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10/05/15 18:05Hyperalgesia - Wikipedia, the free encyclopedia
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HyperalgesiaClassification and external resources
ICD-9 782.0(http://www.icd9data.com/getICD9Code.ashx?icd9=782.0)
DiseasesDB 30788(http://www.diseasesdatabase.com/ddb30788.htm)
MeSH D006930(https://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?field=uid&term=D006930)
HyperalgesiaFrom Wikipedia, the free encyclopedia
Hyperalgesia (/ˌhaɪpərælˈdʒiziə/ or /-siə/; 'hyper'from Greek ὑπέρ (huper, “over”), '-algesia' fromGreek algos, ἄλγος (pain)) is an increasedsensitivity to pain, which may be caused bydamage to nociceptors or peripheral nerves.Temporary increased sensitivity to pain also occursas part of sickness behavior, the evolved responseto infection.[1]
Contents1 Types2 Causes3 Treatment4 See also5 References
TypesHyperalgesia can be experienced in focal, discrete areas, or as a more diffuse, body-wide form. Conditioningstudies have established that it is possible to experience a learned hyperalgesia of the latter, diffuse form.
The focal form is typically associated with injury, and is divided into two subtypes:
Primary hyperalgesia describes pain sensitivity that occurs directly in the damaged tissues.Secondary hyperalgesia describes pain sensitivity that occurs in surrounding undamaged tissues.
Opioid-induced hyperalgesia may develop as a result of long-term opioid use in the treatment of chronic pain.[2]
Various studies of humans and animals have demonstrated that primary or secondary hyperalgesia can developin response to both chronic and acute exposure to opioids. This side effect can be severe enough to warrantdiscontinuation of opioid treatment.
CausesHyperalgesia is induced by platelet-activating factor (PAF) which comes about in an inflammatory or an allergicresponse. This seems to occur via immune cells interacting with the peripheral nervous system and releasingpain-producing chemicals (cytokines and chemokines).[3]
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Look up hyperalgesia inWiktionary, the freedictionary.
One unusual cause of focal hyperalgesia is platypus venom.[4]
Long term opioid (e.g. heroin, morphine) users and those on high-dose opioid medications for the treatment ofchronic pain, may experience hyperalgesia and experience pain out of proportion to physical findings, which isa common cause for loss of efficacy of these medications over time.[2][5][6] As it can be difficult to distinguishfrom tolerance, opioid-induced hyperalgesia is often compensated for by escalating the dose of opioid,potentially worsening the problem by further increasing sensitivity to pain. Chronic hyperstimulation of opioidreceptors results in altered homeostasis of pain signalling pathways in the body with several mechanisms ofaction involved. One major pathway being through stimulation of the nociceptin receptor,[7][8][9] and blockingthis receptor may therefore be a means of preventing the development of hyperalgesia.[10]
Stimulation of nociceptive fibers in a pattern consistent with that from inflammation switches on a form ofamplification in the spinal cord, long term potentiation.[11] This occurs where the pain fibres synapse to painpathway, the periaqueductal grey. Amplification in the spinal cord may be another way of producinghyperalgesia.
The release of proinflammatory cytokines such as Interleukin-1 by activated leukocytes triggered bylipopolysaccharides, endotoxins and other signals of infection also increases pain sensitivity as part of sicknessbehavior, the evolved response to illness.[1][12][13]
TreatmentHyperalgesia is similar to other sorts of pain associated with nerveirritation or damage such as allodynia and neuropathic pain, andconsequently may respond to standard treatment for these conditions,using various drugs such as SSRI or tricyclic antidepressants,[14][15]
Non-steroidal anti-inflammatory drugs,[16] glucocorticoids,[17] gabapentin[18] or pregabalin,[19] NMDAantagonists,[20][21][22] or atypical opioids such as tramadol.[23] Where hyperalgesia has been produced bychronic high doses of opioids, reducing the dose may result in improved pain management.[24] However, aswith other forms of nerve dysfunction associated pain, treatment of hyperalgesia can be clinically challenging,and finding a suitable drug or drug combination that is effective for a particular patient may require trial anderror. The use of a transcutaneous electrical nerve stimulation device has been shown to alleviatehyperalgesia.[25][26]
See alsoAllodynia
References
10/05/15 18:05Hyperalgesia - Wikipedia, the free encyclopedia
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1. Hart BL (1988). "Biological basis of the behavior of sick animals" (http://linkinghub.elsevier.com/retrieve/pii/S0149-7634(88)80004-6). Neurosci Biobehav Rev 12 (2): 123–37. doi:10.1016/S0149-7634(88)80004-6(https://dx.doi.org/10.1016%2FS0149-7634%2888%2980004-6). PMID 3050629(https://www.ncbi.nlm.nih.gov/pubmed/3050629).
