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The Challenge. What are the greatest challenges facing our region, state, nation, and world? What does it take to address them? Who can help the majority of global citizens, including those locally and nationally, who lack access to fundamental resources? What is our role? . - PowerPoint PPT Presentation
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• What are the greatest challenges facing our region, state, nation, and world?
• What does it take to address them?
• Who can help the majority of global citizens, including those locally and nationally, who lack access to fundamental resources?
• What is our role?
The Challenge
INNOVATION PROCESS
INNOVATION PROCESS
INNOVATION PROCESS
INNOVATION PROCESS
Three Translational Methods• Launch innovators into the world.
• Persuade.
• Create social and commercial ventures
Five Recommendations
Prepare faculty, graduate and undergraduate students, staff, and the broader Carolina community with the knowledge, skills, and connections necessary to translate new ideas into innovations.
• Goal 1.2 Build capacity for innovation.– Action 1.2.1 Provide educational opportunities about innovation.
• Build on successful existing programs– The Minor in Entrepreneurship– The Chancellor’s Faculty Entrepreneurship Boot Camp– First Year Seminars– Launching the Venture– Carolina Challenge
– Action 1.2.3 Create Student Innovation Hub
Example
Collaborate with diverse groups on campus and beyond to explore issues, options, and creative approaches that may lead to innovations.
• Goal 2.1 Enhance robust interdisciplinary collaboration– Action 2.1.1 Set as a top priority advancing applied sciences
• 5 Applied Sciences Distinguished Professorships
• Goal 2.2 Collaborate, coordinate around key themes of local, national, and global significance– Action 2.2.1 Create the Key Themes Initiative
Examples
Translate important new ideas more expediently and at an increased volume into innovations that improve society.
• Goal 3.1 Advance social entrepreneurship– Action 3.1.1 Refine and develop an integrated campuswide approach
• Goal 3.2 Optimize the university’s commercialization output– Action 3.2.1 Expand the Entrepreneurs-In-Residence program
• 18 EIRS throughout the campus
Examples
Align people, incentives, resources, and processes to strengthen an intentional culture of innovation at Carolina.
• Goal 4.2 Recruit, retain, and reward faculty, students, and staff who show promise, aptitude, and/or achievement in innovation
– Action 4.2.1 Recruit innovators and future innovators
– Action 4.2.2 Reward activities that contribute to the culture of innovation at Carolina• Create two Innovation Professorships
• Goal 4.4 Provide funds to support nascent and promising innovations on campus
– Action 4.4.1 Establish the Carolina Innovation Fund
Examples
Catalyze innovation at Carolina by facilitating the work of faculty, staff, and students as they put important ideas to use for a better world.
• Goal 5.1 Leverage the talents of leaders across campus to prepare, collaborate, translate, and align resources and processes to strengthen the culture of innovation at Carolina– Action 5.1.1 Create management groups of program leaders from
across the campus
• Goal 5.2 Create the Chancellor’s Catalyze Group to facilitate the implementation of this Roadmap– Action 5.5.2 Help raise funds and manage the single source gateway to
innovation to ensure faculty, students, and staff are aware of available resources and opportunities for innovation.
Examples
• Career Services: Gary Miller, new title, includes innovation. Now hosting the CSIT meetings, opening an incubator on Hanes fourth floor called H4 for this summer. Working on the Navigating concept using their technology.
• Medical School: Appointed Cam Patterson as Associate Dean of Medical Entrepreneurship. Moved TRACS Carolina Kickstart reporting to him. Exploring how the medical and business schools could work together to do innovative work.
• Biomedical engineering – Nancy Allbritton, faculty entrepreneur – joint program with NC State. Integrating graduate and undergraduate. Important step for Applied Sciences.
• Entrepreneur-in-Residence: Expanding and improving. Regular Meetings.
Rethinking & New Programs
• Carolina Kickstart – reinventing itself to better serve startups in the sciences. Building two new funds: Carolina Catalyst (evergreen loan pool, $25K-$75K) and Carolina Capital (seed fund); Carolina Entrepreneur Network of alums.
