PERSONAL INFORMATIONName: Sanjeev GuptaResearcher ID: B-2824-2008Date of birth: 16th August, 1973

URL for web site: http://www.nuigalway.ie/faculties_departments/pathology/research.htmlhttp://scholar.google.com/citations?user=ESImKpcAAAAJ&hl=en&oi=ao

EDUCATION2002 PhD

Centre for cellular and molecular biologyJawaharlal Nehru UniversityNew Delhi, India

1996 Master of Science (Biochemistry)Faculty of Science, Hamdard UniversityNew Delhi, India

1994 Bachelor of ScienceDelhi UniversityNew Delhi, India

CURRENT POSITION2010 – Present Lecturer

Discipline of Pathology School of MedicineNational University of Ireland, Galway (NUIG)Ireland

PREVIOUS POSITIONS2007 – 2010 Senior Researcher

School of Natural Sciences & NCBES, NUIG, Ireland

2006 – 2007 Assistant ProfessorDepartment of BiotechnologyIndian Institute of Technology-Madras (IIT-Madras)Chennai, India

2005 – 2006 Post-doctoral fellowAbramson Cancer CenterUniversity of Pennsylvania, Philadelphia, USA

2003 – 2005 Post-doctoral fellowKimmel Cancer CenterThomas Jefferson University, Philadelphia, USA

FELLOWSHIPS AND AWARDS1997 – 99 Junior Research Fellowship (JRF) from Council for Scientific and Industrial

Research, New Delhi, India1999 – 02 Senior Research Fellowship (SRF) from Council for Scientific and Industrial

Research, New Delhi, India2000 Pre-doctoral Student Travel Award from American Society for Cell Biology

(ASCB).

SUPERVISION OF GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS2010 – Present 2 Postdocs/ 1 PhD/ 1 MD

Discipline of Pathology, School of Medicine, NUIG, Ireland2013 – 2016 Member of Graduate Research Committee (GRC)

1PhD/ 1 MD studentDiscipline of Surgery, School of Medicine, NUIG, Ireland

2007 – 2010 Assisted with supervision of 2 Postdocs/ 4 PhD/ 3 Master StudentsDiscipline of Biochemistry, School of Natural Sciences, NUIG, Ireland

TEACHING ACTIVITIES2010 – Present Lectures & practicals for Health & Disease I in semester 2.2

School of Medicine, NUIG, Ireland2010 – Present Lectures & practicals for Health & Disease II in semester 3.1

School of Medicine, NUIG, Ireland2012 – Present Lectures & practicals for MSc (Cancer Research)

http://www.nuigalway.ie/courses/research-postgraduate-programmes/cancer-research.htmlSchool of Natural Sciences, NUIG, Ireland

2010 – Present 4th year projects for BSc (Biomedical Science)Summer Research Projects for Medical studentsNUIG, Ireland

COMMISSIONS OF TRUST 2013– 2016 Editorial Board, American Journal of Cancer Biology2012 Grant Reviewer, Medical Research Council, UK2013 Grant Reviewer, The National Science Centre

(Narodowe Centrum Nauki), Poland.2014 Grant Reviewer, The French National Research Agency ANR 2008 –Present Refereed for: Journal of Cellular and Molecular Medicine, Apoptosis,

Journal of Biological Chemistry, Oncogene, Cancer Research, Biochemical Biophysical Research Communications, Biochemical Journal, Cell Death and Differentiation, FEBS Letters, Antioxidants and redox signaling, International Journal of Molecular Sciences, PLoS One, Toxicology and Applied Pharmacology, Cancer Chemotherapy and Pharmacology

