Upload
caitlin-greely
View
218
Download
0
Embed Size (px)
Citation preview
What You Need to Know aboutVenous Thromboembolism
By Bill Pruitt, RRT, AE-C, CPFT, MBA and Robin Lawson, RN, DNP
Nursing2009, April 20092.3 ANCC contact hours
Online: www.nursingcenter.com
© 2009 by Lippincott Williams & Wilkins. All world rights reserved.
What is venous thromboembolism (VTE)? An occlusion in a vein caused by a
thrombus (most common)
An embolus of an air bubble, fat droplets, amniotic fluid, clumps of parasites, tumor cells (less common)
In I.V. drug users, a foreign substance such as talc can lead to VTE
Where does VTE occur? Typically in leg veins
2% to 3% occur in arms
Pulmonary embolism can occur when part of a deep vein thrombosis (DVT) breaks loose and travels through the right side of the heart into pulmonary artery
Pulmonary embolism (PE) PE occludes blood flow to part of the
lung and impairs gas exchange
Affected portion of lung becomes necrotic and impairs oxygen delivery to other body tissues
90% of all PEs come from thrombi in the popliteal vein and larger veins above it
What happens in DVT and PE When DVT obstructs venous circulation
in a leg, collateral circulation may develop rapidly
Patient may have few signs and symptoms; when they develop, are related to local inflammation and local tissue ischemia as well as degree of venous outflow obstruction
What happens in DVT and PE Complications of DVT include venous
valvular damage, chronic venous insufficiency (chronic pain, swelling, cramping, skin discoloration, ulceration in affected limb), PE
PE obstructs blood flow in pulmonary arterial system
What happens in DVT and PE Pathologic changes depend on degree of
obstruction and patient’s condition
If blood flow is obstructed in gas exchange areas of lung (alveoli and respiratory bronchioles), you’ll see V/Q mismatch and increased physiologic dead space ventilation
What happens in DVT and PE Extensive PE causes large area of dead
space ventilation, imposing increased work on right ventricle as a result of obstructed right ventricular outflow and pulmonary vasoconstriction from release of vasoactive mediators
What happens in DVT and PE Increased right ventricular afterload
results in right ventricular hypertrophy and decreased right ventricular ejection fraction. Ventricle becomes ischemic and may eventually progress to right ventricular failure
Risk factors Hereditary: deficiency in antithrombin,
protein C, protein S, or plasminogen
Acquired: surgery, trauma, advanced age, cancer, reduced mobility, smoking, use of oral contraceptives, pregnancy
Assessing a patient’s VTE risk Scoring systems based on patient’s
clinical characteristics can estimate patient’s likelihood of developing VTE
Wells prediction rule for DVT, Wells and Geneva prediction rules for PE provide probability ranking for VTE based on history of DVT or PE, cancer, recent surgery/immobilization, age, heart rate
Assessing a patient’s VTE risk Based on type and number of risk
factors, patient’s level of risk can be classified as low, moderate, or high as stipulated in 2008 ACCP guidelines
Appropriate prophylactic treatment can start based on ACCP recommendations. Risk assessment is ideally incorporated into initial assessment form
Comparing VTE Risk
Level of risk Low: mobile patients undergoing minor
surgery; medical patients who are fully mobile
Moderate: patients undergoing general surgery or open gynecologic or urologic surgery; medical patients who are sick or on bed rest
Comparing VTE Risk
Level of risk High: patients undergoing hip or knee
arthroplasty or hip fracture surgery; patients with major trauma or spinal cord injury
Comparing VTE Risk
Risk of DVT if no prophylaxis is given Low: less than 10% Moderate: 10% to 40% Moderate plus high bleeding risk: 10% to
40% High: 40% to 80% High plus high bleeding risk: 40% to 80%
Comparing VTE Risk
Suggested prophylaxis Low: no specific prophylaxis; early and
aggressive ambulation Moderate: low-molecular-weight heparin
(LMWH) at recommended doses, low-dose unfractionated heparin 2 or 3 times/day, or fondaparinux
Comparing VTE Risk Moderate plus high bleeding risk:
mechanical prophylaxis with intermittent pneumatic compression,venous foot pump, graduated compression stockings
