1

W.G. Bessler: List of Publications

001 Stirm, S., Bessler, W., Fehmel, F., Freund-Mölbert, E., and Thurow, H.: Isolation of Spike-

Formed Particles from Bacteriophage Lysates. Virology 45, 303-308 (1971).

002 Stirm, S., Bessler, W., Fehmel., F., Freund-Mölbert, E.: Bacteriophage Particles with Endo-

Glycosidase Activity. J. Virol. 8, 343-346 (1971).

003 Bessler, W.: Isolierung und Charakterisierung einiger virusinduzierter Enzyme aus

Bakteriophagen-Lysaten. Dissertation. Freiburg (1972).

004 Stirm, S., Bessler, W., Fehmel, F., Freund-Mölbert, E., Rudolph, C., and Thurow, H.:

Bacteriophagen-Glycosidasen. Hoppe-Seyler's Z. Physiol. Chem. 353, 760-761 (1972).

005 Stirm, S., Bessler, W., Fehmel., F., and Freund-Mölbert, E.: Escherichia coli-

Kapselphagen. Zbl. Bakt. Hyg., I. Abt. Orig. A 220, 484 (1972).

006 Bessler, W., Freund-Mölbert, E., Knüfermann, H., Rudolph, C., Thurow, H.,and Stirm, S.:

A Bacteriophage-Induced Depolymerase Active on Klebsiella K 11 Capsular

Polysaccharide. Virology 56, 134-151 (1973).

007 Bessler, W., and Goldstein, I. J.: Phytohemagglutinin Purification: A General Method

Involving Affinity and Gel Chromatography. FEBS Lett. 34, 58-62 (1973).

008 Stirm, S., Bessler, W., Fehmel, F., Freund-Mölbert, E., and Thurow, H.: Über eine

Bakteriophagen-induzierte Colansäure-Depolymerase. Zbl. Bakt. Hyg., I. Abt. Orig.

226, 26-35 (1974).

009 Bessler, W., Shafer, J. H., and Goldstein, I. J.: A Spectrophotometric Study of the

Carbohydrate Binding Site of Concanavalin A. J. Biol. Chem. 249, 2819-2822 (1974).

010 Bessler, W., and Goldstein, I. J.: Equilibrium Dialysis Studies on Two Lima Bean Lectins.

Arch. Biochem. Biophys. 165, 444-445 (1974).

011 Ruddon, R. W., Weisenthal, L. M., Lundeen, D. E., Bessler, and W., Goldstein, I. J.:

Stimulation of Mitogenesis in Normal and Leukemic Human Lymphocytes by Divalent

and Tetravalent Lima Bean Lectins. Proc. Nat. Acad. Sci. USA 71, 1848-1851 (1974).

012 Bessler, W., Ruddon, R. W., Weisenthal., L. M., Lundeen, D. E., and Goldstein, I. J.:

Mitogenität di- und tetravalenter Lektine aus Limabohnen (Phaseolus lunatus) gegenüber

normalen und leukämischen Humanlymphozyten. In: Abstracts der 5. Arbeitstagung

für Leukozytenkulturen, Erlangen (1974).

013 Bessler, W., Ruddon, R. W., Goldstein, I. J., Ferber, E., and Resch, K.: Interaktion von

Limabohnen-Lektinen mit Lymphozyten verschiedener Spezies. Z. Immun.-Forsch. 147,

229 (1974).

014 Bessler, W., Fehmel, F., Freund-Mölbert, E., Knüfermann, H., and Stirm, S.: Escherichia

coli Capsule Bacteriophages IV. Free Capsule Depolymerase 29. J. Virol. 15, 976-984

(1975).

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015 Bessler, W., and Braun, V.: Mitogenität von Lipoprotein aus der äußeren Membran von E.

coli gegen Lymphozyten verschiedener Spezies. Z. Immun.-Forsch. 150, 193 (1975).

016 Bessler, W. and Resch, K.: The Role of Valence in Lectin-Lymphocyte Interactions. In:

Abstracts of Symposia, Colloquia, and Poster Contributions 10th Meeting of the

Federation of the European Biochemical Societies, Paris, (ed.: Societe de Chimie

Biologique), Nr. 997 (1975).

017 Bessler, W., Hantke, K.and Resch, K.: Induction of Cell Proliferation and Membrane

Changes by Derivatives of Lipoprotein from the Outer Membrane of E. coli. Z. Immun.-

Forsch. 152, 75 (1976).

018 Bessler, W., Resch., K., and Ferber., E.: Valency-Dependent Stimulating Effects of Lima

Bean Lectins on Lymphocytes of Different Species. Biochem. Biophys. Res. Comm. 69,

578-585 (1976).

019 Frisch, A., Bessler, W., Lipps, H. J., and Ammermann, D.: Immobilization of Ciliates by

Concanavalin A. J. Protozool. 12, 427-430 (1976).

020 Bessler, W. G., and Lipps, H. J.: Concanavalin A-induced Nuclear Division in Stylonychia

mytilus. J. Gen. Microbiol. 92, 221-223 (1976).

021 Bessler, W. G.: Bohnenextrakte zum Kampf gegen den Krebs. Umschau in Wissenschaft

und Technik 76, 83-84 (1976).

022 Kraut, H., and Bessler, W. G.: Valence Dependent Stimulation of Rat Lymphocytes by

Isolectins from the Lima Bean. In: Abstracts of the 10th International Congr. of

Biochemistry, Hamburg, 480 (1976).

023 Bessler, W., Saal, J., Hadam, M., and Rieber, P.: Stimulation of Subpopulations of Normal

and Leukemic Human Lymphocytes with Lima Bean Lectin. In: Abstracts of the 7th

Workshop on Leukocyte Cultures Ulm, (1976).

024 Lipps, H. J., and Bessler, W.: Interaction of Stylonychia mytilus with Concanavalin A. In:

Abstracts of the 10th International Congress of Biochemistry, Hamburg 531 (1976).

025 Bessler, W., and Ottenbreit, B. P.: Studies on the Mitogenic principle of the Lipoprotein

from the Outer Membrane of Escherichia coli. Biochem. Biophys. Res. Comm. 76, 239-

246 (1977).

026 Bessler, W. G., and Hantke, K.: Mitogenicity of Derivatives of the Lipoprotein from the

Outer Membrane of Escherichia coli. In: Regulatory Mechanisms in Lymphocyte

Activation. Academic Press, New York, 420-422 (1977).

027 Bessler, W., Resch, K., Hancock, E., and Hantke, K.: Induction of Lymphocyte

Proliferation and Membrane Changes by Lipopeptide Derivates of the Lipoprotein from

the Outer Membrane of Escherichia coli. Z. Immun.-Forsch. 153, 11-22 (1977).

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028 Büsing, D., and Bessler, W. G.: Lymphocyte Stimulation with Lima Bean Lectins: Valency

Dependent Membrane Alterating Activity of the Isolectins. Z. Immun. Forsch. 153, 293-

294 (1977).

029 Bessler, W. G., Schimmelpfeng, L., and Peters, J. H.: Potentiation of Mitogen-induced

Lymphocyte Stimulation by Polyethylene Glycols. Biochem. Biophys. Res. Comm. 76,

1253-1260 (1977).

030 Lipps, H. J., and Bessler, W. G.: Early Nuclear Events Following the Interaction of the

Ciliate Stylonchia mytilus with the Plant Lectin Concanavalin A. Cell Differentiation 6,

187-197 (1977).

031 Lipps, H. J., Knowles, J. K. C., Nock, A., and Bessler W: Translation of Specific RNA in

an Homologous in vivo System. In: Abstracts, of the 11th FEBS Meeting, Copenhagen

(1977).

032 Bessler, W., and Resch, K.: Studies on the Mitogenic Principle of Lipoprotein. In:

Abstrakts der 8. Arbeitstagung über Leukozytenkulturen. Berlin (1977).

033 Büsing, D., Kraut, H. J., and Bessler, W. G.: Valency Dependent Membrane Phospholipid

Altering Activity of Lima Bean Isolectins in Bovine and Human Lymphocytes. In:

Abstracts of the 11th FEbS Meeting, Copenhagen (1977).

034 Bessler, W. G., Lützeler, E., Rotering, H., and Hantke, K.: Minimal Structure Required for

Mitogenicity of the Lipoprotein from the Outer Membrane of E. coli. In: Abstracts of the

11th FEBS Meeting, Copenhagen (1977).

035 Bessler, W. G., and Braun, V.: Lipoprotein from the Outer Membrane of Escherichia coli:

Molecular Structure and Mitogenicity. In: H. Peters (ed.): Protides of the Biological

Fluids. Pergamon Press, Oxford, New York, Toronto, Sydney, Paris, Frankfurt, 33-

36 (1978).

036 Bessler, W.: Einführung in die Biologie. Studienbrief Biochemie 4: Zellmembranen,

Ultrastruktur der Zelle. Deutsches Institut für Fernstudien. Tübingen (1978).

037 Haas, I., Cybulla, J., and Bessler, W. G.: Lipoprotein from the Outer Membrane of E. coli:

The Minimal Molecular Structures Required for Mitogenicity. Z. Immun.-Forsch. 155,

21 (1978).

038 Peters, J. H., Bessler, W. G., and Schimmelpfeng, L.: On the Significance of a Mitogen

Presentation by Macrophages to Lymphocytes. Z. Immun.-Forsch. 155, 52 (1978).

039 Bessler, W. G., Peters, H. J., and Schimmelpfeng, L.: Two Steps in T-Lymphocyte

Activation: Lymphocyte Stimulating Factors from mitogen-treated Macrophages and from

a Cultured Macrophage Cell Line. In: Abstracts of the 9th Workshop in Leukocyte

Cultures, Mainz. 6c (1978).

040 Peters, J.H., Schimmelpfeng, L., and Bessler, W. G.: Two Steps in Mitogenic T-

Lymphocyte Activation: Conditioning of the Lymphocyte Membrane for a Macrophage

Derived Stimulatory Signal. In: Abstracts of the 9th Workshop on Leukocyte

Cultures, Mainz. 49C (1978).

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041 Bessler, W. G., Lützeler, E., and Rotering, H.: Studies on the Mitogenic Principle of the

Lipoprotein from the Outer Membrane of E. coli: Investigations with Mutant

Lipoproteins. In: Abstracts of the 12th International Leukocyte Culture Conference,

Beersheba, Israel, June 25-30, 8 (1978).

042 Haas, I., Simon, E., and Bessler, W. G.: Effect of the Aggregational State on the

Mitogenicity of the Lipoprotein from the Outer Membrane of Escherichia coli.

Immunobiol. 156, 418-428 (1979).

043 Bessler, W. G., and Henning, U.: Protein I and Protein II* from the Outer Membrane of

Escherichia coli are Mouse B-Lymphocyte Mitogens. Z. Immun.-Forsch. 155, 387-398

(1979).

044 Bessler, W., and Henning, U.: Mitogenic Bacterial Surface Components: B-Lymphocyte

Stimulatory Activity in vitro of Protein I from the Outer Membrane of Escherichia coli.

In: G. Kaplan (ed.): The Molecular Basis of Immune Cell Function. Elsevier/ North

Holland, Biomedical Press, Amsterdam, 503-506 (1979).

045 Bessler, W., and Schindler, P.: Purification of 2-Deoxy-2-Dansylamido-D-Glucose by

Affinity Chromatography on a Lectin-Loaded Agarose Column. Experentia 35, 1292

(1979).

046 Kraut, H., Resch, K., and Bessler, W. G.: Lima Bean Lectins as Mitogens for Human T-

Lymphocytes: Isolation of Receptor Membrane Proteins. In: H. Peters (ed.): Protides of

the Biological Fluids. Pergamon Press, Oxford, New York, Toronto, Sydney, Paris,

Frankfurt, XXVII, 619-622 (1979).

047 Peters, J. H., Bessler, W. G., and Schimmelpfeng, L.: Adherent Cells as Targets in

Mitogenic T-Lymphocyte Stimulation: Replacement of Lymphocyte-Bound Mitogens by

Non-Mitogenic Substances. Immunol. Comm. 8, 425-433 (1979).

048 Bessler, W., Cybulla, J., Frey, A., and Hillemann, J.: Bacterial Cell Surface Components as

B-Lymphocyte Mitogens: Minimal Structures Required for Mitogenicity. Immunobiol.

156, 213-214 (1979).

049 Däumling, C., Lipps, H. J., Schimmelpfeng, L., Peters, J. H., and Bessler, W. G.:

Macrophage Participation in T-Lymphocyte Activation by Mitogens: Mitogenic Factors

from Macrophages and from a Macrophage Cell Line Effect Protein Biosynthesis in vitro.

