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Welcome July 8 , 2020 Topic AHD screening in the out-patient setting CDC/CHAI/Unitaid Advanced HIV Disease Global ECHO Webinar Series: Advanced HIV Disease in the context of the COVID-19 pandemic in Africa Welcome! November 17, 2020

Welcome July 8 , 2020

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Page 1: Welcome July 8 , 2020

WelcomeJuly 8 , 2020

Topic

AHD screening in the out-patient setting

CDC/CHAI/Unitaid Advanced HIV DiseaseGlobal ECHO Webinar Series:

Advanced HIV Disease in the contextof the COVID-19 pandemic in Africa

Welcome!November 17, 2020

Page 2: Welcome July 8 , 2020

EST CET SAST Topic Presenter

9:30 –9:33

3.30 –3.33

4:30 –4:33

Housekeeping Jutta Lehmer (ECHO Insititute)

9:33 –9:38

3.33 –3.38

4:33 –4:38

Welcome and overview of webinar series Tom Chiller (CDC) and Carolyn Amole (CHAI)

9:38 –9:40

3.38 –3.40

4:38 –4:40

Introduction of today's session and speakers Ike Amamilo (CHAI)

9:40 –9:55

3.40 –3.55

4:40 –4:55

CD4 testing as a critical component of the AHD screening package

Ana Moore (CHAI)

9:55 –10:10

3.55 –4.10

4:55 –5:10

Expanding CD4 Access: progress and challenges Dr Cordelia Katureebe(National AIDS Control Program, MOH, Uganda)

10:10 –10:25

4.10 –4.25

5:10 –5:25

Advanced HIV disease care at Lighthouse clinics in Malawi - How far have we come?

Dr. Tom Heller(Lighthouse Clinic Trust)

10:25 –10:55

4.25 –4.55

5:25 –5:55

Live Q&A Ike Amamilo (CHAI) and Amir Shroufi (CDC)

10:55 –11:00

4.55 –5.00

5:55 –6:00

Closing Remarks Tom Chiller (CDC)

Advanced HIV Disease Global Webinar Series Session 1 Agenda: AHD Screening in the out-patient setting

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Page 3: Welcome July 8 , 2020

Advanced HIV disease care at Lighthouse clinics in Malawi - How far have we come?

Dr. Tom HellerClinical TA, Lighthouse Clinic Trust17. Nov 2020

Page 4: Welcome July 8 , 2020

• Describe the setup of Lighthouse Trust clinics in Malawi and the role AHD care play within the clinics

• Share some thoughts on the M&E of AHD services and the importance of training in this field

• Highlight the extent of AHD services currently delivered in Centers of Excellence and in supported districts

Objectives of the presentation

Page 5: Welcome July 8 , 2020

Currently Lighthouse Trust established Centres of Excellence in all Malawian referral hospitals:

Kamuzu Central Hospital, Lilongwe (LH-KCH) Bwaila Hospital, Lilongwe (LH-MPC) Queen Elisabeth Central Hospital, Blantyre (LH-UFC) Zomba Central Hospital (LH-Tisungane) Mzuzu Central Hospital (LH-Rainbow) – under

development

The Centres of Excellence treat more than 60,000 HIV patients with ARVs and including other supported spoke sites this number exceeds 130,000

Lighthouse Clinic Trust operates 5 large referral level HIV/TB clinics and supports 5 districts in Malawi’s North

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LH –Rainbow

LH –KCH

LH –MPC

LH –UFC

LH –Tisungane

Page 6: Welcome July 8 , 2020

All CoE sites offer integrated service delivery: Comprehensive HIV and TB care Kaposi’s sarcoma diagnosis and

treatment Cervical cancer screening and treatment

(cryotherapy) Nutritional and psychosocial counselling

and support NCD diagnosis and treatment

Differentiated service delivery 6 multi-monthly refills Teen clubs and ART kindergarten Nurse led-Community ART program Advanced HIV disease care

Integrated and differentiated care models at Lighthouse

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Page 7: Welcome July 8 , 2020

After results of the REALITY trial were published the “ALUP algorithm” was implemented Patients initiating ART or failing on ART are screened with CD4 and subsequent CrAg and LAM reflex POC-test if results < 200 cells/ml (initially < 100 cells/ml)

CoE clinics are equipped with point of care labs for side effects management (Crea, LFT), POC-VL for “targeted VL”CD4 point of care machines as

well as CrAg and LAM tests are available

Advanced HIV care at Lighthouse KCHwas established in 2016

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ALUP = Advanced, Late, Unstable Patients

Page 8: Welcome July 8 , 2020

• Extensive inpatients HIV testing services • Provision of all AHD tests in the ward• Treatment advice and consultation for the teams• Ultrasound to diagnose EPTB (FASH scan) is

available in all clinics and used for in and outpatients

• GeneXpert MTB/RIF as well as CXR facilities are available through the central hospitals

LH supports AHD inpatient care in referral hospitals where AHD is frequent

Page 9: Welcome July 8 , 2020

• AHD services need to be monitored – but health care workers in ART programs already suffer from overburden of multiple registers

• “Registeritis = every pet initiative in the clinic needs a special, new register” – DHA estimates that there are an endless line of more than 60 registers for the HIV program alone – “severe registeritis”

Some considerations on M&E of AHD

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• LH is currently developing a reasonably comprehensive AHD monitoring system from existing registers and especially from existing electronic data systems (e.g. EMRS, lab machines)

Page 10: Welcome July 8 , 2020

How is the flow of an AHD patient in a large clinic like

LH?

Where to put a paper register?

