

1）Department of Molecular Life Science, Tokai University School of Medicine，2）Micro/Nano Technology Center, Tokai University

W2-1-08 Characterization of newly discovered endogenous bornavirus-like elements in the human genomeDong-Yun Kim1,2），Yahiro Mukai1,2），Shohei Kojima1,2），Yumiko Komatsu1,5），Masayuki Horie1,4），Keizo Tomonaga1,2,3）

1）Lab. of RNA viruses, Institute for Frontier Life and Medical Sciences, Kyoto University，2）Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University，3）Department of Molecular Virology, Graduate School of Medicine, Kyoto University，4）Hakubi Center for Advanced Research, Kyoto University，5）The Keihanshin Consortium for Fostering the Next Generation of Global Leaders in Research (K-CONNEX), Kyoto University

W2-1-09 The characterization of human rotavirus equine-like G3P[8] strains emerged in Tomakomai, 2016Yusuke Akane1），Takeshi Tsugawa1），Yuko Yoto1），Kenji Kondo2），Yoshiki Fujii3）

1）Department of Pediatrics, Sapporo Medical University，2）Department of Pediatrics, Sunagawa City Medical Center，3）Department of Virology 2, National Institute of Infectious Diseases, Japan

WorkshopRoom 2（2F AV Study Room） Day 2　October 29 [Mon]　14：45～15：33

Pathogenesis 1Chairs：Masahiro Fujimuro（ Department of Cell Virology, Kyoto Pharmacentical University）

Jun Arii（ Division of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo）

W2-2-01 Negative regulation of HSV-1 Us3 kinase by tyrosine phosphorylation and its role in viral replication and pathogenesisNami Kimura，Akihisa Kato，Yuhei Maruzuru，Naoto Koyanagi，Jun Arii，Yasushi KawaguchiDivision of Molecular Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo

W2-2-02 FIT-039, a novel CDK9 inhibitor, for HSV-induced facial nerve palsyShinichi Esaki1,2），Fumi Goshima1），Gaku Takano1,2），Takahiro Watanabe1），Yoshitaka Sato1），Takayuki Murata1,3），Yukihiro Nishiyama1），Hiroshi Kimura1）

1）Department of Virology, Nagoya University Graduate School of Medicine，2）Department of Otolaryngology, Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences and Medical School，3）Department of Virology and Parasitology, Fujita Health University School of Medicine

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Virus Research Insight and Serendipity

W2-2-03 HSV type-specific phosphorylation mediated by Us3 kinase: its role in viral pathogenesis and implication in evolution of herpesvirusesMisato Shibazaki1,2），Akihisa Kato1,2），Kosuke Takeshima1,2），Naoto Koyanagi1,2），Yuhei Maruzuru1,2），Jun Arii1,2），Yasushi Kawaguchi1,2）

1）Division of Molecular Virology, Department of Microbiology and Immunology, the Institute of Medical Science, the University of Tokyo，2）International Research Center for Infectious Disease, the Institute of Medical Science, the University of Tokyo

W2-2-04 MicroRNA profiling of cerebrospinal fluid exosomes in HHV-6 encephalitis/encephalopathy children by next-generation sequencingYuka Torii，Jun-ichi Kawada，Toshihiko Okumura，Suguru Takeuchi，Kazuhiro Horiba，Takako Suzuki，Yoshinori ItoDepartment of Pediatrics Nagoya University Graduate School of Medicine

WorkshopRoom 2（2F AV Study Room） Day 2　October 29 [Mon]　15：33～16：21

Pathogenesis 2Chairs：Teruhito Yasui（ Laboratory of Infectious Diseases and Immunity, National Institute of Biomedical Innovation,

Health and Nutrition）Tetsushi Yoshikawa（ Department of Pediatrics, Fujita Health University）

W2-2-05 Proinflammatory responses to varicella-zoster virus infection in human retinal cell linesMasaya Takemoto1），Chikako Yasumura1），Kaede Sawano1），Toshimi Satoh1），Hidetaka Sadanari2），Keiko Matsubara2），Tsugiya Murayama2），Tohru Daikoku2）

