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Will Penny
Wellcome Centre for Neuroimaging at UCL
Methods Physics
Attention
Language Memory
Emotion
Vision fMRI MEG
TheoreticalNeurobiology
Statistical Parametric Mapping (SPM)
RealignmentRealignment SmoothingSmoothing
NormalisationNormalisation
General linear modelGeneral linear model
Statistical parametric mapStatistical parametric mapImage time-seriesImage time-series
Parameter estimatesParameter estimates
Design matrixDesign matrix
TemplateTemplate
KernelKernel
Random Random Field TheoryField Theory
p <0.05p <0.05
StatisticalStatisticalinferenceinference
),,( uxFx Neural state equation:
Electric/magneticforward model:
neural activityEEGMEGLFP
(linear)
Neural model:1 state variable per regionbilinear state equationno propagation delays
Neural model:8 state variables per region
nonlinear state equationpropagation delays
fMRIfMRI MEGMEG
inputs
Hemodynamicforward model:neural activityBOLD(nonlinear)
Dynamic Models of Brain Interactions
Dynamical Neural Network Model for fMRI
1 11 12 1 1 12
2 21 22 2 21 2 2
0 0
0 0
z a a z z ucu
z a a z b z u
u2
u1
z1
z2
u2
z1
z2
u1
a11
a22
c
a1
2
a21
b21
Opportunities
UCL CoMPLEXComputer ScienceEngineeringPhysicsStatistics