Slide 1

Slide 2

Slide 3

What is REGENERATIVE MEDICINE? The regeneration or replacement of cells, tissues or organs to restore or establish normal function. The goal is to help you live a more normal life.

Slide 4

Under investigational protocols, the physicians of the KRMC offer the latest in PRP and Adult Stem Cell treatments. These new modalities may be the answer you are looking for

Slide 5

What is PRP? PRP is made from a patients blood Centrifugation removes the red cells leaving behind plasma with a concentration of platelets These products contain growth factors special proteins that aide wound healing

Slide 6

What are Stem Cells? Stem cells are found throughout your body They have 3 main jobs: Keeping the immune system in check Replacing tissues that are lost in day-to-day life Coordinating repair of injuries

Slide 7

What conditions are being treated? Orthopedic conditions Arthritis, osteonecrosis, non-healing fractures etc. Immune-mediated diseases Multiple Sclerosis (MS), chronic-obstructive pulmonary disease (COPD) etc. Critical limb ischemia Many other diseases are being investigated

Slide 8

Evidence for Osteoarthritis Nathan et al, Tis Eng, 2003, 9(4) Biomechanically, the repair tissue approximated intact cartilage

Slide 9

Evidence for Osteoarthritis Adipose-derived stem cell therapy for elderly patients with knee OA was effective in cartilage healing, reducing pain, and improving function. All clinical results significantly improved at 2-year follow- up Koh et al, Knee Surg Sports Traumatol Arthrosc, 2013 Dec (epub)

Slide 10

Evidence for Osteonecrosis Adipose stem cells AND PRP injected into femoral head of patients with severe osteonecrosis presence of sustained,regenerated medullary bone-like tissue in 2 severely necrotic femoral heads. Pak, J. Pain Physician, 2012; 15

Slide 11

Clinical Study - Fractures J Bone Joint Sx (1998) 80:985-996

Slide 12

Case Study - Fractures J Bone Joint Sx (1998) 80:985-996 Comparison in Fracture Implant without Stem Cells

Slide 13

Case Study - Fractures J Bone Joint Sx (1998) 80:985-996 Comparison in Fracture Implant with Stem Cells

Slide 14

Critical Limb Ischemia #1 Cause of Amputation Miranville et al, Circulation 2004;110; 349-355

Slide 15

Ischemic Limb - #1 Cause of Amputation Das et al, World J Surgery, 2013; 37(4) All were confirmed as no-option patients by a vascular surgeon After a single injection of stem cells, 86% of the limbs treated with stem cells were saved! Mesenchymal stem cells for critical limb ischemia are safe and efficacious

Slide 16

Safety Stem cells are collected by liposuction 1000s are performed daily in the US For PRP all that is required is blood Both these products come from your own body, there is no chance for rejection

Slide 17

Safety MSCs [stem cells] have been used in clinical trials since 1995; currently, more than 80 trials are registered with ClinicalTrials.gov and no significant adverse events have been reported. Sensebe et al, Mesenchymal stem cells for clinical applications, Vox Sanguinis, 2010; 98

Slide 18

Safety this study with 100 joint injections of ADSCs, in the form of SVF, with PRP shows that ADSCs/PRP treatment is safe and provides long-term pain improvement Pak et al, Safety reporting on implantation of autologous adipose tissue- derived stem cells with platelet-rich plasma into human articular joints, BMC Musculoskeletal Disorders, 2013; 14

Slide 19

Think you may be a candidate? www.kansasRMC.com 785-320-4700