1）Research Center for Pharmaceutical Education, Hokuriku University，2）Department of Microbiology and Immunology, Hokuriku University

W2-2-06 Human Cytomegalovirus (HCMV) latency-associated protein ORF152 induces neuropathogenesis of congenital CMV infectionKazuya Shimada，Nobuyuki Kobayashi，Naomi Oka，Mayumi Takahashi，Kazuhiro KondoDepartment of Virology, The Jikei University

W2-2-07 Roles of GP33, a guinea pig CMV homolog of GPCRs, in viral growth and inflammation in pregnant animalsKazuma Noguchi1），Miei Takeda1），Harutaka Katano2），Yuko Sato2），Sayaka Kojima1），Shinji Watanabe1），Naoki Inoue1）

1）Laboratory of Microbiology and Immunology, Gifu Pharmaceutical University，2）Department of Pathology, National Institute of Infectious Diseases

W2-2-08 Oral Neomycin prevents hepatitis of severe infectious mononucleosis-like disease in murine γ-herpesvirus 68 infected IL-27-deficient miceKyosuke Kanai1,2），Ah-Mee Park2），Teruhito Yasui3），Hiroki Yoshida4），Ikuo Tsunoda2），Osamu Yoshie2,5）

1）Division of Virology, Department of Microbiology and Immunology, Faculty of Medicine, Tottori university，2）Department of Microbiology, Kindai University Faculty of Medicine，3）Laboratory of Infectious Diseases and Immunity, National Institute of Biomedical Innovation, Health and Nutrition，4）Division of Molecular and Cellular Immunoscience, Department of Biomolecular Sciences, Saga medical school，5）The Health and Kampo Institute

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The 66th Annual Meeting of the Japanese Society for Virology

WorkshopRoom 3（2F Medium Conference Room） Day 2　October 29 [Mon]　14：45～15：33

Pathogenesis 3Chairs：Toru Okamoto（ Molecular Virology, Research Institute for Microbial Diseases, Osaka University）

Tatsuya Kantou（ The Research Center for Hepatitis and Immunology, National Center for Global Health and Medicine）

W2-3-01 Hepatitis C virus induces the lysosomal degradation of the HNF-1β transcription factor via chaperone-mediated autophagyChieko Matsui，Lin Deng，Takayuki Abe，Ikuo ShojiDivision of Infectious Disease Control, Center for Infectious Diseases, Kobe University Graduate School of Medicine

W2-3-02 Inhibition of signal peptide peptidase restores monoubiquitination of histone H2A and impairs Hox gene expression in HCV-infected cellsHirotake Kasai，Tomohisa Tanaka，Atsuya Yamashita，Teruhime Otoguro，Kohji MoriishiDepartment of Microbiology, Division of Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi

W2-3-03 HCV genome and abnormal organelles in the liver after elimination of hepatitis C virus by drug treatmentHideki Aizaki1），Haruyo Aoyagi1），Hiroko Iijima2），Xin Zheng1），Mami Matsuda1），Koichi Watashi1），Ryosuke Suzuki1），Takahiro Masaki1,3），Noritomo Shimada4），Keizo Kato5），Akihito Tsubota6），Takeshi Saito7），Kazuhiko Hayashi8），Masaru Enomoto9），Ayako Mimata10），Yuriko Sakamaki10），Shizuko Ichinose10），Kenjiro Wake11），Masamichi Muramatsu1），Takaji Wakita1）

1）Department of Virology II, National Institute of Infectious Diseases, Tokyo，2）Department of Internal Medicine, Division of Hepatobiliary and Pancreatic Disease, Hyogo College of Medicine, Hyogo, Japan，3）Department of Laboratory Medicine, The Jikei University School of Medicine, Tokyo, Japan，4）Division of Gastroenterology and Hepatology, Ootakanomori Hospital, Chiba, Japan，5）Division of Gastroenterology and Hepatology, Shinmatsudo Central General Hospital, Chiba, Japan，6）Research Center for Medical Science, The Jikei University School of Medicine, Tokyo, Japan，7）Department of Medicine, Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California, USA，8）Meijo Hospital, Aichi, Japan，9）Department of Hepatology, Osaka City University Graduate School of Medicine, Osaka, Japan，10）Research Core Center for Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan，11）Liver Research Unit, Minophagen Pharmaceutical Co., Ltd., Tokyo, Japan