2. Chu LF, Angst MS, Clark D (2008). "Opioid-induced hyperalgesia in humans: molecular mechanisms and clinicalconsiderations" (http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0749-8047&volume=24&issue=6&spage=479). Clin J Pain 24 (6): 479–96. doi:10.1097/AJP.0b013e31816b2f43(https://dx.doi.org/10.1097%2FAJP.0b013e31816b2f43). PMID 18574358(https://www.ncbi.nlm.nih.gov/pubmed/18574358).
3. Marchand F, Perretti M, McMahon SB (July 2005). "Role of the immune system in chronic pain". Nat. Rev. Neurosci. 6(7): 521–32. doi:10.1038/nrn1700 (https://dx.doi.org/10.1038%2Fnrn1700). PMID 15995723(https://www.ncbi.nlm.nih.gov/pubmed/15995723).
4. de Plater GM, Milburn PJ, Martin RL (March 2001). "Venom from the platypus, Ornithorhynchus anatinus, induces acalcium-dependent current in cultured dorsal root ganglion cells" (http://jn.physiology.org/cgi/pmidlookup?view=long&pmid=11248005). J. Neurophysiol. 85 (3): 1340–5. PMID 11248005(https://www.ncbi.nlm.nih.gov/pubmed/11248005).
5. DuPen A, Shen D, Ersek M (September 2007). "Mechanisms of opioid-induced tolerance and hyperalgesia"(http://linkinghub.elsevier.com/retrieve/pii/S1524-9042(07)00076-8). Pain Manag Nurs 8 (3): 113–21.doi:10.1016/j.pmn.2007.02.004 (https://dx.doi.org/10.1016%2Fj.pmn.2007.02.004). PMID 17723928(https://www.ncbi.nlm.nih.gov/pubmed/17723928).
6. Mitra S (2008). "Opioid-induced hyperalgesia: pathophysiology and clinical implications". J Opioid Manag 4 (3): 123–30. PMID 18717507 (https://www.ncbi.nlm.nih.gov/pubmed/18717507).
7. Okuda-Ashitaka E, Minami T, Matsumura S et al. (February 2006). "The opioid peptide nociceptin/orphanin FQmediates prostaglandin E2-induced allodynia, tactile pain associated with nerve injury"(http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0953-816X&date=2006&volume=23&issue=4&spage=995). Eur. J. Neurosci. 23 (4): 995–1004. doi:10.1111/j.1460-9568.2006.04623.x (https://dx.doi.org/10.1111%2Fj.1460-9568.2006.04623.x). PMID 16519664(https://www.ncbi.nlm.nih.gov/pubmed/16519664).
8. Fu X, Zhu ZH, Wang YQ, Wu GC (January 2007). "Regulation of proinflammatory cytokines gene expression bynociceptin/orphanin FQ in the spinal cord and the cultured astrocytes" (http://linkinghub.elsevier.com/retrieve/pii/S0306-4522(06)01236-X). Neuroscience 144 (1): 275–85. doi:10.1016/j.neuroscience.2006.09.016(https://dx.doi.org/10.1016%2Fj.neuroscience.2006.09.016). PMID 17069983(https://www.ncbi.nlm.nih.gov/pubmed/17069983).
9. Chen Y, Sommer C (May 2007). "Activation of the nociceptin opioid system in rats. Sensory neurons produceantinociceptive effects in inflammatory pain: involvement of inflammatory mediators". J. Neurosci. Res. 85 (7): 1478–88. doi:10.1002/jnr.21272 (https://dx.doi.org/10.1002%2Fjnr.21272). PMID 17387690(https://www.ncbi.nlm.nih.gov/pubmed/17387690).