RESEARCH INTERESTS

Unfolded protein response in cancer: regulation by microRNAsThe stressful conditions in the tumour microenvironment including low oxygen supply, nutrient deprivation and pH changes activate a range of cellular stress-response pathways. Tumour hypoxia is a common microenvironmental factor that adversely influences tumour phenotype and treatment response. Cellular adaptation to hypoxia occurs through multiple mechanisms, including activation of the unfolded protein response (UPR). UPR attempts to restore ER homeostasis by increasing ER bio-genesis, decreasing the influx of new proteins into the ER, promoting the transport of damaged proteins from the ER to the cytosol for degradation, and upregulating protein folding chaperones. Although the unfolded protein response is primarily a pro-survival response, in the event of prolonged or severe ER stress that is not resolved, the unfolded protein response switches to initiation of apoptosis. The molecular mechanisms involved in the

transition of the UPR from a protective to an apoptotic phase are unclear. microRNAs (miRNAs) have been shown to be critically involved in control of cell survival and cell death decisions. The main function of miRNAs is to direct posttranscriptional regulation of gene expression, typically by binding to 3’ UTR of cognate mRNAs and inhibiting their translation and/or stability. Global downregulation of miRNAs is a common feature of human tumours. Loss of miRNA biogenesis has been shown to enhance cancer progression. Further several components of miRNA biogenesis machinery (XPO5, DICER and TRBP) have been shown to act as haploinsufficient tumour suppressors. How the dysregulation of miRNA biogenesis promotes tumour development is not clearly understood.

The main focus of research in my group is to evaluate the role of microRNAs in determining cell fate during

conditions of ER stress. We use a combination of molecular cell biology, transcriptomics, proteomics and miRNA expression profiling to address specific questions such as:

(i) What is the role of miRNAs in ER stress-induced apoptosis?

(ii) Does impaired miRNA biogenesis contribute to cancer progression by inhibiting ER stress-induced apoptosis?

Role of IRE1-XBP1 axis in endocrine resistance in ER-positive breast cancerInvasive breast cancer (IBC) is a heterogeneous disease with varied molecular features, behaviour, and response to therapy. Over the past decade, transcriptome-wide studies of patients with IBC have lead to the identification of clinically relevant subtypes: luminal A, luminal B, HER2-overexpressing, basal-like and normal breast tissue-like. The Cancer Genome Atlas (TCGA) consortium recently reported that most dominant feature of Luminal/ER-positive breast cancers is increased mRNA and protein levels of ESR1, GATA3, FOXA1, XBP1 and MYB. Recent studies indicate a crucial role for the IRE1/XBP1 pathway in several aspects of ER-positive breast cancer (Figure 1). XBP1 is transcriptionally induced during estrogen stimulation and XBP1s protein expression is upregulated following estradiol (E2) treatment of ER-positive human breast cancer cell lines. XBP1 physically interacts with ER and potentiate ER-dependent transcriptional activity in a ligand-independent manner. Ectopic expression of XBP1s in ER-positive breast cancer cells can lead to estrogen-independent growth and reduced sensitivity to anti-estrogens. Expression of XBP1s is significantly associated with clinical outcome of endocrine-treated breast cancer. We are taking a multidisciplinary approach to elucidate the role of the IRE1-XBP1 in regulation of estrogen signalling underpinning anti-estrogen resistance in breast cancer. The central questions are:

(i) How estrogen signalling intersects with the UPRosome to regulate its activation?

(ii) What is the transcriptional network of XBP1s in the context of estrogen signalling?

(iii) What is the therapeutic and prognostic value of IRE1-XBP1 axis in ER-positive breast cancer?

LAB MEMBERS(i) Post doctoral fellows

Ananya GuptaDanielle ReadCarol Gately

(ii) Postgraduate studentsSiobhan KennyMosaraf Hossain

(iii) Undergraduate research project studentsDarren Kilmartin (PathSoc summer research fellowship)Alice Deane (BSc Physiology 4th year project)

John O’Dea (BSc Physiology 4th year project)Kieran McMullan (HRB summer research fellowship)Eamonn McCrave (College of Medicine summer research fellowship)Rachel Nolan (BSc Pharmacology 4th year project)

PUBLICATIONS 34 publications in peer reviewed journals, > 1788 citations, an H-index of 19, with an average citation score of 51 per item. http://scholar.google.com/citations?user=ESImKpcAAAAJ&hl=en&oi=ao .

