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ICP-TEXINFINE Laboratoies

ICP-TEXINFINE Laboratories

TRANSPHYLOGENETIC COMPATIBILITY®

ICP-TEXINFINE Laboratories : Alliance of bioscience expertise

The collection of BIOMIMETIC REGULATORS® is the result of the

alliance of bioscience expertise of two laboratories where work is bolstered

by a humanistic vision instilled by their common creator Gilles

GUTIERREZ.

TEXINFINE is in charge of the control of fundamental research, the

pharmacological efficiency of BIOMIMETIC REGULATORS® and the

Marketing & Development.

ICP (Institute of Cellular Pharmacology) is in charge of all operations

related to the development of concepts, both technically and dosage

preparation and manufacturing industrial items.

Years of studies of the adaptive cell metabolism, common to all

living cells, have led ICP-TEXINFINE Laboratories to formulate

active ingredients. This collection of BIOMIMETIC

REGULATORS®, activate transduction signals.

Science learns from nature to activate the cell’s natural defenses against aging

and stress.

Natural Well-being and Vitality

ICP: Institute of Cellular Pharmacology

The laboratory and manufacture facilities are located in

Malta. ICP (Institute of Cellular Pharmacology Ltd.)

produces vegetal extracts for human and animal use in

large scale for the pharmaceutical, nutraceutical,

cosmetics and veterinary industries in accordance with

recognized quality standards by the United States Food

and Drug Administration(FDA) and its Good

Manufacturing Practices (GMP).

TEXINFINE

In 1982, Gilles Gutierrez (PhD) is pharmacologist. He

creates TEXINFINE laboratory, an entity primarily

dedicated to fundamental research in cell biology and

pharmacology and Marketing & Development.

TEXINFINE laboratory is located in FRANCE and

dedicated to the innovation and the promotion of all the

concepts distributed by the pharmaceutical, nutraceutical,

cosmetics and veterinary industries in accordance with

recognized quality standards by the United States Food

and Drug Administration(FDA) and European

Community.

Worldwide Partnerships

Biologist, Gilles Gutierrez is the author of papers concerning the

transfer of organisms from the plant kingdom to humans and many

patented innovations with applications in biotechnology allowing the

proliferation of opportunities for private and public partnerships. In

addition, ICP-TEXINFINE laboratories are involved in improving the

quality of cultured pearls in French Polynesia in a GDR research in

collaboration with IFREMER, the co-development of a platform of

Biology - Dermatology - cosmetology, in partnership with LAIBO

based in Shanghai (China); and PIC laboratory , based in Brazil…

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How to recover initial homeostasis and anticipate bio-

erosion processus ?

Process in charge of the adaptive

dynamics undergo bio-erosion, and

become less and less successful. The

organism does not compensate any more

effectively for the repetitive imbalance,

that they are endogenous or exogenous.

Gradually our body becomes less

adaptogen.

The accumulation of micro-imbalances

insufficiently compensated induces a

dynamic of mismatch, and its corollary:

diseases.

« Loss of physiological plasticity »

The physiological plasticity of our body makes way for an

unsuitable metabolic tolerance.

BIO-EROSION

The bio-erosion returns the body

lazy, even unfit of benefiting from

any outside help which would

target only the consequences of

the dysfunctions.

!

By epigenetic interactions,

BIOMIMETIC REGULATORS®

manage the recovery of

organism resiliency and

insure its structural and

functional balance.

ICP-TEXINFINE laboratoires

BIOMIMETIC REGULATORS

® restore

and / or awake the endogenous

therapeutic strengths of our body

ICP-TEXINFINE laboratoires

This innovative holistic scientific approach has gained Dr.

Gilles GUTIERREZ, the founder and the scientific Director

of ICP-TEXINFINE Laboratories, the medal from the

Pasteur Institute in France both for his studies on cellular

communication by means of physical signals and

TRANSPHYLOGENETIC COMPATIBILITY®.

A collection of BIOMIMETIC REGULATORS®

DNA-PKASE ® Inhibat

DNA-PKASE® Inhibat

4 years of clinical

experience

Protects DNA from genotoxicity

and promotes homologous DNA

repair. Preserves the inherent

integrity of cellular genomics.