Hoppe-Seyler's Z. Physiol. Chem. 360, 247 (1979).

050 Bessler, W. G., Frey, A., Haas, I., and Resch, K.: Interaction of B-lymphocyte Mitogens

with the Plasma Membrane of Leukocytes. Hoppe-Seyler's Z. Physiol. Chem. 360, 1128

(1979).

051 Bessler, W. G., Ottenbreit, B., Irmscher, G., and Jung, G.: Interaction of Membrane

Modifying Peptide Antibiotics from Trichoderma viride with Leukocytes. Biochem.

Biophys. Res. Comm. 87, 99-105 (1979).

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052 Haas, I. G., and Bessler, W., G.: Mitogenicity of E. coli Lipoprotein Aggregates and the

Effect of Anti-Lipoprotein. In: Abstrakts der 10. Arbeitstagung über

Leukozytenkulturen, Marburg (1979).

053 Bessler, W. G., and Henning, U.: Bacterial Surface Components as Mitogens: B-

Lymphocyte Stimulatory Activity of Protein I from the Outer Membrane of E. coli. In:

Abstrakts der 10. Arbeitstagung über Leukozytenkulturen, Marburg (1979).

054 Bessler, W. G., and Kraut, H.: Interaktion von Lektinen aus Limabohnen (Phaseolus

lunatus) mit Lymphozyten. In: Abstracts, "Kolloquium über natürliche Agglutinine

und Proteinasehemmer", Köln (1979).

055 Resch, K., Bessler, W. G., and Kraut, H.: Lima Bean Lectins as Mitogens for Human T-

Lymphocytes: Isolation of Receptor Membrane Proteins. In: Abstracts, of the 27th

Colloquium, Protides of Biological Fluids (1979).

056 Bessler, W.G., and Henning, U.: Mitogenic Bacterial Surface Components: B-lymphocyte

Stimulatory Activity in vitro of Protein I from the Outer Membrane of E. coli. In:

Abstracts of the 13th International Leucocyte Culture Conference, Ottawa, 98

(1979).

057 Bessler, W., G., Simon, E., and Rotering, H.: Mitogenicity of a Lipid-Deficient Lipoprotein

from a Mutant Escherichia coli Strain. Infect. Immunity 28, 818-823 (1980).

058 Cybulla, J., Brückner, H., Jung, G., Wipperfürth, T., and Bessler, W. G.: The Mitogenic

Principle of Escherichia coli Lipoprotein: B-Lymphocyte Mitogenicity of N-Palmitoyl-

Cysteine and N- Palmitoyl-Glutamic Acid-a-Methyl Esters. Biochem. Biophys. Res.

Comm. 92, 1389-1396 (1980).

059 Scheuer, W., Frey, A., Maldener, M., and Bessler, W. G.: Bacterial Cell-Surface

Components as B-Lymphocyte Receptors from Mouse Splenocytes and from a Mouse

Macrophage Cell Line. Immunobiol. 157, 274-275 (1980).

060 Bessler, W. G., and Resch, K.: Activation of Lymphocyte Populations with Con A or with

Lipoprotein and Lipopeptide from E. coli: Correlation of Early Membrane Changes with

Induction of Macromolecular Synthesis. In: Abstracts of the 4th International

Congress of Immunology, Paris, 7-2-04. (1980).

061 Jung, G., Brückner, H., Maldener, M., Scheuer, W., Resch, K., and Bessler, W. G.: New

Synthetic Mitogens Constituting the Minimal Structure Required for Mitogenicity of the

Lipoprotein from the Outer Membrane of E. coli. In: Abstracts of the 4th International

Congress of Immunology, Paris, 19-1-05 (1980).

062 Cybulla, J., Brückner, H., Jung, G., Wipperfürth, Th., and Bessler, W. G.: The Mitogenic

Principle of Escherichia coli Lipoprotein: B-Lymphocyte Mitogenicity of N-Palmitoyl-

Cysteine and N-Palmitoyl Glutamic Acid a-Methyl Esters. In: Abstrakts der 11.

Arbeitstagung über Leukozytenkulturen, Erlangen, 4-F. (1980).

063 Bessler, W. G.: Abwehrmechanismen gegen bakterielle Infektionen. Biologie in unserer

Zeit 11, 1-6 (1981).

6

064 Resch, K., and Bessler, W. G.: Activation of Lymphocyte Population with Concanavalin A

or with Lipoprotein or Lipopeptide from the Outer Cell Wall of Escherichia coli:

Correlation of Early Membrane Changes with Induction of Macromolecular Synthesis.

Eur. J. Biochem. 115, 247-252 (1981).

065 Johnson, R. B., Köhl, S., Jung, G., and Bessler, W. G: In vivo Polyclonal B-Lymphocyte

Activation with Salmonella typhimurium Lipoprotein and a Synthetic Analogue.

Immunobiol. 160, 50 (1981).

066 Bessler, W. G., Kustermann-Kuhn, B., and Scheuer, W. V.: B-Lymphocyte-Mitogen

Binding Proteins of Mouse Splenocytes: Enrichment of Binding Proteins for the

Lipoprotein from Escherichia coli. In: H. Kirchner, K. Resch (eds.): Mechanisms of

Lymphocyte Activations. Elsevier/North Holland, 476-479 (1981).

067 Bessler, W. G., and Scheuer, W.: Receptors on B-Lymphocytes for Mitogenic Bacterial

Surface Components. In: Abstracts of the 65th FASEB Meeting, Atlanta, USA,

Federation Proc., 5263 (1981).

068 Bessler, W. G., Kustermann-Kuhn, B., and Scheuer, W. V.: B-Lymphocyte Mitogen

Binding Proteins in the Plasma Membrane of Mouse Splenocytes. Immunobiol. 159, 123

(1981).

069 Hermann, G., Schmidt-Horstmann, B., Habets, L., Karalus, I., Guertler, L., and Bessler, W.:

A Polyagglutinating, Non-Mitogenic Lectin from Arion Empiricorum. In: T. C. Bog-

Hansen (ed.): Lectins, Biology, Biochemistry, Clinical Biochemistry. Vol. 2, Walter

de Gruyter, Berlin, New York, 657-677 (1982).

070 Maier, B. F., Baron, D. P., Bockhorn, H., Drautz, H., Langhärig, J., and Bessler, W. G.:

Mitogenic and Suppressive Activity of Mycelia from Gram Positive Bacteria on Murine

and Human Lymphocytes. Immunbiol. 163, 427-435 (1982).

071 Bessler, W.G., Johnson, R.B., Wiesmüller, K.H., and Jung, G.: B-Lymphocyte Mitogenicity

in vitro of a Synthetic Lipopeptide Fragment Derived from Bacterial Lipoprotein. Hoppe-

Seyler’s Z. Physiol.Chem. 363, 767-770 (1982).

072 Mieth, K.B., Johnson, R.B. Köhl, S., and Bessler, W.G.: Defined fragments of bacterial

protein I and lipoprotein are Mouse B-lymphocyte mitogens. Immunobiol. 162, 395

(1982).

073 Bessler, W.G., Wiesmüller, K.H., Scheuer, W., Johnson, R.B., Brückner, H., and Jung, G.:

Synthetic Peptide Derivatives of Bacterial Lipoprotein and Their Interaction with

Lymphocyte Plasma Membranes. In: Abstracts of the 4th Symposium on Chemistry of

Peptides and Proteins, Tübingen (1982).

074 Bessler, W.G., Johnson, R.B., Maier, B.F., Drautz, H., Langhärig, J., Bockhorn, G., and

Baron, D.B.: Mitogenic and Suppressive Activity of Mycelia from Gram-Positive Bacteria

on Murine and Human Lymphocytes. In: Abstracts of the 12th Workshop on

Leukocyte Cultures, Wien, 3 (1982).

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075 Maier, B., Baron, D., Bessler, W., Bockhorn H., Degen H., Hark, T., and Winkelmann, G.:

Die Inhibierung cellulärer in vitro Immunreaktionen durch Herbicolin und

Streptomycetenextrakt. Langenbeck's Arch. f. Chirurgie. 31-35 (1982).

076 Bessler, W.G., Kraut, H., Müller-Hermes, W.H.P., and Peters, J.H.: Membrane Alterations

and Induction of Responsiveness to Interleukin 2 in Lymphocytes by Lima Bean Lectins.

In: Abstracts of the 5th International Lectin Meeting, Bern, Schweiz (1982).

077 Bessler W.G., Kraut, H., Büsing, D., Müller-Hermes, W.J.P., and Peters, J.H.: Membrane

Alterations and Induction of Responsiveness to Interleukin 2 in Lymphocytes by Lima

Bean Lectins. In: T.C. Bog-Hansen, G.A. Spengler (eds.): Lectins. Biology,

Biochemistry, Clinical Biochemistry. Vol. 3, Walter de Gruyter, Berlin, New York,

45-54 (1983).

078 Johnson, R.B., Köhl, S., and Bessler, W.G.: Polyclonal Activation of B-Lymphocytes In

Vivo by Salmonella typhimurium Lipoprotein. Infect. Immun. 39, 1481-1484 (1983).

079 Scheuer, W.V., and Bessler, W.G.: Binding of Bacterial Lipoprotein and Synthetic

Analogues to Histocompatibility-2-Complex Proteins of Mouse Lymphocytes. In:

Abstracts der Jahres-Tagung der DGHM/ASM, Tübingen (1983).

080 Wiesmüller, K.H., Bessler, W., and Jung, G.: Synthesis of the Mitogenic S-(2,3-

Bis(palmitoyloxy)propyl)-N- palmitoylpentapeptide from E. coli Lipoprotein. Hoppe-

Seyler's Z. Physiol. Chem. 364, 593-606 (1983).

081 Jung, G., Hennings, G, Pfeifer, M., and Bessler, W. G.: Interaction of Metal Complexing

Compounds with Lymphocytes and Lymphoid Cell Lines. Mol. Pharmacol. 23, 698-702

(1983).

082 Johnson, R. B., Köhl, S., Wiesmüller, K. H., Jung, G., and Bessler, W. G.: Synthetic

Analogues of the N-Terminal Lipid Part of Bacterial Lipoprotein are B-Lymphocyte

Mitogens in vitro and in vivo. Immunobiol. 165, 27-35 (1983).

083 Johnson, R. B., Scheuer, W. V., and Bessler, W. G.: Serum-Mediated Suppression and

Enhancement of Polyclonal B-Cell Activation. In: Parker, J.W. & O'Brien, R.L. (eds.)

Intercellular Communication in Leucocyte Function. John Wiley & Sons,

Chichester, New York, Brisbane, Toronto, Singapore. 225-228 (1983).

084 Bessler, W. G., Johnson, R. B., Wiesmüller, K. H., v. Tittle,T., and Jung, G.: A Synthetic

Lipopeptide Derivative of Bacterial Lipoprotein is a Potent Polyclonal B-Cell Activator.

In: Parker, J.W. & O'Brien, R.L. (eds.) Intercellular Communication in Leucocyte

Function. John Wiley & Sons, Chichester, New York, Brisbane, Toronto, Singapore.

245-248 (1983).

085 Jung, G., Wiesmüller, K. H., Scheuer, W., and Bessler, W. G.: Synthesis and Biological

Activities of the Mitogenic Principle of E. coli Lipoprotein. In: Abstracts of the 24th

Internat. Conference on the Biochemistry of Lipids, Toulouse (France), 723 (1983).

086 Scheuer, W. V., Müller, H., and Bessler, W. G.: Histocompatibility-2-complex proteins of

mouse leukocytes are binding proteins for mitogenic bacterial lipoprotein and synthetic

analogues. Immunobiol. 165, 349-350 (1983).

8

087 Bessler, W. G., and v. Tittle, T.: Synthetic analogues of bacterial lipoprotein: mitogenicity

of tripalmitoyl pentapeptide towards mouse lymphocytes and the BCL1 lymphoid cell

line. Immunbiol. 165, 240 (1983).

088 Bessler, W. G., Bessler, U., Eck, G., Scheuer, W.V., and Suhr B.: In vitro-Methoden zur

Testung pflanzlicher, bakterieller und synthetischer Agenzien und Toxine unter

Anwendung von Leukozyten-Primärzellkulturen und -Zellinien.

Arzneimittelforschung/Drug Research 35 (II), 1209-1215 (1983).

089 Jung, G., Wiesmüller, K. H., Scheuer, W., and Bessler, W. G.: Synthesis and Biological

Activities of the Mitogenic Principle of E. coli Lipoprotein. In: V.J. Hruby and D.H.