1. Read DE, Gupta A, Ladilov Y, Samali A, Gupta S. (2014) miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts. Cell Biosci. 2014 Sep 19;4(1):56. doi: 10.1186/2045-3701-4-56. eCollection 2014.

2. Deegan S, Saveljeva S, Gupta S, MacDonald DC, Samali A.(2014) ER stress responses in the absence of apoptosome: a comparative study in CASP9 proficient vs deficient mouse embryonic fibroblasts. Biochem Biophys Res Commun. 2014 Aug 29;451(3):367-73. doi: 10.1016/j.bbrc.2014.07.111. Epub 2014 Jul 30.

3. Emer Caffrey, Helen Ingoldsby, Deirdre Wall, Mark Webber, Kate Dinneen, Laura Murillo, Celine Inderhaug, John Newell, Sanjeev Gupta, Grace Callagy. (2013) Prognostic significance of deregulated Dicer expression in breast cancer. PLoS One. 2013 Dec 30;8(12):e83724. doi: 10.1371/journal.pone.0083724.

4. Karen Cawley, Susan E Logue, Adrienne M. Gorman, John Patterson, Sanjeev Gupta, Afshin Samali. (2013). Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion. PLoS ONE 2013 Aug 19;8(8):e73870. doi: 10.1371/journal.pone.0073870.

5. Verfaillie T, van Vliet A, Garg AD, Dewaele M, Rubio N, Gupta S, de Witte P, Samali A, Agostinis P. (2013) Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim. Biochem Biophys Res Commun. 2013 Aug 30;438(3):500-6. doi: 10.1016/j.bbrc.2013.07.107. Epub 2013 Aug 2.

6. Donnelly N, Gorman AM, Gupta S, Samali A. (2013). The eIF2α kinases: their structures and functions. Cell Mol Life Sci. 2013 Oct;70(19):3493-511. doi: 10.1007/s00018-012-1252-6. Epub 2013 Jan 26. Review.

7. Sanjeev Gupta, Zoltan Giricz, Alessandro Natoni, Neysan Donnelly, Shane Deegan, Eva Szegezdi and Afshin Samali. (2012). NOXA contributes to the sensitivity of PERK-deficient cells to ER stress. FEBS Lett. 2012 Nov 16;586(22):4023-30. doi: 10.1016/j.febslet.2012.10.002. Epub 2012 Oct 12

8. Nürnberger S, Miller I, Duvigneau JC, Kavanagh ET, Gupta S, Hartl RT, Hori O, Gesslbauer B, Samali A, Kungl A, Redl H, Kozlov AV. Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats. Am J Physiol Gastrointest Liver Physiol. 2012 Dec 15;303(12):G1373-83. doi: 10.1152/ajpgi.00056.2012. Epub 2012 Oct 11.

9. Sanjeev Gupta, Danielle E. Read, Ayswaria Deepti, Karen Cawley, Ananya Gupta, Deepu Oommen, Tom Verfaillie, Soledad Matus, Mary Anne Smith, Justin L. Mott, Patrizia Agostinis, Claudio Hetz and Afshin Samali. (2012) Perk-dependent Repression of miR-106b-25 Cluster is Required for ER stress-induced Apoptosis. Cell Death and Disease. 2012 Jun 28;3:e333. doi: 10.1038/cddis.2012.74.

10. Tom Verfaillie, Noemí Rubio, Abhishek D. Garg, Geert Bultynck, Rosario Rizzuto, Jean-Paul Decuypere , Jacques Piette, Sanjeev Gupta, Afshin Samali and Patrizia Agostinis. (2012) PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS based ER stress. Cell Death and Differentiation. 2012 Jun 15. doi: 10.1038/cdd.2012.74.

