Question by mavenofmusic: What drugs, other than Metformin/Glucophage, are used to treat Insulin Resistance?

I am slightly insulin resistant with normal blood sugars and other lab levels. I did not tolerate Metformin and my endocrinologist told me to stop it

immediately. What other drugs are used to treat this condition? (And yes, I am aware diet and exercise are important components of treating this disorder and

have already incorporated that part of it into my lifestyle.)

Best answer:

Answer by Tin SIts a shame you can't tolerate Metformin. Its the best drug around for insulin resistance. Your other choices are Actos or Avandia.

The "glitazone" diabetes drugs Actos and Avandia may double or triple the risk of broken bones after a year or two of use.

The finding comes from Swiss researchers who analyzed 12 years of data on U.K. diabetes patients. They compared the 1,020 patients who suffered some kind of

fracture to 3,728 matched patients who did not break any bones.

Related to diabetes diabetes symptoms, hypoglycemia, type 2 diabetes, gestational diabetes, diabetes diet, type 1 diabetes, low blood sugar , glucose,

insulin resistance, diabetic neuropathy, A1c, exercise and diabetes

© 2008 WebMD, Inc. All rights reserved.

Over the course of the study, most of the patients took several diabetes drugs. But those who refilled their Actos or Avandia prescriptions eight times or more

-- about 12 to 18 months of use -- had nearly twice the fracture risk of other patients.

And those who refilled their Actos or Avandia prescriptions 15 times or more -- two or more years of treatment -- nearly tripled their risk of fracture, found

Christophe R. Meier, PhD, head of pharmacoepidemiology research at University Hospital Basel, Switzerland, and colleagues.

"We found a very strong signal here for higher risk of fractures in people taking glitazones," Meier tells WebMD. "Our evidence fits together nicely with animal

models and clinical reports suggesting that these drugs have a detrimental effect on bone. And we did not find any increased risk for other diabetes drugs,

so all together, it looks like something really is going on here."

(What does your doctor have to say about these risks? Talk with others on WebMD's Type 2 Diabetes Support Group message board.)

Animal studies reported late last year strongly suggest that Actos and Avandia promote bone loss. Signs that women taking Avandia might be at increased risk

of upper arm and hand fracture last year led the drug's manufacturer, GlaxoSmithKline, to voluntarily issue a letter warning doctors that Avandia

might increase fracture risk.

Good luck

What do you think? Answer below!

http://metforminsideeffects360.com/?p=1148