Rich (eds) Peptides, Structure and Function. Pierce Chem. Corp., Rockford Ill, 179-

82 (1983).

090 Jung, G., Carrera, C., Brückner, H., and Bessler, W. G.: The Mitogenic Principle of

Escherichia coli Lipoprotein: Synthesis, Spectroscopic Characterization, and Mitogenicity

of N-Palmitoly-S-((2R,S) 2,3-dipalmitoyloxypropyl))-(R)-cysteine Methyl Ester. Liebigs

Ann. Chem. 1983, 1608-1622 (1983).

091 Bessler, W. G., Hennings, G., Pfeiffer, M., Jung, G.: Interaktion Metall-komplexierender

Flavonoide mit Lymphozyten und lymphoiden Zell-Linien. In: Proceedings of an

International Workshop on Cianidanol, Bad Kreuznach. (1984).

092 Bessler, W. G., Wiesmüller, K. H., Scheuer, W., Johnson, R. B., Fouad, H. H., and Jung,

G.: Synthetic Peptide Derivatives of Bacterial Lipoprotein and their Interaction with

Lymphocyte Plasma Membranes. In: W. Völter et al. (eds.): Chemistry of Peptides and

Proteins, Walter de Gruyter Vol. 2, 88-96 (1984).

093 Bessler, W.G., Cox, M., Wiesmüller, K.H., and Jung, G.: The Mitogenic Principle of

Escherichia coli Lipoprotein: B-Lymphocyte Mitogenicity of the Synthetic Analogue

Palmitoyl-Tetrapeptide (PAM-SER-SER-ASN-ALA). Biochem. Biophys. Res. Comm.,

121, 55-61 (1984).

094 Kleine, B., Coutinho, A. und Bessler, W.: Membrane Proteins in Lipopolysaccharide

reactive and nonreactive B-cell blasts and B-cell tumors. In: Abstracts 14.

Leukozytenkulturen Konferenz, Hamburg (1984).

095 Lüdemann, J., Bessler, W. and W. L. Gross: Role of Outer Membrane Proteins in the

Polyclonal B-cell Activation Process Started by a Crude Klebsiella Cell Membrane

Preparation. In: Abstracts 14. Leukozytenkulturen Konferenz, Hamburg (1984).

096 Bessler, W.G., Biesert, L., Lex, A., Mieth, K. and Vordermeier, H.-M.: Recognition of

Bacterial Surface Components by Lymphocytes: The Minimal Molecular Structures of

Bacterial Lipoprotein and Protein I Required for B-Lymphocyte Activation. In: Abstracts

14. Leukozytenkulturen-Konferenz, Hamburg (1984).

097 Lüdemann, J., Schlegelberger, T., Bessler, W., Brade, H.,: Role of Lipopolysaccharides and

Outer Membrane Proteins in the B-Cell Maturation Process Induced by Various

Enterobacteriae. In: Abstracts of the XV. Annual Meeting of the Scandinavian Society

for Immunology, Odense, Denmark (1984).

9

098 Held, H., Lüdemann, J., Brade, H., Bessler, W., Gross, W.L.: Polyklonale Aktivierung

menschlicher B-Zellen durch verschiedene Zellwandkomponenten von

Enterobacteriaceae. In: Abstrakts der 90. Tagung der Deutschen Gesellschaft für

innere Medizin, Wiesbaden (1984).

99 Gross, W.L., Lüdemann, J., Bessler, W., and Braun, V.: Role of Lipoprotein and Murein in

the Polyclonal B-Cell Activation Process Started by a Crude Klebsiella Cell Membrane

Preparation. In: Abstracts der Jahrestagung der Europ. Ges. f. Immunologie, 15

Interlaken, Schweiz (1984).

100 Lex, A., Vordermeier, H.M., Sprenger, R., Suhr, B., Bessler, W.G.: Immunomodulation by

synthetic analogues of bacterial lipoprotein and by fragments of bacterial protein I.

Immunobiol. 168, 71 (1984).

101 Streck, H., Biesert, L., Wiesmüller, K.H., Jung, G., Bessler, W.: Binding proteins for

mitogenic bacterial lipoprotein and synthetic analogues on B-lymphocytes and on

lymphoid B-cell line. Immunobiol. 168, 10 (1984).

102 Lüdemann, J., Gross, W.L., Mayer, H., Bessler, W.: The activation of human lymphozytes

by enterobacteriaceae is not due to enterobacterial common antigen stimulation.

Immunobiol. 168, 5-6 (1984).

103 Bessler, W.G., Flad, H.-D., Schade, U., Rietschel, E.: Lymphokine Induction in Murine and

Human Leukocytes by Bacterial Lipoprotein and a Synthetic Analogue, and by Bacterial

Protein I. Lymphokine Research, 3, 234 (1984).

104 Jung, G., Wiesmüller, K.H., Metzger, J., Lex, A., Bessler, W., Leibfritz, D., Praß, W.,

Ringsdorf, H.: The N-Terminus of E. coli Lipoprotein: Synthesis, Immunogenicity,

Spectroscopy and Monolayer Forming Properties of a Potent Mitogen. In: Proceedings of

the 24th International Conference on the Biochemistry of Lipids, Toulouse (1984).

105 Jung, G., Wiesmüller, K.-H., Metzger, J., Scheuer, W., Lex, A., Bessler, W., Leibfritz, D.,

Praß, W., Ringsdorf, H.: The N-Terminus of E. Coli Lipoprotein: Synthesis,

Immunogenicity, Spectroscopy, and Monolayer Forming Properties of a Potent Mitogen.

In: Proceedings of the 24th International Conference on the Biochemistry of Lipids,

Toulouse (1984).

106 Kleine, B., Martinez, C., Bessler, W., and Coutinho, A.: Functional recognition of B cell

mitogens by reactive B cell blasts and B cell lymphomas: Membrane proteins in

lipopolysaccharide reactive and nonreactive cells. Immunobiol. 167, 5 (1984).

107 Jung G., Wiesmüller K.H., Scheuer W., Lex A., Bessler W.G., Leibfritz D., Praß W.,

Ringsdorf H.: B-Lymphocyte Mitogenicity and Biophysical Properties of Synthetic N-

Terminal Lipopeptides of "E. Coli" Lipoprotein. Sclavo International Conference on

Synthetic Antigens. Siena, Italy, 58-62 (1984); Annali Sclavo, 191-208 (1984).

108 Kleine, B., Bessler W.G., Coutinho A.: Segregation of reactivity to the mitogens

lipopolysaccharide, lipoprotein and dextran sulfate in clones of the B cell lymphoma line

WEHI 279.1. Eur. J. Immunol. 15, 207-209 (1985).

10

109 Bessler W.G., Lex A., Vordermeier H.-M., Sprenger R., Suhr B.: Synthetische Analoge des

bakteriellen Lipoproteins sowie Fragmente von Protein I sind Immunomodulatoren in

vitro und in vivo. In: Abstrakts der Frühjahrstagung ASM, DGHM, Würzburg

(1985).

110 Jung G., Wiesmüller K.H., Metzger J., Becker G., Biesert L., Bessler W.G., Leibfritz D.,

Praß W., Ringsdorf H., Bühring H.: Synthese, mitogene und biophysikalische

Eigenschaften N-terminaler Segmente des Lipoproteins. In: Abstrakts des DFG

Peptidsymposium, Bad Nauheim, 23 (1985).

111 Bessler W.G., Cox M., Lex A., Suhr B., Wiesmüller K.-H., Jung G.: Synthetic lipopeptide

analogs of bacterial lipoprotein are potent polyclonal activators for murine B

lymphocytes. In: The Journal of Immunology, The American Association of

Immunologists, 1900-1905 (1985).

112 Lex A., Ortmann A., Wiesmüller K.H., Jung G., Bessler W: Lymphocyte activation and

immunomodulatory activity of synthetic analogues of bacterial lipoprotein and by

fragments of bacterial protein I. In: Abstracts der 1. Frühjahrstagung der Gesellschaft

für Immunologie, Tübingen, WS 1-5 (1985).

113 Grygar G., Köhl S., Dopfer R., Bessler W., Wiesmüller K.H., Jung G., Niethammer D:

Activation of human granulocytes by bacterial surface components and their synthetic

analoga. In: Abstracts der 1. Frühjahrstagung der Gesellschaft für Immunologie,

Tübingen, WS 6-5 (1985).

114 Sprenger R., Kleine B., Bessler W.G: Screening of reactivitiy to bacterial Lipoprotein in H-

2 Recombinant inbred mice and in newly established strains derived from wild mice. In:

Abstracts der 1. Frühjahrstagung der Gesellschaft für Immunologie, (1985)

115 Bessler W., Schlecht S., Lex A., Ortmann A., Wiesmüller K.H., Jung G: Synthetic analoga

of bacterial lipoprotein are potent immunoadiuvants. Abstract. Proceedings of the Joint

Conference. Ithaca, New York, August 3-8, (1985).

116 Jung G., Becker G., Bessler W., Biesert L., Bühring H., Metzger J., Muller C., Wiesmüller

K.H: Potent B-Lymphocyte mitogens as covalently bound carriers for the presentation of

antigens and enhancement of immune response. Abstract. In: Proceeding of the USSR-

FRG Symposium on Peptides and Proteins. 21, Odessa, May 1985.

117 Lex A., Ortmann A., Wiesmüller K.H., Jung G., Bessler W: Lymphocyte-activation and

immunomodulatory activity of synthetic analogues of bacterial lipoprotein.

Posterbeitrag, Würzburg, ASM (1985).

118 Gross W.L., Lohmann C., Wuthe H.H., Bessler W: Lymphozytenantwort auf

hochgereinigte Biostrukturen gramnegativer Bakterien bei reaktiven Arthritiden. In:

Klinische Wochenschrift, Autoreferate zur 91. Tagung der Deutschen Gesellschaft

für innere Medizin, Wiesbaden, 39, 14.-18. April (1985).

119 Bessler W., Suhr B., Bühring H.J., Muller C.P., Wiesmüller K.H., Becker G., Jung G:

Specific antibodies elicited by antigen covalently linked to a synthetic adjuvant.

Immunobiol. 170, 6-7 (1985).

11

120 Bessler W.G., Suhr B., Bühring H.J., Muller C.P., Wiesmüller K.H., Becker G., Jung G:

Specific antibodies elicited by antigen covalently linked to a synthetic adjuvant.

Immunobiol. 170, 239-244 (1985).

121 Hoffmann P., Vordermeier H.M., Biesert L., Heinle S., Bessler W.G: Induction of

interleukin I in murine adherent cells by a synthetic analogue, and by bacterial protein.

Immunobiol. 170, 1/2, 33 (1985).

122 Sprenger R., Kleine B., Bessler W: Reactivity to bacterial lipoprotein and lipopolysaccharid

qualitative and quantitative analysis in a panel of murine strains including H-2

recombinant lines with established and newly derived haplotypes. Immunobiol. 170, 1/2,

92 (1985).

123 Kleine B., Dölker I., Sels F., Bessler W: Membrane proteins specific for B-lymphocytes in

vitro translation of membrane bound mRNA and comparison of products of B and T cells.

Immunobiol. 170, 1/2, 42-43 (1985).

124 Jung G., Wiesmüller K.-H., Becker G., Bühring H.-J., Bessler W.G.: Increased Production

of Specific Antibodies by Presentation of the Antigen Determinants with Covalently

Coupled Lipopeptide Mitogens. In: Angewandte Chemie:VCH Verlagsgesellschaft

mbH, Weinheim, 872-873 (1985)

125 Jung G., Wiesmüller K.H., Metzger J., Bühring H.J., Muller C.P., Biesert L., Bessler W:

Enhancement of Immune Response Using B-Lymphocyte Mitogens Covalently Linked to

Antigens. Proceedings of the Ninth American Peptide Symposium Proceedings.

Toronto, Canada (1985).

126 Lüdemann J., Gross W.L., Bessler W., Braun V: Human B-Cell Differentiation Induced by

Murein. Immunol. Lett., 10, 293-296 (1985).

127 Bessler W: Bakterielle Immunadjuvantien und synthetische Analoga. In: Volker Sill (ed)

Kongreßbericht der 19. Wissenschaftlichen Tagungen der Norddeutschen

Gesellschaft für Lungen-und Bronchialheilkunde, Universimed Verlag, Frankfurt,

166-172 (1985).