11. Ananya Gupta, Emer Caffrey, Grace Callagy, Sanjeev Gupta. (2012) Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat. Biochemical Society transactions. Aug;40(4):752-8.

12. Danielle E. Read, Karen Cawley, Ananya Gupta, and Sanjeev Gupta. (2012) Regulation of ER Stress Responses by microRNAs. (Book Chapter) Endoplasmic Reticulum Stress in Health and Disease, DOI 10.1007/978-94-007-4351-9_6, © Springer Science.

13. Chris Linehan, Sanjeev Gupta, Afshin Samali and Lynn O’Connor. (2012) Bisphenol A-mediated suppression of LPL gene expression inhibits triglyceride accumulation during adipogenic differentiation of human Adult Stem Cells. PLoS One. 2012;7(5):e36109. Epub 2012 May 25.

14. Karen Cawley, Tara Sugrue, Afshin Samali, Sanjeev Gupta, Adrienne M. Gorman. (2012) MicroRNA Regulation of Apoptosis in Breast Cancer. Cancer Reports 2012:2(1) 1–8.

15. Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A.(2011) Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders. J Cell Mol Med. 2011 Oct;15(10):2025-39. doi: 10.1111/j.1582-4934.2011.01374.x.

16. Karen Cawley, Shane Deegan, Afshin Samali, Sanjeev Gupta (2011) Assays for detecting the unfolded protein response. Methods in Enzymology: Unfolded Protein Response and Cellular Stress, Vol 490, Pt B Volume: 490 Pages: 31-51.

17. Sanjeev Gupta, Gerlach, J; Miura, Y; Yamazaki, T; Nakahara, T; Asada, H; Samali, A; Joshi, L. High Throughput Glycanmap (R) Analysis of Glycosylation during ER Stress and Apoptosis in a Colon Cancer Model. (2010) Glycobiology Volume: 20 Issue: 11 Pages: 1471-1471.

18. Sanjeev Gupta. Pathologic impact of ER stress: regulation by Hsp72. (2010) e: Inflammation Research. Volume: 59 Supplement: 1 Pages: S159-S160.

19. Gupta S, Deepti A, Deegan S, Lisbona F, Hetz C, Samali A. HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction. PLoS Biol. 2010 Jul 6;8(7):e1000410.

20. Samali A, FitzGerald U, Deegan S, Gupta S (2010) Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response. Int J Cell Biol 2010:830307. Epub 2010 Jan 19.

21. Gupta S, Cuffe L, Szegezdi E, Logue SE, Neary C, Healy S, Samali A (2010) Mechanisms of ER stress-mediated mitochondrial membrane permeabilization. Int J Cell Biol 2010:170215. Epub 2010 Feb 7.

22. Healy SJ, Gorman AM, Mousavi-Shafaei P, Gupta S, Samali A (2009). Targeting the endoplasmic reticulum-stress response as an anticancer strategy. Eur J Pharmacol. Dec 25;625(1-3):234-46.

23. Szegezdi E, Macdonald DC, Ní Chonghaile T, Gupta S, Samali A (2009) Bcl-2 family on guard at the ER. Am J Physiol Cell Physiol. May;296(5):C941-53.

24. Gupta S, Kass GE, Szegezdi E, Joseph B (2009) The mitochondrial death pathway: A promising therapeutic target in Diseases. J Cell Mol Med.13: 6: 1004-1033.

25. Hu S, Du M-Q, Park S-M, Alcivar A, Qu L, Gupta S, Tang J, Baens M, Ye H, Lee TH, Marynen P, Riley JL, Yang X (2006) cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas. J Clin. Invest. 116(1)174-181.

26. Sadasivam S, Gupta S, Radha V, Batta K, Kundu TK, Swarup G (2005) Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis. Oncogene 24: 627-636.

