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Welcome to the 2016 in-FLAME Annual Meeting in Maastricht, Netherlands!
Network Chair: Prof Susan Prescott, University of Western Australia Telethon Kids Institute
As always, the main goal of this meeting will be to create a collaborative space for creative discussions, productive partnerships and long term friendships. Continuing the themes of our previous meetings, our meeting will have a core focus on key early exposures - namely nutrition, the microbiome, early microbial diversity, nature relatedness, pollutants and the built environment - and how these interact to modify early immune development, to impact many aspects of development. Our multisystem focus includes a range of early outcomes including allergy and asthma, obesity and metabolism, mental health and behaviour.
Yet again we are indebted to Prof Diane Campbell (University of Sydney) and Prof Anita Kozyrskyj (University of Alberta) for their help in all of our ongoing network activities. This year has been a wonderful opportunity to work with local organisers A/Prof Carel Thijs, Dr. John Penders and Dr. Monique Mommers from Maastricht University. They have made a contribution to the program, fundraising and the venue and social activities of the meeting. For the first time this year we have a Systems Biology Workshop, lead by local expert Prof Ilja Arts (Maastricht Centre for Systems Biology (MaCSBio). We’re also looking forward to hearing updates on a large number of collaborative project stats were initiated in 2015. In particular, we are keen to hear from our early career researchers who have been rallying together to create their own network. This promises to be another productive and very enjoyable meeting!
A warm welcome from Our Maastricht hosts! Following an inspiring meeting in Marburg, we now have the pleasure of welcoming in-FLAME to our home in Maastricht in 2016! We also welcome the opportunity to provie both a stimulating scientific and social program, with ample informal opportunities to exchange ideas with colleagues, find new collaborations and find new inspirations. Enjoy the pleasant atmosphere of this old provincial town, now home of the youngest Dutch university. Welcome!
About our town! The city of Maastricht is located in the most southern part of the Netherlands on both sides of the river Meuse. Maastricht developed from a Roman settlement, to a religious centre, a garrison city and an industrial city. Nowadays, it is known as a city of history, culture and education. Maastricht University, founded in 1976, celebrates its 40th anniversary this year. After Amsterdam, Maastricht has the highest amount (1677) of national heritage sites in the Netherlands. The city has become internationally known, by way of the Maastricht Treaty, as the birthplace of the European Union, European citizenship and the single European currency.
John Penders, Monique Mommers and Carel Thijs, Maastricht University, WUN in-FLAME local organising committee
Launched in 2012, the in-FLAME Network addresses the risk factors, pathways and strategies to overcome the rising propensity for chronic inflammatory disorders, with a focus on early effects on the developing immune system. Led from UWA by Professor Susan Prescott, it involves 9 WUN universities and WUN+ partners from 47 institutions, and 20 countries around the world. Together our 175 current members are working on an integrated program of population studies, biological studies and intervention studies aimed at preventing inflammation and the burden of subsequent disease.
‘…There has been an unprecedented rise in non-communicable diseases (NCDs) such as allergies, asthma, cancer, diabetes, mental ill health and obesity. Inflammation and immune dysregulation are common features, often associated with similar environmental and lifestyle risk factors such as dietary patterns, environmental pollutants, microbial patterns and stress. Given the central role of the immune system in health and development, inflammation must be examined as both a common element and target for the prevention of NCDs…’
About the in-FLAME Network
Getting there • Schiphol (Amsterdam) and Brussels International Airport (Brussels, Belgium) are the
nearest airports • Maastricht is accessible by train from both airports (~2.5 hours) • An airport shuttle is available between Brussels International Airport (Brussels, Belgium)
airport and Maastricht (~1.5 hours)
Contacts Local : • [email protected] • [email protected] General: • [email protected] • [email protected]
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Venue The Systems Biology and Birth Lactoactive pre-conference workshops as well as the in-FLAME meeting will be held at the School of Business and Economics, a former Jesuit Monastery, located at the Tongersestraat 53 in Maastricht. This venue is on 5-10 min. walking distance from hotels in the city center. For more info on how to get there, see: http://www.maastrichtuniversity.nl/web/Faculteiten/HowToFindUs.htm
Accommodation
The following hotels are our official conference hotels, with block bookings made by WUN. Student volunteers will be available in the lobbies of these hotels at key times to assist delegates with questions and directions. Buses will also make stops at these official hotels. A list of other hotels along with a hotel map will be provided to delegates, who will be free to make their own bookings.