.

Learn more: http://www.icp-texinfine.com/images/uploads/file/Singapour%20BIOMIMETIC%20REGULATORS.pdf

DNA-PKASE® Inhibat may be used in the following instances:

Corrective Bioregulation:

Reduces the risk of emergence of MDR in a programmed or

random exposure to chemicals or ionizing radiation.

Reduces the risk of onset or replication of anarchical cells induced

by genotoxic substances.

Helps eliminate anarchical cells by promoting homologous repair.

Prophylactic Bioregulation:

Promotes the homologous restoration of DNA.

Helps to fight against the advent of anarchical (mutagen) cells.

Helps to decrease the risk of onset or recurrence of anarchical cell.

Cinchona Officinalis,

Vanilla tahitensis Actions

Expected Physiological Benefits

Homeostasis of genome

integrity

Homologous DNA

reparation Identification

and elimination of

anarchical (mutagen)

cells

Strengthening of

antimutagenic

treatments

Restores the genomic integrity

Helps prevent the advent of

anarchical (mutagen) cells

Protects upstream integrity of our

proteins

Promotes the natural mechanism of

genetic remediation, of the immune

system

Facilitates the removal of anarchical

(mutagen) cells by decreasing the

MDR.

DNA-PKASE® Inhibat

DNA-PKASE® Inhibat: an alliance of 2 plants

The powder of Cinchona officinalis:

Malignant cells can develop resistance in response to exposure to chemical

repairers or even to ionizing radiation exposure. This resistance known as MDR

(M=Multi D=Drug R=Resistance) seems to be proportional to the duration of the

contact between the cell and the restorative substance. It results in an excessive

expression of a protein on the membrane’s cell surface that has begun an

antimutagenic treatment.

This protein functions as a pump, delivering to the extracellular area, substances

intended to affect radical cell metabolism. The powder of Cinchona officinalis, by

inhibiting the operation of "pump proteins," allows restorative substances to more

easily reach the cytoplasm of malignant cells and stay there longer. The powder of

Cinchona officinalis promotes, not only the effectiveness of substances intended

to control malignant cells, but also saves healthy cells by preventing their

exposure to genotoxic substances.

DNA-PKASE® Inhibat: an alliance of 2 plants

The standard extract of Vanilla tahitensis:

The in vitro studies show antimutagenic effects of the

standard Vanilla tahitensis extract. The standard extract of

Vanilla tahitensis suppresses non-homologous repair

pathways by inhibiting the activity of DNA-PKcs

complex initiator of the pathway.

MILACTIF® 200: Portulaca oleracea

BIOMIMETIC REGULATOR® PNV™

Apoptose

MILACTIF®

MILACTIF® may be used in the following instances:

Prophylactic regulation: - Protects the brain, the skin and all sensitive tissues during exposure to

chemotherapy or radiotherapy.

- Boosts cerebral performance: concentration, treatment of memorized

information, alertness by protecting neurons from excessive apoptosis.

- Slows down the ageing of our organs due to excessive programmed cell

death.

Corrective regulation: - Helps the body to regenerate its immune system after an ordeal.

- Restores the vitality of the skin after exposure to UV and/or other radiation.

- Eases the cytotoxic effects of certain harmful endogenous or environmental

substance.

How the PNV™ bioregulator works

The ICP-TEXINFINE laboratories have shown that the whole extract of

purslane or Portulaca oleracea: PNV™ contained in MILACTIF® 200 has

regulatory and cytoprotective effects on neurons, immune cells and

keratinocytes in cell culture systems. Researchers at the ICP-TEXINFINE

laboratories have extracted and patented the PNV™ active substance – the

secret to the purslane’s vitality. The longevity of this plant lies in its ability to

synthesise bioactive regulators that are capable of maintaining the balance

between cell division and cell death, even in the presence of harmful substances.

MILACTIF® 200 regulates cellular loss related to premature or chronological

ageing. Results obtained in a cellular culture suggest that MILACTIF® 200 can

be recommended principally as prevention against neurodegenerative disorders

that can occur during the course of ageing.