W2-3-04 Large hepatitis B surface antigen accumulation selectively predisposes hepatocytes to direct IFNα-mediated apoptosisIan Baudi，Masanori Isogawa，Keigo Kawashima，Yasuhito TanakaDepartment of Virology, Graduate School of Medical Sciences, Nagoya City University

WorkshopRoom 3（2F Medium Conference Room） Day 2　October 29 [Mon]　15：33～16：21

Pathogenesis 4Chairs：Motohiro Horiuchi（ Faculty of Veterinary Medicine, Hokkaido University）

Ryuichiro Atarashi（ Department of Infectious Diseases, Division of Microbiology, Faculty of Medicine, University of Miyazaki）

W2-3-05 Characterization of rabbit HEV infection in Japanese white rabbitsWenjing Zhang1），Sayaka Yoshizaki1），Yuriko Suzaki1），Yasushi Ami1），Suljid Jirintai2），Masaharu Takahashi2），Masamichi Muramatsu1），Hiroaki Okamoto2），Tiancheng Li1）

1）Department of Virology 2, National Institute of Infectious Diseases，2）Jichi Medical University School of Medicine

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Virus Research Insight and Serendipity

W2-3-06 Comparison of virulence in piglets between recombinant porcine epidemic diarrhea viruses of S genesTohru Suzuki1），Wataru Kamitani2）

1）Division of Viral Disease and Epidemiology, National Institute of Animal Health, NARO，2）Research Institute for Microbial Diseases, Osaka University

W2-3-07 Identification and transcriptome analysis of brain regions vulnerable to neuronal loss in prion infectionMotohiro Horiuchi，Takeshi Yamasaki，Rie HasebeGraduate School of Infectious Diseases, Faculty of Veterinary Medicine, Hokkaido University

W2-3-08 Comparison of intracerebral spread of abnormal isoform of prion protein between three rodent prion strainsTakeshi Yamasaki，Akio Suzuki，Rie Hasebe，Motohiro HoriuchiFaculty of Veterinary Medicine, Hokkaido University

WorkshopRoom 4（3F Conference Room B & C） Day 2　October 29 [Mon]　14：45～15：33

Structure 1Chairs：Yorihiro Nishimura（ Department of Virology Ⅱ, National Institute of Infectious Diseases）

Kazuhiro Kondo（ Department of Virology, The Jikei University School of Medicine）

W2-4-01 Molecular interaction of a human herpesvirus 6B glycoprotein complex with a host receptor and neutralizing antibodiesMitsuhiro Nishimura1），Dian Novita Krisdianto1），Bochao Wang1），Aika Wakata1），Anna Lystia Poetranto1），Lidya Handayani Tjan1），Takayuki Kato2），Keiichi Namba2），Taiki Aoshi3），Yasuko Mori1）

1）Division of Clinical Virology, Center for Infectious Diseases (CID), Kobe University Graduate School of Medicine，2）Protonic NanoMachine Group, Graduate School of Frontier Biosciences, Osaka University，3）Vaccine Dynamics Project, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases (RIMD), Osaka University

W2-4-02 Cis-allosteric regulation of the interaction surfaces of enterovirus A71 capsid protein by the VP1 single amino acid residue at position 145Osamu Kotani1），Masaru Yokoyama1），Kyousuke Kobayashi2），Noriyo Nagata3），Hiroyuki Shimizu4），Satoshi Koike2），Hironori Sato1）

1）Pathogen Genomics Center, National Institute of Infectious Diseases，2）Neurovirology Project, Tokyo Metropolitan Institute of Medical Science，3）Department of Pathology, National Institute of Infectious Diseases，4）Department of Virology II, National Institute of Infectious Diseases

