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Antonius [email protected]
What is Life: A Bioenergetics Perspective
What is Life?
Alam Raya: Saling Melengkapi. Interconnected
C6H12O6
CO2 H2O
O2
Universe: Everything is connected
C6H12O6 + O2 CO2 + H2O
ATP
ATP e-e-
Electron translocation: Bioconversion of C and O Life Energy: Electron Translocation
CO2 C6H12O6
e
SH2S
Fe+2 Fe+3
H2O O2
4
3
2
1
0Billions years ago
Microbes have altered atmospheric gases since almost 4 billion years ago
O2: Byproducts of new technology to extract electron from H2O
EARTH: A Microbial Planet Apa yang kita ketahui dari kehidupan seluler?
Swarming behavior in locust: From shy, solitary, to aggressive
Cohesion pheromone Why single inoculum often fail, or inconsistent?
They need friends
Life outside lab is not easy
Let's work together.Synergistically!
Khanna et al, 2020
Kindness in
bacteria
From Bacterial Defense system to Genetic Engineering & Genome Editing
Self vs Non-self How to escape from Bacterial scissors?
Continuously creating novel & sophisticated defense systems
Winner or loser: Only temporary
Life did not take over the globe by combat but by networking
Lynn Margulis
You are your Genetics
Geneticmaterials
Membrane
Metabolism
DNA DNA
DNA
DNA
RNA
ProteinRNA
DNA
RNA
Protein
Transcription
Translation
?
Epigenetik: Faktor Lingkungan
Berbeda untuk saling melengkapiBukan untuk menyeragamkan
• Mau jadi otot, jantung, hati, usus, atau otak silahkan
• Itulah kebebasan berekspresi tiap sel dalam tubuh manusia
• Tapi kalau jadi kanker, tanpa kecuali akan dihancurkan oleh
killer cells
• Itulah sistem kontrol tubuh agar tidak mematikan
kebebasan ekspresi itu sendiri
10,000,000,000,000 cells
Alam Raya: Saling Melengkapi. Tak ada yang superior atau inferior
Alam kecil
Life: Random & Organized
You are: Nature + Nurture
Genetik (Nature)
Lingkungan (Nurture)
Add to complexity
Epi (=above) Genetics
Bibit, Bebet, BobotWhat we learn from molecular evolution?• Living system is a “giant
pool” of genes and pseudo-genes
• This gene pool is not static, but continuously makes changes
• Mutation is random & unpredictable
• Multicellularity requires networking & Cooperation
• It is misleading to talk something absolute about gene: human gene, pig gene, rice gene, bacterial gene etc.
