What happens when Meiosis Goes WRONG??

When homologous chromosomes fail to separate it is called “nondisjunction”

Abnormal # chromosomes will make their way into gametes

This may occur during Meiosis 1 or Meiosis 2

A fetus may be naturally aborted A disorder may occur

Trisomy - three of the same number of chromosome

Down Syndrome Trisomy 21 Three copies of the 21st chromosome Mild to severe Mental Retardation Increased susceptibility to many

diseases and higher frequency of some birth defects

When something goes wrong with the division of the sex chromosome…..

Turners- only one X chromosome is inherited

Women are sterile, Sex organs don’t develop at puberty

Kleinefelter’s syndrome XXY Kleinfelters small testes, man is

sterile, female characteristics

Trisomy 18 Birth defects , increase in infant mortality,

developmental delay Trisomy 13

Small head, birth size, heart defects, vision and hearing problems, disabilities

Your Job…

Create a Karyotype Determine the diagnosis Downsyndrome, Klienfelters, or Turners

Syndrome