Padina pavonica harvesting

DICTYOLONE® 500: l’algue Padina pavonica

BIOMIMETIC REGULATOR® : EPP™

Biomineralisation

DICTYOLONE® 500

Restores and protects bone

density and skin structure.

The alga Padina pavonica is a formidable source of a biomimetic regulator

EPP™ that maintains the integrity of the organic and mineral framework of

the bone. The cells on the surface of this plant developed a protective mechanism

that involved the construction of a calcified exoskeleton, even when the early

ocean lacked mineral salts. Well conserved over time, this basic mechanism is

transferable to human beings and all animal species, terrestrial or marine, by

phylogenetic cross-compatibility. The bioregulator offered by this distant

phylogenetic relative is a duplicate of the physiological molecules involved with

in utero development and the biomineralisation processes throughout our

development. When our regulatory mechanisms fail, these ancestral regulators

have the ability to relaunch the mechanisms of cellular qualification (phenotype)

along with biomineralisation that are deeply anchored in the functional

intelligence of our organism.

How the EPP™ Bioregulator works

Our in vitro studies have shown objectively that the bioregulator extracted

from Padina pavonica alga, EPP™, has a role in the production of the

whitish felting that coats the external part of the fronds. The EPP™

bioregulator has the ability to conserve the biological authenticity of the cells in

support tissues (mesenchymal), especially that of the osteoblasts (cells involved

in the building of bone) and keratinocytes (skin cells). The EPP™ bioregulator

triggers not only the differentiation of progenitor cells into osteoblasts, but also

the re-establishment of the organic framework that is crucial to the

biomineralisation process of our bones and the structure of our skin. Thus, from

one generation to another, these cells keep their ability to maintain the

equilibrium of bone tissue, by stimulating biomineralisation and the production

of collagens and glycosaminoglycans (GAGs). Among other factors, it is the

proportion in which these three components are combined that give bone,

cartilage and skin their particular characteristics.

How the EPP™ Bioregulator works

DICTYOLONE® 500 may be used in the following instances: Corrective bioregulation :

Restarts biomineralisation by restoring the integrity of the organic framework of bone.

Restores biomineralisation mechanisms to overcome the ageing of the skeleton and joints

during acute exacerbation.

Supports the organism in cases of bone fragility linked to age.

Helps to repair fractures and tendon injuries.

Normalizes the function and quality of the skin.

Prophylactic bioregulation :

Maintains the natural biomineralisation functions ready to respond to erosion linked to

chronological ageing, menopause, etc.

Supports the growth phase in people who are predisposed to faulty regulation of the

biomineralisation mechanisms.

Prevents ageing of the skin and keratinous tissues such as nails and hair from the inside as

an adjunct to localized treatment.

DICTYOLONE® 500

Biomimetic

Regulator

EPP™

Bioregulatory actions Expected physiological benefits

Functional

homeostasis of

tissues

Phenotypic expression of cells. Restores the original role of cells altered by age or unfavourable

circumstances.

Homeostasis of the

integrity of bone and

cartilage tissue

Osteogenesis and differentiation of

progenitor cells into osteoblasts and

chondrocytes.

Integrity of the bone’s organic matrix:

forms a framework to which calcium can

attach itself. This matrix forms a reservoir

for cytokines and triggers the bio-

mineralisation pathway.

Integrity of the chondrocyte phenotype.

Preservation of joint tissue and joint

surfaces.

Integrity and repair of tendons.

Restores the function of cells in joints and in the bone framework.

Restores the innate capacity of cells to fix calcium on the

extracellular matrix.

Protects joints from accelerated deterioration due to ageing, life-

style, etc. by restoring the synthesis of glycosaminoglycans such

as chondroitin sulphate.

Improves and restores the synthesis of collagens, even during

episodes of inflammation.

Homeostasis of the

integrity of the skin

Structure of the extracellular matrix: the

architectural and functional framework of

the skin cells: fibroblasts and

keratinocytes.

Synthesis of collagen fibres and inhibition

of the activity of collagenases (enzymes

involved in the destruction of collagen

fibres).

Enables the skin to fulfil its role as a protective barrier.