128 Jung, G., Wiesmüller, K.-H., Becker, G., Bühring, H.-J., Bessler, W.G.: Verstärkte

Produktion spezifischer Antikörper durch Präsentation der antigenen Determinanten mit

kovalent verknüpften Lipopeptid-Mitogenen. Sonderdruck Angewandte Chemie 97, 883-

885 (1985)

129 Bessler W., Schlecht S., Bühring H., Jung G: Enhancement of the Immune Response by

Mitogenic Lipopeptide Adjuvants Combined with or Covalently Bound to Antigens.

Eingereicht: International Symposium on Immunological Adjuvants and Modulators

of Non-Specific Resistance to Microbial Infections. Columbia, Maryland, USA, 30

June - 3 July 1986.

130 Reitermann, A.C., Riehle, A., Metzger, J., Wiesmüller, K.H., Jung, G., and Bessler, W.G.:

Mitogenic lipopeptide derivatives of bacterial lipoprotein enhance the immune response

combined with or covalently coupled to antigens or haptens. Immunobiol. 173, 199

(1986).

12

131 Kleine, B., Biesert, L., and Bessler, W.G.: Specific expression of membrane proteins in

lipopolysaccharide or lipoprotein activated B lymphocytes. Immunobiol. 173, 155-156

(1986).

132 Wagner-Roos, L., Hauschildt, S., and Bessler, W.G.: Effects of synthetic lipopeptide B-

lymphocyte mitogens on proteinkinase C and phosphoinositide metabolism. Immunbiol.

173, 164 (1986).

133 Bessler, W., and Suhr, B.: Die Aktivierung von B-Lymphozyten bei der Immunantwort.

Biologie in unserer Zeit 16, 33-38 (1986).

134 Bessler, W., Kleine, B., Cox, M., Lex, A., Suhr, B., Wiesmüller, K.H., Jung, G., and

Martinez-Alonso, C.: Synthetic lipopeptide analogues of peptidoglycan-associated

lipoprotein are potent novel B-lymphocyte mitogens. In: Seidel, P.H., Schleifer, K.H.

(Eds.): Biological Properties of Peptidoglycan, Walter de Gruyter, Berlin, New

York, 335-340 (1986).

135 Bessler, W., Jung, G., Bühring, H., and Schlecht, S.: Mitogenic Lipopeptides as Covalently

Bound Carriers for the Presentation of Antigens and Enhancement of the Immune

Response. In: Abstracts of the 6th International Congress of Immunology, Toronto,

Canada (1986).

136 Vordermeier, M., Stäb, K., and Bessler, W.: A Defined Fragment of Bacterial Protein I

(OmpF) is a Polyclonal B-Cell Activator. Inf. Immunity 51, 233-239 (1986).

137 Vordermeier, M., Wagner-Roos, L., Rau, D., Reitermann, A., Bessler, W.: B-Lymphocyte

Activation by Defined Fragments of Bacterial Protein I and by Synthetic Analogues of

Bacterial Lipoprotein. In: Abstracts der 2. Frühjahrstagung der Gesellschaft für

Immunologie, Erlangen (1986).

138 Bessler, W., Lex, A., Suhr, B., Ortmann, A., Schlecht, S., Bühring, H., Muller, C., Metzger,

J., Wiesmüller, K.H., and Jung, G.: The Synthetic Analoga of Bacterial Lipoprotein are

Potent Immunoadjuvants in Combination with or Covalently Linked to Antigen.

Leukocytes and Host Defense, 337-344 (1986).

139 Lex, A., Wiesmüller, K.H., Jung, G., and Bessler, W.: A Synthetic Analogue of Escherichia

coli Lipoprotein, Tripalmitoyl Pentapeptide, Constitutes a Potent Immune Adjuvant. J.

Immunol. 137, 2676-2681 (1986).

140 Scheuer, W.V., Biesert, L., and Bessler, W.: Binding of a Synthetic Analogue of Mitogenic

Bacterial Lipoprotein to Murine Major Histocompatibility Complex (MHC) Gene

Products. Biol. Chem. Hoppe-Seyler 367, 1085-1094 (1986).

141 Biesert, L., Scheuer, W., and Bessler, W.: Interaction of mitogenic bacterial lipoprotein and

a synthetic analogue with mouse lymphocytes: Isolation and characterization of binding

proteins. Eur. J. Biochem. 162, 651-657 (1987).

142 Kleine, B., Biesert, L., Dölker, I., Sprenger, R., Vordermeier, H.M., Countinho, A., and

Bessler, W.G.: Funktional Recognition of Bacterial Mitogens by Reactive B Lymphocytes

Related to Membrane Protein Composition. In: E. Wagner et al. (Eds.): The Cell

Surface in Signal Transduction. Springer Verlag Berlin Heidelberg, 87-99 (1987)

13

143 Kleine, B., Sprenger, R., Martinez-Alonso, C., and Bessler, W.G.: Polyclonal B-cell

activation by a synthetic analogue of bacterial lipoprotein is functionally different from

activation by bacterial lipopolysaccharide. Immunol. 61, 29-34 (1987).

144 Vordermeier, H.M., and Bessler, W.G.: Polyclonal activation of Murine B Lymphocytes in

vitro by Salmonella typhimurium Porins. Immunobiol. 175, 245-251 (1987).

145 Vordermeier, H.M., Drexler, H., and Bessler W.G.: Polyclonal activation of human

peripheral blood lymphocytes by bacterial porins and defined porin fragments. Immunol.

Lett. 15, 121-126 (1987).

146 Hauschildt, S., Wagner-Roos, L., Möck, W., and Bessler W.G.: Lipopeptide Mediated

Transmembrane Signaling in Macrophages and B-Lymphocytes. In: Abstracts der

Frühjahrstagung der Deutschen Gesellschaft für Zellbiologie, Heidelberg (1987).

147 Böltz, T., Jung, G., Wiesmüller, K.H., Metzger, J., and Bessler W.G.: Enhancement of the

Immune Response Using a Synthetic B-Lymphocyte Mitogen Covalently Linked to

Antigens. In: Abstracts of the 18th International Leucocyte Culture Conference, La

Grande-Motte, France (1987).

148 Schlecht, S., Jung, G., and Bessler W.G.: Immunoenhancing activity of heterologous

bacteria and some of their cell wall components on the protective capacity of

S.typhimurium vaccines. In: Abstracts of the International Symposium on

Immunomodulators and Nonspecific Host Defence Mechanisms Against Microbial

Infections, Berlin (1987).

149 Hauschildt, S., Wagner-Roos, L., Möck, W., and Bessler, W.G.: Biochemical Events

During Transmembrane Signaling in B-Lymphocytes and Macrophages Induced by

Mitogenic Lipopeptides and Lipopolysaccharide. In: Abstracts of the 3.

Frühjahrstagung der Gesellschaft für Zellbiologie, Heidelberg (1987).

150 Wagner-Ross, L., Kleine, B., Hauschildt, S., and Bessler, W.G.: Early signals during

lymphocyte activation triggered by mitogenic lipopeptide or lipopolysaccharide (LPS).

Immunobiol. 175/4, 368-369 (1987).

151 Böltz, T., Schauerte, K., Koch, P., Metzger, J., Wiesmüller, K.H., Jung, G., and Bessler

W.G.: Immunoglobulin subclass-specific responses to synthetic B lymphocyte-activating

lipopeptides covalently linked to antigens. Immunobiol. 175/4, 365 (1987).

152 Hoffmann, P., Kreutz, M., Reitermann, A., Hauschildt, S., Jung, G., and Bessler W.G.:

Induction of cytotoxicity and interleukin 1 production in bone marrow derived

macrophages by synthetic analogues of bacterial lipoprotein. Immunobiol. 175/4, 373

(1987).

153 Hauschildt, S., Wagner-Roos, L., and Bessler W.G.: Role of proteinkinase C and

phospatidylinositol metabolism in lipopeptide-induced leukocyte activation as signal

transducing mechanism. In:Molecular Immunology, 1081-1086 (1988)

14

154 Hauschildt, S., Wagner-Roos, L., Bessler, W.G.: Lipopeptide induced transmembrane

signalling in leucocytes. Evidence for the involvement of protein kinase C and inositol

trisphosphates. In: Abstracts der Herbsttagung der Gesellschaft für Biologische

Chemie, Erlangen (1987).

155 Szamel, M., Goppelt-Strübe, M., Bessler, W., Wiesmüller, K.H., and Resch, K.: Separation

of plasma membrane domains of calf thymocytes by affinity chromatography on ouabain-

Sepharose. Biochim. Biophys. Acta 899, 247-257 (1987).

156 Bessler, W. G.: Bakterielle Oberflächenkomponenten als Adjuvantien der Immunantwort in

vitro und in vivo. Asthma, Bronch., Emphes. 7, 23-24 (1987).

157 Wagner-Roos, L., Hauschildt, S., Möck, W., and Bessler, W.G.: Synthetic lipopeptides as

B-lymphocyte growth and differentiation factors: Effects on proteinkinase C and

phosphoinositide metabolism. In: Lymphokine Research 6, 1821 (1987).

158 Bessler, W.G., and Hauschildt, S.: Bakterielle Lipopeptide als Immunadjuvantien. Forum

Mikrobiologie, 4, 106-111, (1987).

159 Prass, W., Ringsdorf, H., Bessler, W., Wiesmüller, K.H., and Jung, G.: Lipopeptides of the

N-terminus of E. coli lipoprotein: synthesis, mitogenicity and properties in monolayer

experiments. Biochim. Biophys. Acta. 900, 116-128 (1987).

160 Böltz, T., Schauerte, K., Koch, P., Reitermann, A., Jung, G., Wiesmüller, K.-H., Metzger,

J., and Bessler, W.G.: Synthetic lipopeptide B-lymphocyte mitogens covalently linked to

antigens enhance the antigen specific humoral immune response. In: Abstracts der 3.

Frühjahrstagung der Gesellschaft für Immunologie, Lübeck (1987).

161 Jung, G., Kabatek, U., Kern, A., Metzger, J., Wiesmüller, K.-H., Bühring, H.-J., Muller,

C.P., and Bessler, W. G.: Efficient Production of Antibodies by Antigen Presentation via a

New Carrier/Adjuvant System. In: Chmiel, H., Hammes, W.P. & Bailey J.E. (eds.),

Biochemical Engineering Gustav Fischer Verlag, Stuttgart (1987).

162 Bessler, W.G., Hauschildt, S., and Wagner-Roos, L.: Leukocyte activation by synthetic

analogs of bacterial lipoprotein: lipopeptide induced transmembrane signaling involving

protein kinase C and inositol trisphosphates. In: Abstracts of the Second International

Conference on Lymphocyte Activation and Immune Regulation, Newport Beach,

USA (1988).

163 Kleine, B., Hirner, K., and Bessler, W.G.: Specific Dephosphorylation of a 110 kDa

Membrane Phosphoprotein by Lipopolysaccharide Exclusively in B Lymphocytes and

Macrophages of the C57BL/6 Strain. In: Abstracts der Frühjahrstagung der

Gesellschaft für Immunologie, Hannover (1988).

164 Becker, G., Bühring, H.J., Jung, C.C., Jung, G., Muller, C., Tröger, W., Wiesmüller, K.-H.,

and Bessler, W.G.: Specific humoral immune response towards predicted epitopes of the

epidermal growth factor receptor (EGFR) conjugated to lipopeptide adjuvant. Submitted

for publication (1988).

15

165 Böltz, T., Bessler, W.G., Jung, G., Wiesmüller, K.H., and Metzger, J.: Enhancement of the

immune response using a synthetic B-lymphocyte mitogen covalently linked to antigens.

In: J.C. Mani, J.C. Dornand (Eds.): Lymphocyte Activation and Differentiation.

Walter de Gruyter & Co. Berlin, New York, 379-382 (1988).

166 Hauschildt, S., Hirt, W., and Bessler, W.G.: Modulation of protein kinase C activity by NaF

in bone marrow derived macrophages. FEBS Lett. 230, 121-124 (1988).

167 Heinle, S., Stünkel, K., Zähner, H., Drautz, H., and Bessler, W.G.: Immunosuppressive

Effects of the Macrolide Antibiotic Bafilomycin towards Lymphocytes and Lymphoid

Cell Lines. Arzneimittelforsch./Drug Research 38, 1130-1133 (1988).

168 Schlecht, S., Jung, G., and Bessler, W.G.: Immunoenhancing Activity of Heterologous

Bacteria and Some of Their Cell Wall Components on the Protective Capacity of

S.typhimurium Vaccines. Adv. Biosci. 68, 317-321 (1988).