Hotel Name
Rooms available per night
Rate Comments
Crowne Plaza
60 €175 US style hotel, located across the river with riverviews. Approx. 15 minute walk to UM venues via Hige Bruge.
http://www.crowneplazamaastricht.com
Hotel Derlon
45 €175 Elegant boutique hotel overlooking the famous Onze Leive Frauw Plein in Maastricht, with cafes and restaurants in easy walking distance. Approx. 10 minute walk to UM venues.
https://www.derlon.com
Du Casque 20 €120 Charming art-deco style hotel overlooking Vrijthof Square and famous cathedrals in the centre of town. Some tired interiors but renovated rooms. Approx. 5 minute walk to UM venues.
http://www.amrathhotels.nl/ducasque
Hotel Boticelli
<20 €110-€160
Charming, small boutique hotel with only 20 rooms. No elevator (stairs needed to get to rooms). Some tired interiors but charming and quaint. Closest hotel to university venues at less than 5 minute walk.
http://hotelbotticelli.nl/?lang=en
Hotel Les Charmes
? €120 Charming, small boutique hotel. No elevator (stairs needed to get to rooms). Some tired interiors but charming and quaint. Close and convenient hotel to university venues at less than 5 minute walk. http://www.hotellescharmes.nl/eng/index.html
Travel grants! • This year we will provide travel support for up to 8 delegates, with priority
to early career researchers (students and postdocs) who submit abstracts - $1500 (travelling from the Southern Hemisphere) - $1000 (from the Northern Hemisphere, outside the EU) - $500 (travelling from other regions of the EU)
• Selection will be based on the abstracts (completed research or new proposals) that demonstrate or enhance collaboration across the network.
Deadline: December 21st 2015
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Topics: Any topic that is relevant to the goals in-FLAME network (see ‘About us’ page 2) Format: Standard format. 1 page. 300 words. Posters: All selected abstracts will be invited as posters Oral: Some abstracts will be also selected for oral presentation Abstracts will be selected based on relevance and scientific merit. Preference will be given to those that demonstrate collaboration between centres.
Abstracts:
Program at a glance:
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Day 1 Friday April 1
Day 2 Saturday April 2
Day 3 Sunday April 3
SYSTEMS BIOLOGY
WORKSHOP
Keynote 2 Keynote 4
In a nut shell (II) (bus stop abstracts)
Early Environment
workshop
BIRTH LACTOACTIVE WORKSHOP
REPORTS- existing projects
Metabolism workshop
University Tour
New friends and new projects
6pm start: Welcome
Keynote 1
In a nut shell (I)
(bus stop abstracts)
Dinner at Winery
Keynote 3 Break out:
Specific project focused session
Microbiome Workshop
Excursion to the Marl Caves, then
Dinner at Slavante
General Business Review & Finale
WUN Dinner on Vrithof Square
DAY 1 –Workshops Venue: School of Business and Economics (Aula)
Frday 1st April
SYSTEMS BIOLOGY WORKSHOP
8:45 8:50 9:15 9:45 10:15
Greeting and workshop goals Introduction to Systems Biology Computational modeling of human gut microbes Complexity and reductionism in the omics era Pathway analyses & nutrigenomics
John Penders(Nl) Ilja Arts (Nl) Ines Thiele (L) Kristel van Steen (B) Chris Evelo (Nl)
10:45-11:15 TEA (Ad Fundum)
11:15 11:30 11:45 12:00 12:15
Studying the infant microbiome: COPSAC2010 A Systems Biology approach to study the gut microbiome capacity Novel methods to study longitudinal microbiota patterns and infant growth Integration of Volatile Organic Compounds and microbiota data to predict disease activity Discussion
Jakob Stokholm (Dk) Susanne Brix (Dk) Siddhartha Mandal (In) Agnieszka Smolinska (Nl ) All (moderated by Chairs)
12:30-13:30 LUNCH (Mensa)
BIRTH LACTOACTIVE WORKSHOP This workshop will focus on progress and new strategies to
develop collaborative breast milk studies
13.00 Greeting and workshop goals Anita Kozyrskyj (Ca) Daniel Munblit (UK)
