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1Healthy Aims IST-2002-1-001837
Wireless Pressure Sensor System for Intracranial Pressure
Monitoring
Campus Micro TechnologiesMatthias Wenzel
[email protected]
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Healthy Aims Partner
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Hydrocephalus
Hydrocephalus describes state of excessive accumulation of CSF
within the fluid system of the head causing high intracranial
pressure Therapy: draining CSF from the CNS by shuntsNPH market:
375,000 cases each year in the U.S., $500 Mio market sizeApprox 40
per 100,000 Individuals have shunts in placeShunt failure
40% shunts fail in 1st year, 50% by 2nd yearShunts are revised
about two times in the first ten years of use per patient!
There is currently no practical way to measure shunt performance
in vivo!
www.motiv-medtech.comCSF – Cerebro Spinal FluidCNS – Central
Nervous SystemNPH – Normal Pressure Hydrocephalus
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Neuromonitoring
ICP monitoring in the management of severe head injuryToday‘s
techniques use strain gauge tip transducers and intraventricular
cathetersMain pitfalls of today’s techniques
http://connection.lww.com
High risk of infectionCatheter occlusionNeeds reposting of
transducer level with change in head position
Intraventricularcatheter
Increasing drift over timeHigh risk of infectionReduction of
patient mobility
Tip transducer
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Neurosurgical Applications
1. ICP monitoring in the clinical management of severe head
injury and other conditions causing high ICP
Alternative approach to conventional tip transducers2.
Continuous monitoring of ICP in hydrocephalus patients
Monitor shunt performance in-vivoTherapy optimization
3. Closed-loop hydrocephalus
shuntsFeedback-controllingEvent-driven therapy
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Requirements
Miniaturized and flexible for minimal invasive deliveryWireless
communicationNo battery or internal power sourceHighly
biocompatibleWave form analysis Minimal drift and temperature
stable Easy measurement at home
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System Overview
Inter
face
Modulation
Voltageregulator
AC
DC
Power
RF-tr
ansm
itter
Demodulator
Interface
Interface
Signal processing
Pressuresensor
ReferenceBase station
Inter
face
Wireless power and datatransmission
Pressure sensing tipInternal telemetry unitExternal telemetry
unit
Skin Pressure
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System Overview (Cont.)
Inductive coupling
RF communication
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Prototypes
Flexible substrate
Encapsulation into polymer
Electronics FC/SMD on flex
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Device Characteristics
Telemetric powering and data read-outIntraventricular or
parenchymal measurement‘Drift-free’ capacitive pressure
sensorTemperature stable readingsDynamic measurement possibleEasy
to insert and position; flexible
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Device Benefits
Scalp barrier reduces risk of infectionMinimal drift of
sensorProlonged monitoring possibleNo replacement required
Independent from shunt therapyHome monitoring Therapy control
and optimization
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Development Roadmap
2007200620052004
P8P7P6P5P4P3P2P1
Clinical trials and regulatory approval process
Frenchay Hospital, UK
2nd prototypeSystem optimization and
Design validation
Functional demonstratorComplete assembly:
SMT & FC on flex circuit
EU Market launch
Spin-off applications
Bench testingSystem design verification, in bench tests and
animal model
1st prototypeSMT & FC on flex circuit;Polymer encapsulation
&
Biocompatible barrier coating
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Spin-Off Applications
Monitoring endoluminal stent-grafts in abdominal aortic aneurysm
repairHome monitoring of patients suffering from congestive heart
failureWireless monitoring of urinary bladder pressure
…
Feed-back systems for gentle control and
therapy-optimization
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Conclusion
Implantable telemetric sensor systems will be of significant
value for cost-effective continuous monitoring of therapeutic
procedures even under everyday life conditions.Close collaboration
with clinical end-users guarantees development closely along the
market needs and medical requirements.High integration of
technology partners during development enables the introduction of
new add reliable products.First prototypes have raised high
expectations and are currentlybeing validated in bench
tests.Opportunity for new commercial partner
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Universitätsallee 29D-28359 Bremen
Germany
T: +49 421 20 20 783F: +49 421 20 20 900
[email protected]