27. Jain N*, Gupta S*, Sudhakar Ch, Radha V, Swarup G (2005) Role of p73 in regulating human caspase-1 gene transcription induced by interferon- and cisplatin. J Biol Chem. Nov 4;280(44):36664-73. *Equal contribution.

28. Cilenti L, Soundarapandian MM, Kyriazis GA, Stratico V, Singh S, Gupta S, Bonventre JV, Alnemri ES, Zervos AS (2004) Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death. J Biol Chem. 2004 Nov 26;279(48):50295-301.

29. Gupta S, Singh R, Datta P, Zhang Z, Orr C, Lu Z, DuBois G, Zervos AS, Meisler MH, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES (2004) The carboxy terminal tail of Presenilin regulates Omi/HtrA2 protease activity. J. Biol. Chem. 279(44):45844-54.

30. Srinivasula SM, Gupta S, Datta P, Zhang Z, Hegde R, Cheong N, Fernandes-Alnemri T, Alnemri ES (2003) Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2. J Biol Chem. 78:31469-31472.

31. Jones JM, Datta P, Srinivasula SM, Weizhen J, Gupta S, Zhang Z, Saunders TL, Margaret L. Van Keuren, Fernandes-Alnemri T, Alnemri ES (2003) Loss of Omi/HtrA2 protease activity causes neuromuscular disorder in mnd2 mutant mice. Nature. 425: 721-7.

32. Gupta S, Radha V, Sudhakar Ch, Swarup G (2002) A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis. FEBS Letters. 532, 61-66.

33. Ganapati U, Gupta S, Radha V, Manogaran PS, Swarup G (2001) A Nuclear protein tyrosine phosphatase induces shortening of G1 phase and increase in c-myc protein level. Exp.Cell Res. 265,1-10.

34. Gupta S, Radha V, Furukawa Y, Swarup G (2001) Direct transcriptional activation of human caspase-1 by tumor suppressor p53. J. Biol. Chem. 276, 10585-10588.

PATENT APPLICATION1. Gupta S, Samali A (2009) Protein Targets in Disease (2009/0047).2. Gupta S, Deepti A, Samali A (2011) Manipulation of Hsp70 and IRE-alpha interaction (PCT/IB2011/052499).

INVITED PRESENTATIONSDr Gupta has delivered oral presentations to major international audiences (Children’s Hospital of Philadelphia, USA; National Institute of Immunology, New Delhi, India; Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India; National Centre for Biological Sciences, Bangalore, India), as well as invited seminars at established conferences.

Unfolded Protein Response: Jekyll and Hyde in cancer progression. Annual IAS Meeting 2011 - Protein folding and misfolding: mechanisms and consequences, 1-2 December 2011, Glenroyal Hotel/National University of Ireland, Ireland.

Perk-dependent Repression of miR-106b-25 Cluster is required for ER stress-induced Apoptosis. FASEB-Science Research Conference June 12-17, 2011. From Unfolded Proteins in the ER to Disease, Saxtons River, Vermont, USA

Pathologic Impact of ER Stress: regulation by Hsp72. 8th World Congress on Trauma, Shock, Inflammation and Sepsis, March 9th-13th, 2010, Munich/Germany.

POSTERS/ABSTRACTS PUBLISHED IN CONFERENCES1. Characterisation of miR-4726 and miR-4728 in breast cancer. H Ingoldsby, E Caffrey, M

Webber, D Wall, A Gupta, J Newell, S Gupta, G Callagy. 18-21 June. Edinburgh Pathology 2013, Joint Meeting with the BDIAP. Edinburgh, UK.

2. Prognostic Significance of Deregulated Dicer Expression in Breast Cancer. E Caffrey, D Wall, M Webber, K Dinneen, H Ingoldsby, L Murillo, CR Inderhaug, J Newell, S Gupta, G Callagy. 18-21 June. Edinburgh Pathology 2013, Joint Meeting with the BDIAP. Edinburgh, UK.