Page 11: Welcome July 8 , 2020

M&E is always an effort and not all data can be monitored at all times…

• “sniper M&E”(process oriented)

• “shotgun M&E”(domain oriented)

• reality

Page 12: Welcome July 8 , 2020

Indicators from the EMRS1. AHD cascade for newly initiating in CoEs

(excluding inpatients, excluding failing)2. Outcome of newly initiating patients by

CD4 strata (after one Q)

Monitoring of AHD and HIV-ass. TB

Indicators NOT from the EMRS1. Medical inpatient testing coverage

(including admission denominator) 2. Aggregated data for Inpatient

Support services 3. CoE Lab utilization rate (new and

failing patients)4. TB data incl. diagnostic modality 5. Utilization of GeneXpert

Page 13: Welcome July 8 , 2020

AHD lab data – Comparison of the referral level clinics

• The large Lighthouse clinics did 7705 CD4 (35% <200), 2890 CrAg (10% pos) and 3095 LAM (18% pos) tests from January to Oct 2020

• The proportion of patients with AHD differ significantly - highest in LH and Umodzi based in the larger Lilongwe KCH and Blantyre QECH referral hospital

• LH KCH Lilongwe has substantially more CrAg positives while this is very low in Bwaila-MPC (which is mainly a “walk-in” clinic) and Rainbow MCH in the North

• Also LAM positivity is higher in the LH KCH – but surprisingly also high in Rainbow clinic in the North which geographically has a lower TB prevalence in general

Page 14: Welcome July 8 , 2020

AHD cascade – some thoughts about the denominator

• These cascade can be grounded on the denominator of all NEWLY initiating patients

• But CD4 counts are also done for patients failing on ART or clinically suspicious – the correct denominator of these can not be known – these have to be reported extra !!

Page 15: Welcome July 8 , 2020

• Patients with CD4 count >200 and with a CD4 <200 generally initiated all after a median of 0,0 weeks [IQR 0,0-0,0 weeks].

• Patients CrAg posinitiated a after a median of 2,0 weeks [IQR 1,5-3,1 weeks]; LAM pos patients initiated a after a median of 1,9 weeks [IQR 1,9-2,0 weeks] => delay to lower risk of IRIS and drug side effects

• Over 90% of new ART patients had baseline CD4 tests done. 41% had advanced HIV.• Of those with advanced HIV disease both LAM and CrAg coverage was 98% with a

yield 16% for LAM diagnosed TB and 8% for cyptococcemia.

AHD in newly initiating patients – LH, Q2 2020

Page 16: Welcome July 8 , 2020

Two HIV/TB cohorts in two LH clinics 2020

• LH-KCH: mainly focusing on HIV based on the ground of the referral hospital with “sicker” patients

• LH-MPC: a walk-in clinic close to the main bus station with one of the largest TB cohorts in country

Page 17: Welcome July 8 , 2020

AHD implementation in Northern District Hospitals

• Five district hospitals operate ADH diagnostics

• Although absolute numbers are smaller in district hospital than in the referral hospital the yield is not negligible

• “Remote district” (Likoma) still pending implementation

Mzuzu Central hospital

NB district hospital

Mzimba district hospital

Likoma district hospital

Rhumpi district hospital

Page 18: Welcome July 8 , 2020

AHD implementation in Northern District Hospitals - decentralization in the making!

• AHD data from Q3 (July-Sept 2020)

• It is planned to roll-out AHD services (PIMA/CrAg/LAM) in 13 more rural hospitals and health centers in this quarter

• Initial provider training has been done

Page 19: Welcome July 8 , 2020

• Provision of tests is important – but it is equally important to train clinicians and nurses to adequately act upon the results

• Since LH operates clinics far apart, basic telemedicine needs to play an important role

• WhatsApp clinician group• ECHO sessions

Training considerations for AHD

Lighthouse ECHO AHD series1-CD4 cells -Immunology, clinical implications and testing methods 2-LAM and TB – updates and innovations (Bianca Sossen, Cape Town, RSA) 3-Cryptococcus – diagnostic tests and current treatment of cryptococemia and and CM (Angela Loyse, London, UK)4-Other Opportunistic infections (PCP, Toxo, PML, MAC) (Dr. Claudia, Germany)5- M&E of AHD (Angellina, with help from Christine)6- TB diagnosis with GeneXpert- incl. “Ultra” in TBM and general use (Fiona Creswell, Kampala Uganda)

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Page 20: Welcome July 8 , 2020

• Development of training material for AHD is an ongoing priority for Lighthouse

• Case manual• Chest X-ray manual

Training considerations for AHD

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Page 21: Welcome July 8 , 2020

• Lighthouse has a history of AHD care and in the large clinics algorithms are well established

• Proportion of AHD is high and yield of CrAg and LAM is significant• AHD services can be successfully rolled out in districts and further

decentralized services are planned• M&E is important but should not come with excessive new

documentation• Training in AHD is another important point - which should not be

forgotten over the provision of the relevant tests

Summary

Page 22: Welcome July 8 , 2020

• Lighthouse Clinic Team working relentlessly in care of AHD in all clinics including clinicians, nurses, lab staff and others

• Angellina Nhlema and the rest of the M&E team of Dr. Hannock Tweyaworking hard to collect the data on AHD

• Prof. Sam Phiri, Ex-ecutive director • Christine Kamamia, M&E TA to Lighthouse through I-TECH• Finally our main funders: Ministry of Health Malawi, PEPFAR through CDC

Malawi, Global Fund through Dept. of HIV/AIDS,

Acknowledgements