Maintains skin density.

Helps to conserve the flexibility and softness of the skin thanks to

the ability of glycosaminoglycans (hyaluronic acid, dermatan

sulphate, heparan sulphate,etc.) to hold water like a sponge.

DICTYOLONE® 500

Synthèse du Collagène

0,0

0,5

1,0

1,5

2,0

2,5

3,0

3,5

4,0

4,5

Control IL-1 Estradriol Estradriol+ IL-1

(72h)

EPP EPP+ IL-1

(72h)

Vitamine D3

(72h)

D3+ IL-1 (72h)

CP

M

Fibroblasts 46 Y

Osteoblasts 58Y

Chondrocytes G292

Manchester Presented

Les molécules actives contenues dans la padine sont les seules à activer la synthèse du

collagène des ostéoblastes et des chondrocytes en situation inflammatoire (Interleukine 1).

Synthèse des Glycosamino glycanes

0,0

0,5

1,0

1,5

2,0

2,5

3,0

3,5

4,0

4,5

Contrôle IL-1 Estradiol Estradiol+

IL-1 (72h)

EPP EPP+ IL-1

(72h)

Vitamine

D3

D3+ IL-1

(72h)

Cal

ciu

m F

ixé

en μ

g *

ml-

1

Fibroblasts 46 Y

Chondrocytes

DICTYOLONE® 500

Manchester Presented

Les molécules actives contenues dans la padine sont les seules à activer la

synthèse des glycosaminoglycanes en situation inflammatoire.

Ostéoblastes traités par : inhibiteur calcique,

estradiol et EPP™

0,0

0,5

1,0

1,5

2,0

2,5

3,0

3,5

Control EPP EPP +

diltiazem

Verapamil diltiazem Estradiol + 10-

7 M

Verapamil +

estradiol

Diltiazem +

Estradiol 10-

7M

Ind

ice

de

Va

ria

tion

de

Fix

atio

n d

u C

alc

ium

UMR 106G292Primary osteoblast 73y

Manchester Presented

DICTYOLONE® 500

Les molécules actives contenues dans la padine sont les seules à maintenir la fixation

du calcium par les ostéoblastes en présence d’inhibiteur du canal calcique.

34

% d

iffe

ren

ce f

rom

base

lin

e

DICTYOLONE® 500: Lumbar spine bone Density

0m 3m 6m 9m 12m -2.000

-1.000

0.000

1.000

2.000

3.000

4.000

5.000

6.000

7.000

0 mg/D

400 mg/D *

* p<0.05

Time from start of treatment

Dictyolone

Contrôle

35

% d

iffe

ren

ce f

rom

base

lin

e

0m 3m 6m 9m 12m

-6.000

-4.000

-2.000

0.000

2.000

4.000

6.000

200 mg/D

0 mg/D

**

** p<0.01

Time from start of treatment

Dictyolone

Contrôle

DICTYOLONE® 500 : Femur neck bone Density

36

DICTYOLONE® 500

PRESERVATION® : Opuntia ficus indica

BIOMIMETIC REGULATOR®TEX-OE™

PRESERVATION® restores and protects the natural

repair and defense capacities of the organism against cellular stress.

PRESERVATION®

PRESERVATION ®

optimizes the adaptive potential of the organism.

PRESERVATION®

Keeps the HSPs at a

sufficient level, thereby

ensuring that the body is

protected. TEX-OE™

TEX-OE™ to keep your body:

Reactive – Resistante - Resiliente

PRESERVATION®improves the

body’s response to stress by

inducing the recreation of stress

proteins or HSPs.

PRESERVATION ®

: TEX-OE™

Biomimetic

Regulator®

TEX-OE™ Actions Expected physiological benefits

Homeostasis of

the adaptive

potential of the

organism

Transcription of HSPs, initiated

by the decoupling of the HSP-

HSF complex.

Conformation of the spatial and

functional structure of proteins.

Identification and elimination of

self-proteins that have become

foreign.

Preservation of the threshold

supply of HSPs, which are

essential for triggering our

natural protective mechanisms.

Restoration of damaged proteins

and elimination of proteins that

cannot be repaired.