169 Hauschildt, S., Steffens, U., Wagner-Roos, L., and Bessler, W.: Role of Proteinkinase C

and Phosphatidylinositol Metabolism in Lipopeptide-Induced Leukocyte Activation as

Signal Transducing Mechanism. Mol. Immunol. 25, 1081-1086 (1988).

170 Bessler, W.G., Hauschildt S., and Wagner-Roos L.: Leukocyte activation by synthetic

analogues of bacterial lipoprotein: Lipopeptide induced transmembrane signalling

involving protein kinase C and inositol trisphosphates. In: Abstracts of the Second

International Conference on Lymphocyte Activation and Immune Regulation,

Newport Beach, USA (1988).

171 Bessler, W.G., Böltz, T., Tröger, W., Hummel, P., Jung, G.: Charakterisierung der

Immunantwort gegen synthetische HIV-Peptid- Adjuvans-Konjugate. In: Abstracts, 1.

Deutscher AIDS-Kongress, München, 1988.

172 Tröger, W., Hummel, P., Gombert, F., Böltz, T., Bessler, W.G. und Jung, G.: Entwicklung

vollsynthetischer HIV-Vakzine auf der Basis niedermolekularer Lipopeptid-Carrier-

Adjuvants Konjugate. In: Abstracts, 1. Deutscher AIDS-Kongress, München, 1988.

173 Hauschildt, S., Wagner-Roos, L., Wiesmüller, K.-H., Jung, G., and Bessler, W.G.:

Phosphatidylinositol Metabolism and Protein Kinase C Activation in Leukocytes by

Lipopeptides. Immunobiol. 177, 267-277 (1988).

174 Schlecht, S., Wiesmüller, K.H., Jung, G., and Bessler, W.: Enhancement of Protection

against Enterobaceriaceae in Mice Mediated by Synthetic Lipopeptide Analogues of

Bacterial Lipoprotein added in Bacterial Vaccines. Zbl. Bakteriol. 82, in press (1988).

175 Hoffmann, P., Heinle, S., Schade, U.F., Loppnow, H., Ulmer, A.J., Flad, H.D., Jung, G.,and

Bessler, W.G.: Stimulation of Human and Murine Adherent Cells by Bacterial

Lipoprotein and Synthetic Lipopetide Analogues. Immunobiol. 177, 158-170 (1988).

176 Jung, G., and Bessler, W. G.: The Synthetic Lipopeptide Pam3Cys-Ser-Asn-Ala, an Analog

of the N-Terminal Part of Bacterial Lipoprotein, Constitutes a Potent Macophage and B

Lymphocyte Activator. In: Abstracts of the Second International Conference on

Lymphocyte Activation and Immune Regulation, Newport Beach, USA (1988).

16

177 Hauschildt S., Wagener-Roos, L. M., Wiesmüller, K.-H., Jung, G., Bessler, W. G.: The

Synthetic Lipopeptide Pam3CYS-Ser-SER-ASN-ALA, an analog of the N-Terminal Part

of Bacterial Lipoprotein, constitutes a potenet Macrophage and B Lymophocyte Activator.

In: Abstracts of the Second International Conference on Lymphocyte Activation and

Immune-Regulation, Newport Beach, USA (1988).

178 Kleine, B., and Bessler, W.G.: A 110 KD Membrane Phosphoprotein is the Prime

Candidate for the Functional Lipopolysaccharide (LPS) Receptor. FASEB J. 2: A 1230

(1988).

179 Hauschildt, S., Steffens, U., and Bessler, W.: Lipopeptide Induced Activation of

Leukocytes: Role of Proteinkinase C and Phosphatidylinositol Metabolism. In: Abstracts

of the 19th International Leucocyte Culture Conference, Banff, Canada (1988).

180 Steffens, U., Hauschildt, S., and Bessler, W.G.: Induction of B Cell stimulation by

lipopeptide through a mechanism not Involving cAMP, cGMP and inositoltrisphosphate.

Immunobiol. 178, 54 (1988).

181 Bender, A., Nain, M., Hinder, F., Horch, S., Bessler, W. and Gemsa, D.: Influenza A virus-

induced release of tumor necrosis factor-alpha (TNF-alpha) from macrophages is

enhanced by lipopolysaccharide (LPS), lipid A, and lipopeptides. Immunobiol. 178, 59

(1988).

182 Wiedemann, F., Böltz, T., Hummel, R.-P., Tröger, W., Jung, G., Schauerte, K., and Bessler,

W.G.: Detection of HIV-1 and HIV-2 infections using lipopeptide conjugates as antigens

in enzyme immunoassay. Immunobiol. 178, 73-74 (1988).

183 Reitermann, A., Metzger, J., Jung, G., Bessler, W.G., and Böltz, T.: B cell autoreactive

repertoire following immunization with the polyclonal B cell activators lipopeptide and

LPS. Immunobiol. 178, 51 (1988).

184 Link, R., Böltz, T., Hummel, R.-P., Tröger, W., Jung, G., Koch, P., and Bessler, W.G.:

Immunogenicity of synthetic oligopeptides corresponding to epitopes of friends murine

leukemia virus glycoprotein covalently linked to lipopeptides. Immunobiol. 178, 64

(1988).

185 Wolf, B., Hauschildt, S., Uhl, B., Metzger, J., Jung, G., and Bessler, W.G.: Electron energy

loss spectroscopy (EELS) as a novel method to localize the leukocyte activator

lipopeptide in the lymphoid cell line BCL1 and in bone marrow-derived macrophages.

Immunobiol. 178, 101 (1988).

186 Hoffmann, P., and Bessler, W.G.: Tumor cytotoxicity involving TNF induced in bone

marrow-derived macrophages by two lipopeptide analogues of bacterial lipoprotein.

Immunobiol. 178, 94 (1988).

187 Böltz, T., Hummel, R.-P., Tröger, W., Rübsamen-Waigmann, H., Biesert, L., Müller-

Lantzsch, N., Koch, P., Bessler, W., and Jung, G.: Distinction between HIV-1 and HIV-2

infection using novel synthetic lipopeptide conjugates as antigens in enzyme

immunoassays. J. of Virol. Meth. 22, 173-182 (1988).

17

188 Brade, L., Bessler, W.G., and Brade, H.: Mitogenic Activities of Synthetic Escherichia coli

Lipid A and a Synthetic Partial Structure (Tripalmitoyl Pentapeptide) of E. coli

Lipoprotein. Infect. Immun. 56, 1382-1384 (1988).

189 Bessler, W.G., und Baron, D.: Die Herstellung und Anwendung monoklonaler Antikörper.

Naturwissenschaften 75, 496-502 (1988).

190 Hauschildt, S., and Bessler, W.G.: Role of inositol starvation on ecto-5'-nucleotidase

activity during mitogen-induced lymphocyte activation. Immunol. Lett. 19, 71-76 (1988).

191 Bessler, W.G.: Bakterielle Oberflächenkomponenten und synthetische Analoga als

Adjuvantien der Immunantwort in vitro und in vivo. Asthma, Bronch. Emphys. 1, 9-10

(1988).

192 Hauschildt, S., Steffens, U., Wolf, B., and Bessler, W.: Lipopeptide induced signal transfer

in bone marrow derived macrophages. Biol. Chem. Hoppe-Seyler 369, 833 (1988).

193 Hummel, R.-P., Tröger, W., Jung, G., Bessler, W.G., and Böltz, T.: Development of a HIV-

1 and HIV-2 specific ELISA. In: Abstracts Intern. Conf. on AIDS, Stockholm, Sweden

(1988).

194 Andreesen R., Brugger, W., Galanos, C., Bessler, W., Rehm, A., and Löhr, G.W.: Sensitive

Inhibition of Human Monocyte to Macrophage Differentiation by Bacterial Endotoxins

and Synthetic Lipoeptide Analogues. In: Abstracts 30th Annual Meeting of The

American Society of Hematology, (1988).

195 Hummel, R.-P., Tröger, W., Böltz, T., Bessler, W.G., and Jung, G.: Development of HIV-1

and HIV-2 Specific and Selective Enzyme Linked Immunosorbent Assay Based on

Tripalmitoyl-S-Glyceryl-Cysteinyl-Peptides. In: Abstracts 20th Europ. Peptide

Symposium, Tübingen (1988).

196 Lovett, D. H. Burnsten, S. L. Gemsa, D., Bessler, W. G., Resch, K., And Ryan, J. L:

Activation of Glomerular Masangial Cells by Gram-Negative Bacterial Cell Wall

Components. Am. J. Path., 33, 472-484 (1988).

197 Steffens, U., Bessler, W. G., and Hauschildt, S.: B Cell Activation by Synthetic

Lipopeptide Analogues of Bacterial Lipoprotein Bypassing Phosphatidylinositol

Metabolism and Proteinkinase C Translocation. Mol. Immunol. 26, 897-904 (1989)

198 Hoffmann, P., Wiesmüller, K.-H., Metzger, J., Jung, G. and Bessler, W.G.: Induction of

Tumor Cytotoxicity in Murine Bone Marrow-Derived Macrophages by Two Synthetic

Lipopeptide Analogues. Biol. Chem. Hoppe-Seyler 370, 575-582 (1989).

199 Wolf, B., Hauschildt,S., Uhl, B., Metzger, J., Jung, G., and Bessler, W.G.: Localization of

the cell activator lipopeptide in bone marrow-derived macrophages by electron energy

loss spectroscopy (EELS). Immunol. Lett. 20, 121-126 (1989).

200 Schlecht, S., Wiesmüller, K.-H., Jung, G., and Bessler, W.G. Enhancement of Protection

against Salmonella Infection in Mice Mediated by a Synthetic Lipopeptide Analogue of

Bacterial Lipoprotein in S. typhimurium Vaccines. Zbl. Bakt. 271, 493-500 (1989).

18

201 Wolf, B., Uhl, B., Hauschildt, S., Metzger, J., Jung, G., and Bessler, W.: Interaction of the

Lymphoid Cell Line BCL1 with Lipopeptide Analogues of Bacterial Lipoprotein: Electron

Energy Loss Spectroscopy (EELS) as a Novel Method to Detect the Distribution of the

Activator within the Cells. Immunobiol., 180, 93-100 (1989)

202 Scheipers, P., Hauschildt, S., Philippi, S., Martinez-Alonso, C., Jung, G., and Bessler,

W.G.: Mechanism of Leukocyte Activation by Bacterial Lipopeptides. In: Abstracts, 7th

Intern. Congress of Immunol., Berlin (1989)

203 Bessler, W.G.: Bacterial lysates and purified bacterial surface components as

immunomodulators. In: Abstracts of the International Symposium on Mucosal

Immunity of the Respiratory Tract, Bad Lippspringe (1989).

204 Kleine, B., and Bessler, W.G.: Lipopolysaccharide Induced Signal Transduction

Mechanism in B Cells and in Bone Marrow-derived Macrophages May Involve

Dephosphorylation of a 185 KD Phosphoprotein. In: Abstracts, 7th Intern. Congress of

Immunol., Berlin (1989)

205 Hauschildt, S., Wolf, B., Uhl, B., Lückhoff, A., and Bessler, W.G.: Lipopeptide Induced

Signal Transfer in B Cells and in Bone Marrow derived Macrophages. In: Abstracts, 7th

Intern. Congress of Immunol., Berlin (1989)

206 Bessler, W., Link, R., Böltz, T., Hummel, R.-P., Tröger, W., Koch, P., and Jung, G.:

Immunogenität synthetischer FMuLV- und HIV-Oligopeptid-Lipopeptid-Konjugate in

Balb/c und STU-Mäusen. In: Abstracts 2. Deutscher AIDS-Kongress, Berlin (1989).

207 Uhl, B., Wolf, B., Hug, R., Hauschildt, S., and Bessler, W.G.: Ultrastructural Alterations in

Bone Marrow derived Macrophages after Stimulation with Lipopeptides. In: Abstracts

der Jahrestagung der Deutschen Gesellschaft für Zellbiologie, Bielefeld (1989).

208 Muller, C.P., Bühring, H. J., Becker, G., Jung, C.C., Jung, G., Tröger, W., Wiesmüller, K.-

H., Saalmüller, A., and Bessler, W.G.: Specific antibody response towards predicted

epitopes of the epidermal growth factor receptor induced by a thermostable synthetic

peptide adjuvant conjugate. Clin. Exp. Immunol., 78, 499-504 (1989).

209 Hummel, R.P., Tröger, W., Biesert, L., Rübsamen-Waigmann, H., Böltz, T., Bessler, W.G.,

and Jung, G.: Distinction of HIV-1 and HIV-2 infection using novel synthetic lipopeptide-

conjugates as antigens in ELISA. In: Jung, G., and Bayer, E. (eds.): Peptides 1988,

Walter de Gruyter, Berlin, New York (1989).

