Advanced Genetics Minilecture 2: Gene Expression and Regulation

I. A brief review of gene expression

http://www.nature.com/scitable

II. Gene Regulationa. Chromatin Structure and Gene Expression

i. Chromatin Structure

ii. Epigenetic Modifications1. Cytosine Methylation

https://www.caymanchem.com/article/2153

2. Histone modificationsa. Acetylation

https://en.wikipedia.org/wiki/Histone_acetylation_and_deacetylation

b. Methylation

https://www.shmoop.com/dna/dna-packaging.html

https://www.slideshare.net/somannaan/gene-silencing-by-histone-modification

https://www.youtube.com/watch?v=hgYMgNrr7mQ

b. During Transcriptioni. Prokaryotes: The Lac operon

ii. Eukaryotes: Combinatorial Control

c. During Splicing

d. Regulation of Translation

e. Spatial Translation

f. Post-translational modifications to proteins