3. Prognostic Significance of Deregulated Dicer Expression in Breast Cancer. E Caffrey, D Wall, M Webber, K Dinneen, H Ingoldsby, L Murillo, CR Inderhaug, J Newell, S Gupta, G Callagy. 28 Feb - 1 March, Annual Meeting 2013. Irish Association for Cancer Research. Dublin, Ireland.

4. Regulation of NCOA3/AIB1 expression by UPR in Breast Cancer: Implications for Endocrine Therapy. Ananya Gupta, Mark Webber, Grace Callagy, Sanjeev Gupta. 28 Feb - 1 March, Annual Meeting 2013. Irish Association for Cancer Research. Dublin, Ireland.

5. Disruption of miRNA biogenesis confers resistance to ER stress-induced cell death. Karen Cawley, Afshin Samali and Sanjeev Gupta. 7-12 February, 2012. Keystone symposia: Gene silencing by small RNAs. Fairmont Hotel Vancouver, Vancouver, British Columbia, Canada.

6. Perk-dependent Repression of miR-106b-25 Cluster is Required for ER stress-induced Apoptosis. Danielle E. Read, Patrizia Agostinis, Claudio Hetz, Afshin Samali, and Sanjeev Gupta. 7-12 February, 2012. Keystone symposia: Gene silencing by small RNAs. Fairmont Hotel Vancouver, Vancouver, British Columbia, Canada.

7. Perk-dependent Repression of miR-106b-25 Cluster is Required for ER stress-induced Apoptosis. Danielle E. Read, Karen Cawley, Ananya Gupta, Patrizia Agostinis, Claudio Hetz, Afshin Samali, and Sanjeev Gupta. 1-2 December 2011. Annual IAS Meeting 2011. Protein folding and misfolding: mechanisms and consequences, Glenroyal Hotel/National University of Ireland, Ireland.

8. Disruption of miRNA biogenesis confers resistance to ER stress-induced cell death. Karen Cawley, Afshin Samali and Sanjeev Gupta. 1-2 December 2011. Annual IAS Meeting 2011- Protein folding and misfolding: mechanisms and consequences, Glenroyal Hotel/National University of Ireland, Ireland.

9. Mechanism of Sestrin2 Induction During ER Stress-Mediated Autophagy. Svetlana Saveljeva, Shane Deegan, Sanjeev Gupta, Afshin Samali. September 14-17, 2011. 19th Euroconference on Apoptosis “Metabolism, Epigenetics and Cell Death” Stockholm, Sweden.

10. Loss of PERK sensitises to ER stress-induced apoptosis through upregulation of NOXA. Neysan Donnelly, Zoltan Giricz, Shane Deegan, Alessandro Natoni, Sanjeev Gupta and Afshin Samali. September 14-17, 2011. 19th Euroconference on Apoptosis “Metabolism, Epigenetics and Cell Death” Stockholm, Sweden.

11. Hsp72 differentially regulates pro- and anti-apoptotic signalling of IRE1 during ER stress. Lisa Vincenz, Sanjeev Gupta, Ayswaria Deepti, Shane Deegan and Afshin Samali. 21-25 August, 2011. Fifth Cell Stress Society International Congress, Québec, Canada.

12. Hsp27 attenuates ER-stress induced apoptosis. Donna Kennedy, Deepu Oommen, Richard Jaeger, Sanjeev Gupta, Afshin Samali. 21-25 August, 2011. Fifth Cell Stress Society International Congress, Québec, Canada.

13. Regulation of IRE1 signalling by Heat shock protein Hsp70. Lisa Mullee, Lisa Vincenz, Sanjeev Gupta, and Afshin Samali. June 12-17, 2011. From Unfolded Proteins in the ER to Disease, Saxtons River, Vermont, USA.