• IAH – new $100,000 award for Faculty Innovation Grants.• Innovation Scholars – first one this year, four more for next year.
4-year full scholarship.• Dean’s Innovation Fund in Journalism from Innovation Circle
member.• Campus Y – strategic planning to strengthen it social innovation
work.• Buck Goldstein working with IAH to host a series of seminars on
the co-authored book with Holden Thorp: Engines of Innovation.
Rethinking & New Programs
• Students: CSIT just elected their new leader, Hudson Vincent. Working on Digital Navigator. Student Innovation Fair in April.
• Speaker Series: Desh Deshpande, Steve Case, Cheryl Dorsey. Bob Langer MIT
• Global Education Center and School of Public Health working on Entrepreneur-in-residence program about big challenges. Water conference huge success.
• First Year Seminars: Revupinnovation.com• The Minor in Entrepreneurship in the College of Arts and
Sciences, academic committee, getting closer to endowment goal.
• University Entrepreneur-in-Residence, received endowment for position.
• Grant from Blackstone Charitable Foundation for entrepreneurial development in the Triangle. Brought in Duke, NC State, NC Central, CED as partners.
Rethinking & New Programs
National CTSA & TraCS Goals• To improve how biomedical research is conducted
across the country• To reduce the time it takes for laboratory discoveries
to become treatments for patients• To engage communities in clinical research efforts• To train the next generation of clinical and
translational researchers
18
About TraCS• North Carolina Translational and Clinical Sciences
(NC TraCS) Institute • Home of the NIH CTSA – Clinical and Translational
Sciences Award• 1 of 55 CTSA institutions ; 60 total expected• Infrastructure grant; Funded May ’08• ~ 260 faculty/staff involved in 15 cores and
programs and 59 specific aims, serving over 2,000 members across the state
• Home on 2nd floor of Brinkhous-Bullitt Bldg.
19
NC TraCS Activities Throughout North Carolina Counties
NC TraCS Activities has spanned across 68 of the 100 NC Counties
Javacia C. Jackson
20
NC TraCS Academic Partners• Academic Partners
• Duke University• Durham Technical Community College• East Carolina University• NC Agricultural and Technical University• NC Central University• UNC Charlotte• NC State University
• Activities with Partners vary:• Faculty at UNC and partner schools collaborate; partners
match $50K program; share resources and educational activities
21
NC TraCS Community Partners
22
American Indian Mothers, Inc. Area L Health Education Center Carolinas Medical Center Charlotte Area Health Education Center Communities in Schools of Orange County, Inc. Community Care Networks of North Carolina Duke Primary Care Research Network Durham Committee on the Affairs of Black People Durham County Health Department Eastern Carolina Association for Research and Education El Centro Latino Family Support Network of North Carolina GlaxoSmithKline Greensboro Area Health Education Center The Hamner Institute for Health Sciences Healthy Carolinians IBM Levine Children’s Hospital McNeil Consumer Healthcare Mecklenburg Area Partnership for Primary Care Research
Mid Carolina Cardiology Moses Cone Health System National Institute of Environmental Health Sciences (NIEHS) New Hanover Medical Center North Carolina Biotechnology Center North Carolina Coalition Against Domestic Violence North Carolina Dept Health & Human Services/Division Public
Health North Carolina Family Medicine Research Network North Carolina Healthcare Information and Communications
Alliance (NCHICA) North Carolina Institute of Medicine NC Multi Site Adolescent Research Consortium for Health North Carolina Research Campus, Kannapolis, NC Quintiles Transnational Corp. Renaissance Computing Institute (RENCI) Research Triangle Institute Robeson County Primary Care Research Network SAS SouthEast Area Health Education Center Wake Area Health Education Center
SouthEastern CTSA Consortium (SECC)
• Eight CTSAs: Duke, Emory, MUSC, UNC, UAB, U Arkansas, U Florida, Vanderbilt
• First Meeting early 2010• Current activity:
– Emory, Duke and UNC are moving forward on a project to share electronic medical record data for clinical research; comparative effectiveness research on hypertension across the south east. We intend to seek funding for this project.