Regeneration of other BIOMIMETIC REGULATORS

®

Quickly reactivate the natural protective, adaptive

capacities.

Optimize the capacity for self-defense and self-

repair, avoiding the functional deviations in

proteins, for a more resilient and more combative

body.

Precondition the body to make it combative and

resistant to new contacts with cell stress factors.

Regenerate the immune regulation conduits.

Maintains the potential for self-regulation

essential for physiological resiliency.

PRÉSERVATION® may be used in the following instances:

• Preparing the body for

stresses related to planned

activities: - Exposure to heat and exposure to cold.

- Exposure to electromagnetic radiation:

visible light, sunlight, UV light, X-rays

and gamma rays.

- Intense/prolonged effort, such as sports

training or competition.

- Changes in pressure: diving, altitude,

air travel or changes in metabolism

caused by jet lag, seasonal changes,

overwork.

- Scheduled medical procedures, such as

anesthesia, invasive investigations,

surgery, laser surgery, dermabrasion, etc.

• Repairing damaged

tissues, whatever the cause: - After sun exposure, surgery,

radiotherapy, etc.

- During recovery: diet, prolonged

fasting, long-term bed rest, etc.

- Physiological disorders caused

by alcoholic drinks, toxic

substances, smoking, etc.

- Natural and premature ageing.

- During treatments for sickle cell

anemia.

PRESERVATION® optimizes all our BIOMIMETIC

REGULATORS®

TEX-OE™

CAE™ PNV™

OESF™ EPP™

EPP™

HEXAPORINE® : Punica granatum

REGULATEUR BIOMIMETIQUE® CAE™

Aquaporine

HEXAPORINE®

Restores and preserves correct water levels

within the organism.

HEXAPORINE®

optimizes water channels’ activities

II – HEXAPORINE®

regulates the

water channels‘ activities, and restores

both the PH and water volume that are

indispensable for normal cellular

performance.

I - Increases the rate of active

aquaporine

III – HEXAPORINE®

dietary

supplement improves the functional

properties of aquaporines.

Corrective bio-regulation

- Reduces the sensation of heavy legs.

- Improves body contours by helping to eliminate the feeling of bloating

due to water retention.

- Prevents dehydration induced by: physical exertion, very high

temperatures, or exposure to sun and/or cold.

- Relieves dry skin caused by: ageing, loss of water from sweating,

exposure to sun, detergent products, or aggressive treatments.

- Resorbs the oedema that occurs after surgery.

Prophylactic bio-regulation

- Improves hydric drainage, intestinal and renal transit and removal of

metabolic waste.

- Reinforces a healthy diet by regulating the removal of toxins.

- Reduces gynaecological problems, such as water retention and tissue

tautness.

HEXAPORINE®

: CAE™

HEXAPORINE®

Biomimetic

Regulator

CAE™

Actions Expected physiological benefits

Homeostasis of

water volume in the

extra- and intra-

cellular milieu.

Increases the expression of

Aquaporins.

Opens water channels by removing

blockages accumulated over time or

due to pathological conditions.

Protects water channels from

obstruction by substances of

endogenous (oestrogen surge at

ovulation) or exogenous origin,

allowing water to flow freely.

Regulates the mechanisms that open

and close water channels.

Replenishes cell water.

Restores the correct volume and rate of water

replenishment in cells: elimination of metabolic waste,

better cellular nutrition and communication.

Optimises the vital function of certain hydric-secreting

glands.

Restores the liquid equilibrium between the intra-cellular

and extra-cellular environment.

Maintains an optimal level of hydration in the organism.

Regulates blood pressure.

Limits water loss from the skin, allowing it to fulfil its

function as a protective barrier. The outer layer of the

skin, which depends on the underlying dermis for its

water supply, is the organ most exposed to dehydration.

The Aquaporin type 3 proteins found in the skin are

involved in the transport of glycerol, a substance

naturally present within the body whose hygroscopic

effect protects the skin’s water reserves.