210 Hauschildt, S., Lückhoff, A., Philippi, S., and Bessler, W.G.: Activation of Mouse Bone

Marrow-Derived Macrophages by Bacterial Lipopeptide. In: The Macrophage, Third

Symposium of the Upper Rhine Universities, Freiburg (1989).

211 Kleine, B., Biesert, L., and Bessler, W.G.: The Membrane Protein Compositions of

Lipopolysaccharide- or Lipoprotein-Activated B Lymphoblasts from C57BL LPS-

Responder and Non-Responder Mice are Qualitatively Indistinguishable. Res. Immunol.

140, 685-695 (1989).

19

212 Schlecht, S., Metzger, J., Wiesmüller, K.-H., Jung, G., Bessler, W. G.: Lipopeptide

Analogues of the N-Terminus of Bacterial Lipoproteins are Adjuvants in S-typhimurium

Vaccines. In: Abstracts der 42. Jahrestagung der Deutschen Gesellschaft für Hygiene

und Mikrobiologie, Hannover (1989).

213 Bessler, W.G. and Jung, G.: Therapy and Prophylaxis of HIV-Infections: Preparation and

Tests of New Lipopeptide Immunogens and Inhibitors. In: Abstracts des 2.

Statusseminars der AIDS-Forschungsförderimg, Bonn (1989).

214 Kline, B., Bessler, W. G., Coutinho, J., Kettman, J.: Global Analysis of Membrane

Proteinsfrom WEHI 279.1 Subclones Reveals Co-Expression of Groups of Proteins. In:

Abstracts for UCLA-Symposion: B-Cell Development, Park City, Utah, USA (1989).

215 Metzger, J., Wiesmüller, K.-H., Kabatek, U., Kerm, A., Schaude, R., Hess, G., and Jung,

G.: New Applications of Low Molecular Weight Antigens Presenting Carrier-Adjuvant

Systems for Elecitation of Antibodies. In: König, W.A. Voelter, W. (eds.), Chemistry of

Peptides and Proteins, 263-268 (1989).

216 Reitermann, A. Metzger, J. Wiesmüller, K.-H., Jung, G., and Bessler W. G.: Lipopeptide

Derivatives of Bacterial Lipoprotein Constitute Potent Immune Adjuvants Combined with

or Covalently Coupled to Antigen or Hapten. Biol. Chem. Hoppe-Seyler 370, 343-352

(1989).

217 Mülsch, A., Hauschildt, S., Bessler, W.G., Bassenge, E., and Busse, R.: Cytosolic Nitric

Oxide Synthesis from L-arginine by Murine Bone Marrow Macrophages and Porcine

Aortic Endothelial Cells. In: Abstracts for the Royal Society London (1989).

218 Bessler, W. G., and Jung, G.: Therapy and Prophylaxis of HIV-Infections: Preparation and

Tests of Novel Lipopeptide Immunogens and Inhibitors. In: Progress in Aids Research

in the Federal Republic of Germany, Bonn (1989).

219 Strecker, M., Jung, G., Bessler, W. G.: The active principle of bacterial surface

components: bacterial lysates and synthetically prepared membrane components as

immunomodulators. In: Abstracts des 8th Congress of SEP, The European

Respiratory Journal, European Society of Pneumology, European Pediatric

Respiratory Society, Freiburg 1989).

220 Bessler, W.G., Kleine, B., Martinez-Alonso, C., Biesert, L., Strecker, M., Wiesmüller, K.-

H., Metzger, J., and Jung, G.: Biological Activity of Bacterial Surface Components:

Bacterial Extracts and Defined Bacterial Cell Wall Components as Immunmodulators. In:

Lung, Vol. 168, Suppl. 1990, 707-715 (1990).

221 Vordermeier, H.-M., Hoffmann, P., Gombert, F.O., Jung, G., and Bessler W. G.: Synthetic

Peptide Segments from the Escherichia coli Porin OmpF Constitute Leukicyte Activators.

Infection and Immunity 58, 2719-2724 (1990).

222 Hoffmann, P., Jimenez-Diaz, M., Loleit, M., Tröger, W., Jung, G., and Bessler, W.G.:

Preparation of human and murine monoclonal antibodies: Lipopeptide antigen conjugates

constitute potent immunogens for in vitro and in vivo immunizations. In: Abstracts 1st

International Conference on Human Antibodies and Hybridomas, Orlando, Florida,

USA (1990).

20

223 Wolf, B. and Bessler, W. G.: Elektronen-Energieverlust-Spektroskopie (EELS) als Methode

zur Lokalisierung von Antigenen und anderen Substanzen in Zellen und Geweben.

Naturwissenschaften 77, 110-115 (1990).

224 Seifert, R., Schultz, G., Richter-Freund, Metzger, J., Wiesmüller, K.-H., Jung, G., Bessler,

W.G., and Hauschildt, S.: Activation of superoxide formation and lysozyme release in

human neutrophils by the synthetic lipopeptide Pam3Cys-Der-(Lys)4: Involvement of

guanine-nucleotide-binding proteins and synergism with chemotactic peptides. Biochem.

J. 267, 795-802 (1990).

225 Wiesmüller, K.-H., Hess, G., Bessler, W. G., and Jung, G.: Diastereomers of tripalmitoyl-S-

glyceryl-L-cysteinyl carrier adjuvant systems induce different mitogenic and protective

immune response. In: Holmstedt, G., Frank, H., and Testa, G. (eds.): Chirality and

Biological Activity, A. Liss Inc. New York, 267-272 (1990).

226 Kreutz, M., Hauschildt, S., Bessler, W. G., and Andreesen, R.: Induction of the cytokine

repertoire in human monocytes and monocyte-derived macrophages by synthetic bacterial

lipopeptides. In: The Macrophage, Fourth Symposium of the Upper Rhine

Universities, Freiburg (1990).

227 Hauschildt, S., Bassenge, E., Bessler, W., Busse, R., and Mülsch, A.: l-arginine dependent

nitric oxide formation and nitrite release in bone marrow-derived macrophages stimulated

with bacterial lipopeptide and lipopolysaccharide. Immunology 70, 332-337 (1990).

228 Bessler, W.G., Jung, G., and Hauschildt, S.: Modulation of B lymphocyte activation by

lipopeptides: Molecular mechanisms of transmembrane signalling. In: Abstracts 3rd

International Conference on Lymphocyte Activation and Immune Regulation,

Newport Beach (1990).

229 Seifert, R., Hauschildt, S., and Bessler, W.G.: A Synthetic Lipopeptide Activates Human

Neutrophils through Pertussis Toxin-Sensitive and -Insensitive Mechanisms. Naunyn-

Schmiedeberg's Arch. Pharmacol., suppl. to Vol. 341 (1990).

230 Loleit, M., Tröger, W., Wiesmüller, K.-H., Jung, G., Strecker, M., and Bessler, W.G.:

Conjugates of synthetic lymphocyte activating lipopeptides with segments from HIV

proteins induce protein specific antibody formation. Biol. Chem. Hoppe-Seyler 371, 967-

975 (1990).

231 Müller, B., Wiesmüller, K.-H., Jung, G., Bessler, W.G., Hoffmann, P.: Induction of tumor

cytotoxicity in murine bone marrow-derived macrophages by chemically altered

lipopeptide analogues of bacterial lipoprotein. In: Abstracts der 6. Frühjahrstagung

der Gesellschaft für Immunologie, Marburg, (1990).

232 Hauschildt, S., Mülsch, A., Busse, R., and Bessler, W.: A lipopeptide derived from

bacterial lipoprotein induces the "oxidative L-arginine pathway" in bone marrow derived

macrophages. In: Abstracts der 6. Frühjahrstagung der Gesellschaft für

Immunologie, Marburg, (1990).

21

233 Kaufmann, H., Kleine B., and Bessler, W.G.: Dephosphorylation of a 185 kd

phosphoprotein may be involved in lipopolysaccharide induced signal transduction

mechanisms in B cells and in bone marrow derived macrophages. In: Abstracts of the 1st

Congress of the International Endotoxin Society, San Diego, California, (1990).

234 Hauschildt, S., Lückhoff, A., Mülsch, A., Kohler, J., Bessler, W.G., and Busse, R.:

Induction and activity of NO synthase in bone-marrow-derived macrophages are

independent of Ca²+. Biochem. J. 270, 351-356 (1990).

235 Hauschildt, S., Wolf, B., Uhl, B., Lückhoff, A., and Bessler, W.G.: Lipopeptide uptake and

signal transfer in leukocytes. In: Abstracts of the 10th Meeting of the European

Federation of Immunological Societies, Edinburgh, (1990).

236 Bessler, W. G., Kleine, B., Biesert, L., Schlecht, S., Schaude, R., Wiesmüller, K.-H.,

Metzger, J., and Jung, G.: Bacterial surface components as immunomodulators. In: K. N.

Masihi, W. Lange (eds.): Immunotherapeutic Prospects of Infectious Diseases,

Springer Verlag Berlin, 37-48 Heidelberg (1990).

237 Hauschildt, S., Wolf, B., Lückhoff, A., and Bessler, W.G.: Determination of second

messengers and protein kinase C in bone marrow derived macrophages stimulated with a

bacterial lipopeptide. Molec. Immunol. 27, 473-479 (1990).

238 Hoffmann,, P., Jimenez-Diaz, M., Loleit, M., Tröger, W., Wiesmüller, K.-H., Metzger, J.,

Jung, G., Kaiser, I., Stöcklin, S., Lenzner, S., Peters, J.H., Grimm, R., Schäfer, E. and

Bessler, W.G.: Preparation of human and murine monoclonal antibodies: antigens

combined with or conjugated to lipopeptides constitute potent immunogens for in vitro

and in vivo immunizations. Hum. Antibod. Hybridomas 1 (3) 137-144 (1990).

239 Scheipers, P., Bessler, W.G., and Hauschildt, S.: Lipopeptide induced B-lymphocyte

activation - transmembrane signalling mechanisms and role of G proteins. 6.

Frühjarstagung d. Gesellsch. f. Immunologie, Marburg, 28 (1990).

240 Kleine, B., Bessler, W.G., and Kettman, J.: Global analysis of membrane proteins: A way

to measure tumor differentiation. In: Abstracts of the International Society of Onco-

developmental Biology and Medicine, Moscow, USSR (1990).

241 Wiesmüller, K.-H., Metzger, J., Schaude, R., Beck, A., Hess, G., Haas, B., Bessler,W. G.

and Jung, G.: Synthetic low-molecular weight foot-and-mouth disease virus vaccine and

novel lipopeptides for the synthesis of immunogenic lipopeptide-antigen conjugates. In:

R. Epton (ed.): Innovation and Perspectives in Solid Phase Synthesis: Peptides,

Polypeptides and Oligonucleotides, Macro-organic Reagents and Catalysts. SPPC

Ltd., Kingswinford U.K., 601-607 (1990).

242 Scheipers, P., Bessler, W.G., and Hauschildt, S.: Lipopeptide induced leukocyte activation:

Transmembrane signalling mechanisms and role of G Proteins. In: Abstracts, 19th

Annual UCLA Symposia, Journal of Cellular Ciochemistry,155 (1990).

243 Loleit, M., Haas, G., Tröger, W., Wiesmüller, K.-H., Jung. G., Strecker, M., and Bessler,

W. G.: Synthetic lymphocyte activating lipopeptide conjugates with segments from HIV

proteins induce protein specific antibody formation. In: Abstracts des 3. Deutschen

AIDS-Kongresses, Hamburg (1990).

22

244 Hauschildt, S., Mülsch, A., Lückhoff, A., and Bessler, W.G.: Nitric oxide formation and

nitrite release in bone marrow derived macrophages stimulated with bacterial mitogens.

In: The Macrophage, Fourth Symposium of the Upper Rhine Universities, Freiburg

(1990).

245 Wiesmüller, K.-H., Jung, G., Gillessen, D., Loffl, C., Bessler, W. G., and Böltz, T.: The

antibody response in BALB/c mice to the Plasmodium falciparum crircumsporozoite

repetitive epitope covalently coupled to synthetic lipopeptide adjuvant. Immunol. 72,

109-113 (1991).

246 Wolf, B., Uhl, B., Schwinde, A., Hauschildt, S., and Bessler, W.G.: Electron energy loss

spectroscopy as an alternative method to follow up the route of activators and drugs in

cells and tissues. In: Proceedings of the 12th International Congress for Electron

Microscopy, San Francisco, USA (1990).