13.05 Breast milk metabolites cluster by maternal atopy Anita Kozyrskyj Manjeet Kumari
13.30 Breast milk fatty acids and health outcomes in children
Lenie van Rossem
14.00 Antenatal immune modulation and postnatal gut pathologies; important lessons for feeding strategies
Tim Wolfs
14.30 Afternoon tea
15.00 Breast milk molecules, metabolites and cells: research from Down Under
Donna Geddes
Tuesday 2nd June
In a nut shell – rapid fire oral poster session
Goal: Short and snappy ‘bus stop’ presentations • Your world in 3 minutes! No more than 5 slides
Anita Kozyrskyj Daniel Munblit
15.35 Breast milk cytokines in relation with atopic manifestations of mothers and infants: study in Asian population
Narissara Suratannon
15.40 Relationship between milk microbiota, bacterial load, macronutrients and human cells during lactation
Alba Boix
15.45 Breast milk TGF-B2 is associated with neonatal gut microbiome composition
Alexandra Sitarik
15.50 Mechanisms of early life priming for allergy by house dust mite allergen in breast milk: role of protease and impact of prebiotics
Akila Rekima
15.55 Impact of colostrum, the first physiological food, on early post-natal and adult metabolic and immune homeostasis
Valérie Verhasselt
16.00 The effect of maternal dietary egg intake in early lactation on human milk ovalbumin concentration: a randomized controlled trial
Debra Palmer
16.05 PANEL DISCUSSION (Q AND A for all presentations)
16:30-17:30 City Tour by foot
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DAY 1 –Welcome and Keynote Lecture Venue: Thiessen Wijnkoopers – Grote Gracht 18
Session 1: The journey begins MAIN WORKSHOP
17.30 Drinks and canapés
18.00 Welcome: Carel Thijs Susan Prescott
18.15 Keynote 1: The Gut Microbiota in Health and Disease
Karsten Kristiansen
18.45 Questions and Discussion
Tuesday 2nd June
In a nut shell – rapid fire oral poster session (I)
Goal: Short and snappy ‘bus stop’ presentations • Your world in 3 minutes! No more than 5 slides
Dianne Campbell John Penders (Ne)
19.00 Metabolomics profile of amniotic fluid and early recurrent wheezing
Silvia Carraro
19.04 Preeclampsia is associated with reduced regulatory t-cell proportions in infants during the first year of life
Fiona Collier
19.08 The Influence of Vitamin D and UV Exposure on the Developing Immune Phenotype in Infancy
Kristina Rüter
19.12 Differential loading of IgE on circulating CD19-cKit+CD38+ cells between atopic and non-atopic individuals
Catherine Li Lai
19.16 Non-digestible oligosaccharides reduce the sensitizing capacity of don in a dose-dependent manner
Desiree Veening-Griffioe
19.20 Dietary GOS prevent eosinophilic airway inflammation in HDM-model: role of Treg
Kim Verheijden
19.24 Reduction in allergic features in offspring of mice supplemented with specific non-digestible oligosaccharides during lactation
Astrid Hogenkamp
19.28 Dietary targeting of maternal gut health for better child outcomes: the healthy parents, healthy kids RCT protocol
Samantha Dawson
19.32 Vitamin-D deficiency augments cytokine expression in murine Th2-cells
Ayşe Kılıç
19.36 Maternal prenatal bisphenol A exposure and child social communication at 18 months of age in the Barwon Infant Study
Christos Symeonides
19.39 PANEL DISCUSSION (Q AND A for all presentations)
20.00 DINNER 6
DAY 1 –Welcome and Keynote Lecture Venue: Thiessen Wijnkoopers – Grote Gracht 18
Session 2: Getting inspired – thinking outside the box
08.30 Setting the scene for the workshop Susan Prescott (Au)
08.40 Keynote 2: The Microbe-Mind Connection and Global Dysbiosis. Why the Big Picture Matters
Alan C. Logan (USA)
09.10 Discussion and ideas ALL
09.25 Mini Break
DAY 2 – Main Program
Session 3: Rapid fire oral poster session (II)
Goal: Short and snappy ‘bus stop’ presentations Chairs: • Your world in 3 minutes! No more than 5 slides
Cecile Svanes Susanne Brix