How the CAE™ Bioregulator works

The researchers in the ICP-TEXINFINE laboratories found that the

pomegranate is one of the rare fruits that are rich in oestrogens, and that it

effectively manages its water assets, in part, by means of hormones, molecules

similar to human sex steroids. The laboratories work with cultured human cells

allowed us to verify that this fruit possesses a rival action of oestrogen on water

movement. The mechanisms, which have allowed the pomegranate, Punica

granatum, to adapt to its environment over many millennia, involve a substance

contained in the fleshy part of the fruit which regulates the function of the

water channels. This substance, the CAE™ regulator, is the main component of

the HEXAPORINE® nutritional supplement.

The ICP-TEXINFINE laboratories have shown objectively, in vitro, the

regulatory function that CAE™ performs in water channels. In

fact, as in the pomegranate, the CAE™ regulator is able to remove

substances that are incongruously attached to water channels. The

presence of these substances can lead to the blockage of the water

channel. If the channel is blocked in the open position, the consequence is

water retention. If the channel remains closed, this induces, among other

things, dehydration of the tissue in question. The bioregulator used by the

pomegranate is cross-compatible and allows hydric balance to be

restored in humans who have lost this regulatory ability.

How the CAE™ Bioregulator works

CYCLOTELIA® : OLEUM EX FLOS SALIS(OEFS™ )

BIOMIMETIC REGULATOR® : OEFS™

β-endorphine: Well-being booster

CYCLOTELIA®

Corrective bio-regulation :

- Stabilizes mood alterations: irritability, anxiety, sluggishness, etc.

- Moderates behavioral problems: lack of energy, insomnia, food

addictions, etc.

- Optimizes the potential to adapt to: emotional shocks, life

changes, seasonal changes, convalescence, withdrawal symptoms.

- Helps to better live with mood fluctuations due to: over-exertion,

premenstrual syndromes, menopause, post-partum periods.

Prophylactic bio regulation :

- Potentiates and preserves our capacity for emotional adaptation in

all cases of scheduled stress.

CYCLOTELIA® : OEFS™

OESF™ Actions Expected physiological

benefits

Homeostasis

of mental

dynamism

Increased release

of ß-endorphin, a

natural substance

essential to

managing well-

being.

Protection of ß-

endorphin through

the storage role of

heparan sulphate.

Extended release

of ß-endorphin.

• Regulates the perception of

emotions: pleasure, pain,

desire, emptiness, etc.

Provides sufficient energy to

face micro-stress, a source of

overload.

Stabilizes the sensation of

well-being.

CYCLOTELIA® : Flos salis

Before

After

β-endorphine synthesise variations with OESF™

y = 0,9644e-0,291x

R2 = 0,9879

y = 0,9962e-0,0542x

R2 = 0,9447

0%

20%

40%

60%

80%

100%

120%

0 1 2 3 4 5 6 7 8 9

Vitesse de dégradation de β-endorphine dans le tampon

PBS avec ou sans héparane-sulfate

Sans HS

Avec HS

0

0,5

1

1,5

2

2,5

Flu

ore

sc

en

ce

(u

n.a

rb

.)

24H 48H 72H 7J

Expression de beta-Endorphine par des kératinocytes en culture

(HaCaT) : Effets croisés de Cycl. et de HPS-3

Contrôle

Cycl.

HPS-3

Cycl.+HPS-3

0,000

0,500

1,000

1,500

2,000

2,500

Flu

orescen

ce

(u

n.a

rb

.)

24H 48H 72H 7J

Expression de beta-Endorphine par des fibroblastes (FPH) :

Effets croisés de Cycl. et de HPS-3

Contrôle

Cycl.

HPS-3

Cycl.+HPS-3

LA VANILLE POTENTIALISE L’EFFET DE FLOS SALIS

-

0,50

1,00

1,50

2,00

2,50

3,00

3,50

Contrôle Flos salis E de Vanilla t. FS VT

Regulate your

endogenous cellular

potential!

Science learns from nature to activate the cell's natural defenses against

aging and stress.

Natural Well-being and Vitality

CONTACT US:

Gilles GUTIERREZ: g.gutierrez@icp-texinfine.fr

Khâdidja BILINSKI : k.bilinski@icp-texinfine.fr

www.icp-texinfine.fr