23
TraCS Cores and Programs
Biomedical InformaticsBiostatisticsClinical & Community DisseminationCommunity EngagementCommercializationClinical Data ManagementClinical & Translational
Research Center Clinical Dental & Inflammation
Research
EducationGovernanceGrant Proposal Assistance Novel MethodologiesPilot Grant ProgramRecruitmentRegulatoryResearch EthicsStrategic OpportunitiesTranslational TechnologiesTraCS Central
24
TraC$2K Web form submitted from TraCS website
Deadlines every month
TraC$10K Application submitted via email to TraCS; 5 page research plan
Quarterly deadlines; March, June, Sept and December
TraC$50K*(*=requires 50/50 match)
Application submitted via email to TraCS; 5 page research plan
Deadlines 3x/year;Jan, April & Aug
Total of 515 unique investigators funded since January 2009255 of 707 applications submitted were funded (36%)
TraCS Offers 3 Levels of General Pilot Funding
25
$100K Planning Grants - Aimed at:
• Stimulating UNC-CH investigators to serve as PIs for new centers, roadmap initiatives, and multicenter clinical trials.
• Reducing the barrier for faculty who conceive of large-scale proposals but never move forward because of the daunting process
26
Projects outside UNC• 17 funded pilot grants have PIs outside UNC,
including these academic institutions:• East Carolina University• Elizabeth City State University• North Carolina State University• UNC Charlotte
And at community organizations including: • The Hamner Institutes for Health Sciences• Haywood Regional Medical Center• Mecklenburg Area Partnership for Primary
Care Research• WakeMed Health and Hospitals
27
Submitted, Funded Pilot Grants by PI/Co-PI, School
School/Unit # funded** # submitted % funded
Arts & Sciences 10 25 40%
Dentistry 9 37 24%
Education 1 2 50%
Information & Library Sciences 1 1 100%
Journalism & Mass Comm 1 3 33%
Medicine 156 438 36%
Nursing 13 23 57%
Pharmacy 24 52 46%
Public Health 32 89 36%
Social Work 3 8 38%
Outside Institutions 10 40 25%
** this total is greater than the total # of awarded grants due to multiple PIs & PIs with joint appointments 28
Preliminary Outcomes - TraCS Pilot Program
29
Program External Grants Publications Presentations
$50kgrants awarded32 grants completed 1st grants completed in fall 2010
10 NIH grants and 3 other grants – include R01s (3); R21; U01, K23, NCI GO grant, ARRA2 NIH grant subcontracts, CF Foundation, Pfizer Foundation, Simons Foundation
5 publications:- Diabetes-Hepatology (2 papers)-Journal of Applied Physiology-Pharmacoepidemiology and Drug Safety
34 presentations
$10kgrants awarded61 grants completed1st grants completed in fall 2010
7 NIH grants; 10 other grants – include R01s (3), K23, NHLBI GO grant, NICHD and NCRR grants, Angelman Syndrome Foundation, Johnson & Johnson, Natl Alliance Research on Schizophrenia and Depression, EPA Environ. Justice, UNC-CH Cancer Center grants (2), Orange County, UNC-CH U Research Council (2), SAMSHA
15 publications including:-Journal of Immunology-American Association of Pharmaceutical Scientists (AAPS) Journal-Journal of the International Society on Thrombosis and Haemostasis - Computerized Medical Imaging/ Graphics- Environmental Justice- Intl Jrnl of Computer Assisted Radiol/Surg- Journal of Medicinal Chemistry- Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontics- Thrombosis Research
75 presentations
$2kgrants awarded55 grants completed1st grants completed spring 2010
3 NIH and 1 other grant - R01,R24, F32, Merck plus assisted with renewal of Program Project grant
13 publications including:- American Journal of Clinical Pathology - American Journal of Obstet & Gynecology- American Journal of Perinatology- American Journal of Respiratory and Critical Care Medicine- International Urogyncological Journal- Journal of Bone and Mineral Research-Osteoarthritis & Cartilage-Drug Disposition
