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Why Open Source Drug Discovery Needs a “Champion”
Sean Ekins, Ph.D., D.Sc.
Collaborations In Chemistry, Fuquay Varina, NC
Inspiration
• Jill Wood –Jonah’s Just Begun• Lori Sames – Hannah’s Hope Fund• Allison Moore – Hereditary Neuropathy
Foundation• Alex Clark – Molecular Materials Informatics• Antony Williams – Royal Society of Chemistry
Insert disease of choice here
Learning from OSDD TB and Malaria efforts
Open Source Drug Discovery (OSDD) is the concept of drug discovery where all data and ideas are shared in real time, and anyone may participate at any level.
This prior disclosure means that there will be no patents and that any technology is both academically and commercially exploitable by whoever wishes to do so.
The Big Ask
• Can we do something that helps people become champions of Open Source Drug Discovery
The Problem – Opposites Attract
• Neglected & Rare Diseases
A handful of diseasesBiology well knownMillions die – affects poorNo incentive for pharmaTreatments need to be cheap (cents)
Thousands of diseasesBiology not well knownAffects 10s- 1000s per disease – affects richPharma targeting bigger rare diseasesTreatments need to be expensive $1M/yr pp
Bacteria, Parasites etc Genetic mutations etc
Neglected Diseases
• BMGF funded these and now more research efforts ongoing
Neglected Diseases
• Many researchers chasing a relatively small amount of funding for a handful of diseases
• Difficult to treat, faster cures elusive
• Massive clinical trials needed
Rare Diseases
Rare Diseases
• Very few researchers chasing >7000 diseases. Funding likely a long tail.
• Relatively easy to treat. At the forefront of gene therapy resurgence
• Only miniscule clinical trials possible
This is Jonah’s Story
• He needs a cure for MPS IIIC and fast
• Researchers just developed a KO mouse funded by Sanfilippo foundations globally
• Searching for small molecule therapy
• Working on gene therapy• Treatment years away
Scientists Chase Funding Through Crowdfunding
Ethan raised to $25K using crowdfunding to fund research on methamphetamineOther bigger team projects have raised $100’sK
Parents Funding Scientists To Cure Their Children Though Crowdfunding
The Rare Disease Parent Odyssey
• Diagnosis of child• Try to find out about disease – papers behind paywall• Try to connect with scientists • Form not-for-profit• Raise funds• Fund Scientific research on disease• Advocate for support from NIH, FDA etc• Start a company• Try to find a cure before its too late
Let me repeat….A Parent/ Patient Advocate with no Ph.D. can do all this
• Start a foundation• Raise funds• Become an expert on their/childs disease• Set up a scientific advisory board• Fund scientific projects• Submit NIH grants• Start a company• Leverage social media, traditional media
Proposal
Why don’t we apply Open Source Drug Discovery to Rare diseases as
well as neglected diseases??
Examples of Open Science and Tools to Share Openly
Linked Open data cloud 2011 (Wikipedia)
A Mobile App for Open Drug Discovery
A flipboard for science #ODDT
Embraced by rare disease advocates
Getting people to share data openly is a challenge
NIH SBIR reviewers want closed systems to preserve IP
Developed with Alex Clark
Open Drug Discovery Teams – brings data from Twitter and the internet together
Challenges of Open Source Drug Discovery
Tools, Systems, IP concerns, organizational support
What is needed?
• “Helpers” to take the weight off the parent/patient• How to manage the complex data?• How to make sense of the literature?• How to foster collaboration?• How to leverage what is learnt from other diseases?• How scientists find funding or projects to work on?• How parents find scientists to solve their problems?• How to accelerate the process of discovery?
Support human Champions with software and systems
• Parents need expert advice• Drug Discovery advice• Preclinical advice• Awareness of research outside of their
disease
This could be you here
Support human Champions with software and systems
• To share and store the data they are funding
• To network with others doing the same for other diseases
• Bring scientists and parents/patients together
• To rank scientists for funding their research
Helpers
Extend from Rare to Neglected Diseases
• If we can do this for small diseases….• Why not do it for bigger diseases?• Why not expand to common diseases? • Could Pharma use as their open innovation
platform?
A mashup of..
• Crowdfunding• Crowdsourcing• Open Innovation• Open Source• Open Science• Precompetitive Initiative• Open Collaboration
Evolution of Systems Support for Open Source Drug Discovery
• Extending ODDT – can we improve the model?
It could be:An appA websiteA companyA technologyConsultancy
Components Needed to Support Open Source Drug Discovery
Fund ResearchGet Research Done by
CrowdExternalize Research to
Companies
Share Research Openly Precompetitive Collaboration
Find Collaborators Openly
Share Research Openly
Fund Research Externalize to CompaniesCrowdsource Research
Find CollaboratorsPrecompetitive Collaboration
Components Needed to Support Open Source Drug Discovery
Fund Research Crowdsource Research Externalize to Companies
Share Research Openly Precompetitive Collaboration Find Collaborators
Fund Research
Fund Research
Fund Research functions
• Scientists post project ideas they want funded• Parents / crowd / foundations fund research• Parents post ideas for projects they want to
see done• Scientists and parents / foundations engage in
dialog• Go beyond the current crowdfunding sites –
all money goes to science
Components of Champion
Fund Research Get Research Done by Crowd
Externalize to Companies
Share Research Openly Precompetitive Collaboration Find Collaborators
Get Research Done by Crowd
Crowdsource Research
Crowdsource Research Functions
• Scientists and parents propose work they cannot do
• Basically a help wanted advert• What expertise can people offer whether paid
or free• Innocentive but more open on challenges
Components Needed to Support Open Source Drug Discovery
Fund Research Crowdsource research Externalize Research to Companies
Share Research Openly Precompetitive Collaboration Find Collaborators
Externalize Research to Companies
Externalize to Companies
Externalize to Companies Functions
• So you want something beyond what the academics can do
• Contract Research Organization connection• Can you connect to companies to get their
compounds to screen?
Components Needed to Support Open Source Drug Discovery
Fund Research Crowdsource Research Externalize to Companies
Share Research Openly Precompetitive Collaboration Find CollaboratorsShare Research Openly
Share Research Openly
Share Research Openly Functions
• Blends ODDT with a database element• Search by compounds, by text• Store molecules• Bring in open data from external sources• Could imagine a closed component or some
halfway point
Components Needed to Support Open Source Drug Discovery
Fund Research Get Research Done by Crowd
Externalize Research to Companies
Share Research Openly Precompetitive Collaboration
Find Collaborators Openly
Precompetitive Collaboration
Precompetitive Collaboration
Precompetitive Collaborations Functions
• Why do we need an actual organization to do these things?
• Provide a point for discussion on the topic • Get people to propose projects• Project teams self organize • Provide a means for delivering content/projects
to be shared• An index of collaborations
Components Needed to Support Open Source Drug Discovery
Fund Research Crowdsource Research Externalize to Companies
Share Research Openly Precompetitive Collaboration
Find Collaborators Openly
Find Collaborators Openly
Find Collaborators
Find Collaborators Functions
• Can we involve preexisting similar tools?• Enable people to search by topic, disease,• Search grants, etc.• Find scientists that can do the research• Connect to them
Benefits of Integration
• “One stop shop” for all needs• Crossover between topics and services• Create a pipeline for Open R&D within an app• Some users may have use for multiple features• Cheaper to develop than 6 separate apps