09.30 Whole genome methylation patterns in circulating cd4+ cells of infants participating in a probiotic intervention study
Johanna Huoman
09.34 Three twin studies investigating the role of early life inflammation and epigenetic change on the susceptibility to chronic and neurodevelopmental disorders
Jeff Craig
09.38 Zoonotic exposure to helminths and association with allergic sensitization in a norwegian population
Nils Oskar Jõgi
09.42 influenza-induced memory t-cells confer protection over allergen-mediated acute airway inflammation
Chrysanthi Skevaki
09.46 Maternal depression, birth weight and fecal metabolites at 3 months
Manjeet Kumari
09.50 Early life priming for allergy by house dust mite allergen transfer through breast milk
Valérie Verhasselt
10.58 Placenta histone acetylation in several immune regulatory genes is a potential predictor of allergy development
Hanii Harb
09.02 Preeclampsia associates with Asthma, Allergy and Eczema in Childhood.
Jakob Stokholm
10.06 Developing effective strategies to improve pregnancy and neonatal outcomes in youth with type 2 diabetes
Aveni Haynes
10.06 Longitudinal study of persistent organic pollutants in human milk: changes in lactation stages and effect on infant
Jian Du/ Donna Geddes
10.10 DISCUSSION (Q and A for all abstracts)
10:30-11:00 TEA BREAK (Ad Fundum)
Wednesday 3rd June
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DAY 2 –Main Program Saturday 2nd April
Session 4: Microbiome, inflammation, behaviour and other early outcomes
Chairs: Alan Landay Annika Scheynius
11:00 A combination of dietary prebiotics and the probiotic lgg modulate behavioural and cognitive reponses to early life stress
Siobbain O’Mahoney
11.10 Dietary intervention in pregnancy to modulate maternal and infant gut microbiota
Felice Jacka
11.20 Dietary fibers and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways
Laurence Macia
11.30 Microbial influences: Asthma and novel gene expression profiles and signaling pathways in children
Bianca Schaub
11.40 The microbiome and early immune programming Tina West
11.50 Immune modulation by environmental microbes – new directions for research
Ganesa Wegienka Christine Cole Johnson,
12.00 Immunomodulatory effects of foodborne microbes in atopic Dutch adults: proposal for A proof of concept study
Berber Vlieg-Boerstra
12:10 Discussion: New opportunities
ALL Moderated by Chairs
12:30-13:30 LUNCH (Mensa)
DAY 2 – Main Program Wednesday 3rd June
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DAY 2 –Main Program Venue: School of Business and Economics (Aula)
Saturday 2nd April
DAY 2 – Main Program
9
Saturday 2nd April
Session 6: Microbiome Workshop
Goal: To develop collaborative projects Chairs: Maria Jenmalm, Tina West
15.30
Keynote 3 First results of metagenomics analysis from KOALA
John Penders
16:00 Workshop: How to extend microbiome studies ALL
16.45 Summary Chairs
17.45 TAKE OFF TO SOCIAL EVENT & DINNER BY BUS
Session 5: Food for thought
Chairs: Ralph Nanan, Peter Hsu
13:30 A randomised, controlled trial of a dietary intervention for adults with major depression (the “SMILES” trial)
Felice Jacka
13.40 IgA and local mucosal responses to the gut microbiota in and the risk of infant allergy
Majda Dzidic Maria Jenmalm
13.50 Results from the BEAT study: RCT of infant feeding with allergenic food to prevent sensitisation
Dianne Campbell
14.00 Preliminary data from the STEP study: RCT of infant feeding wih allergenic food to prevent food allergy
Debbie Palmer
14.10 Results from the QuEST study: a RCT of egg in lactation Debbie Palmer
14.20 Food allergy and sensitisation in urban and rural South African children with and without eczema
Mike Levin
Rapid fire bus-stop presentations related to this topic (3min)
14.30 Cord blood monocyte-derived inflammatory cytokines suppress IL-2 and induce non-classic ‘Th2-type’ immunity associated with development of food allergy
