WEARABLE SENSORS: MJFF'S WEARABLE SENSOR PLATFORM TO QUANTIFY PD IN CLINICAL TRIALS AND ACROSS PATIENT POPULATIONS

Ken Kubota Director of Data Science at the Michael J Fox Foundation

Shahar ShpigelmanIntel Big Data Analytics

2

Our MissionTo accelerate the development of improved therapies, and ultimately a cure, for people living with Parkinson’s disease today.

» $500 million in research funded to date

» $70 million in research grants funded in 2014

» 1,500 projects funded to date

» 500 active grants in current portfolio

» 30% of funded project are outside of the U.S.

» Fund academics, biotechs and pharma

MJFF IS THE WORLD’S LARGEST NONPROFIT FUNDER OF PD RESEARCH

3

THE PAUCITY OF “REAL” CLINICAL MEASURES, COST OF TRIALS AND THE ABILITY TO SCALE.

Need for more sensitive diverse measures

Continuous measures in the real world

Detect natural progression <1yr

AVERAGE TRIAL SIZE

< 100PATIENTS

VERY SMALLnumber of patients contribute to research

COST OF TRIALS are in the scales of

$M

4

HISTORY

Big data Big data analyticsanalytics

IOTIOT

5

IMPORTANT NEXUS IN TECHNOLOGY

“Biosensing wearable products being developed today could not have existed just 4 years ago”

•Bluetooth Low Energy radio, iPhone 4s was the 1st to implement•Wireless Qi charging coil standard•MEMS accelerometers price drops 5x

PROGRAM TO IMPLEMENT WEARABLE SENSOR TECHNOLOGIES FOR PD

Aims:

•Speed trials while reducing cost

•Identify new phenotypes of Parkinson’s disease

•Improve the quality of care of Parkinson’s disease patients

MANAGE THE DISEASE USING DATA

Data for Analysis

RESEARCHER

BIG DATA CLOUDAnalytics

INSIGHT / VALUE

7

THE SYSTEM

Patient and

CLINICIAN

Clinically Meaningful Data

8

OUR DATA INFRASTRUCTURE

•Patient stratification (unsupervised analysis)•Disease progression models (machine learning)•Report sharing

Historical trials

Time series data model

Historical trials

Curation

ETL tool

Patient de-identification

Initial phase of portal

KEY LEARNING

9

10

Iterative Design and Discovery

17

CLINICAL TRIALS

CLINICAL TRIALS

Create and Validate Algorithm & Measures

L-DOPA RESPONSE TRIAL

DATA GATHERING TRIAL

SCRIPPS TREMOR TRIAL

Population Trials

18

POPULATION STUDY

Generate insightsUsing Big data

analytics

REAL PD

FOX INSIGHT WEAR

19

THE ROAD AHEAD

»This Summer:

– Integration of mPower as our pilot

iPhone offering

»This Winter:

– Integration of features across both

Android and IOS as our cross platform

offering

» Let’s free the data• Write broad consent forms that allow data to be

shared openly• Let the patient own the data

» Put research in the hands of the patient• Come to us with your ideas and proposals

CALL TO ACTION

Q&A