49 presentations
Examples of how NC TraCS is improving research at UNC-CH
• Commercialization – NC KickStart: – Offering assistance to faculty with their commercial start-up
ventures, including access to business experts, education, mentoring, and pilot funding
– Numerous faculty companies assisted to date
• Research Navigation– Four faculty each 49% effort assist investigators develop new
ideas or relate a research question to translational medicine and assist in the development of clinical and translational investigator teams
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Biomedical TranslationBench Bedside
Boardroom
Commercialization
University
University Startup(NewCo)
BiomedicalInnovation
Patent
BusinessConcept
Management Team
Investment
Product Development
License
CommercializationPaths
Established Company(BigCo)
Sponsored Research
Product Development
Product Strategy
CommercialProduct
Mission
Increase the impact of biomedical innovations by fostering and promoting entrepreneurial
commercialization
BackgroundOriginally formed as NC BioStart
• Driven by faculty frustrationWritten into CTSA proposal
• Aim: Mentor faculty in commercialization effortsProgram expanded in last 1.5 years
• Renamed Carolina KickStart• Full-time director• Programs beyond mentoring
Goals of Carolina KickStartEducate faculty and students as to the process and expectations
of commercializing technologies through startups.Mentor faculty and students during the process of
entrepreneurial commercialization.Connect outside resources and talent (entrepreneurs, advisors,
investors, and services providers) with UNC startup opportunities to help facilitate the commercialization process.
Fund technology and venture development by providing internal funding and facilitating external funding (SBIR, investors).
Incubate startup companies by providing suitable space
PersonnelCam Patterson, MD, MBA Executive DirectorDon Rose, PhD DirectorAndrew Kant, MS Assistant DirectorJustin Brown, PhD Technology Scout
John Strenkowski, MBA Business FellowRicky Spero, PhD Technology Fellow
Joel Shaffer, PhD Entrepreneur-in-ResidenceTom Mercolino, PhD Entrepreneur-in-ResidencePerry Genova, PhD Entrepreneur-in-Residence
Biomedical Product
Capital SBIR Grants
AngelsVCs
PeopleFaculty
StudentsEntrepreneurs
Biomedical Innovations
DrugsDevices
Diagnostics
Carolina KickStart
Faculty
OTD
Kenan-Flagler Business School
Entrepreneurs
Investors
Partners
Features of the Program• Webinars• Kenan-Flagler’s Launch the Venture• Founder’s Handbook
Education
• Entrepreneurs-in-Residence• Technology ScoutsMentoring
• Networking events, meetings at coffee shops• Innovation Fellowship Program• Database of entrepreneurs, investors
Connecting
• NC TraCS Pilot Grants• Commercialization Awards• Carolina Investment Group
Funding
• Facility Use Agreements• Off-campus incubation spaceIncubation
KickStart Portfolio CompaniesKatharos—dialysis device for serum phosphateNovoLipid—lipid-modified chemotherapy agentsCortical Metrics —non-invasive brain assessmentHibernaid—pharmacological hypothermiaRheomics—mechanical biology micrcoscopyCell Microsystem —cell isolation and culture deviceEnci Therapeutics —anti-angiogenesis mAb for cancerNeuroGate—therapeutics for neuropathic painKL Medical —minimally invasive portal for heart surgeryVascular Pharma —mAb for reducing diabetes-induced CHDG-Zero—therapies for chemo induced immunosuppressionSynereca—co-therapeutics for potentiating antibioticsQualiber—liposomal drug delivery platformClinical Sensors —NO sensor for early sepsis detectionIronwood Material Science —materials for dental implantsX-in8—therapeutics to reduce organ transplant rejection
What will Holden release at University Day?????
Innovate.unc.edu