Wire Magazine 25 2016 Model Sergey Boytcov Through The Lens Of David Vance

A Transformation From Within

EGRIFTA® (tesamorelin for injection) is the only FDA-approved treatment for excess HIV-related abdominal VAT

Help Curb Excess Abdominal VAT

EGRIFTA® was shown to reduce VAT in 2 clinical trials of 816 total adult patients who received 2 mg of EGRIFTA® or placebo (26-week Main Phase and 26-week Extension Phase).a

Trial 1: 18% average reduction. Trial 2: 14% average reduction.

EGRIFTA® is not indicated to treat health issues beyond the reduction of excess abdominal VAT.

If you’re living with HIV, you may face another clinical challenge to healthy aging

Please see brief summary of full Important Patient Information on next page.

Visceral adipose tissue (VAT) isn’t regular fat. VAT is a hard fat that surrounds organs, may be associated with serious health issues, and can be difficult to control with diet and exercise alone.

SELECTED RISK INFORMATIONWhat is EGRIFTA®?

• EGRIFTA® is an injectable prescription medicine to reduce the excess in abdominal fat in HIV-infected patients with lipodystrophy. The impact and safety of EGRIFTA® on cardiovascular health has not been studied.

• EGRIFTA® is not indicated for weight loss management.• It is not known whether taking EGRIFTA® helps improve

compliance with anti-retroviral medications.

EGRIFTA® may cause serious side effects including:

• Serious allergic reaction. Stop using EGRIFTA® and get emergency help right away if you have symptoms such as a rash over your body, hives, shortness of breath or trouble breathing, swelling of your face or throat, fast heartbeat, and feeling of faintness or fainting.

• Swelling (fluid retention). EGRIFTA® can cause swelling in some parts of your body.

• Increase in glucose (blood sugar) intolerance and diabetes.• Injection site reactions. Change (rotate) your injection site to help

lower your risk for injection site reactions. The following symptoms around the area of the injection site can occur: redness, itching, pain, irritation, bleeding, rash, and swelling.

The most common side effects of EGRIFTA® include:joint pain, pain in legs and arms, swelling in your legs, muscle soreness, tingling, numbness and pricking, nausea, vomiting, rash, and itching.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

Learn more at EGRIFTA.com

aFor additional trial details, see the full Prescribing Information at EGRIFTA.com.

®

®

IMPORTANT PATIENT INFORMATION

The following is a brief summary only. See complete Prescribing Information at EGRIFTA.com or request complete Prescribing Information by calling 1-844-347-4382. This information does not take the place of talking to your doctor about your medical condition or your treatment.

What is EGRIFTA® (tesamorelin for injection)?




Do not use EGRIFTA® if you:

• have pituitary gland tumor, pituitary gland surgery or other problems related to your pituitary gland.

• have active cancer or are receiving treatment for cancer• are allergic to tesamorelin or mannitol. • are pregnant or become pregnant. If you become pregnant,

stop using EGRIFTA® and talk with your healthcare provider.

Talk to your doctor to find out if EGRIFTA® is right for you.

How should I use EGRIFTA®?

• Read the detailed “Instructions for Use” that comes with EGRIFTA® before you start using EGRIFTA®. Your healthcare provider will show you how to inject EGRIFTA®.

• Use EGRIFTA® exactly as prescribed by your healthcare provider.

• Inject EGRIFTA® under the skin (subcutaneously) of your stomach area (abdomen).

• Change (rotate) the injection site on your stomach area (abdomen) with each dose. Do not inject EGRIFTA® into scar tissue, bruises or your navel.


• Serious allergic reaction. Some people taking EGRIFTA® may have an allergic reaction.

Stop using EGRIFTA® and get emergency help right away if you have any of the following symptoms:

• a rash over your body

• hives

• swelling of your face or

throat

• shortness of breath or trouble breathing

• fast heartbeat

• feeling of faintness or fainting

• Swelling (fluid retention). EGRIFTA® can cause swelling in some parts of your body. Call your healthcare provider if you have an increase in joint pain, or pain or numbness in your hands or wrist (carpal tunnel syndrome).

• Increase in glucose (blood sugar) intolerance and diabetes. Your healthcare provider will measure your blood sugar periodically.

• Injection-site reactions. Change (rotate) your injection site to help lower your risk for injection-site reactions. Call your healthcare provider for medical advice if you have the following symptoms around the area of the injection site:

• redness • bleeding

• itching • rash

• pain • swelling

• irritation

The most common side effects of EGRIFTA® include: • joint pain • nausea

• pain in legs and arms • vomiting

• swelling in your legs • rash

• muscle soreness • itching

• tingling, numbness and pricking

These are not all the possible side effects of EGRIFTA®. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

You may also report side effects to toll-free at 1-844-EGRIFTA (1-844-347-4382).

For more information about EGRIFTA®, go to www.EGRIFTA.com or contact toll-free at 1-844-EGRIFTA (1-844-347-4382).