W2-4-03 Cryo-electron microscopic structure of the Ebola virus nucleoprotein-RNA complex at near-atomic resolutionYukihiko Sugita1,2），Hideyuki Matsunami2），Yoshihiro Kawaoka3,4），Takeshi Noda5），Matthias Wolf2）

1）Institute for Protein Research, Osaka University，2）Okinawa Institute of Science and Technology Graduate University，3）Institute of Medical Science, University of Tokyo，4）University of Wisconsin-Madison，5）Institute for Frontier Life and Medical Sciences, Kyoto University

W2-4-04 Lectin microarray analyses reveal strain- and host cell-specific glycan profiles of influenza A virusesTakahiro Hiono1），Atsushi Matsuda2），Takanori Wagatsuma2,3），Masatoshi Okamatsu4），Yoshihiro Sakoda4），Atsushi Kuno1）

1）Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST)，2）School of Medicine, Keio University，3）Japan Bioindustry Association，4）Faculty of Veterinary Medicine, Hokkaido University

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The 66th Annual Meeting of the Japanese Society for Virology

WorkshopRoom 4（3F Conference Room B & C） Day 2　October 29 [Mon]　15：33～16：09

Pathogenesis 5Chairs：Fumitaka Momose（ Laboratory of Viral Infection Ⅱ, Kitasato Institute for Life Sciences, Kitasato University）

Yoshihiro Sakoda（ Laboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University）

W2-4-05 Comparison of pathogenicity in mice between A(H5N1) isolates of Indonesian and Eurasian lineagesJezzy R Dewantari1），Resti Yudhawati1,2），Rima R Prasetya1），Aldise M Nastri1），Muhammad Amin2），Fedik A Rantam3），Emmanuel Djoko Poetranto1），Laksmi Wulandari1），Gatot Soegiarto1），Yohko K Shimizu1,4），Yasuko Mori4），Kazufumi Shimizu1,4）

1）Indonesia-Japan Collaborative Research Center for Emerging and Re-emerging Infectious Diseases, Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia，2）Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Airlangga University, Surabaya, Indonesia，3）Department of Virology and Immunology, Faculty of Veterinary Medicine / Stem Cell Research and Development Center, Airlangga University, Surabaya, Indonesia，4）Center for Infectious Diseases, Kobe University Graduate School of Medicine, Kobe, Japan

W2-4-06 Clade 2.3.4.4 H5 highly pathogenic avian influenza viruses showed various pathogenicity in domestic ducksKosuke Soda，Maya Yamane，Hiroshi Ito，Toshihiro ItoJoint Department of Veterinary Medicine, Faculty of Agriculture, Tottori University

W2-4-07 The effect of cigarette smoking on the pathogenicity of avian influenza A(H7N9) virus infection in miceSatoshi Fukuyama1），Dongming Zhao1），Jason E Shoemaker1,2），Noriko Nakajima3），Yuriko Tomita1），Tadashi Maemura1,4），Tiago Jose Da Silva Lopes1,4），Tokiko Watanabe1），Hideki Hasegawa3），Yoshihiro Kawaoka1,4,5）

1）Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo，2）Department of Chemical and Petroleum Engineering, Swanson School of Engineering, University of Pittsburgh，3）Department of Pathology, National Institute of Infectious Diseases，4）Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison，5）Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo

WorkshopRoom 4（3F Conference Room B & C） Day 2　October 29 [Mon]　16：09～16：45

Pathogenesis 6Chairs：Taisuke Horimoto（ Graduate School of Agricultural and Life Sciences, The Universtiy of Tokyo）

Ken Maeda（ Joint Faculty of Veterinary Medicine, Yamaguchi University）

W2-4-08 Withdrawal

W2-4-09 Study of the role of untranslated regions of the S segment genome of Lymphocytic Choriomeningitis VirusSatoshi Taniguchi1），Tomoki Yoshikawa1），Masayuki Shimojima1），Shuetsu Fukushi1），Takeshi Kurosu1），Hideki Tani2），Fumihiro Kato1），Takahiro Maeki1），Shigeru Tajima1），Chang-Kweng Lim1），Shigeru Morikawa3），Masayuki Saijo1）