247 Bessler, W.G., Sedelmeier,E., Loleit, M., Martinez-Alonso, C., Schlecht, S., und Jung, G.:

Bakterielle Oberflächenstrukturen als Immunmodulatoren. Allergologie 8, 309 (1990).

248 Hoffmann, P., Jimenez-Diaz, M., Loleit, M., Jung, G., Grimm, R., Schäfer, E., and Bessler,

W.G.: Antigens combined with or conjugated to lipopeptides constitute potent

immunogens for in vitro and in vivo immunizations and for the preparation of human and

murine monoclonal antibodies. Immunobiol. 181, 211 (1990).

249 Kleine, B, Bessler, W.G., Coutinho, A., and Kettman, J.: Using global analysis of

membrane proteins from WEHI 279.1 B-cells subclones co-expression of protein Groups

is revealed. Immunobiol. 181, 123-124 (1990).

250 Hauschildt, S., Hoffmann, P., Beuscher, H. U., Dufhues, G., Heinrich, P., Wiesmüller, K.-

H., Jung. G., and Bessler, W. G.: Activation of bone marrow-derived mouse macrophages

by bacterial lipopeptide: cytokine production, phagocytosis and Ia expression. Eur. J.

Immunol. 20, 63-68 (1990).

251 Bender, A., Schmidt, A., Bessler, W. G., Nain, M. and Gemsa, D.: TNF- production of

influenza A virus-infected macrophages: Temporally selective potentiation by bacterial

lipopolysaccharides (LPS) and lipoproteins. Immunobiol. 183, 247 (1991).

252 Müller, B., Hauschildt, S., Jung, G., Bessler, W. G. and Hoffmann, P.: Molecular

mechanisms of tumor cytotoxity and cytostasis induced in murine bone marrow-derived

macrophages by different synthetic analogues of bacterial lipoprotein. Immunobiol. 183,

308 (1991).

253 Bessler, W. G., Beck, P., Konetznick, U., Loleit, M., Sedelmeier, E., Hoffmann, P.,

Strecker, M. and Stöcklin, S.: Biological activity of bacterial surface components:

Immunogenicity and immunomodulatory properties of a bacterial extract from Escherichia

coli. Arzneimittelforsch./drug Research 41, 274-279 (1991).

254 Hoffmann, P., Müller, B., Körner, S., Höltje, J.-V., Wiesmüller, K.-H., Metzger, J., Jung,

G., and Bessler, W.G.: Cytostatic and cytotoxic activity of murine bone marrow-derived

macrophages stimulated with bacterial cell wall components and synthetic analogues.

Pathobiologie 59(4) 270 (1991).

23

255 Metzger, J., Wiesmüller, K.-H., Schaude, R., Bessler, W. G. and Jung, G.: Synthesis of

novel immunologically active tripalmitoyl-S-glycerylcysteinyl lipopeptides as useful

intermediates for immunogen preparations. Int. J. Pept. Prot. Res. 37 (1), 46-57 (1991).

256 Uhl, B., Wolf, B., Schwinde, A., Metzger, J., Jung, G., Bessler, W. G., and Hauschildt, S.:

Intracellular Localization of a Lipopeptide Macrophage Activator: Immunocytochemical

Investigations and EELS Analysis on Ultrathin Cryosections of Bone Marrow-Derived

Macrophages. J. Leukocyte Biol., 50, 10-18 (1991).

257 Hauschildt, S., Lückhoff, A., Langhorne, J., Wiesmüller, K.-H., Jung, G., Bessler, W.G.,

and Cambier, J.C.: Increase in the intracellular free calcium concentration is not an

obligatory early event in lipopeptide-induced B Cell activation. Immunol. 73, 366-368

(1991).

258 Wiedemann, F., Link, R., Pumpe, K., Jacobshagen, U., Schäfer, H.E., Wiesmüller,

Hummel, R.P., K.-H., Tröger, W., Jung, G., Bessler, W.G., Böltz, T.: Histopathological

studies on the local reactions induced by complete Freund's adjuvant (CFA), bacterial

lipopolysaccharide (LPS), and synthetic lipopeptide (P3C) conjugates. J. Pathol. 164,

265-271 (1991).

259 Uhl, B., Speth, V., Wolf, B., Bessler, W. G., and Hauschildt, S.: Rapid alterations in the

plasma membrane structure of macrophages stimulated with bacterial lipopeptides. In:

Abstracts, Deutsche Gesellschaft für Zell Biologie, Göttingen (1991).

260 Bessler, W.G., Haas G., Tröger, W., Wiesmüller. K.-H., and Jung, G.: Immune regulation

by synthetic lymphocyte activating lipopeptide conjugates: segments from HIV proteins

induce cefined isotype patterns in protein specific antibody formation. Midwinter

Conference of Immunologists, Asilomar (1991).

261 Hoffmann, P., Jimenéz-Dias, M., Müller, B., Richter, L., Strecker, M., Jung, G., and

Bessler, W.G.: Human monoclonal antibodies produced by primary in vitro immunization

with antigens combined with or covalently coupled to lipopeptides. Frühjahrstagung für

Immunologie, Berlin (1991).

262 Wolf, B., Hauschildt, S., Bessler, W. G. , Uhl, B., Dinger, V., Fiebig, H. H.: Subzelluläre

Mikropharmakokinetik von Immunmodulatoren und Cytostatika mittels analytischer

Elektronenmikroskopie. European Journal of Cell Biology, Supp. 32 (54), 79 (1991).

263 Bessler, W. G., Sedelmeier, E: In vivo assessment of the biological activity of bacterial

extract OM-89. In: Abstracts of the Symposium of the International Association of

biological Standardization, Annecy (1991).

264 Hauschildt, S., Mülsch, A., Scheipers, P., Busse, R., Bessler, W. G.: L929 murine

fibroblasts express a constitutive and a TNTa-induced calcium-calmodulin independent

nitric oxide (NO) Synthase. In: Abstracts of the Second International Meeting of the

Biology of Nitric Oxide, London (1991).

24

265 Bessler, W. G.: Synthetic lipopeptide immunomodulators derived from bacterial

lipoprotein: Tools for the standardization of in vitro assays. In: Abstracts of the

Symposium of the International Association of Biological Standardization, Annecy

(1991).

266 Metzger, G., Jung, G., Bessler, W. G., Hoffmann, P., Strecker, M., Lieberknecht, A.,

Schmidt, U.: Lipopeptides containing 2-(Palmitoylamino)-6,7-bis(palmitoyloxy)heptanoic

Acid: Synthesis, Sterospecific Stimulation of B-Lymphocytes and Macrophages and

Adjuvanticity in vitro and in vivo. J. Med. Chem. 34, 1969-1974 (1991).

267 Müller, B., Hauschildt, S., Körner, S., Jung, G., Bessler, W. G. Hoffmann, P.: Murine bone

marrow-derived macrophages stimulated with synthetic analogues of bacterial lipoprotein

express several cytostatic and cytotoxic activities. In: Abstracts of the Fifth Annual

Conference of the Upper Rhine Universities, The Macrophage, Strasbourg (1991).

268 Müller, B., Hauschildt, S., Jung, G., Bessler, W. G., Hoffmann, P.: Molecular mechanisms

of tumor cytotoxicity and cytostasis induced in murine bone marrow-derived macrophages

by different synthetic analogues of bacterial lipoprotein. In: Abstracts of the 22nd

Annual Meeting of the Gesellschaft für Immunologie, (1991).

269 Kaufmann, H., Löffler, G., Bessler, W. G., Kleine, B.: Lipopolysaccharide-dependent

dephosphorylation in isolated lymphocyte Mmebranes. In: Abstracts für die erste

gemeinsame Frühjahrstagung der Gesellschaft für klinische und experimentelle

Immunologie, Berlin (1991).

270 Kaufmann, H., Löffler, G., Bessler, W. G., Kleine, B.: Protein dephosphorylation as

lipopolysaccharide induced signal transduction mechanism in murine macrophages. In:

Abstracts of the Fifth Annual Conference of the Upper Rhine Universities,

Strasbourg (1991).

271 Hauschildt, S., Scheipers, P. Bessler, W. G.: Inhibitors of poly(ADP-Ribose) polymerase

supress lipopolysccharide-induced nitrite formation in macrophages. Biochem. Biophy.

Res. Comm. 179, 865-871 (1991).

272 Hauschildt, S., Uhl, B., Wolf, B., Bessler, W.G.: Early events in lipopeptide-induced

macrophage activation. In: Abstracts of the 28th Annual Meeting of the Society for

Leukocyte Biology, Aspen (1991).

273 Hauschildt. S., Uhl, B., Wolf, B., Bessler, W.G.: Early Events in B Cell Activation In:

Abstracts of the 11th European Immunology Meeting, Helsinki (1991).

274 Uhl, B., Wolf, B., Bessler, W. G., and Hauschildt, S.: Intracellular localization of

lipopeptides in quiescent B-lymphocytes using EELS analysis. In: Abstrakts der

Frühjahrstagung der Deutsche Gesellschaft für Immunologie, Berlin (1991).

275 Bessler, W. G., Kleine, B., Martinez-Alonzo, C., Biesert, L., Strecker, M., Wiesmüller, K.-

H., Metzger, J. and Jung, G.: Biologische Aktivatät bakterieller Oberflächenkomponenten:

Bakterielle Extrakte und definierte bakterielle Zelloberflächenkomponenten als

Immunomodulatoren. In: Abstracts of the 11th European Immunology Meeting,

Helsinki (1991).

25

276 Wiesmüller, K.-H., Bessler, W. G., Jung, G.: Solid phase peptide synthesis of lipopeptide

vaccines eliciting epitope-specific B-,T-helper and T-killer cell response. Int. J. Peptide

Protein Res. 40, 255-260 (1992).

277 Bessler, W. G.: Aids-Forschung: Neuer Ansatz zur Impfstoffentwicklung. Freiburger Uni

Magazin, 1 Feb., 16-17 (1992).

278 Hauschildt, S., Scheipers, P., Bessler, W. G., Mordvintcev, P., Vanin, A. and Mülsch, A.:

Nitric oxide production and ADP-ribosylation in macrophages. In: Abstracts of the

European Conference on Basic and Clinical Aspects of Macrophage Biology,

Regensburg (1992).

279 Hoffmann, P., Loleit, M., Jimenez-Diaz, M., Hass, G., Spohn, R., Ihlenfeldt, H.-G., Jung,

G., Bessler, W. G.: In vitro and in vivo immunization with lipopeptide-antigen-conjugates:

Mapping of B-cells epitopes with polyclonal and monoclonal antibodies. In: Abstracts of

the 23rd Annual Meeting of the Gesellschaft für Immunologie, Mainz (1992).

280 Bessler, W. G., Jung, G.: Bacterial immunoadjuvans: synthetic lipopeptides as novel

stimulants. In: Masseyeff et al. (eds.), Methods of Immunological Analysis, Vol. 2,

Chapter 3.8.2, Verlag Chemie, Weinheim (1992).

281 Hauschildt, S., Scheipers, P., Bessler, W. G. and Mülsch, A.: Inhibitors of Poly(ADP-

Ribose) Polymerase Suppress a TNF-J Inducible NO Synthase Isoform in L929 Cell. In:

Abstracts of the 23rd Annual Meeting of the Gesellschaft für Immunologie, Mainz,

(1992).

282 Hauschildt, S., Scheipers, P., Bessler, W.G., Mülsch, A.: Induction of nitric oxide synthase

in L 929 cells by tumor-necrosis factor- is prevented by inhibitors of poly(ADP-ribose)

polymerase. Biochem. J. 288, 255-260 (1992).

283 Kleine, B., Löffler, G., Kaufmann, H., Scheipers, P., Schickle, H., Westermeier, R.,

Bessler, W.G. Reduced chemical and radioactive liquid waste during electrophoresis

using polymerized electrode gels. Electropheresis 13, 73-75 (1992).

284 Bessler, W.G.: Synthetic lipopeptide immunomodulators derived from bacterial lipoprotein:

tools for the standardization of in vitro assays. Develop. Biol. Standard. 77, 49-56

(1992).

285 Seifert, R., Serke, S., Huhn, D., Bessler, W. G., Hauschild, S., Metzger, J., Wiesmüller and

K.-H., Jung, G.: Incomplete functional differentiation of HL-60 leukemic cells by

synthetic lipopeptides: partial inhibition by pertussis toxin of enhanced auperoxide

formation. Eur. J. Biochem. 203, 143-151 (1992).