High: LMWH at recommended doses, fondaparinux, oral vitamin K antagonists to maintain INR between 2 and 3
High, plus high bleeding risk: mechanical prophylaxis as above
Recognizing VTE Patient with DVT: edema, pain, warmth in
one leg, venous stasis ulcers, venous varicosities, venous insufficiency
Patient with PE: dyspnea, hemoptysis, cough, wheezes, tachypnea, pulmonary crackles, chest pain, palpitations, tachycardia, lightheadedness; suspect massive PE with sudden hypotension, syncope, severe hypoxemia, cardiac arrest
Diagnosing VTE Based on patient’s risk factors, physical
assessment findings, diagnostic study results
Physical assessment for DVT: examine patient’s legs, noting erythema, tenderness, pain; palpation could dislodge and cause PE
Diagnosing VTE D-dimer: normal value less than 500
ng/mL; if high, needs duplex ultrasound
Duplex ultrasound: two-dimensional ultrasound with Doppler; provides vein images, blood flow measurements; loses accuracy in calf vein
Contrast venography: gold standard; invasive with potential complications
Is it PE? Diagnostic testing aimed at:
- confirming condition- defining severity- ruling out conditions that mimic PE (pneumonia, myocardial infarction)
If massive PE suspected, treatment takes priority over testing
Diagnosing PE Chest X-ray: helps rule out other causes
ECG: useful for ruling out cardiac causes; may show ST, T wave changes
Arterial blood gases: will show ventilation perfusion mismatch
Diagnosing PE
D-dimer: can help rule out PE
Spiral computed tomography pulmonary angiography; can help confirm diagnosis of PE and rule out other causes
Preventing VTE after surgery Risk depends on type of surgery,
presence of other risk factors
Procedures with prolonged immobility are at highest risk: orthopedic, neurosurgery, major vascular surgery, major abdominal or pelvic surgery
Preventing VTE after surgery Latest guidelines from ACCP
recommend all hospitals develop formal prevention strategy to include:- computerized decision support - preprinted or standing orders- regular audits to monitor adherence
Guidelines recommend against using aspirin alone and early ambulation in low-risk general surgery patients
Treating VTE Anticoagulants, warm compresses, leg
elevation are first-line treatment
Oxygen, ventilation, I.V. fluids, fibrinolytics may be ordered for PE
Vena cava filter may stop traveling thrombi
Embolectomy: for patients with massive PE who don’t respond to fibrinolytics
Inferior vena cava (IVC) filter Some newer filters are called retrievable
or optional filters
Can be retrieved after a period or left in permanently
Recommended for patients with documented VTE who have difficulty receiving full-dose anticoagulation
Prevention Hospitalized patients should be routinely
assessed for VTE risk
Measure and use graduated compression stockings correctly
Make sure pneumatic compression devices function properly
Prevention Explain importance of these devices to
patient
Encourage early ambulation after surgery
Surgical patients on unfractionated heparin will need baseline aPTT, hematocrit, and platelet counts
Prevention If long-term anticoagulation is needed,
warfarin will be started for 4 to 5 days before heparin is discontinued
Heparin discontinued when INR is in therapeutic range (2.0 to 3.0) on two consecutive measurements 24 hrs apart
Monitor patient for signs of bleeding
Educating your patient Teach patient risk factors for DVT
Teach preventive measures
Instruct patient to call HCP if signs and symptoms of DVT develop
Warfarin therapy patient education Eat limited foods high in vitamin K
Keep blood work appointments
Check with HCP or pharmacist before taking vitamin supplements
Warfarin therapy patient education Limit alcohol intake
Alert HCP about anticoagulant therapy before undergoing medical procedures
Protect from injury (soft toothbrushes, electric razors) due to bleeding/bruising
Warfarin therapy patient education Stop smoking, lose weight, drink lots of
fluids
Women should not use oral contraceptives if history of DVT/PE
Travel Long air flights, car rides linked to DVT/PE
ACCP recommends anyone sitting for more than 8 hours avoid constrictive clothing and stay hydrated
For patients at high risk for DVT, wear graduated compression stockings or receive single dose of LMWH before departure