1）Department of Virology I, National Institute of Infectious Diseases，2）Department of Virology, University of Toyama，3）Department of Veterinary Science, National Institute of Infectious Diseases

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Virus Research Insight and Serendipity

W2-4-10 SFTS virus causes lethal severe fever with thrombocytopenia syndrome in catsEun-Sil Park1），Masayuki Shimojima2），Tomoki Yoshikawa2），Noriyo Nagata3），Naoko Iwata3），Shuetsu Fukushi2），Shumpei Watanabe2），Yasushi Ami4），Takeshi Kurosu2），Ken Maeda5），Koichi Imaoka1），Masayuki Saijo2），Shigeru Morikawa1）

1）Department of Veterinary Science, National Institute of Infectious Diseases，2）Department of Virology I, National Institute of Infectious Diseases，3）Department of Pathology, National Institute of Infectious Diseases，4）Experimental Animal Research, National Institute of Infectious Diseases，5）Laboratory of Veterinary Microbiology, Yamaguchi University

WorkshopRoom 5（3F Conference Room D） Day 2　October 29 [Mon]　14：45～15：33

Pathogenesis 7Chairs：Hirohumi Akari（ Primate Research Institute, Kyoto University）

Yuko Morikawa（ Laboratory of Viral Infection Ⅱ, Kitasato Institute for Life Sciences, Kitasato University）

W2-5-01 Establishment of HTLV-1 infected non-human primate model; towards the mechanistic insights into infection and disease developmentEmiko Urano1），Yuetsu Tanaka2），Yasuhiro Yasutomi1）

1）Tsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition，2）Department of Immunology, Graduate School of Medicine University of the Ryukyus

W2-5-02 Establishment of in vitro transendothelial migration system of T cells for lymph node homing analysis of latently HIV-infected cellsReou Tanabe1），Fumitaka Momose2），Yuko Morikawa2）

1）Graduate School of Infection Control Sciences, Kitasato University，2）Kitasato Institute for Life Science, Kitasato University

W2-5-03 Kinetic behaviors of latently HIV-infected cells in coculture with stromal cellsSatoko Minakawa1），Fumitaka Momose2），Yuko Morikawa2）

1）Graduate School of Infection Control Sciences, Kitasato University，2）Kitasato Institute for Life Science, Kitasato University

W2-5-04 A consensus Nef Ser-9 residue across HIV-1 non-B subtypes paradoxically impairs HLA-B downregulation and associates with viremia controlFrancis Method Mwimanzi1），Isaack Ngare1），Jaclyn Mann3），Thumbi Ndung'u3），Phillip Goulder4），Takamasa Ueno1,2）

1）Center for AIDS research, Kumamoto University, Kumamoto, Japan，2）International Research Center for Medical Sciences (IRCMS), Kumamoto University, Japan，3）HIV Pathogenesis Programme, University of KwaZulu-Natal, Durban, South Africa，4）Department of Paediatrics, University of Oxford, Oxford, UK

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The 66th Annual Meeting of the Japanese Society for Virology

WorkshopRoom 5（3F Conference Room D） Day 2　October 29 [Mon]　15：33～16：33

Pathogenesis 8Chairs：Akifumi Takaori-Kondo（ Depatment of Hematology and Oncology, Graduate School of Medicine, Kyoto

University）Takeshi Yoshida（ Department of Molecular Virology, Tokyo Medical and Dental University）

W2-5-05 The primate APOBEC3H crystal structure and insight into its interaction with HIV-1/SIVcpz VifYasumasa Iwatani1,4），Tatsuya Matsuoka1,2），Takayuki Nagae2,3），Hirotaka Ode1），Akiko Hamano1），Kazuhiro Matsuoka1），Mayumi Imahashi1），Atsuko Hachiya1），Yoshiyuki Yokomaku1），Nobuhisa Watanabe2,3）

1）Clinical Research Center, National Hospital Organization Nagoya Medical Center，2）Department of Biomolecular Engineering, Nagoya University Graduate School of Engineering，3）Synchrotron Radiation Research Center, Nagoya University，4）Department of AIDS Research, Nagoya University Graduate School of Medicine