286 Bessler, W. G. and Jung, G.: Synthetic lipopeptides as novel adjuvants. Res. Immunol.

143, 548-552 (1992).

287 Loleit, M., Haas, G., Ihlenfeldt, H. G., Jung, G., Müller, B., und Bessler, W. G.: Induktion

spezifischer T-Lymphozyten gegen Peptide der Reversen Transkriptase von HIV-1 mittels

synthetischer Lipopeptid-Peptid-Konjugate. In: Abstracts, 4 Deutscher Aids-Kongress,

Wiesbaden (1992).

26

288 Bessler, W. G.: AIDS - Facts and Fantasy. In: Schülerzeitung des Kreisgymnasium,

Gundelfingen (1992).

289 Bessler, W. G.: Induktion einer spezifischen Immunantwort nach Immunisierung mit Uro-

Vaxom. Jatros Urologie - Nephrologie 8, 7-9, Frankfurt/Main (1992).

290 Hoffmann, P., Jiminéz-Diaz, Jung, G., Bessler, W. G.: Production of human monoclonal

antibodies: lipopeptide antigen mixtures or conjugates as tools for the primary in vitro

immunization of human peripheral blood lymphocytes. In: Second International

Conference on Human Antibodies and Hybridomas, Queens' College, Cambridge

(1992).

291 Bessler, W.G., Jung, G., Haas, G., Loleit, M.: T Cell-B Cell interactions in lymphocyte

activation with synthetic lipopeptide-peptide conjugates: activation of Th-cells and

induction of defined isotype patterns. In: Abstracts of the Fourth International

Conference on Lymphocyte Activation and Immune Regulation, Newport Beach

(1992).

292 Müller, B., Hoffmann, P., Mülsch, A., Bessler, W. G., Hauschildt, S.: Macrophage

mediated cytotoxicity. Role of nitric oxide in target cells In: Abstracts der 8.

Frühjahrstagung der Gesellschaft Für Immunologie, München (1992).

293 Uhl, B., Speth, V., Wolf, B., Jung, G., Bessler, W. G., Hauschildt, S.: Rapid alterations in

the plasma membrane structure of macrophages stimulated with bacterial lipopeptides.

Eur. J. Cell Biol. 58, 90-98 (1992).

294 Bessler, W. G.: Lipopeptide als Immunmodulatoren. In: Abstracts, 2. Kongreß der

Deutschen Gesellschaft für Krankenhaushygiene e.V., Erfurt (1993)

295 Bessler, W. G.: Lipopeptide als Immunomodulatoren. Med-Report, Blackwell

Wissenschafts-Verlag Berlin, 24:17 (1993).

296 Bessler, W. G., and Sedelmeier, E.: Biological activity of bacterial cell wall components:

Immunogenicity of an immunostimulating bacterial extract. Arzneim.-Forsch./Drug Res.

43 (I) 502-507 (1993).

297 Kleine, B., Edinger, Kammerer, R., Hoffmann, P., Bessler, W. G., von Kleist, S.: Isolation

and expansion of human tumour infiltrating B-lymphocytes from several colon

carcinomas. In: Abstrakts der 9. Frühjahrstagung der Gesellschaft für Immunologie,

Erlangen (1993).

298 Hoffmann, P., Wiesmüller, K.-H, Jung, G., Bessler, W.G.: Use of lipopeptide antigen

conjugates to enhance immunogenicity of low molecular weight antigens/haptens. In:

Cell & Tissue Culture: Laboratory Procedures. John Wiley & Sons, Ltd. Chichester

(1993).

299 Schlecht, S., Wiesmüller. K.-H., Jung, G., and Bessler, W. G.: Lipopeptide als natürliche

Adjuvantien für Impfstoffe aus Gram-negativen Bakterien. Naturwissenschaften 80, 9-17

(1993).

27

300 Kleine, B., Edinger, M., Kaufmann, H., Bessler, W. G.: Synergistic activation of human B-

lymphocytes by anti-CD40 MAB, IL-4, and synthetic lipopeptides, but not

lipopolysaccharides. In: Abstrakts der 9. Frühjahrstagung der Gesellschaft für

Immunologie, Erlangen (1993).

301 Bessler, W. G., Beck, W., Wiesmüller, K.-H., and Jung, G.: Modulation of the immune

system by bacterial products: Hapten specific humoral immune responses induced by

lipopeptides conjugated to T helper cell epitopes. In: Abstracts of the International

Symposium on Immunotherapy of Infections, Berlin (1993).

302 Hoffmann, P., Jimenez-Diez, M., Schaude, R., Jung, G., Bessler, W. G.: Administration of

lipopeptide antigen conjugates in the form of immunocomplexes: a further improvement

in primary in vitro immunization of human peripheral blood lymphocytes. In: Abstracts

of the International Conference on Human Antibodies and Hybridomas III, San

Antonio (1993).

303 Bessler, W. G.: Lipopeptide als Immunmodulatoren. In: Proceedings der

Fortbildungsveranstaltung "Forschritte der Allologie und Immunologie" Davos,

Blackwell Wissenschafts-Verlag GmbH, Berlin (1993).

304 Bessler, W. G.: Induktion einer Bakterien-spezifischen Immunantwort durch einen

immunstimulierenden bakteriellen Extrakt (IBEc). Urologe B 33, 323-325 (1993).

305 Kreutz, M., Riedel, D., Ackermann, U., Hauschildt, S., Bessler, W. G., Andereesen, R.:

Synthetic lipopetides are potent stimuli of the cytokine repertoire in human monocytes

and monocyte-derived macrophages. Blood 82,10 (1993).

306 Beck W., Benz, I., Bessler, W. G., Jung, G., Kohlhardt, M. : Responsiveness of cardiac Na+

channels to a site-directed antiserum against the cytosolic linker between domains III and

IV and their sensitivity to other modifying agents. J. Membrane Biol. 134, 231-239

(1993).

307 Bessler,W. G.: Establishing a cell culture laboratory. In: Methods and Applications of

Single Cells and Cell Cultures in Physiology and Pharmacology, Biomeßtechnik-

Verlag, March (1993).

308 Metzger, J. W., Sawyer, W.H., Wille, B., Biesert, L., Bessler, W. G. and Jung, G.:

Interaction of immunologically-active lipopeptides with membranes. Biochim. Biophy.

Acta 1149, 29-39 (1993).

309 Hauschildt, S., Bessler, W. G., Uhl, B., Wolf, B.: Role of synthetic bacterial lipopeptides in

leukocyte activation. In: Abstracts of the 3rd International Congress on the Immune

Consequences of Trauma, Shock and Septis Mechanisms and Therapeutic

Approaches, München (1993).

310 Bessler W. G.: Lipopeptide als Immunmodulatoren. In: Abstracts der

Fortbildungsveranstaltung"Forschritte der Allergologie und Immunologie", Davos

(1993).

311 Bessler W. G.: Lipopeptide als Immunomodulatoren. In: Abstrakts des Symposiums

Fortschritte der Allergologie und Immunologie, Davos (1993).

28

312 Bessler, W. G., Beck, W., Uhl, B., Müller, B., Hoffmann, P., Wiesmüller, K.-H., and Jung,

G.: Enhanced hapten specific humoral immune response induced by lipopeptide-hapten-

conjugates attached to T helper cells epitopes. In: Abstracts of the 24th Annual

Meeting of the Gesellschaft für Immunologie, Leipzig (1993).

313 Bessler, W. G. and Jung, G.: Lipopeptide based vaccines. In: Abstracts of the Second

International Conference on Vaccines: New Technologies & Applications,

Alexandria, VA., USA (1994).

314 Hauschildt, S., Scheipers, P.,and Bessler, W. G.: Lipopolysaccharide-induced change of

ADP-ribosylation of a cytosolic protein in bone-marrow-derived macrophages. Biochem.

J. 297, 17-20 (1994).

315 Hauschildt, S., Bessler, W.G., Uhl, B., Wolf, B.: Synthetic lipopeptides derived from

bacterial lipoprotein and their interactions with immune cells. Trauma, Shock and

Sepsis, 3:2-5 (1994).

316 Maltsev, V. A., Karimov, D.P., Ataullakhanov, R.I., and Bessler, W. G.: Patch-clamp

studies of membrane condactance upon B cell activation induced by lipopolysaccharide, a

synthetic lipopeptide analogue of bacterial lipoprotein and a new plant immunostimulant

vitan. Phys. Chem. Biol. & Med. 1(2), 127-135 (1994).

317 Kleine, B., Rapp, W., Wiesmüller, K.-H., Edinger, M., Beck, W., Metzger, J.,

Ataullakhanov, R., Jung, G., and Bessler, W. G.: Lipopeptide-Polyoxyethylene-

Conjugates as Mitogens and Adjuvants. Immunobiol. 190, 53-66 (1994).

318 Erhard, M.H., Kellner, J.,Bessler, W. G., and Lösch, U.: Ein Lipopeptid als Adjuvans zur

Immunisierung von Hühnern. Biochemica Information, Boehringer Mannheim 94

(1994)

319 Loleit, M., Deres, K., Wiesmüller, K.-H., Jung, G., Eckert, M., and Bessler, W. G.:

Biological activity of the E.coli lipoprotein: detection of novel lymphocyte activating

peptide segments of the molecule and their conformational characterization. Biol. Chem.

Hoppe-Seyler 375, 407-412 (1994).

320 Beck, W., Jung, G., Bessler, W. G., Benz, I., Kohlhardt, M.: Conformational mapping of

the cytosolic linker between domains III and IV of the cardiac Na+ channel protein and

binding studies with a site-directed channel modifying antibody. Biochimica et

Biophysica Acta 1206, 263-271 (1994).

321 Bessler, W. G.: Unspezifische Immunstimulation: Lipopeptid-Analoga des bakteriellen

Lipoproteins als Adjuvantien/non-specific immunostimulation: lipopeptide analogues of

bacterial lipoprotein as adjuvants. Hyg. Med. 19: 396-403 (1994).

322 Hauschildt, S., Beuscher, H. U., Jung, G., Bessler, W. G., Ulmer, A.: Intraperitoneal

injection of synthetic bacterial lipopeptides does not cause a rise in circulating

inflammatory cytokines. FEMS Immunol. Med Microbiol. 8, 77-82 (1994).

29

323 Edinger, M., Bessler, W. G., and Kleine, B.: Synergistic stimulation of human B

lymphocytes by anti-CD40 monoclonal antibodies and synthetic lipopeptide analogues

from E.coli lipoprotein. Immunology 81, 205-210 (1994).

324 Bessler, W. G., Müller, B., Uhl, B., Heinevetter, L., Beck, W., and Jung, G.: Bacterial

lipopeptides as leukocyte activators and adjuvants in LPS responder and nonresponder

mice. In: Abstracts der XXV Tagung der Gesellschaft für Immunologie, Konstanz,

(1994).

325 Bessler, W. G., Müller, B., Uhl, B., Kleine, B., Beck, W., and Jung, G.: Bacterial

lipopeptides as leukocyte activators and adjuvants in LPS responder and nonresponder

mice. J. Endotox. Res. 1:60 (1994).

326 Kleine, B., Baumgartner, A., Müller, B., Bessler, W..G., IgG positive, IgM negative

memory cells in human tonsils are strongly CD38/CD71 positive and CD23 negative. In:

Abstracts der 10. Frühjahrstagung der Gesellschaft für Immunologie, Heidelberg

(1994).

327 Hoffmann, P., Skibinski, G., Wiesmüller, K-H., Ihlenfeldt, H.G., Jung,G., Bessler, W.G.,

and James, K.: In vitro activation of human B lymphocytes using three-dimensional tissue

explants of lymphoid organs. In: Abstracts der 10. Frühjahrstagung der Gesellschaft

für Immunologie, Heidelberg (1994).

328 Bessler, W. G.: Synthetic lipopeptide conjugates constitute efficient novel immunogens and

vaccines. In: Abstracts, Cold Spring Harbor Conference "Molecular Approaches to

the Control of Infectious Diseases", New York: 45 (1994).

329 Bessler, W. G., Beck, W., Wiesmüller, K.-H., Jung. G.: Modulation of the immune system

by bacterial products: hapten-specific humoral immune responses induced by lipopeptides

conjugated to T helper cell epitopes. In: Masihi (ed.) Immunotherapy of Infections, pp

329-338, Marcel Dekker, Inc., New York (1994)

330 Mattner, E. Bessler, W. G., Simon, M. M. and Alber, G.: Induction of interleukin-12 (IL-

12) by different microbial species and isolated cell wall compounds. Abstract, 11.

Füh