10. Tamai H, Sawamura S, Takeda K, Orii R, Hanaoka K (March 2005). "Anti-allodynic and anti-hyperalgesic effects ofnociceptin receptor antagonist, JTC-801, in rats after spinal nerve injury and inflammation"(http://linkinghub.elsevier.com/retrieve/pii/S0014-2999(05)00063-4). Eur. J. Pharmacol. 510 (3): 223–8.doi:10.1016/j.ejphar.2005.01.033 (https://dx.doi.org/10.1016%2Fj.ejphar.2005.01.033). PMID 15763246(https://www.ncbi.nlm.nih.gov/pubmed/15763246).
11. Ikeda H, Stark J, Fischer H et al. (June 2006). "Synaptic amplifier of inflammatory pain in the spinal dorsal horn"(http://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=16778058). Science 312 (5780): 1659–62.doi:10.1126/science.1127233 (https://dx.doi.org/10.1126%2Fscience.1127233). PMID 16778058(https://www.ncbi.nlm.nih.gov/pubmed/16778058).
12. Kelley KW, Bluthé RM, Dantzer R et al. (February 2003). "Cytokine-induced sickness behavior"(http://linkinghub.elsevier.com/retrieve/pii/S0889159102000776). Brain Behav. 17 (Suppl 1): S112–8.doi:10.1016/S0889-1591(02)00077-6 (https://dx.doi.org/10.1016%2FS0889-1591%2802%2900077-6). PMID 12615196(https://www.ncbi.nlm.nih.gov/pubmed/12615196).
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Página 4 de 5http://en.wikipedia.org/wiki/Hyperalgesia
13. Maier SF, Wiertelak EP, Martin D, Watkins LR (October 1993). "Interleukin-1 mediates the behavioral hyperalgesiaproduced by lithium chloride and endotoxin" (http://linkinghub.elsevier.com/retrieve/pii/0006-8993(93)91446-Y). BrainRes. 623 (2): 321–4. doi:10.1016/0006-8993(93)91446-Y (https://dx.doi.org/10.1016%2F0006-8993%2893%2991446-Y). PMID 8221116 (https://www.ncbi.nlm.nih.gov/pubmed/8221116).
14. Sindrup SH, Otto M, Finnerup NB, Jensen TS (June 2005). "Antidepressants in the treatment of neuropathic pain"(http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1742-7835&date=2005&volume=96&issue=6&spage=399). Basic Clin. Pharmacol. Toxicol. 96 (6): 399–409.doi:10.1111/j.1742-7843.2005.pto_96696601.x (https://dx.doi.org/10.1111%2Fj.1742-7843.2005.pto_96696601.x).PMID 15910402 (https://www.ncbi.nlm.nih.gov/pubmed/15910402).
15. Matsuzawa-Yanagida K, Narita M, Nakajima M et al. (July 2008). "Usefulness of antidepressants for improving theneuropathic pain-like state and pain-induced anxiety through actions at different brain sites". Neuropsychopharmacology33 (8): 1952–65. doi:10.1038/sj.npp.1301590 (https://dx.doi.org/10.1038%2Fsj.npp.1301590). PMID 17957217(https://www.ncbi.nlm.nih.gov/pubmed/17957217).
16. Koppert W, Wehrfritz A, Körber N et al. (March 2004). "The cyclooxygenase isozyme inhibitors parecoxib andparacetamol reduce central hyperalgesia in humans" (http://linkinghub.elsevier.com/retrieve/pii/S0304395903004998).Pain 108 (1–2): 148–53. doi:10.1016/j.pain.2003.12.017 (https://dx.doi.org/10.1016%2Fj.pain.2003.12.017).PMID 15109518 (https://www.ncbi.nlm.nih.gov/pubmed/15109518).
17. Stubhaug A, Romundstad L, Kaasa T, Breivik H (October 2007). "Methylprednisolone and Ketorolac rapidly reducehyperalgesia around a skin burn injury and increase pressure pain thresholds". Acta Anaesthesiol Scand 51 (9): 1138–46.doi:10.1111/j.1399-6576.2007.01415.x (https://dx.doi.org/10.1111%2Fj.1399-6576.2007.01415.x). PMID 17714578(https://www.ncbi.nlm.nih.gov/pubmed/17714578).