W2-5-06 Strucural and RNA binding model of APOBEC3G N-terminal domain for new drug designsHirofumi Fukuda1），Anamaria Daniela Sarca1），Kazuo Yamashita2），Songling Li2），Hirotaka Ebina3），Kotaro Shirakawa1），Kei Sato3,5），Daron Standley2,4），Yoshio Koyanagi4），Taisuke Izumi1），Akifumi Takaori-Kondo1）

1）Department of Hematology and Oncology, Kyoto University, Japan，2）WPI Research Center Immunology Frontier Research Center, Osaka University, Japan，3）Institute for Virus Research, Kyoto University, Japan，4）Laboratory of Integrated Biological Information, Kyoto University, Japan，5）Division of Systems Virology, Department of Infectious Disease Control, Institute of Medical Science, The University of Tokyo

W2-5-07 Biochemical characteristics of the HIV-1 Vif PPLP motif regionKazuhiro Matsuoka1），Hirotaka Ode1），Akiko Hamano1），Tatsuya Matsuoka1,2），Sayaka Sukegawa1），Atsuko Hachiya1），Mayumi Imahashi1），Yoshiyuki Yokomaku1），Yasumasa Iwatani1,3）

1）Clinical Research Center, National Hospital Organization Nagoya Medical Center，2）Department of Biotechnology, Nagoya University Graduate School of Engineering，3）Department of AIDS Research, Nagoya University Graduate School of Medicine

W2-5-08 HIV-1 Nef expression cause T-cells kinetic changingMegumi Inanaga1），Fumitaka Momose2），Yuko Morikawa2）

1）Graduate School of Infection Control Sciences, Kitasato University，2）Kitasato Institute for Life Science, Kitasato University

W2-5-09 HIV-1 core morphology assessment using single virion imaging based on FRETAnamaria Daniela Sarca1），Hirofumi Fukuda1），Kotaro Shirakawa1），Kazuki Horikawa2），Taisuke Izumi1），Akifumi Takaori-Kondo1）

1）Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University，2）Division of Bioimaging, Institute of Health Biosciences, University of Tokushima Graduate School

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WorkshopRoom 6（3F Conference Room No.2） Day 2　October 29 [Mon]　14：45～15：21

Pathogenesis 9Chairs：Chang-Kweng Lim（ Department of Virology Ⅰ, Laboratory of Arboviruses, National Institute of Infectious

Diseases）Ryousuke Suzuki（ Laboratory of Hepatitis Viruses Ⅱ, Department of VirologyⅡ, National Institute of Infectious

Diseases）

W2-6-01 Zika virus infection of common marmosets in early pregnancy leads to miscarriageToshifumi Imagawa1），Masahiko Ito1），Hideto Kino1），Shuji Takabayashi2），Kazuo Tanaka2），Mami Matsuda3），Ryosuke Suzuki3），Tomohiko Takasaki4），Tetsuro Suzuki1）

1）Department of Virology and Parasitolog, Hamamatsu University School of Medicine，2）Education & research Center for Preeminent Medical Photonics, Hamamatsu University School of Medicine，3）Department of Virology II, National Institute for Infectious Disease，4）Kanagawa Prefectural Institute of Public Health

W2-6-02 Hematopathogenesis of chimeric dengue mouse modelSupranee Phanthanawiboon1），Takeshi Kurosu2），Masayuki Shimojima2），Shuetsu Fukushi2），Tomoki Yoshikawa2），Shumpei Watanabe2），Tadaki Suzuki2），Noriyo Nagata2），Naoko Iwata-Yoshikawa2），Masayuki Saijo2）

1）RCEID, Department of Microbiology，2）National Institute of Infectious diseases, Japan

W2-6-03 Functional analysis of subgenomic flavivirus RNA derived from tick-borne encephalitis virusShoko Nishiyama1），Minato Hirano2），Memi Muto2），Mao Kambara2），Shintaro Kobayashi2），Hiroaki Kariwa2），Kentaro Yoshii2）

1）Laboratory of Zoonotic Disease, Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University，2）Laboratory of Public Health, Faculty of Veterinary Medicine, Hokkaido University