Peter Vuillermin
14.34 IgE mediated food sensitisation and allergy in unselected rural and urban South African Toddlers
Maresa Botha
14.38 Domestic pets and risk of IgE-mediated food allergy in infancy: findings from a cohort study.
John Molloy
14.42 Towards the development of a food frequency questionnaire to assess dietary microbial exposure in dutch adults
Anastriyani Yulviatun
14.42 Sensitizing capacity of raw and processed cow’s milk in a murine sensitization model for food allergy
Suzanne Abbring
14.45 Discussion and ideas ALL
15:00-15:30 TEA BREAK (Ad Fundum)
DAY 3 – Main Program Location: School of Business and Economics (Aula)
Sunday 3rd April
Session 8: Metabolism and Immunomodulation WORKSHOP
Chairs Valerie Verhasselt Catherine Thornton
10.45 Linking T cell metabolism to functional responses at birth
Cathy Thornton
11.15 The obesity epidemic: implications of maternal pre-pregnancy body mass on infant growth, adiposity and inflammation
Kate McCloskey
10.45 Association of leptin and adiponectin in human milk with maternal body composition
Donna Geddes
11.15 WORKSHOP - How to further the investigation of metabolism and immunomodulation in inFLAM
ALL
12.15 Summary Discussion and more new ideas Chairs
12:30-13:30 LUNCH (Mensa) 10
Session 7: Early environment WORKSHOP Chair: Daniel Munblit
08.30 Understanding the long term impact of the Early Environment on health outcomes
Cecile Svanes
08.40
Chronic mild inflammation prevents asthma, insight into a new paradoxon
Harald Renz
08.50 Examining diverse aspects of the Early Environment on immune, metabolic and neuro-development: - updates from the Barwon Infant Study - and the ORIGINS Projects
Peter Vuillermin (5min) Susan Prescott (5min)
09:00 Practical approaches approving to improve the Early Environment – what strategies can we test?
Jeff Craig/Alan Logan
09:10 WORKSHOP How to further investigate the built environment (pollutants/greenspace/other)
ALL
10:15 Summary Chair
10:30-10:45 TEA BREAK (Ad Fundum)
Session 9: BREAK-OUT GROUPS
Goal: To plan details of a specific project for 2015-16 for each of the three workshops (prior to breakout brief discussion to identify best groupings for this session) 13.30 SUGGESTED groupings: other groups may form of these may combine
depending on interests and discussions
Previous Breakout Groups have included: • Early Environment • Microbiome • Metabolism • Development • Brain and Behaviour • Allergy and Immunity
Each group must nominate a spokes person to present summary of discussions (Session 10), this person also to prepare a brief written report.
15.00-15:30 TEA BREAK (Ad Fundum)
Session 10: Reporting back
Goal: Each ‘Breakout Group’ to report back on discussions and new proposals
Chair: Anita Kozyrskyj
15.30 Report: BREAKOUT group project Selected representative
15.45 Report: BREAKOUT group project Selected representative
16.00 Report: BREAKOUT group project Selected representative
16.15 Any further discussion ALL
Session 11: General Business and Conclusions
16.45 House keeping Dianne Campbell
16.50 Thinking of 2017 and beyond Susan Prescott and ALL
17.20 Wrap-up and summary Susan Prescott and ALL
19.00 Assembly at Vrijthof Square for WUN-dinner
DAY 3 – Main Program Location: School of Business and Economics (Aula)
Sunday 3rd April
WUN will be inviting pre-conferences and workshops to take place in Rochester or UMass Amherst to showcase those campuses. In-FLAME could consider these or other venues in the NYC area.
WUN goes back to the USA in 2017
The WUN AGM for 2017 planned for either New York City or Boston