18. Gottrup H, Juhl G, Kristensen AD et al. (December 2004). "Chronic oral Gabapentin reduces elements of centralsensitization in human experimental Hyperalgesia." (http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0003-3022&volume=101&issue=6&spage=1400). Anesthesiology101 (6): 1400–8. doi:10.1097/00000542-200412000-00021 (https://dx.doi.org/10.1097%2F00000542-200412000-00021). PMID 15564948 (https://www.ncbi.nlm.nih.gov/pubmed/15564948).
19. Chizh BA, Göhring M, Tröster A, Quartey GK, Schmelz M, Koppert W (February 2007). "Effects of oral pregabalin andaprepitant on pain and central sensitization in the electrical hyperalgesia model in human volunteers"(http://bja.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17251214). Br J Anaesth 98 (2): 246–54.doi:10.1093/bja/ael344 (https://dx.doi.org/10.1093%2Fbja%2Fael344). PMID 17251214(https://www.ncbi.nlm.nih.gov/pubmed/17251214).
20. Warncke T, Stubhaug A, Jørum E (August 1997). "Ketamine, an NMDA receptor antagonist, suppresses spatial andtemporal properties of burn-induced secondary Hyperalgesia in man: a double-blind, cross-over comparison withmorphine and placebo.". Pain 72 (1–2): 99–106. doi:10.1016/S0304-3959(97)00006-7(https://dx.doi.org/10.1016%2FS0304-3959%2897%2900006-7). PMID 9272793(https://www.ncbi.nlm.nih.gov/pubmed/9272793).
21. De Kock MF, Lavand'homme PM (March 2007). "The clinical role of NMDA receptor antagonists for the treatment ofpostoperative pain". Best Pract Res Clin Anaesthesiol 21 (1): 85–98. doi:10.1016/j.bpa.2006.12.006(https://dx.doi.org/10.1016%2Fj.bpa.2006.12.006). PMID 17489221 (https://www.ncbi.nlm.nih.gov/pubmed/17489221).
22. Klein T, Magerl W, Hanschmann A, Althaus M, Treede RD (January 2008). "Antihyperalgesic and analgesic propertiesof the N-methyl-D-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenicHyperalgesia." (http://linkinghub.elsevier.com/retrieve/pii/S1090-3801(07)00029-8). Eur J Pain 12 (1): 17–29.doi:10.1016/j.ejpain.2007.02.002 (https://dx.doi.org/10.1016%2Fj.ejpain.2007.02.002). PMID 17449306(https://www.ncbi.nlm.nih.gov/pubmed/17449306).
23. Christoph T, Kögel B, Strassburger W, Schug SA (2007). "Tramadol has a better potency ratio relative to morphine inneuropathic than in nociceptive pain models". Drugs R D 8 (1): 51–7. doi:10.2165/00126839-200708010-00005(https://dx.doi.org/10.2165%2F00126839-200708010-00005). PMID 17249849(https://www.ncbi.nlm.nih.gov/pubmed/17249849).
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24. Vorobeychik Y, Chen L, Bush MC, Mao J (September 2008). "Improved opioid analgesic effect following opioid dosereduction." (http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1526-2375&date=2008&volume=9&issue=6&spage=724). Pain Med 9 (6): 724–7. doi:10.1111/j.1526-4637.2008.00501.x(https://dx.doi.org/10.1111%2Fj.1526-4637.2008.00501.x). PMID 18816332(https://www.ncbi.nlm.nih.gov/pubmed/18816332).
25. DeSantana, JM; Walsh, DM; Vance, C; Rakel, BA; Sluka, KA (December 2008). "Effectiveness of transcutaneouselectrical nerve stimulation for treatment of hyperalgesia and pain."(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746624/#R4). Current rheumatology reports 10 (6): 492–9.PMC 2746624 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746624). PMID 19007541(https://www.ncbi.nlm.nih.gov/pubmed/19007541).
26. Sluka, KA; Chandran, P (November 2002). "Enhanced reduction in hyperalgesia by combined administration ofclonidine and TENS.". Pain 100 (1-2): 183–90. PMID 12435471 (https://www.ncbi.nlm.nih.gov/pubmed/12435471).
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