WorkshopRoom 6（3F Conference Room No.2） Day 2　October 29 [Mon]　15：21～15：57

Pathogenesis 10Chairs：Satoshi Koike（ Neurovirology Project, Department of Genome Medicine, Tokyo Metropolitan Institute of Medical

Science）Wataru Kamitani（ Research Institute for Microbial Diseases, Osaka University）

W2-6-04 Autophagy inhibition through AMP-activated protein kinase degradation in West Nile virus-induced neurological diseaseShintaro Kobayashi1），Kentaro Yoshii1），Wallaya Phongphaew2），Memi Muto1），Minato Hirano1），Yasuko Orba2），Hirofumi Sawa2），Hiroaki Kariwa1）

1）Laboratory of Public Health, Faculty of Veterinary Medicine, Hokkaido University，2）Division of Molecular Pathobiology, Hokkaido University Research Center for Zoonosis Control

W2-6-05 TLR ligands stimulate in vivo pathogenicity of Japanese encephalitis virusTatsuya Suzuki1），Yuka Miyata1），Yasuko Orba1,2），Yuki Eshita2），Hirofumi Sawa2），Takasuke Fukuhara1），Toru Okamoto1），Yoshiharu Matsuura1）

1）Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University，2）Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University

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The 66th Annual Meeting of the Japanese Society for Virology

W2-6-06 Inflammation amplifier plays a critical role in severe dengue hemorrhagic feverTakeshi Kurosu1），Daisuke Okuzaki2），Shuetsu Fukushi1），Masayuki Shimojima1），Supranee Phanthanawiboon1），Masayuki Saijo1）

1）National Institute of Infectious Diseases，2）Research Instgitute for Microbial Diseases, Osaka University

WorkshopRoom 6（3F Conference Room No.2） Day 2　October 29 [Mon]　15：57～16：45

Pathogenesis 11Chairs：Yoshio Mori（ Department of Virology Ⅲ, National Institute of Infectious Diseases）

Hiroyuki Shimizu（ Department of Virology Ⅱ, National Institute of Infectious Diseases）

W2-6-07 Tissue culture adaptation of enterovirus 71 selects mutant viruses that bind to HS and are attenuated in vivo

Kyousuke Kobayashi1），Son Thanh Chu2），Ayako Takashino1），Yoko Aoki3），Yohei Matoba3），Katsumi Mizuta3），Hidekazu Nishimura4），Hiroshi Ichimura2），Satoshi Koike1）

1）Neurovirology Project, Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science，2）Department of Viral infection and International Health, Graduate School of Medical Sciences, Kanazawa University，3）Department of Microbiology, Yamagata Prefectural Institute of Public Health.，4）Virus Research Center, Clinical Research Division, Sendai Medical Center

W2-6-08 Murine models of persistent infection by coxsackievirus B2 isolatesNoriyo Nagata1），Naoko Iwata-Yoshikawa1），Yen Hai Doan2），Hiroyuki Shimizu2），Hideki Hasegawa1）

1）Department of Pathology, National Institute of Infectious Diseases，2）Department of Virology II, National Institute of Infectious Diseases

W2-6-09 Theiler's virus-induced myocarditis model with acute viral replication, subacute T cell infiltration, and chronic fibrosis in the heartFumitaka Sato1），Seiichi Omura1），Eiichiro Kawai2），Nicholas E Martinez3），Madan M Acharya3），Pratap C Reddy3），J. Steven Alexander3），Ikuo Tsunoda1）

1）Kindai University Faculty of Medicine，2）Tohoku Medical and Pharmaceutical University，3）Louisiana State University Health Sciences Center-Shreveport

W2-6-10 Self-control in virus infections: Tuned activity of a potyvirid P1 protease defines viral replicative capacity and host rangeFabio Pasin1,2），Hongying Shan1），Carmen Simon-Mateo1），Bernardo Rodamilans1），Juan Antonio Garcia1）

1）Centro Nacional de Biotecnologia (CNB-CSIC)，2）Agricultural Biotechnology Research Center, Academia Sinica