14. Perk-dependent Repression of miR-106b-25 Cluster is required for ER stress-induced Apoptosis. Sanjeev Gupta, Danielle E. Read, Ayswaria Deepti, Karen Cawley, Ananya Gupta, Patrizia Agostinis, Claudio Hetz and Afshin Samali , June 12-17, 2011. From Unfolded Proteins in the ER to Disease, Saxtons River, Vermont, USA.

15. High Throughput Glycanmap (R) Analysis of Glycosylation during ER Stress and Apoptosis in a Colon Cancer Model. Sanjeev Gupta, Gerlach, J; Miura, Y; Yamazaki, T; Nakahara, T; Asada, H; Samali, A; Joshi, L. 7-10 November, 2010. Annual Conference of the Society for Glycobiology, Florida USA.

16. Upregulation of p53 and NOXA sensitize PERK-deficient cells to ER stress induced apoptosis. Sanjeev Gupta, Zoltan Giricz, Alessandro Natoni and Afshin Samali. March 3-6, 2010.Annual Meeting of the Irish Association for Cancer Research, Galway, Ireland

17. Hsp70 overexpression inhibits ER stress-induced apoptosis by enhancing IRE1-XBP1 signaling. Ayswaria Deepti, Sanjeev Gupta and Afshin Samali. ASCB 49th Annual Meeting. December 5-9, 2009, San Diego, CA.

18. PERK deficiency protects against ROS-mediated cell death by impairing the production of pro-apoptotic UPR target genes. Verfaillie T, Dewaele M, Buytaert E, Martinet W, Sanjeev Gupta, Samali A and Agostinis P. 17th ECDO Euroconference, September 23-26, 2009, Institut Pasteur, Paris, France

19. Role of the PERK-eIF2-ATF4 pathway in ER Stress-induced Apoptosis. Zoltan Giricz, David MacDonald, Eva Szegezdi, Sanjeev Gupta and Afshin Samali. Apoptosis 2008, From mechanisms to applications, January 23 - 26, 2008, Luxemburg.

20. Hsp27 inhibits ER stress-induced apoptosis and suppresses caspase activation inPC12 cells. Deepu Oommen, Sanjeev Gupta, Eva Szegezdi and Afshin Samali. Apoptosis 2008, From mechanisms to applications, January 23 - 26, 2008, Luxemburg.

21. The carboxy terminal tail of presenilin regulates Omi/HtrA2 protease activity. Sanjeev Gupta , singh R, Datta P, Zhang Z, srinivasula SM, Fernandes-Alnemri T, Alnemri ES. 5th symposium of the International cell death Society, June 25-28, 2004 Maynooth, Ireland.

22. A nuclear protein tyrosine phosphatase acts upstream of p53 to regulate the induction of caspase-1 and initiate apoptosis. Sanjeev Gupta, Vegesna Radha and Ghanshyam Swarup. NCBS Symposium on Cancer and Cell Death, January 10-13, 2002 Bangalore.

23. Transcriptional regulation of caspase-1 and caspase-3 gene expression by p53 homologue p73. Sanjeev Gupta, T. Subhash, Ch.Sudhakar, Vegesna Radha and Ghanshyam Swarup 70th Society of Biological Chemists (INDIA), Dec 27-29, 2001 Osmania University, Hyderabad.

24. Transcriptional activation of human caspase-1 by tumor suppressor p53. Sanjeev Gupta, Vegesna Radha, Yusuke Furukawa and Ghanshyam Swarup 40th Annual meeting of American Society for Cell Biology, Dec 9-13, 2000. San Francisco, USA.

25. Transcriptional regulation of human caspase-1 by tumor suppressor p53 provides a link between p53 and inflammation. Sanjeev Gupta, Vegesna Radha, Yusuke Furukawa and Ghanshyam Swarup XXIV All India Cell Biology Conference, November 24-26, 2000 held at JNU, New Delhi.