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Weather and meningitis in Ghana. Benjamin Lamptey,PhD (Meteorologist) Regional Maritime University, Accra Ghana [email protected]. An update on the google-funded UCAR Meningitis Weather Project. - PowerPoint PPT Presentation
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Weather and meningitis in Ghana
Benjamin Lamptey,PhD (Meteorologist)Regional Maritime University, Accra Ghana
An update on the google-funded UCAR Meningitis Weather Project
Abudulai Adams-Forgor, Patricia Akweongo, Anaïs Columbini, Vanja Dukic, Mary Hayden, Abraham Hodgson, Thomas Hopson, Benjamin Lamptey, Jeff Lazo, Roberto Mera, Raj Pandya, Jennie Rice, Fred Semazzi, Madeleine Thomson, Sylwia Trazka, Tom Warner, Tom Yoksas
NC STATE UNIVERSITY2
Slide from Mary
Hayden
Outline: Short-term weather forecasts to help allocate scarce meningitis vaccine
• Project goals:1. Minimize meningitis incidence by providing 1-14 day weather
forecasts to target dissemination of scarce vaccine2. Contribute to better understanding of disease transmission with a
focus on intervenable factors
• Activities: 1. Predict district level onset of high humidity, a factor that may
contribute to the end of an epidemic2. Verify and quantify the historical relationship between weather and
meningitis3. Build an information system to support vaccination decisions in real
time 4. Examine human-environmental factors that influence meningitis 5. Evaluate the economic benefit of improved weather prediction
Humidity and meningitis
• In April 2009, the Kano epidemic stopped after relative humidity crossed above a 40% threshold
• Attack rates fell in D’jamena and Gaya when average relative humidity for the week rose above 40%.
Slide from Roberto Mera
Modeling meningitis-weather dependence
• Uses a differential equation-based model of MRSA• Adds physical insight into meningitis transmission• Numerous assumptions:
– Number of cases small compared to overall population– District population is constant– Carriage is proportional to population– Proximity to neighboring districts with cases influences the chances of
having a case– Same mechanisms determine transmission and infection across belt– The disease cycle is less than two weeks– Weather in the centroid of the district is representative of district-wide
weather
Slide from Vanja Dukic and Tom Hopson
Data from Clement Lingani (via Stéphane Hugonnet)
Vapor pressure (current, lagged by 1 and 2 weeks) correlated with probability of case occurrence. Other variables such as temp, wind or wind from the NE not significantly
correlated with probability of cases (stochastic data set)
Forecasting the end of an epidemic
1. Use relationship between (current and lagged) VP and probability of epidemic :• To determine which districts show historic variance in
epidemic end time as predicted by vapor pressure• For those districts, to predict a vapor pressure at which the
epidemic typically declines
2. Predict vapor pressure using quantile regression and global models
3. Use those forecasts of vapor pressure to predict the probable end of epidemic
Using ‘Quantile Regression’ to better predict vapor pressure from global ensembles
Without Quantile Regression:Observations outside range of ensembles
With Quantile Regression: Ensembles bracket observations
From Tom Hopson
Map of Ghana
Ghana (I)• UCAR currently has a statistical model that makes use of
THORPEX Interactive Grand Global Ensemble (TIGGE) data to predict meningitis cases within the season (summary from earlier slides)
• UCAR team currently using the Kasena-Nankana district in Navrongo a city in the Upper East Region of Ghana for pilot studies.
• Previous work on weather and meningitis had been done by some researchers at the Navrongo Health Research Institute (NHRI). So at least 10 years of district level data available.
Ghana (II)• Customize WRF: The Weather Research and Forecast (WRF)
model is to be installed and run within Ghana to generate higher resolution data than the coarser TIGGE data. The model must first be customized for the region.
• Hindcast: Use WRF to simulate a retrospective season (e.g. 2010 or 2011) for the meningitis belt and use that high resolution data and meningitis data to look at the relationship between meningitis and weather variables
• Semi-operational WRF: The WRF output will enable forecasts of weather and meningitis outbreak likelihoods (as WRF output will be used as input to the statistical model) to be generated for use by WHO and other interested institutions
Climate Change related work
• What is the probability of a meningitis outbreak in the future compared to current conditions. Does the probability increase or decrease and by how much?
• Given the mortality rate of the disease, what is the change in the number of deaths as the climate across the meningitis belt changes?
Way forward• Have infrastructure to access satellite dust products, dust model output• Explore relation between dust and meningitis using available model
data as well as observation. Start with testing various hypothesis• Eventually have a dust model
– run as stand alone– Coupled to WRF to explore what value can be added with regards to dust
prediction?• Couple an air quality model to WRF (e.g. coupled WRF-CMAQ system)• Investigate the contribution of dust to meningitis outbreak through
modeling• Analyze CCSM data and MERRA reanalysis data for climate change work
Thank you for your attention