Manufactured by: Jubilant HollisterStier General Partnership, 16751 Trans-Canada Highway, Montreal, Québec, Canada H9H 4J4

Distributed by: Theratechnologies Inc., 2015 Peel Street, Montreal, Québec, Canada H3A 1T8.

EGRIFTA® and EGRIFTA ASSIST ® are registered trademarks of Theratechnologies Inc. © 2016 Theratechnologies Inc. All rights reserved. 190-01-12/15

®

®

IMPORTANT PATIENT INFORMATION

The following is a brief summary only. See complete Prescribing Information at EGRIFTA.com or request complete Prescribing Information by calling 1-844-347-4382. This information does not take the place of talking to your doctor about your medical condition or your treatment.

What is EGRIFTA® (tesamorelin for injection)?




Do not use EGRIFTA® if you:

• have pituitary gland tumor, pituitary gland surgery or other problems related to your pituitary gland.

• have active cancer or are receiving treatment for cancer• are allergic to tesamorelin or mannitol. • are pregnant or become pregnant. If you become pregnant,

stop using EGRIFTA® and talk with your healthcare provider.

Talk to your doctor to find out if EGRIFTA® is right for you.

How should I use EGRIFTA®?

• Read the detailed “Instructions for Use” that comes with EGRIFTA® before you start using EGRIFTA®. Your healthcare provider will show you how to inject EGRIFTA®.

• Use EGRIFTA® exactly as prescribed by your healthcare provider.

• Inject EGRIFTA® under the skin (subcutaneously) of your stomach area (abdomen).

• Change (rotate) the injection site on your stomach area (abdomen) with each dose. Do not inject EGRIFTA® into scar tissue, bruises or your navel.


• Serious allergic reaction. Some people taking EGRIFTA® may have an allergic reaction.

Stop using EGRIFTA® and get emergency help right away if you have any of the following symptoms:

• a rash over your body

• hives

• swelling of your face or

throat

• shortness of breath or trouble breathing

• fast heartbeat

• feeling of faintness or fainting

• Swelling (fluid retention). EGRIFTA® can cause swelling in some parts of your body. Call your healthcare provider if you have an increase in joint pain, or pain or numbness in your hands or wrist (carpal tunnel syndrome).

• Increase in glucose (blood sugar) intolerance and diabetes. Your healthcare provider will measure your blood sugar periodically.

• Injection-site reactions. Change (rotate) your injection site to help lower your risk for injection-site reactions. Call your healthcare provider for medical advice if you have the following symptoms around the area of the injection site:

• redness • bleeding

• itching • rash

• pain • swelling

• irritation

The most common side effects of EGRIFTA® include: • joint pain • nausea

• pain in legs and arms • vomiting

• swelling in your legs • rash

• muscle soreness • itching

• tingling, numbness and pricking

These are not all the possible side effects of EGRIFTA®. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

You may also report side effects to toll-free at 1-844-EGRIFTA (1-844-347-4382).

For more information about EGRIFTA®, go to www.EGRIFTA.com or contact toll-free at 1-844-EGRIFTA (1-844-347-4382).

Manufactured by: Jubilant HollisterStier General Partnership, 16751 Trans-Canada Highway, Montreal, Québec, Canada H9H 4J4

Distributed by: Theratechnologies Inc., 2015 Peel Street, Montreal, Québec, Canada H3A 1T8.

EGRIFTA® and EGRIFTA ASSIST ® are registered trademarks of Theratechnologies Inc. © 2016 Theratechnologies Inc. All rights reserved. 190-01-12/15

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TERMS AND CONDITIONS: O�ers valid through 6/6/16 and require activation of new qualifying DISH service with 24-month commitment and credit quali�cation. An Early Termination fee of $20 for each month remaining will apply if service is terminated during the �rst 24 months. All prices, fees, charges, packages, programming, features, functionality and o�ers subject to change without notice. PROGRAMMING DISCOUNT: Requires qualifying programming. Receive a discount for each of the �rst 12 months as follows: $35 per month with America’s Top 250; $30 per month with America’s Top 200; $25 per month with America’s Top 120, America’s Top 120 Plus; $15 per month with Smart Pack; $25 per month with DishLATINO Dos, DishLATINO Max; $20 per month with DishLATINO Plus; $15 per month with DishLATINO Clásico; $5 per month with DishLATINO Basico. After 12-month promotional period, then-current monthly price applies and is subject to change. You will forfeit discount in the case of a downgrade from qualifying programming or service disconnection during �rst 12 months. HD FREE FOR LIFE: Requires qualifying programming and continuous enrollment in AutoPay with Paperless Billing. Additional $10/mo. HD fee is waived for life of current account. O�er is limited to channels associated with selected programming package. Qualifying programming packages are America’s Top 120 and above, DishLATINO Plus and above. You may forfeit free HD in the case of service disconnection. PREMIUMS FREE FOR 3 MONTHS: Receive Showtime, Starz, Blockbuster @Home and Encore free for the �rst 3 months. You must maintain all four movie services during the promotional period. O�er value $132. After 3 months, then-current prices will apply unless you elect to downgrade. 6 FREE MONTHS OF PROTECTION PLAN: Receive the Protection Plan free for the �rst 6 months. O�er value $48. After 6 months, then-current price will apply unless you elect to downgrade. Change of Service fee will apply if you cancel the Protection Plan during the �rst 6 months. DIGITAL HOME ADVANTAGE: EQUIPMENT: All equipment remains the property of DISH at all times and must be returned to DISH within thirty days of account deactivation or you will be charged an unreturned equipment fee ranging from $100 to $400 per receiver. Lease Upgrade fees are not deposits and are non-refundable. Maximum of 6 leased receivers (supporting up to 6 total TVs) per account. You will be charged a monthly equipment rental fee for each receiver beyond the �rst, based on model of receiver. WHOLE-HOME HD DVR: Monthly fees: Hopper, $12; Joey, $7, Super Joey, $10; second Hopper, $12. First Hopper HD DVR receiver and up to 3 Joey receivers available for a one-time $199 Upgrade fee. $199 Upgrade fee waived at time of service activation with subscription to America’s Top 120 and above or DishLATINO Plus and above. A second Hopper HD DVR receiver is available for a one-time Upgrade fee: $49 for a Hopper, $99 for a Hopper with Sling. With a second Hopper HD DVR receiver, one additional Joey receiver is available for a one-time $99 Upgrade fee. Hopper and Joey receivers cannot be combined with any other receiver models or types. PrimeTime Anytime and AutoHop features must be enabled by customer and are subject to availability. With PrimeTime Anytime record ABC, CBS, FOX and NBC plus two channels. With addition of Super Joey record two additional channels. AutoHop feature is available at varying times, starting the day after airing, for select primetime shows on ABC, CBS, FOX and NBC recorded with PrimeTime Anytime. Recording capacity varies; 2000 hours based on SD programming. Equipment comparison based on equipment available from major TV providers as of 12/01/14. Watching live and recorded TV anywhere requires an Internet-connected, Sling-enabled DVR and compatible mobile device. On Demand availability varies based on your programming subscription. Requires Android OS 4.0 or higher to watch on an Android device and iOS 7.0 or higher to watch on iPhone or iPad. Select DVR recordings cannot be transferred. ALL OTHER RECEIVER MODELS: Lease Upgrade fee(s) will apply for select receivers, based on model and number of receivers. Monthly DVR and receiver fees may apply. Digital Home Advantage o�er is available from DISH and participating retailers for new and quali�ed former DISH residential customers in the continental United States. You must provide your Social Security Number and a valid major credit card. Participating retailers may require additional terms and conditions. The �rst month of DISH service must be paid at time of activation. Number of channels may decline. Local and state sales taxes and state reimbursement charges may apply. Where applicable, monthly equipment rental fees and programming are taxed separately. Standard Professional Installation includes typical installation of one single-dish antenna con�guration, typical hook-up of an eligible receiver con�guration and equipment testing. More complex installations may require additional fees; other installation restrictions apply. Prices valid at time of activation only; additional fees will apply to upgrade after installation. Any unreturned equipment fees will automatically be charged to your DISH account or credit or debit card provided to DISH. DISH shall determine eligibility for this o�er in its sole and absolute discretion. Programming and other services provided are subject to the terms and conditions of the Digital Home Advantage Customer Agreement and Residential Customer Agreement, available at www.dish.com or upon request. Blackout and other restrictions apply to sports programming. All service marks and trademarks belong to their respective owners. ©2015 DISH Network L.L.C. All rights reserved. HBO®, Cinemax® and related channels and service marks are the property of Home Box O�ce, Inc. HBO On Demand® and Cinemax On Demand® require compatible HD DVR receiver model. HBO GO® and MAX GO® are only accessible in the US and certain US territories where a high-speed connection is available. Minimum connection of 3 Mbps required for HD viewing on laptop. Minimum 3G connection is required for viewing on mobile devices. Some restrictions may apply. SHOWTIME and related marks are registered trademarks of Showtime Networks Inc., a CBS Company. STARZ and related channels and service marks are property of Starz Entertainment, LLC. ESPN GamePlan, NHL Center Ice, NBA League Pass, ESPN Full Court and MLS Direct Kick automatically continue at a special renewal rate each year provided DISH carries this service, unless you call to cancel prior to the start of the season. ESPN GamePlan, NHL Center Ice, NBA League Pass, ESPN Full Court and MLS Direct Kick are nonrefundable, nonproratable and nontransferable once the season begins. NHL, the NHL Shield and Center Ice name and logo are registered trademarks and The Game Lives Where You Do is a trademark of the National Hockey League. NHL and NHL team marks are the property of the NHL and its teams. © NHL 2015. All Rights Reserved. NBA, the NBA logo and team identi�cations are the exclusive property of NBA Properties, Inc. © 2015. All rights reserved. © 2015 NFL Enterprises LLC. NFL and the NFL Shield design are registered trademarks of the National Football League. MLS Direct Kick is a trademark of MLS. Sling is a registered trademark of Sling Media, Inc. All new customers are subject to a one-time processing fee.

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